Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule ...
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Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule material,
This presentation discusses the important role of bioequivalence(BE)study in drug product development,the adjusting of BE evaluation strategy of CDE in recent years,and common defects in BE studies of drug *** discuss...
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This presentation discusses the important role of bioequivalence(BE)study in drug product development,the adjusting of BE evaluation strategy of CDE in recent years,and common defects in BE studies of drug *** discussion also deals with consideration and suggestion on BE test design,handling and retention of test samples,food-effect BE study,revision of guidelines about BE study,etc.
Attachment of poorly soluble and cytotoxic drugs to water soluble polymers can enhance delivery to solid tumors by enhanced permeability and retention effect or active targeting strategies[1].One class of water solubl...
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Attachment of poorly soluble and cytotoxic drugs to water soluble polymers can enhance delivery to solid tumors by enhanced permeability and retention effect or active targeting strategies[1].One class of water soluble polymers used in targeted tumor therapy is N-(2-hydroxypropyl)methacrylamide(HPMA)copolymers[2].A
In the present study,a specific targeting nucleic acid delivery system was rationally designed,which comprised quaternary components(Q-complexes)as a multifunctionally cationic peptide formed of polyarginine conjugati...
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In the present study,a specific targeting nucleic acid delivery system was rationally designed,which comprised quaternary components(Q-complexes)as a multifunctionally cationic peptide formed of polyarginine conjugating with Cell-penetrating peptides with targeting capabilities,cationic liposome self-assembled
Polymeric micelle(PM)drug delivery systems have an enormous potential for improving the efficacy of cancer *** this article,a brain delivery system was engineered by conjugation of cholesterol to polyoxyethylene sorbi...
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Polymeric micelle(PM)drug delivery systems have an enormous potential for improving the efficacy of cancer *** this article,a brain delivery system was engineered by conjugation of cholesterol to polyoxyethylene sorbitol oleate(CPSO)to form an amphipathic material,subsequently facilitating the transport of the micelles
pH-sensitive amphiphilic poly(ethylene glycol)-imine-benzoic-dipalmitate(PEG-I-dC16)polymers with two different PEGs molecular weight were designed and *** molecular structures of the polymers were confirmed with IH *...
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pH-sensitive amphiphilic poly(ethylene glycol)-imine-benzoic-dipalmitate(PEG-I-dC16)polymers with two different PEGs molecular weight were designed and *** molecular structures of the polymers were confirmed with IH *** block polymers readily self-assembling into core/shell micelles in water with
RNA interference(RNAi)is emerging as one of promising strategies for tumor therapy,especially for inhibiting tumor ***,an efficient and safety non-virus delivery system for siRNA is still one of the major *** this work,
RNA interference(RNAi)is emerging as one of promising strategies for tumor therapy,especially for inhibiting tumor ***,an efficient and safety non-virus delivery system for siRNA is still one of the major *** this work,
Poly(DL-lacticco-glycolic acid)(PLGA)microspheres were widely prepared by many methods,such as solvent evaporation,solvent extraction and co-solvent ***,very limited studies have compared the differences between the p...
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Poly(DL-lacticco-glycolic acid)(PLGA)microspheres were widely prepared by many methods,such as solvent evaporation,solvent extraction and co-solvent ***,very limited studies have compared the differences between the properties of microspheres fabricated by these *** is partly because that broad size
Objective:This study was aimed to reveal the exposure of ropinirole in brain after intravenous(Ⅳ),intranasal(IN)or intragastric(IG)administration using in vivo pharmacokinetic and microdialysis ***,the role of the di...
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Objective:This study was aimed to reveal the exposure of ropinirole in brain after intravenous(Ⅳ),intranasal(IN)or intragastric(IG)administration using in vivo pharmacokinetic and microdialysis ***,the role of the direct nose-brain transportation was inspected.
It is well known that febrication process plays an important role in the properties of drug-loaded microparticles(MPs),including encapsulation efficiency,release behavior and so ***,we focused on the effect of two dif...
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It is well known that febrication process plays an important role in the properties of drug-loaded microparticles(MPs),including encapsulation efficiency,release behavior and so ***,we focused on the effect of two different febrication methods on
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