Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(G...
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Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(GA),and provide experimental evidence to evaluate the feasibility of the compound liposomes.
Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells ...
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Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells and currently is undergoing a phase II clinical trial in ***,the poor aqueous solubility（≈10μg/mL）
Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule ...
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Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule material,
Intraocular drug delivery is extraordinarily hampered by the defensive barriers of the eye,which makes the bioavailability of topically applied formulations usually less than 7%.It is more difficult for bioactive macr...
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Intraocular drug delivery is extraordinarily hampered by the defensive barriers of the eye,which makes the bioavailability of topically applied formulations usually less than 7%.It is more difficult for bioactive macro molecules to treat the posterior segment ocular diseases via noninvasive pathway because of their low permeability
Glioma is the most abundant of all primary central nervous system(CNS)*** to the severity of the disease,ghoma is graded fromⅠ(benign)toⅣ(highly mahgnant).And the fow-grade tumors usually evolved into a high-grade g...
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Glioma is the most abundant of all primary central nervous system(CNS)*** to the severity of the disease,ghoma is graded fromⅠ(benign)toⅣ(highly mahgnant).And the fow-grade tumors usually evolved into a high-grade glioblastoma ***,irrespective of their grading,primary ghoma
The applications of superparamagnetic iron oxide nanoparticles (SPIONs), especially in the biomedical field, is rapidly increasing for tumor diagnosis and ***, two problems are common confronted when applying these pa...
The applications of superparamagnetic iron oxide nanoparticles (SPIONs), especially in the biomedical field, is rapidly increasing for tumor diagnosis and ***, two problems are common confronted when applying these particles in vivo: (1) conventional SPIONs have severely nonspecific uptake by non-target cells under the action of an external magnetic field, which weakens the targeting efficiency of SPIONs;(2) at size less than 15 nm, the particles have very limited drug-loading capacity which undermines the curative effect severely.
Typically,sustained drug release is expected to reach high tumor accumulation and reduce drug leakage during the systemic circulation of ***,only drugs that exist as free molecules are able to interact with target mol...
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Typically,sustained drug release is expected to reach high tumor accumulation and reduce drug leakage during the systemic circulation of ***,only drugs that exist as free molecules are able to interact with target molecules and act their pharmacological *** TDDS have been shown to substantially increase
RNA interference(RNAi)is emerging as one of promising strategies for tumor therapy,especially for inhibiting tumor ***,an efficient and safety non-virus delivery system for siRNA is still one of the major *** this work,
RNA interference(RNAi)is emerging as one of promising strategies for tumor therapy,especially for inhibiting tumor ***,an efficient and safety non-virus delivery system for siRNA is still one of the major *** this work,
Poly(DL-lacticco-glycolic acid)(PLGA)microspheres were widely prepared by many methods,such as solvent evaporation,solvent extraction and co-solvent ***,very limited studies have compared the differences between the p...
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Poly(DL-lacticco-glycolic acid)(PLGA)microspheres were widely prepared by many methods,such as solvent evaporation,solvent extraction and co-solvent ***,very limited studies have compared the differences between the properties of microspheres fabricated by these *** is partly because that broad size
OBJECTIVE:Cisplatin is a chemotherapeutic drug commonly used in ***,to overcome the acquired resistance to cisplatin,a combination of chemotherapy and photothermal therapy has emerged as a promising strategy for drug-...
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OBJECTIVE:Cisplatin is a chemotherapeutic drug commonly used in ***,to overcome the acquired resistance to cisplatin,a combination of chemotherapy and photothermal therapy has emerged as a promising strategy for drug-resistant cancer *** therapy is a promising new medical
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