The combination of a rapidly dissolving and supersaturating"spring"with a precipitation retarding"parachute"has often been pursued as an effective formulation strategy for amorphous solid dispersio...
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The combination of a rapidly dissolving and supersaturating"spring"with a precipitation retarding"parachute"has often been pursued as an effective formulation strategy for amorphous solid dispersions(ASDs)to enhance the rate and extent of oral absorption of poorly soluble ***,the interplay between these two rate
In order to prevent non-specific internalization of the drug;and concomitantly enhance the physical stability and tumor target ability of poly(ethylene glycol)-poly(D,L-lactide)(PEG-PLA)micelles,two novel sets of pH-s...
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In order to prevent non-specific internalization of the drug;and concomitantly enhance the physical stability and tumor target ability of poly(ethylene glycol)-poly(D,L-lactide)(PEG-PLA)micelles,two novel sets of pH-sensitive charge-reversal systems,the cell penetrating decapeptide arginine-glycine(RG)s and a pH-sensitive
Angelica sinensis polysaccharide(ASP),one of the active components isolated from Angelica sinensis,being found to be effective in enhancing hematopoiesis,anti-tumor and liver-protect.80%of the liver volume is occupied...
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Angelica sinensis polysaccharide(ASP),one of the active components isolated from Angelica sinensis,being found to be effective in enhancing hematopoiesis,anti-tumor and liver-protect.80%of the liver volume is occupied by parenchymal cells,are the chief functional cells of the Uver and perform an astonishing number of metabolic,endocrine and
Esterase inhibitor screen:As is shown in Table 1,different inhibitors inhibit the degradation of clevidipine to different *** most efficient inhibitor is 4%citric acid,followed by TTFA,BNPP,and *** weakest inhibitor i...
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Esterase inhibitor screen:As is shown in Table 1,different inhibitors inhibit the degradation of clevidipine to different *** most efficient inhibitor is 4%citric acid,followed by TTFA,BNPP,and *** weakest inhibitor is *** general,the degradation of an analyte in biological matrix is significantly sfower when the sample is processed on ice（℃）compared with at room *** order to prevent analytes from oxidation,0.1 M（final concentration）
OBJECTIVE:Functionalized graphene oxide(GO)exhibits near-infrared(NIR)absorbance,photothermal properties,and can be designed to target tumor,and therefore has been recently explored for photothermal therapy(PTT).Howev...
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OBJECTIVE:Functionalized graphene oxide(GO)exhibits near-infrared(NIR)absorbance,photothermal properties,and can be designed to target tumor,and therefore has been recently explored for photothermal therapy(PTT).However,it is highly desired to develop GO-based
A major bottleneck in cancer chemotherapy therapy is to achieve specific drug accumulation at tumor ***-based therapeutic products have been approved to target delivery drug for clinically cancer ***,most nanoparticle...
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A major bottleneck in cancer chemotherapy therapy is to achieve specific drug accumulation at tumor ***-based therapeutic products have been approved to target delivery drug for clinically cancer ***,most nanoparticles are predominantly located near the blood vessels and only delivery to the
*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attent...
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*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attention and offer a promising cancer therapy strategy,as its properties of increasing drug concentration within the
Plasmonic photothermal therapy(PPTT)is a minimally invasive strategy in which photon energy absorbed by plasmonic nanoparticals is converted to localized heat to destroy *** and adequate tumor destruction by PPTT requ...
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Plasmonic photothermal therapy(PPTT)is a minimally invasive strategy in which photon energy absorbed by plasmonic nanoparticals is converted to localized heat to destroy *** and adequate tumor destruction by PPTT requires a lethal dose of heat to be precisely delivered to the entire tumor and ablative ***,
Pachtaxel has been approved for treatment of a variety of carcinomas,including ovarian cancer,breast cancer and non-small-cell lung cancer[1].However,its application is limited because of the solvents:Cremophor EL and...
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Pachtaxel has been approved for treatment of a variety of carcinomas,including ovarian cancer,breast cancer and non-small-cell lung cancer[1].However,its application is limited because of the solvents:Cremophor EL and dehydrated ethanol,which caused the side effects including hypersensitivity reactions,nephrotoxicity and
The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier...
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The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier(BBB).In contrast to oral and parenteral
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