Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,hav...
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Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,have multiple functional groups that are suitable for the bio-conjugation of drugs,signaling groups,and targeting
Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatb...
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Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatbn"states that antiangio genic therapies turn abnormal tumor vessel structure and function return to
Asthma is a common disease of pediatrics that can be treated withtulobuterol patch,avoiding inconvenience of injecting including pains and repeated administration as well as of oral route such as difficulty in *** are...
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Asthma is a common disease of pediatrics that can be treated withtulobuterol patch,avoiding inconvenience of injecting including pains and repeated administration as well as of oral route such as difficulty in *** are are natural,biocompatible molecules and similar to biomembrane composition,thus they are
The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier...
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The development of effective therapies for central nervous system(CNS)disorders remains a critical challenge for the pharmaceutical *** of the most important obstacles for drag brain delivery is the bbod brain barrier(BBB).In contrast to oral and parenteral
The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid dru...
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The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid drugs from lysosomes and endosomes,we prepared anovel photosensitive carrier(C60-Dex-NH2)
OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A n...
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OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A new class of multifunctional theranostic agents based on bovine serum
Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high ...
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Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high biocompatibility and biological stability.[1]However,the difficulty in their synthesis,low molecular weight,
There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug de...
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There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug delivery systems(NDDS)offer many more advantages,which include improved therapy by increasing the efficacy and duration of drug activity,increased
Traditional Chinese medicine in hospital is the foundation of the development of new drug and also a well complement of pharmaceutical *** leadership of maternal and child health hospital of hunan province closely com...
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Traditional Chinese medicine in hospital is the foundation of the development of new drug and also a well complement of pharmaceutical *** leadership of maternal and child health hospital of hunan province closely combines pharmacy and Clinical Journal of Chinese Medicine,set up quality guarantee system in accordance with GMP standard and traditional Chinese
Aim:To develop a theranostic nanoemulsion(TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel(PTX) and a hydrophilic imaging probe sulforhodamine B(SRB).Materials & methods:The TNE was establi...
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Aim:To develop a theranostic nanoemulsion(TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel(PTX) and a hydrophilic imaging probe sulforhodamine B(SRB).Materials & methods:The TNE was established using core-matched technology,and can achieve high encapsulation efficiency and synchronized release of the loaded *** has been examined for a correlation between the dynamic uptake of PTX and the intensity of SRB imaging signal in different *** & discussion:Our data demonstrates that the TNE,with improved circulation time,increases therapeutic efficacy and imaging efficiency in both drug-sensitive and drug-resistant *** TNE could not satisfy the demand of visual diagnosis in the living animal because of *** therefore formulated a long-circulating theranostic nanoemulsion(LCTNE).Results showed that the LCTNE can meet imaging requirements in ***:The LCTNE increases therapeutic efficacy and imaging efficiency for both tumor types *** LCTNE plays a good therapeutic and diagnostic role for subcutaneous tumors in the hving *** The LCTNE reported here provides insights into the development of new theranostic nanocarriers for the treatment of MDR in cancer.
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