OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A n...
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OBJECTIVE:To develop a hybrid nanoprobe for simultaneous triple-modality MRI-photoacoustic-NIR imaging and photothermal *** approach is clinically important,as it can minimize invasiveness and deleterious side ***:A new class of multifunctional theranostic agents based on bovine serum
Objective: In the past few years, aptamer physisorbed on graphene oxide (GO) has emerged as a useful sensing platform In a typical assay, a fluorescently labeled aptamer probe is adsorbed by GO and the target analyte ...
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Objective: In the past few years, aptamer physisorbed on graphene oxide (GO) has emerged as a useful sensing platform In a typical assay, a fluorescently labeled aptamer probe is adsorbed by GO and the target analyte induces probe desorption and fluorescence ***, in these systems, some non-target analytes can also desorption the physisorbed *** address the non-specific displacement, we herein report a covalent linked aptamer probe for ATP detection (Figure 1).
There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug de...
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There are more than 1400 sustained or controlled release drugs approved all over the *** within the global generics market reached an estimated value of$265 b in 2012,showing a growth of 9.3%throughout the *** drug delivery systems(NDDS)offer many more advantages,which include improved therapy by increasing the efficacy and duration of drug activity,increased
Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)wer...
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Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)were conjugated to poly
Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to ca...
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Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to cancer may come from a drug stimulus,leading to the overexpression of ATP-binding cassette
*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attent...
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*** Chlorambucil(CHL)is used tor chemotherapy of lymphocytic leukemia,ovarian and breast carcinomas,and Hodgkin's ***,its use is limited by its toxic side *** carriers for drug delivery have attracted great attention and offer a promising cancer therapy strategy,as its properties of increasing drug concentration within the
Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy a...
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Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy and ***,few people focused on its application in drug delivery and *** this study,we roundly investigated 5 kinds of PHAs(PHB,PHBV,PHBHHx,PHBVHHx and P3HB4 HB,respectively) to prepare microspheres as novel drug carriers for application in drug delivery.
Esterase inhibitor screen:As is shown in Table 1,different inhibitors inhibit the degradation of clevidipine to different *** most efficient inhibitor is 4%citric acid,followed by TTFA,BNPP,and *** weakest inhibitor i...
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Esterase inhibitor screen:As is shown in Table 1,different inhibitors inhibit the degradation of clevidipine to different *** most efficient inhibitor is 4%citric acid,followed by TTFA,BNPP,and *** weakest inhibitor is *** general,the degradation of an analyte in biological matrix is significantly sfower when the sample is processed on ice（℃）compared with at room *** order to prevent analytes from oxidation,0.1 M（final concentration）
Obejective There is a large amount of evidence demonstrating that many tumors have high bw density lipoprotein(LDL)requirements and express relatively high levels of LDL receptors on their *** this account,LDL has ins...
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Obejective There is a large amount of evidence demonstrating that many tumors have high bw density lipoprotein(LDL)requirements and express relatively high levels of LDL receptors on their *** this account,LDL has instinctive cancer targeting potential and has been used to incorporate various hpophihc molecules to transport
The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid dru...
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The clinical applications of cationic non-viral vectors are limited because of their low transfection *** difficulty of lysosome escape is one of the main *** order to improve the escape efficiency of nucleic acid drugs from lysosomes and endosomes,we prepared anovel photosensitive carrier(C60-Dex-NH2)
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