Efficient drug delivery via polymeric nanocarriers has to cope with multiple challenges,one of which is the dilemma of premature drug release and site-specific controlled drug ***- triggered drug release is a versatil...
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Efficient drug delivery via polymeric nanocarriers has to cope with multiple challenges,one of which is the dilemma of premature drug release and site-specific controlled drug ***- triggered drug release is a versatile strategy to address such dilemma due to the abundance of pH gradients in human body and the presence of a large collection of acid-liable *** we report four examples utilizing pH as a trigger at organ and cellular ***,the acne skin is characteristic of a relatively lower pH microenvironment compared to the healthy *** anti-acne agent,adapalene,was encapsulated in pH-responsive polymer(Eudragit EPO)nanocarriers that exhibited enhanced drug release at acidic conditions;this indicated that the pH abnormality of diseased skin could be a useful trigger for to enhance topical drug ***,we found that hydro zone-linked polymer-drug conjugate micelles demonstrated improved intracellular drug delivery,but the split amino-ended polymer also showed considerable *** results are encouraging for chemotherapy due to the potential of enhanced efficacy,but present the issue of elevated side-effects to healthy ***,a pleiotropic agent,curcumin was selected to generate two types of amphophilic polymer-curcumin conjugates with hydrazone as a pH-liable linker;one is linear and the other is *** was revealed that the conjugate architecture played a significant role in determining the pharmaceutical properties and delivery efficiency of nanocarriers assembled by these *** linear one is superior to its counterpart regarding loading,release,cellular uptake,and cytotoxicity,except the ***,tailored dendrimer surfece engineering was employed to produce uniform nanocarriers with tunable surfece hydrophobicity for controlled drug *** neutral condition,the drug was secured inside the nanocarriers,whereas a rapid drug release was observed under the acidic circumstances.T
Nanotechnology brings great opportunities to solve the problems of drug absoroption and the development of nanoproduct has achieved great ***,the mechanisms of nanocarriers improve drug absorption are limit *** resear...
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Nanotechnology brings great opportunities to solve the problems of drug absoroption and the development of nanoproduct has achieved great ***,the mechanisms of nanocarriers improve drug absorption are limit *** researchers have summarized the main factors influencing the
Doxorubicin(DOX)is a commonly used chemotherapy drug for treating ***,the severe non-selective toxicity and development of multiple drug resistance(MDR)hinder its clinical ***,it is imperative to devefop a novel drug ...
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Doxorubicin(DOX)is a commonly used chemotherapy drug for treating ***,the severe non-selective toxicity and development of multiple drug resistance(MDR)hinder its clinical ***,it is imperative to devefop a novel drug delivery system,which can not only dehver DOX to tumor sites but also overcome MDR
Background:Following ingestion,dietary triglycerides(TG)are digested,absorbed,resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipop...
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Background:Following ingestion,dietary triglycerides(TG)are digested,absorbed,resynthesised and highly efficiently transported into and through the intestinal lymphatic system in the form of enterocyte-assembled lipoproteins(LP).This provides a potential conduit for drug delivery via the design of prodrugs that mimic the structural intermediates
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events,such as ...
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Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events,such as overexpression of ATP-binding cassette transporters(typically,p-glycoproteins,P-gp)and malfunction of ***-penetrating peptide-based strategies were developed for overcoming the barriers against effective cancer drug delivery,through the mechanisms including increased tumor penetration,enhanced intracellular and intranuclear delivery,prolonged intracellular drug retention,thus yielding promising treatment benefits in the animal models.
With the progressive development of pharmaceutical science,many novel processing methods and technologies are becoming ***,very few of such technologies are emptoyed in the pharmaceutical industry and the development ...
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With the progressive development of pharmaceutical science,many novel processing methods and technologies are becoming ***,very few of such technologies are emptoyed in the pharmaceutical industry and the development of products by which are significantly ***,it is essentially urgent to
According to the EMA"Guideline on Pharmaceutical Development of Medicines for Paediatric Use"the'Taediatric Regulation"aims to facilitate the devebpment and accessibility of age-appropriate paediatr...
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According to the EMA"Guideline on Pharmaceutical Development of Medicines for Paediatric Use"the'Taediatric Regulation"aims to facilitate the devebpment and accessibility of age-appropriate paediatric medicines,whereas this aim should be achieved without subjecting children to unnecessary clinical trials.A critical objective
As a platform for life cycle management,fixed-dose combinations(FDC)have attracted increasing attention in the pharmaceutical *** tablets are often utilized as a cost effective platform to formulate FDCs with chemical...
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As a platform for life cycle management,fixed-dose combinations(FDC)have attracted increasing attention in the pharmaceutical *** tablets are often utilized as a cost effective platform to formulate FDCs with chemically incompatible API components,uncoated bilayer cores for osmotic pump or matrix tablet formulations with
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