One of the major obstacle in achieving effective tumor drug therapy is the membrane barrier of tumor cells that is permeable to only small (<700 Da) and hydrophobic *** most widely used method to-date in achiev...
One of the major obstacle in achieving effective tumor drug therapy is the membrane barrier of tumor cells that is permeable to only small (<700 Da) and hydrophobic *** most widely used method to-date in achieving intracellular drug delivery is via the receptor-mediated endocytosis.
Purpose A subcutaneous exenatide delivery system was developed to achieve sustained release via mesoporous silicon *** Exenatide was loaded into mesoporous silicon *** vitro, EXT@SBA-15 release was investigated by ***...
Purpose A subcutaneous exenatide delivery system was developed to achieve sustained release via mesoporous silicon *** Exenatide was loaded into mesoporous silicon *** vitro, EXT@SBA-15 release was investigated by *** vivo, EXT plasma concentrations were analyzed after delivery in *** they were determined using the exendin-4 *** use diabetic mice to monitor blood glucose.
Development of safe and efficient small interfering RNA (siRNA) delivery systems still remains elusive in clinical applications of siRNA for cancer treatment.[1] An ideal siRNA delivery system is required to be stable...
Development of safe and efficient small interfering RNA (siRNA) delivery systems still remains elusive in clinical applications of siRNA for cancer treatment.[1] An ideal siRNA delivery system is required to be stable in the blood for preferential tumor targeting and overcome a variety of physiological barriers followed by efficient intracellular siRNA release for enhanced therapeutic efficacy.
With the progressive development of pharmaceutical science,many novel processing methods and technologies are becoming ***,very few of such technologies are emptoyed in the pharmaceutical industry and the development ...
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With the progressive development of pharmaceutical science,many novel processing methods and technologies are becoming ***,very few of such technologies are emptoyed in the pharmaceutical industry and the development of products by which are significantly ***,it is essentially urgent to
As a platform for life cycle management,fixed-dose combinations(FDC)have attracted increasing attention in the pharmaceutical *** tablets are often utilized as a cost effective platform to formulate FDCs with chemical...
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As a platform for life cycle management,fixed-dose combinations(FDC)have attracted increasing attention in the pharmaceutical *** tablets are often utilized as a cost effective platform to formulate FDCs with chemically incompatible API components,uncoated bilayer cores for osmotic pump or matrix tablet formulations with
Biological macro molecular drugs such as polypeptides,proteins,nucleic acid,etc.,are generally administered by injection due to their poor stability,short half-life,not easy to pass through the biological membrane and...
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Biological macro molecular drugs such as polypeptides,proteins,nucleic acid,etc.,are generally administered by injection due to their poor stability,short half-life,not easy to pass through the biological membrane and low oral ***,as long term
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