Understanding the performance of engineered micro/nano materials in a biological context is an important issue for guiding their biomedical *** two-dimensional nanomaterial graphene oxide(GO)has attracted explosive in...
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Understanding the performance of engineered micro/nano materials in a biological context is an important issue for guiding their biomedical *** two-dimensional nanomaterial graphene oxide(GO)has attracted explosive interests in various ***,its performance in biological environments is still largely
According to the EMA"Guideline on Pharmaceutical Development of Medicines for Paediatric Use"the'Taediatric Regulation"aims to facilitate the devebpment and accessibility of age-appropriate paediatr...
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According to the EMA"Guideline on Pharmaceutical Development of Medicines for Paediatric Use"the'Taediatric Regulation"aims to facilitate the devebpment and accessibility of age-appropriate paediatric medicines,whereas this aim should be achieved without subjecting children to unnecessary clinical trials.A critical objective
Chemotherapy is widely used to treat *** is nonetheless accompanied by terrible side-effects resulting from the ubiquitous exposure in the body to cytotoxic chemicals that are intended to eliminate malignant *** the s...
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Chemotherapy is widely used to treat *** is nonetheless accompanied by terrible side-effects resulting from the ubiquitous exposure in the body to cytotoxic chemicals that are intended to eliminate malignant *** the systemic toxicities is the universal utilization of carrier chemicals to deliver the c he mo therapeutic drugs.
Recent studies have shown that many promising new drug candidates were abandoned due to poor pharmacokinetic properties(PKs).Therefore,it is desirable to develop effective and accurate methods for estimating the pharm...
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Recent studies have shown that many promising new drug candidates were abandoned due to poor pharmacokinetic properties(PKs).Therefore,it is desirable to develop effective and accurate methods for estimating the pharmacokinetic properties of a candidate drug as early as possible during drug discovery and ***
During the last two decades,many modern technologies have been established in the pharmaceutical research and development *** automation of the drug discovery process by technologies such as high-throughput screening,...
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During the last two decades,many modern technologies have been established in the pharmaceutical research and development *** automation of the drug discovery process by technologies such as high-throughput screening,combinatorial chemistry,and computer-aided drug design is leading to
Mesoporous silica nanoparticles (MSNs) are new material system at the end of 20th *** have unique properties such as large surface area(~1000 m2g-1),large pore volume (~1cm3g-1) ,controllable pore size (2~50 nm), very...
Mesoporous silica nanoparticles (MSNs) are new material system at the end of 20th *** have unique properties such as large surface area(~1000 m2g-1),large pore volume (~1cm3g-1) ,controllable pore size (2~50 nm), very narrow particle size distribution and open pore ***, MSNs are widely used in the field of drug delivery system, protein separation, adsorption, molecular sieving and catalysis.
This paper reports a drug-loaded three-phase microbubble fabrication method using a silicon capillary inserted three-phase microfluidic chips(Figure la),which can precise control fluid,to improve the size uniformity,t...
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This paper reports a drug-loaded three-phase microbubble fabrication method using a silicon capillary inserted three-phase microfluidic chips(Figure la),which can precise control fluid,to improve the size uniformity,the drug entrapment efficiency and the
Hot melt extrusion(HME)is a powerful technology to enhance the solubility and bioavailability of poorly water-soluble drugs by producing amorphous/crystalline solid dispersions or *** the number of articles and patent...
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Hot melt extrusion(HME)is a powerful technology to enhance the solubility and bioavailability of poorly water-soluble drugs by producing amorphous/crystalline solid dispersions or *** the number of articles and patents about HME increased dramatically in the past twenty years,there are very few commercial products by *** main
Objective:The aim of this study is to provide a theoretical method on the basis of Hansen solubility parameters(HSPs)for screening drug-polymer pairs in the early stage of grafted polymeric micelles ***:The compatibil...
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Objective:The aim of this study is to provide a theoretical method on the basis of Hansen solubility parameters(HSPs)for screening drug-polymer pairs in the early stage of grafted polymeric micelles ***:The compatibility of drug and polymer was evaluated by HSPs with the
Computational pharmaceutics integrates computer modelling technique and experimental approaches to investigate molecular mechanism of pharmaceutical formulations for better medicines.[1]Two examples were discussed,inc...
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Computational pharmaceutics integrates computer modelling technique and experimental approaches to investigate molecular mechanism of pharmaceutical formulations for better medicines.[1]Two examples were discussed,including solid dispersion and siRNA *** solid dispersion,the molecular structure of solid
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