Development of therapeutic tumor vaccine is a very hot topic in ***,as both tumor-related and tumor-specific antigens generally suffer from short in vivo half-lives,as well as poor uptake and processing efficiency by ...
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Development of therapeutic tumor vaccine is a very hot topic in ***,as both tumor-related and tumor-specific antigens generally suffer from short in vivo half-lives,as well as poor uptake and processing efficiency by antigen presenting cells(APCs),ineffective antigen presentation and weak immune stimulation
The usage of many solid dosage form drugs is often limited by its bioavailability,which is often limited by their physicochemical properties,such as solubility,stabihty and so *** formation is the most common method f...
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The usage of many solid dosage form drugs is often limited by its bioavailability,which is often limited by their physicochemical properties,such as solubility,stabihty and so *** formation is the most common method for improving solubihty and dissolution rates of acidic and basic drugs,while cocrystal formation plays an
Drug packaging materials should present a good compatibility with drugs so as to ensure the stabihty,eflectivity as well as the safety of the contained drug products,avoiding introducing leachables that may cause safe...
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Drug packaging materials should present a good compatibility with drugs so as to ensure the stabihty,eflectivity as well as the safety of the contained drug products,avoiding introducing leachables that may cause safety *** the infusion product is one of the high-risk pharmaceutical products,the tests of compatibility between
Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells ...
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Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells and currently is undergoing a phase II clinical trial in ***,the poor aqueous solubility（≈10μg/mL）
Objective:to investigate the effect of high temperature,high humidity,strong light conditions on release behavior of Vera Pammy sustained release ***:placing Vera Pammy hydrochloride sustained release microspheresres ...
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Objective:to investigate the effect of high temperature,high humidity,strong light conditions on release behavior of Vera Pammy sustained release ***:placing Vera Pammy hydrochloride sustained release microspheresres pectively at 60℃,relative humidity 90%±5%,4500lx±500lx conditions for 10 days.
Purpose:Here,we report the safety,tumor accumulation and potential of polyethylene glycol-grafted graphene oxide(pGO)as a multimodal nanocarrier of photosensitizers and synergistic anticancer ***:First,both graphene o...
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Purpose:Here,we report the safety,tumor accumulation and potential of polyethylene glycol-grafted graphene oxide(pGO)as a multimodal nanocarrier of photosensitizers and synergistic anticancer ***:First,both graphene oxide(GO)and pGO were synthesized,and their in
Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(G...
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Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(GA),and provide experimental evidence to evaluate the feasibility of the compound liposomes.
Poor water-solubility is becoming the leading hurdle for water-insolubility drug to reach the *** the varbus technobgies to improve the oral bioavailability of water-insolubility drugs,nanocrystal technique is quite e...
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Poor water-solubility is becoming the leading hurdle for water-insolubility drug to reach the *** the varbus technobgies to improve the oral bioavailability of water-insolubility drugs,nanocrystal technique is quite eye-catching,for which could break the drug into nano scale,thus enhancing the saturatbn solubility and
Objective:The objective of this study was to investigate the feasibility of MD as a tool to determine the skin concentration of mometason furoate(MF),a lipophilic,highly protein-bound *** and results:The relative reco...
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Objective:The objective of this study was to investigate the feasibility of MD as a tool to determine the skin concentration of mometason furoate(MF),a lipophilic,highly protein-bound *** and results:The relative recovery(RR)of mometasone fliroate was
Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule ...
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Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule material,
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