Developing pediatric drug products with poorly water soluble drugs is a challenging *** oral delivery technologies are required to improve both the rate and extent of absorption of these poorly soluble *** presentatio...
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Developing pediatric drug products with poorly water soluble drugs is a challenging *** oral delivery technologies are required to improve both the rate and extent of absorption of these poorly soluble *** presentation will review the fundamental principles and key attributes of commonly used enabling formulation approacheswith respect to practical applications suitable for pediatric *** particular,it is intended to provide a balanced review of both benefits and limitations among these enabling technologies.
OBJECTIVE:Cisplatin is a chemotherapeutic drug commonly used in ***,to overcome the acquired resistance to cisplatin,a combination of chemotherapy and photothermal therapy has emerged as a promising strategy for drug-...
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OBJECTIVE:Cisplatin is a chemotherapeutic drug commonly used in ***,to overcome the acquired resistance to cisplatin,a combination of chemotherapy and photothermal therapy has emerged as a promising strategy for drug-resistant cancer *** therapy is a promising new medical
A full understanding of the molecular basis of diseases depends on the development of molecular probes able to recognize disease targets of *** very recently,such tools have been absent from the clinical practice of *...
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A full understanding of the molecular basis of diseases depends on the development of molecular probes able to recognize disease targets of *** very recently,such tools have been absent from the clinical practice of *** newest molecular probe,and one that holds most promise,is a new class of designer nucleic acids,termed aptamers,which are single-stranded DNA/RNAable to recognize specific targets,such as single proteins and even small ***,we applied a simple,fast and
Chitosan has been adopted to have great potentials in pharmaceutical science due to its outstanding properties of nontoxicity,biocompatibility,biodegradability,and tow *** cater to specific clinical requirements,we de...
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Chitosan has been adopted to have great potentials in pharmaceutical science due to its outstanding properties of nontoxicity,biocompatibility,biodegradability,and tow *** cater to specific clinical requirements,we developed a series of novel chitosan-based mciro/nano spheres and testified their potenials in pharmaceutical
Background:Owing to the magnetic properties,the MSNs provides unique opportunities for simultaneous diagnosis and therapy with the MSN-based multifunctional nanocomposites both as drug dehvery system but also as an im...
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Background:Owing to the magnetic properties,the MSNs provides unique opportunities for simultaneous diagnosis and therapy with the MSN-based multifunctional nanocomposites both as drug dehvery system but also as an imaging *** our study,chitosan,one of the well-recognized biocompatibfe coating
The overexpress of certain integrins on cancer cells have been used as the basis for drug design and dehvery of anticancer agents in cancer drug *** integrin with RGD binding sites has widely explored for targeted dru...
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The overexpress of certain integrins on cancer cells have been used as the basis for drug design and dehvery of anticancer agents in cancer drug *** integrin with RGD binding sites has widely explored for targeted drug dehvery in the integrin family,while other integrins only have limited reports as target for this *** strategies to deliver anticancer agents to integrin overexpressing
In this study,we carried out experiments to investigate the growth inhibitory effects of lentinan atone and its combination with oxalip latin against human HepG2 cells in vitro and H22 tumor-bearing mice in vivo.
In this study,we carried out experiments to investigate the growth inhibitory effects of lentinan atone and its combination with oxalip latin against human HepG2 cells in vitro and H22 tumor-bearing mice in vivo.
Objective To develop a novel type of vincristine sulfate(VCR)-baded multifunctional nanoparticles(VCR-Fol/R7 NPs),and to confirm their tumor targeting and multidrug resistance(MDR)characters in vivo and in *** Firstly...
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Objective To develop a novel type of vincristine sulfate(VCR)-baded multifunctional nanoparticles(VCR-Fol/R7 NPs),and to confirm their tumor targeting and multidrug resistance(MDR)characters in vivo and in *** Firstly,in vitro HPLC analysis method was established for VCR detectioa Then VCR-Fol/R7 NPs composed of PLGA-mPEG,PLGA-PEG-Folate,PLGA-PEG-
Background Mucosal adhesion is a prerequisite for successful oral film in buccal delivery *** present research work focused on the comparative assessment of adhesive materials complex and modified in order to devebp a...
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Background Mucosal adhesion is a prerequisite for successful oral film in buccal delivery *** present research work focused on the comparative assessment of adhesive materials complex and modified in order to devebp a high adhesion for film,but the surface morphobgy involved were seldom investigated.
The research interest in nanomedicine has grown rapidly over the last *** various nanostructures,poly(N-(2-hydroxypropyl)methacrylamide(PHPMA)-drug conjugates have demonstrated numerous advantages.1 However,although H...
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The research interest in nanomedicine has grown rapidly over the last *** various nanostructures,poly(N-(2-hydroxypropyl)methacrylamide(PHPMA)-drug conjugates have demonstrated numerous advantages.1 However,although HPMA copolymer-anticancer drug conjugates have been evaluated in clinical trials
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