Development of therapeutic tumor vaccine is a very hot topic in ***,as both tumor-related and tumor-specific antigens generally suffer from short in vivo half-lives,as well as poor uptake and processing efficiency by ...
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Development of therapeutic tumor vaccine is a very hot topic in ***,as both tumor-related and tumor-specific antigens generally suffer from short in vivo half-lives,as well as poor uptake and processing efficiency by antigen presenting cells(APCs),ineffective antigen presentation and weak immune stimulation
Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,hav...
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Introduction:Dendrimers are a new class of polymeric materials that possess various advantagesand,have emerged as one of the most promising drug delivery *** addition,dendrimers have a low polydispersity index and,have multiple functional groups that are suitable for the bio-conjugation of drugs,signaling groups,and targeting
Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatb...
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Introduction:Tumor-specific abnormalities in the microenvironment play a critical role in hanpering drug treatment efficacy and contributing to drug *** emerging therapeutic strategy of"tumor vascular normalizatbn"states that antiangio genic therapies turn abnormal tumor vessel structure and function return to
Asthma is a common disease of pediatrics that can be treated withtulobuterol patch,avoiding inconvenience of injecting including pains and repeated administration as well as of oral route such as difficulty in *** are...
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Asthma is a common disease of pediatrics that can be treated withtulobuterol patch,avoiding inconvenience of injecting including pains and repeated administration as well as of oral route such as difficulty in *** are are natural,biocompatible molecules and similar to biomembrane composition,thus they are
Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells ...
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Gambogic acid(GA;CHO),the main active ingredient isolated from the dry gum-resin of Garcinia hanburyi,has recently been established as a potent anticancer agent that can inhibit the growth of a variety of tumor cells and currently is undergoing a phase II clinical trial in ***,the poor aqueous solubility（≈10μg/mL）
Objective:to investigate the effect of high temperature,high humidity,strong light conditions on release behavior of Vera Pammy sustained release ***:placing Vera Pammy hydrochloride sustained release microspheresres ...
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Objective:to investigate the effect of high temperature,high humidity,strong light conditions on release behavior of Vera Pammy sustained release ***:placing Vera Pammy hydrochloride sustained release microspheresres pectively at 60℃,relative humidity 90%±5%,4500lx±500lx conditions for 10 days.
Purpose:Here,we report the safety,tumor accumulation and potential of polyethylene glycol-grafted graphene oxide(pGO)as a multimodal nanocarrier of photosensitizers and synergistic anticancer ***:First,both graphene o...
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Purpose:Here,we report the safety,tumor accumulation and potential of polyethylene glycol-grafted graphene oxide(pGO)as a multimodal nanocarrier of photosensitizers and synergistic anticancer ***:First,both graphene oxide(GO)and pGO were synthesized,and their in
Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(G...
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Objective We research in vivo pharmacokinetics and tissue distribution of GS-lip to investigate the reasonability of compatibility of compound liposomes which contain Salvianolic acid B(Sal B)and Glycyrrhetinic acid(GA),and provide experimental evidence to evaluate the feasibility of the compound liposomes.
Poor water-solubility is becoming the leading hurdle for water-insolubility drug to reach the *** the varbus technobgies to improve the oral bioavailability of water-insolubility drugs,nanocrystal technique is quite e...
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Poor water-solubility is becoming the leading hurdle for water-insolubility drug to reach the *** the varbus technobgies to improve the oral bioavailability of water-insolubility drugs,nanocrystal technique is quite eye-catching,for which could break the drug into nano scale,thus enhancing the saturatbn solubility and
Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high ...
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Dendrimers with defined 3-D spherical hyperb ranched structures are promising carriers for drug and imaging probe *** various dendritic carriers,polyglycerol dendrimers(PGDs)attracted great interest due to their high biocompatibility and biological stability.[1]However,the difficulty in their synthesis,low molecular weight,
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