A tumor cell-targeted prodrug was developed for quercetin,using hyaluronic acid as polymeric *** acid-quercetin(HA-QT)bioconjugates were synthesized by linking the hydroxy of quercetin via a succinate ester to adipic
A tumor cell-targeted prodrug was developed for quercetin,using hyaluronic acid as polymeric *** acid-quercetin(HA-QT)bioconjugates were synthesized by linking the hydroxy of quercetin via a succinate ester to adipic
The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past *** acid labile hydrazine bonds were formed by conjugating DOX onto side *** other drugs such as Paclitaxel (PT...
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The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past *** acid labile hydrazine bonds were formed by conjugating DOX onto side *** other drugs such as Paclitaxel (PTX) and cisplatin are not applicable for the lack of special functional *** this study, diblock copolymers, poly(ethylene glycol)-hydrazone-poly (lactic acid) (PEG-Hz-PLA) containing pH-responsive hydrazone bond between hydrophilic and hydrophobic segments were synthesized.
Inhibiting tumor-associated angiogenesis is a validated major strategy in cancer *** drug targets desired to be excavated for the poor response and resistance of the early antiangiogenic ***, Dll4-Notch signaling path...
Inhibiting tumor-associated angiogenesis is a validated major strategy in cancer *** drug targets desired to be excavated for the poor response and resistance of the early antiangiogenic ***, Dll4-Notch signaling pathway has emerged as a critical regulator of the development and maintenance of tumor ***-like ligand 4 (Dl14), the only Notch ligand to be selectively over-expressed on endothelial cells, is involved in tumor ***, Dll4 is a negative-feedback regulator of angiogenesis and strongly upregulated in tumor vasculature.
The OX26-PEG-CSLN was prepared by the emulsion evaporation-solidification at low temperature method and mercaptan modification *** average particle size of OXe26-PEG-CSLN was 47.68±1.65 nm and the zeta potent...
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The OX26-PEG-CSLN was prepared by the emulsion evaporation-solidification at low temperature method and mercaptan modification *** average particle size of OXe26-PEG-CSLN was 47.68±1.65 nm and the zeta potential was-0.533±0.115 mV.
A variety of pharmaceutical agents have been developed for cancer ***,because the hydrophobic cell membrane hampers cellular uptake in the absence of active transport,it is not trivial for anti-tumor agents to reach t...
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A variety of pharmaceutical agents have been developed for cancer ***,because the hydrophobic cell membrane hampers cellular uptake in the absence of active transport,it is not trivial for anti-tumor agents to reach their designated intracellular *** internalization of c he mo therapeutic
We took advantage of the poor solubihty of cisplatin to prepare a nano-precipitate which is stabilized with a single lipid bilayer *** resulting nanopartkles,containing 80-90%cisplatin by mass,are further functionaliz...
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We took advantage of the poor solubihty of cisplatin to prepare a nano-precipitate which is stabilized with a single lipid bilayer *** resulting nanopartkles,containing 80-90%cisplatin by mass,are further functionalized with anisamide for sigma receptor *** cisplatin releases cisplatin inside the cells over-expressing the *** associated fibroblasts(TAFs)are the major cells
Polymeric micelles represent a promising drug carrier system that has gained considerable attention due to its simplicity,small sizes(10-100 nm),and the ability to solubilize water-insoluble drugs and accumulate speci...
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Polymeric micelles represent a promising drug carrier system that has gained considerable attention due to its simplicity,small sizes(10-100 nm),and the ability to solubilize water-insoluble drugs and accumulate specifically at the *** of the carrier materials in polymeric drug delivery systems(including lipid-core micellar
INTRODUCTION:Immunotherapy is to generate a robust immune response that confers long-lasting protection against tumor invasion,metastasis or *** T cell immunity using antigen-adjuvant combinations has been achieved by...
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INTRODUCTION:Immunotherapy is to generate a robust immune response that confers long-lasting protection against tumor invasion,metastasis or *** T cell immunity using antigen-adjuvant combinations has been achieved by encapsulating them in *** reduce systemic dispersion and promote DCs
The changing landscape both in the pharmaceutical industry and in academia has led to an increased need to better prepare graduate students for careers in industry,academia,and *** a 2013 AAPS retreat focusing on the ...
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The changing landscape both in the pharmaceutical industry and in academia has led to an increased need to better prepare graduate students for careers in industry,academia,and *** a 2013 AAPS retreat focusing on the needs of our graduates,certainly a strong scientific knowledge is deemed important,but also "soft
In drug delivery systems,protein-based capsules have attracted attention among various hollow vehicles due to the good biocompatibihty and distinct mechanical properties of natural proteins.[l,2]In this study,silk fib...
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In drug delivery systems,protein-based capsules have attracted attention among various hollow vehicles due to the good biocompatibihty and distinct mechanical properties of natural proteins.[l,2]In this study,silk fibroin nanocapsules were
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