Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule ...
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Background:PLGA-based microspheres are widely used in sustained delivery of chemicals,but PLGA will produce acid degradation products(lactic acid and glycolic acid),which will impact protein ***,a novel macromolecule material,
This presentation discusses the important role of bioequivalence(BE)study in drug product development,the adjusting of BE evaluation strategy of CDE in recent years,and common defects in BE studies of drug *** discuss...
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This presentation discusses the important role of bioequivalence(BE)study in drug product development,the adjusting of BE evaluation strategy of CDE in recent years,and common defects in BE studies of drug *** discussion also deals with consideration and suggestion on BE test design,handling and retention of test samples,food-effect BE study,revision of guidelines about BE study,etc.
Attachment of poorly soluble and cytotoxic drugs to water soluble polymers can enhance delivery to solid tumors by enhanced permeability and retention effect or active targeting strategies[1].One class of water solubl...
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Attachment of poorly soluble and cytotoxic drugs to water soluble polymers can enhance delivery to solid tumors by enhanced permeability and retention effect or active targeting strategies[1].One class of water soluble polymers used in targeted tumor therapy is N-(2-hydroxypropyl)methacrylamide(HPMA)copolymers[2].A
Polymeric micelle(PM)drug delivery systems have an enormous potential for improving the efficacy of cancer *** this article,a brain delivery system was engineered by conjugation of cholesterol to polyoxyethylene sorbi...
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Polymeric micelle(PM)drug delivery systems have an enormous potential for improving the efficacy of cancer *** this article,a brain delivery system was engineered by conjugation of cholesterol to polyoxyethylene sorbitol oleate(CPSO)to form an amphipathic material,subsequently facilitating the transport of the micelles
pH-sensitive amphiphilic poly(ethylene glycol)-imine-benzoic-dipalmitate(PEG-I-dC16)polymers with two different PEGs molecular weight were designed and *** molecular structures of the polymers were confirmed with IH *...
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pH-sensitive amphiphilic poly(ethylene glycol)-imine-benzoic-dipalmitate(PEG-I-dC16)polymers with two different PEGs molecular weight were designed and *** molecular structures of the polymers were confirmed with IH *** block polymers readily self-assembling into core/shell micelles in water with
Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy a...
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Polyhydroxyalkanoate(PHA) is a class of polyesters and synthesized in various *** to biodegradable and good biocompatibility,PHA have been widely researched and applied in medicine,tissue engineering,food,bio-energy and ***,few people focused on its application in drug delivery and *** this study,we roundly investigated 5 kinds of PHAs(PHB,PHBV,PHBHHx,PHBVHHx and P3HB4 HB,respectively) to prepare microspheres as novel drug carriers for application in drug delivery.
Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to ca...
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Background Multidrug resistance(MDR)is most common reason related to the failure of chemotherapy in *** multidrug resistance includes intrinsic multidrug resistance and acquired multidrug *** acquired resistance to cancer may come from a drug stimulus,leading to the overexpression of ATP-binding cassette
Objective:This study was aimed to reveal the exposure of ropinirole in brain after intravenous(Ⅳ),intranasal(IN)or intragastric(IG)administration using in vivo pharmacokinetic and microdialysis ***,the role of the di...
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Objective:This study was aimed to reveal the exposure of ropinirole in brain after intravenous(Ⅳ),intranasal(IN)or intragastric(IG)administration using in vivo pharmacokinetic and microdialysis ***,the role of the direct nose-brain transportation was inspected.
It is well known that febrication process plays an important role in the properties of drug-loaded microparticles(MPs),including encapsulation efficiency,release behavior and so ***,we focused on the effect of two dif...
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It is well known that febrication process plays an important role in the properties of drug-loaded microparticles(MPs),including encapsulation efficiency,release behavior and so ***,we focused on the effect of two different febrication methods on
Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)wer...
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Nanocarriers with low toxicity,high stability,long circulation in blood and triggered drug release at target sites are extremely needed for cancer *** this study,different molar ratios of poly(ethylene glycol)(PEG)were conjugated to poly
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