Aim:Glutamatergic neurotransmission in nucleus accumbens(NAc)is crucial for the relapse to heroin ***,whether the type 5 metabotropic glutamate receptors(mGluR5)in NAc core or shell is involved in heroin seeking behav...
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Aim:Glutamatergic neurotransmission in nucleus accumbens(NAc)is crucial for the relapse to heroin ***,whether the type 5 metabotropic glutamate receptors(mGluR5)in NAc core or shell is involved in heroin seeking behavior remains ***:Male Sprague-Dawley rats were self-administrated heroin under fixed-ratio 1(FR1)reinforcement schedule for 14 days,then the rats were withdrawn for 2 weeks,after which reinstatement of heroin-seeking was induced by conditioned cues or heroin ***:Microinjection of 2-methyl-6-phenylethynyl-pyridine(MPEP)at doses of 0,3 or 10?g/0.5?l/side into the NAc shell potently decreased the heroin seeking induced by either cues or heroin priming in a dose-dependent *** contrast,microinjection of MPEP into the NAc core failed to alter the heroin seeking induced by cues or heroin *** addition,the rats pre-treatment with MPEP into NAc shell were reversed both percentage of open arms entries(OE%)and percentage of time in open arms(OT%)after heroin ***,the most effective dose of MPEP(10?g/0.5?l/side)into the striatum as a control anatomical site did not affect the heroin *** administration of MPEP in three nucleuses did not change the locomotion ***:These results demonstrated that blocking the mGluR5 in NAc shell specifically inhibited the relapse to heroin-seeking and anxiety-like behavior,and suggested that mGluR5 antagonists may be a potential candidate for the therapy of heroin addiction.
Background Chronic unpredictable stress(CUS)can cause behavioral and physiological abnormalities that are important to the prediction of symptoms of depression that may be associated with cerebral glucose metabolic **...
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Background Chronic unpredictable stress(CUS)can cause behavioral and physiological abnormalities that are important to the prediction of symptoms of depression that may be associated with cerebral glucose metabolic *** showed potential antidepressant effects,but whether or not it can reverse cerebral functional abnormalities and so ameliorate depression remains *** To investigate the effects of curcumin on brain activity in CUS rats,rats were subjected to 3 weeks of CUS and then treated with curcumin orally at a dose of 40 mg/kg/day for one month.18F fluorodeoxyglucose(18F-FDG)-micro positron emission tomography(micro-PET)neuroimaging was used to detect changesin cerebral *** weight,sucrose preference,and open field tests were used to record depressive behaviors during CUS and after curcumin *** Three weeks of CUS significantly decreased body weight,sucrose preference,sucrose consumption,total distance travelling,and the number of rearing *** also induced metabolic alterations in several parts of the brain,showing increased glucose metabolism in the right *** curcumin treatment for one month,sucrose preference,sucrose consumption,total distance travelling,and the number of rearing events returned to normal *** treatment also induced strong deactivation of the left primary auditory cortex and activation of amygdalohippocampal *** Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS,which may account for its antidepressive effects.
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