抗VEGFR2单克隆抗体进行靶向治疗原发性肝癌是一种新的治疗思路.用杂交瘤技术制备抗VEGFR2单克隆抗体的杂交瘤细胞系,酶联免疫法、亲和力测定、质谱分析、等方法鉴定该抗体(命名为：A8H1),证书具有高亲和力和高特异性.Huang J,et al.A high-affinity human/mouse cross-reactive monoclonal antibody, specific for VEGFR-2 linear and conformational ***.62(1)：61-71;2010用A8H1经免疫组化检测肝癌组织中VEGFR2的表达,其高表达和癌直径大、分化差等有关;生存分析VEGFR2在肝癌中的高表达患者预后差.VEGFR2可作为靶向治疗肝癌的靶点.
B7-H3 was highly expressed in the cell line Eca-109 and TE-1, the high expression level of B7-H3 in esophageal cancer tissues was significantly associated with tumor invasion and patient's poor *** higher B7-H3 ex...
B7-H3 was highly expressed in the cell line Eca-109 and TE-1, the high expression level of B7-H3 in esophageal cancer tissues was significantly associated with tumor invasion and patient's poor *** higher B7-H3 expression was significantly and inversely correlated to the CD3+T cells infiltration in tumor nest of the cancer *** regulation of B7-H3 expression could suppress the proliferation, colony formation ability,migration and invasion in Eca-109 *** high B7-H3 expression was involved in the cancer progression of human esophageal cancer, and might contributed to the negative regulation of T-cell mediated antitumor response in tumor microenvironment, and the proliferation and mobility of esophageal cancer cells.
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