目的 NLR pyrin domain-containing protein 3 (NLRP3)inflammasome, a multi-protein complex that activates the caspase-1 cascade which produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, may contribute...
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目的 NLR pyrin domain-containing protein 3 (NLRP3)inflammasome, a multi-protein complex that activates the caspase-1 cascade which produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, may contribute to the development of airway inflammation in chronic obstructive pulmonary disease (COPD)。 This study is aimed at determining the activation of circulating and local airway NLRP3 inflammasome in patients with stable and acute exacerbation, heavy smokers, and healthy subjects (HS)。
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