目的 Intermittent hypoxia(IH),as the most important pathophysiologic characteristic of obstructive sleep apnea(OSA)and arecognized risk factor for cardiovascular disorders,may lead to proliferation of smooth muscle ce...
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目的 Intermittent hypoxia(IH),as the most important pathophysiologic characteristic of obstructive sleep apnea(OSA)and arecognized risk factor for cardiovascular disorders,may lead to proliferation of smooth muscle cells(SMCs)and then pulmonaryarterial remodeling through the RhoA/ROCK signaling *** this preliminary study,an IH animal model was developed,andthe muscularization of small pulmonary arteries and RhoA/ROCK levels in these rats exposed to IH were studied.
目的 通过对不同病程、不同严重程度OSA对患者非酒精性脂肪性肝病(NAFLD)的肝脏形态、肝功进行对比，探讨OSA对NAFLD的影响及其作用机制.方法 比较83例不同病程和病情的OSA患者和对照组进行脂肪肝的患病率及肝功能、肝脏超声参数变化，随机选取经腹部彩超确诊为脂肪肝10例重度OSA患者，空腹行瞬时弹性成像技术(FibroTouch)检查，记录有效检测的肝脏脂肪衰减参数值以及肝脏硬度值.结果 1、OSA组NAFLD患病率明显增加，与对照组比较差异有统计学意义.2、ALT增高随着病程的延长及病情严重程度的加重而增加;但AST水平只较对照组并有统计学差异，而不同程度及病情严重程度 OSA 患者血清GGT、TBIL、TBA水平均无统计学意义.3、经CPAP治疗后重度OSA患者脂肪变性程度可降低.结论 1、OSA 患者NAFLD的患病率随OSA体重指数增加和发病时间延长、病情的加重而增高.2、血清ALT、AST改变随着 OSA 发病时间的延长及病情的加重而更加明显.***缺氧和缺氧导致的肥胖是引起OSA患者非酒精性脂肪肝的主要原因.4、CPAP治疗后脂肪变性程度可能降低.
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