目的 Previously,we demonstrated that pyroptosis in alveolar macrophages(AMs)plays an essential role in LPS-induced acutelung injury(ALI).However,the underlying mechanism remains largely unclear.方法 Here we show that ...
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目的 Previously,we demonstrated that pyroptosis in alveolar macrophages(AMs)plays an essential role in LPS-induced acutelung injury(ALI).However,the underlying mechanism remains largely unclear.方法 Here we show that the absence of interferon regulatory factor 1(IRF-1)in genetic knock-out mice strongly abrogatespyroptosis in AMs and alleviates the LPS-induced lung injury and systemic inflammation.
目的 The regulation of Notch/Hes signaling in inflammatory responses has become a research highlight in recent *** thereare few studies addressing the roles of Notch/Hes signaling in the pathological process of lung c...
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目的 The regulation of Notch/Hes signaling in inflammatory responses has become a research highlight in recent *** thereare few studies addressing the roles of Notch/Hes signaling in the pathological process of lung cells involved in severe acutepancreatitis(SAP).The present experiment was performed to examine the effect of Notch-1/Hes signal transduction pathway inthe development of acute lung injury(ALI)after severe acute pancreatitis(SAP).
目的 To investigate the role of tissue factor (TF) and autophagy and their interactions during chronic thromboembolic pulmonary hypertension (CTEPH) pathogenesis in a rat *** investigate the role of tissue factor (TF)...
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目的 To investigate the role of tissue factor (TF) and autophagy and their interactions during chronic thromboembolic pulmonary hypertension (CTEPH) pathogenesis in a rat *** investigate the role of tissue factor (TF) and autophagy and their interactions during chronic thromboembolic pulmonary hypertension (CTEPH) pathogenesis in a rat model.
目的 To investigate the molecular mechanism of miR-338-5p in the pathological process of pulmonary fibrosis. 方法 we first analyzed the expression of miR-338-5p in the human diploid fibroblast cell line-IMR-90 and hum...
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目的 To investigate the molecular mechanism of miR-338-5p in the pathological process of pulmonary fibrosis. 方法 we first analyzed the expression of miR-338-5p in the human diploid fibroblast cell line-IMR-90 and human airway epithelial (HAE) cell line-NuLi-1 by quantitative RT-PCR.
目的 Evidence regarding the impact of improvement in air pollution on hospital admission is *** occurrence andexacerbation of COPD are closely related to air pollution;yet,the underlying biological mechanisms are not ...
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目的 Evidence regarding the impact of improvement in air pollution on hospital admission is *** occurrence andexacerbation of COPD are closely related to air pollution;yet,the underlying biological mechanisms are not well *** to examine the impacts of air pollution reduction during the 2010 Asian Games on hospital admissions and oninflammatory biomarker levels in COPD patients.
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