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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： xiaoLiu yiqingQu yunhongYin chunyuLi yanYang xuejiaoXi weixiaoXue 山东大学齐鲁医院

目的 This report provides us more understanding of Sj(o)gren's syndrome (pSS) presenting diffuse cystic lung changes preceding systemic lupus erythematosus (SLE). 方法 Primary Sj(o)gren's Syndrome was diagnosed based on the presence of xerophthalmia and xerostomia, biopsy of the minor salivary glands,Schirmer's test, positive anti-SS-A and anti-SS-B antibody in the serum. SLE was finally diagnosed based on the symptoms of bilateral lower limb skin rash,gonarthritis and omarthritis, once a white cell count of 2100 cells/mL and a lymphocyte count of 610 cells/mL, antinuclear antibody (ANA) 1：640 and positive antibodies to double-stranded DNA (dsDNA). Chest computed tomography (CT) showed diffuse cystic changes with a wide variation in cyst size.

关键词： primary Sj(o)gren's syndrome diffuse cystic lung changes systemic lupus erythematosus

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Erythromycin Suppresses Development of Th17 Cells from CD4+TCells Induced by Dendritic Cells Exposed to Cigarette Smoke Extract

Erythromycin Suppresses Development of Th17 Cells from CD4+T...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： LeileiYa Tenth Affiliated Hospital of Guangxi Medical University

目的 To investigate the effect of erythromycin on polarizing naive CD4+T cells to Th17 cells which induced by dendritic cell(DC)exposed to cigarette smoke extract(CSE).方法 DCs were generated from bone marrow-derived mononuclear cells of male Balb/c mice and randomly divided into a controlgroup,a CSE-exposed group,a CD40-antibody blocking CSE-exposed group and a Erythromycin treating CSE-exposed *** surface CD40 and CD86 expression were detected by flow cytometry,and their mRNA expression was measured byfluorescence quantitative real-time *** function of DC,CSE treated-DCs,Erythromycin treated-DCs and anti-CD40 blockedDCs was assayed by mixed lymphocyte reaction(MLR)of na？ve CD4+T cells polarized to Th17 cells.

关键词： Cigarette smoke extract Dendritic cells Th17cells Erythromycin Effect

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Associations of acute exposure to fine particulate air pollution and hospital visits in Beijing, China

Associations of acute exposure to fine particulate air pollu...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： RuixueXia PekingUniversityFirstHospital

目的 PM2.5 is a risk factor for respiratory diseases, but health effects associated with its extreme change are not well understood. To determine whether the number of hospital visits are sensitive to the PM2.5 extreme changes, we use an opportunity offered by greatly restricted air pollution emissions and the smog event in Beijing, China to measure pollutants daily and the outcomes during our study period. 方法 We used generalized additive modeling with a log link and allowed a time-series Poisson regression model to address possible serial correlation between PM2.5 concentrations levels and the number of hospital visits to estimate the improvement in outcome levels during the good air quality and the anticipated reversal of outcome levels in the followed smog period, and as sensitivity analyses, we replaced daily mean PM2.5 with daily hourly maximum or minimum PM2.5 to examine whether our results were robust to the use of alternative indicators.

关键词： PM2.5 respiratory diseases cardiovascular diseases acute exposure

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The inhibitory effects of the DNA vaccine co-expressing CEA tandem repeat epi-topes and IL-18on the in vivo growth of the lungs carcinomas in mice

The inhibitory effects of the DNA vaccine co-expressing CEA ...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： jinhongwang BingbingWang The Third Affiliated Hospital of Southern Medical University

目的 To observe inhibitory effects of DNA vaccine co-expressing CEA tandem repeat epitopes and IL-18 on cancer cells in mice.方法 Methods：The encoding sequences for CEA tandem repeats and IL-18 were inserted into plasmid pcDNA3.0,constructingpcDNA-CEA625-667,pcDNA-triCEA625-667 and pcDNA-triCEA625-667-IL-18 recombinant plasmid using gene recombinanttechnique.C57BL/6 mice were immunized intramuscularly with the co-expressing DNA *** mice survival time and tumorsize were measured and the specific CTL cytotoxicity activity which splenic lymphocytes were collected from immunized mice asthe effector cells and tumor cells TC1-CEA+as the target cells was detected by125I-UdR release method.

关键词： Carcinoembryonic antigen IL-18 Antigen epitope Gene vaccine

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Pulmonary infiltration with eosinophilia complicated with mucosa-associated lymphoid tissue lymphoma: A case report

Pulmonary infiltration with eosinophilia complicated with mu...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： YinLiu YonglongXiao MinCao Department of Respiratory Medicine Nanjing Drum Tower Hospital

目的 Tissue eosinophilia is rarely observed in cases of non-Hodgkin's lymphoma of B cell origin.方法 The present study describes a rare case of mucosa？associated lymphoid tissue lymphoma, which was initially misdiagnosed as eosinophilic *** initial diagnosis was formed based on the results of chest radiography, peripheral eosinophilia tests and bronchoalveolar lavage, and the clinical course of the *** administration of methylprednisolone (40 mg/day), the clinical course rapidly improved and the eosinophil count immediately decreased a to normal ***, abnormal shadows observed on computed tomography (CT) scans of the chest did not diminish.结果 At 6 months after the initiation of treatment, CT-guided percutaneous lung biopsy was performed, and a final diagnosis of primary pulmonary mucosa-associated lymphoid tissue lymphoma was made based on immunohisto-chemical examination.结论 Primary lung MALT lymphoma remains a rare entity, with an indolent course and a reasonably favorable *** diagnosis can be challenging.

关键词： eosinophilic pneumonia mucosa-associated lymphoid tissue lymphoma bronchoalveolar lavage

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Kleine-Levin Syndrome: A Case Report in a Chinese Teenager

Kleine-Levin Syndrome: A Case Report in a Chinese Teenager

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： QianWang QiongOu Guangdong General Hospital

目的 Kleine-Levin syndrome (KLS) is a rare disorder primarily occur in adolescents with a tendency of four times higher morbidity in male than female, is characterized by intermittent episodes of hypersomnolence, cognitive and behavioral disturbances and *** research has been conducted, especially in Chinese *** case describes a 14-year-old Chinese girl with recurrent *** experienced four attacks before diagnosed, behaved normally between each attack, and present down mood before each *** was seen by a psychiatrist with no focal findings and then monitored in our sleep center using polysomnography during an *** result was negative for sleep apnea and the electroencephalogram signals showed no epileptiform *** first three episodes, she was evaluated without a clear diagnosis, and therefore unable to attend *** was then diagnosed and treated at our Sleep Disorders Center during her fourth *** patient was treated with methylphenidate 10 mg daily for 1 month and was under weight controll and behavioral Intervention treatment after withdrawn from *** didn't experienced attack again and was followed-up by our Center regularly.

关键词： Kleine-Levine syndrome a 14-year-old girl hypersomnolence

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Bio-electricalcontrolofdirectionalmigrationofhumanlungcancercellsthroughCaveolin-1-mediatedSTAT3activation

Bio-electricalcontrolofdirectionalmigrationofhumanlun...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者： LiLi YongHe ThirdMilitaryMedicalUniversity

目的 Thebiologicalandmolecularmechanismsofmetastasisoflungcancerarenotfully***establishsecondarytumors,cancercellshavetoinvadesurroundingtissuesandbloodvesselsandmigrateawayfromtheprimary***thisprocess,cellhavetomigratedirectionallytomigrateawayfromtheprimary***environmentalcuesincludingextracellularmatrix,cytokinesandgrowthfactorsfromautocrineandparacrinesourceshavebeendemonstratedtocreatechemotacticsignalstostimulatemigrationofmammarycancer***hasalsobeenreportedthatendogenouselectricfields(EFs)mayexistbetweentumorandnormaltissue,whilelittledirectevidencewas***,EFshavebeenshowntodirectmigrationofhighly-metastaticlungcancercellsandshowedlittleeffectonweak-metastaticlungcancercellsbutthemechanismis***thusaimtostudywhetherendogenousEFsexistatsitesoflungcancerofthemechanismofEF-guideddirectionalmigrationoflungcancercells.

关键词： lungcancer directionalmigration electricfield STAT3 tumormicroenvironment

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钟南山院士荣获CTS“终身呼吸成就奖”

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中华医学信息导报 2016年第18期31卷 7-7页

作者：张广有《中华医学信息导报》编辑部

9月22日，在西安举行的2016年中华医学会呼吸病学分会（CTS）年会暨第十七次全国呼吸病学学术会议上，原中华医学会会长、

关键词：呼吸病学钟南山院士 CTS 中华医学会

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高原地区藏族居民脉氧饱和度和血红蛋白含量之间临床意义分析

高原地区藏族居民脉氧饱和度和血红蛋白含量之间临床意义分析

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者：边巴穷达北京大学人民医院

目的研究海拔4200米高原地区藏族居民指端脉氧饱和度(SpO2)水平及其影响因素.方法于2012年1月4日至2月4日对西藏自治区山南地区隆子县热荣村藏族居民(海拔4200米)进行健康体检,在人口统计学基础上,采集居民指端脉氧饱和度,依据调查居... 详细信息

目的研究海拔4200米高原地区藏族居民指端脉氧饱和度(SpO2)水平及其影响因素.方法于2012年1月4日至2月4日对西藏自治区山南地区隆子县热荣村藏族居民(海拔4200米)进行健康体检,在人口统计学基础上,采集居民指端脉氧饱和度,依据调查居民性别、年龄和吸烟史等情况进行分组,观察各组间数据是否存在统计学差异.结果一共收集308名健康藏族居民的临床资料,其中男性141名(45.78％),所有居民的平均年龄为31.26±17.12岁,统计结果发现不同性别的居民在静息状态下脉氧饱和度(分别为86.50±3.23％和86.41±4.48％)和心率(分别为81.71±11.99次/分和82.94±12.56次/分),二者无统计学差异(p值分别为0.842和0.373),但男性居民血红蛋白(Hb)含量要显著高于女性(分别为158.11±16.74和138.08±18.14g/L,p=0.000).随着年龄增长,尤其是年龄大于50岁居民和50岁以下的居民相比较,其SpO2明显降低(p=0.003),而血红蛋白含量则呈逐渐升高的趋势(p=0.000);吸烟史大于5年的居民的SpO2明显低于吸烟史小于5年的居民,而血红蛋白水平显著升高(p=0.000).结论(1)海拔4200米以上高原地区藏族居民SpO2和Hb水平与年龄和吸烟等因素呈负相关;(2)静息状态下,各年龄组人群间心率变化无统计学差异;(3)SpO2无创监测方便快捷,可有效观察人群的缺氧状态和趋势,有利于早期干预,避免过度代偿产生并发症.

关键词：高原地区藏族居民脉氧饱和度

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重组人血管内皮抑制素注射液联合顺铂注射液胸腔灌注治疗晚期非小细胞肺癌恶性胸腔积液的临床疗效

重组人血管内皮抑制素注射液联合顺铂注射液胸腔灌注治疗晚期非小...

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

作者：陈瑞琳张程程吴桦杨淑梅陕西省人民医院

目的探讨重组人血管内皮抑制素联合顺铂胸腔灌注治疗晚期非小细胞肺癌恶性胸腔积液的临床疗效.方法选取2011—2014年我院收治的晚期非小细胞肺癌恶性胸腔积液患者90例,随机分为治疗组与对照组,各45例.治疗组予以重组人血管内皮抑制素... 详细信息

目的探讨重组人血管内皮抑制素联合顺铂胸腔灌注治疗晚期非小细胞肺癌恶性胸腔积液的临床疗效.方法选取2011—2014年我院收治的晚期非小细胞肺癌恶性胸腔积液患者90例,随机分为治疗组与对照组,各45例.治疗组予以重组人血管内皮抑制素联合顺铂胸腔灌注治疗,对照组予以顺铂胸腔灌注治疗.观察两组临床疗效、生活质量、治疗前后免疫功能指标自然杀伤细胞(NK)、T细胞亚群(CD3、CD4、CD8)、CD4/CD8)及不良反应发生情况.结果治疗组总有效率高于对照组,差异有统计学意义(P＜0.05).治疗组KPS评分优于对照组,差异有统计学意义(P＜0.05).治疗前两组NK、CD3、CD4、CD8水平及CD4/CD8比较,差异无统计学意义(P＞0.05);治疗后治疗组NK、CD3、CD4水平及CD4/CD8高于对照组,CD8水平低于对照组,差异有统计学意义(P＜0.05).两组发热、恶心呕吐、乏力、白细胞和/或血小板计数减少发生率比较,差异无统计学意义(P＞0.05).结论重组人血管内皮抑制素联合顺铂胸腔灌注治疗晚期非小细胞肺癌恶性胸腔积液的临床疗效显著,可有效地改善患者的生活质量,增强患者免疫功能,且不良反应少.

关键词：非小细胞肺癌恶性胸腔积液重组人血管内皮抑制素

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