The aim of this study is to evaluate primitively whether the extent and component ofastigmatism influence the regression in degree of spherical (DS) and the best corrected visual acuity (BCVA) of children with hyperop...
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The aim of this study is to evaluate primitively whether the extent and component ofastigmatism influence the regression in degree of spherical (DS) and the best corrected visual acuity (BCVA) of children with hyperopia of +5.00 diopters (D) or *** were screened from outpatient refraction database in the Wenling No.1 People's Hospital in Zhejiang province and in Eye & ENT Hospital of Fudan University between June 2005 and December *** eyes were divided into three groups according to the extent of the astigmatism: group of astigmatism ≤-2 D of cylinder,group without astigmatism or with astigmatism >-0.5 D of cylinder, and the group with astigmatism >-0.75 D and ≤-1.75D of *** the component of astigmatism, eyes with astigmatism as ≤-0.75 D of cylinder were divided into 3 groups: with the rule (WTR), against the rule (ATR) and the group with the *** in the changes of BCVA and Refractive error(RE)during follow-up terms were compared within and among *** in the mean DS or BCVA were not statistically significant between-group according to the extent of the astigmatism at the last visit (P=0.2396 and P=0.2131, respectively).As for the component of astigmatism, the group with the oblique astigmatism had more severe hyperopia than the group of WTR (P<0.0001) and mean BCVA in the group of ATR were inferiorto that of the other two groups (P<0.0001) at the first ***, the among-group changes were not significant at the end of the observation (P>0.1).The regression of DS and improvement of the BCVA in children with hyperopia of +5.00D or greater may be irrespective of the component and the extent of astigmatism.
Background: Keratoconus normally occurs as a sporadic *** different studies have found sequence variants of visual system homeobox 1 (VSX1) gene associated with keratoconus in humans, no research detected VSX1 sequenc...
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Background: Keratoconus normally occurs as a sporadic *** different studies have found sequence variants of visual system homeobox 1 (VSX1) gene associated with keratoconus in humans, no research detected VSX1 sequence variant in sporadic keratoconus patienets from *** investigate the possibility of VSX1 gene as a candidate susceptibility gene for Chinese patients with sporadic keratoconus, we performed a sequence screening of VSX1 gene in unrelated patients with keratoconus from ***: Genomic DNA was obtained from the leukocytes in peripheral venous blood of 50 patients with sporadic keratoconus and 50 control subjects without the ocular *** chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct DNA sequencing technology were used for detection of sequence variant in five exons and the splice region of intron of VSX1 *** sequencing results were analyzed using DNAstar ***: One novel missense heterozygosity sequence variant (***131Pro) was found in exon 1 of VSX1 gene in one keratoconus *** heterozygosity sequence variant (***160Val) in exon 2 was found in two keratoconus *** the ***131Pro and ***160Val were not detected in the control *** intron 3 of VSX1 gene, one c.8326G>A nucleotide substitution (including heterozygosity and homozygosity change) was *** frequency of c.8326G>A variation in patients and controls showed no statistically significant difference, so it belonged to single nucleotide polymorphism (SNP) of VSX1 ***: In this research, we added one novel missense sequence variation (***131Pro) in the coding region of VSX1 gene to the existing repertoire of VSX1 coding variations observed in patient with sporadic keratoconus from *** study suggests that VSX1 sequence variant might be involved in pathogenesis of sporadic keratoconus but its precise role in disease causation needs further investigation.
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