Hydrocephalus combined with communicating syringomyelia secondary to aneurysmal subarachnoid hemorrhage (SAH)is an extremely rare clinical entity with few reported *** presentation,management,and pathogenesis of syrin...
Hydrocephalus combined with communicating syringomyelia secondary to aneurysmal subarachnoid hemorrhage (SAH)is an extremely rare clinical entity with few reported *** presentation,management,and pathogenesis of syringomyelia and hydrocephalus in this setting are poorly ***,we describe the presentation,radiology,and the outcomes in one patient with hydrocephalus combined with syringomyelia secondary to aneurysmal *** patient was successfully treated with a ventriculoperitoneal shunt for the symptoms of ***,this case study contributes to the limited literature available on hydrocephalus combined with syringomyelia occurring secondary to SAH-associated arachnoiditis.
Introduction/Background: Subarachnoid hemorrhage (SAH) is one of the most common acute craniocerebral *** has a high mortality rate and survivors often suffer from remaining neurological *** etiology of SAH is *** dia...
Introduction/Background: Subarachnoid hemorrhage (SAH) is one of the most common acute craniocerebral *** has a high mortality rate and survivors often suffer from remaining neurological *** etiology of SAH is *** diagnosis and differential diagnosis are difficult,and methods of assisted examination are ***,the process of diagnosis is fraught with traps,and the rates of misdiagnosis and missed diagnosis are *** Presentation: The patient,a 39-year-old woman,had complained of headache combined with transient *** had a medical history of *** examination suggested probable positive neck *** CT showed no obvious *** of the head by fluid-attenuated inversion recovery (FLAIR) and susceptibility weighted imaging (SWI) suggested subarachnoid *** digital subtraction angiography (DSA) indicated spinal arteriovenous *** final diagnosis was spinal arteriovenous malformation combined with spinal subarachnoid *** diagnosis,appropriate drugs were administered and interventional embolization was *** prognosis was ***: When clinicians encounter similar patients,they should avoid stereotypes,choose reasonable methods of auxiliary examination,and be alert to traps;this can significantly reduce the rates of misdiagnosis and missed diagnosis.
Deterioration of mental functions during aging and Alzheimer's disease (AD) progression is always accompanied by loss of neurons,presumably through *** aim of the study is to investigate the effects of SS31 peptid...
Deterioration of mental functions during aging and Alzheimer's disease (AD) progression is always accompanied by loss of neurons,presumably through *** aim of the study is to investigate the effects of SS31 peptide on cognitive impairment and neuronal degeneration in the hippocampus of SAMP8 mice,as well as the potential *** cognitive function was tested by Morris Water Maze,neuronal changes in morphology in the CA1 and CA3 subregions of hippocampus were tested by Nissl's staining with cresyl *** injection of SS31 peptide with a dose of 2 mg/kg daily and 5 mg/kg daily for 8 weeks apparently alleviated cognitive disorders and neuronal *** blot analyses demonstrated that SS31 peptide significantly decreased Bax/Bcl2 ratio in the hippocampus of SAMP8 *** addition,SS31 peptide effectively attenuated the upregulation of the mitochondrial matrix protein cyclophilin D (CypD) *** findings suggest that SS31 peptide may be a potential neuroprotective agent through against apoptosis.
Alzheimer's disease (AD) is a common neurodegenerative disease associated with aging and widespread neuronal death,which via an apoptotic mechanism *** research is a rapidly developing area,but the role of apoptos...
Alzheimer's disease (AD) is a common neurodegenerative disease associated with aging and widespread neuronal death,which via an apoptotic mechanism *** research is a rapidly developing area,but the role of apoptosis in AD is still *** this study,we aimed to investigate the effects of aging and SS31 on the mitochondria-related apoptotic status in SAMP8 *** blot and real-time reverse transcription-quantitative PCR analysis revealed that aging increased the expression of BCL-2 associated X protein (BAX),and Dynamin related protein 1 (DRP1),as an apoptotic fission protein,and decreased the expression of B-cell lymphoma-2 (BCL-2) in the hippocampus of SAMP8 ***,our results indicated that SS31 down-regulated the expression of BAX and DRP 1,and up-regulated the expression of BCL-2 in the hippocampus of SAMP8 *** conclusion,our findings demonstrate that SAMP8 mice show an age-related enhanced apoptotic status,while SS31 can play a potentially protective role in AD and age-related disorders by anti-apoptotic mechanism.
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