This paper deals with novel approaches established by our group for the construction of a functionalized poly(ethylene glycol) (PEG) layer, PEG-brushed layer possessing a reactive group at the free end of tethered PEG...
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ISBN:
(纸本)0780364651
This paper deals with novel approaches established by our group for the construction of a functionalized poly(ethylene glycol) (PEG) layer, PEG-brushed layer possessing a reactive group at the free end of tethered PEG chain, on substrates. An AB-type block copolymer composed of /spl alpha/-acetal-poly(ethylene glycol) (PEG) as the hydrophilic segment and polylactide (PLA) as the hydrophobic segment was synthesized, and utilized to construct the functionalized PEG layer on the biodegradable polylactide surface by simple coating. In this way, a PEG-brushed layer with a terminal aldehyde group was readily prepared which may have both non-fouling and ligand-binding properties. Non-fouling property of PEG strands eliminates nonspecific and uncontrolled interactions of the surface with biological components, including cells and proteins, while presentation of tethered ligands attached to the chain end of PEG brush allows cell behavior at the surface to be modulated in a specific manner via receptor-mediated signaling. Based on the characterization of these PEGylated surfaces from a physicochemical (contact angle, atomic force microscopy, electron spin resonance) as well as biological (protein adsorption/cell adhesion) point of view, our strategy to construct a functionalized PEG layer was confirmed. Active functional groups were present at the tethered PEG-chain end, these materials will provide new insights into controlling cell behavior at surfaces for tissue engineering and biomedical applications.
A new pass-transistor circuit synthesis method is presented in this paper. Several pass-transistor logic families were introduced recently, but no systematic synthesis method is available that takes into account impac...
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ISBN:
(纸本)0780352351
A new pass-transistor circuit synthesis method is presented in this paper. Several pass-transistor logic families were introduced recently, but no systematic synthesis method is available that takes into account impact of signal arrangement on circuit performance. The method is applied to generation of basic two-input and three-input logic gates in CPL, DPL and DVL, but it is general and can be expanded to synthesis of a random pass-transistor circuit.
In this paper an original method is proposed for digital circuit topological delays estimation which is based on standard logic simulation mechanisms. The inverse circuit simulation (ICS) method is intended for intera...
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ISBN:
(纸本)0780352351
In this paper an original method is proposed for digital circuit topological delays estimation which is based on standard logic simulation mechanisms. The inverse circuit simulation (ICS) method is intended for interactive use in conjunction with circuit logic verification. Inverse circuit model propagates signal transitions in inverse direction: from circuit outputs toward circuit inputs. One simulator run provides the longest path delay for a chosen, rising or falling, edge at one circuit output. At the same time, the part of the circuit is detected which is the subject of redesign or delay optimization if the longest path delay does not satisfy required circuit operating frequency. Due to path reconvergence delay overestimation can occur which can be measured at each signal and propagated through the circuit together with logic states. The efficiency of the proposed method is tested on ISCAS'85 benchmark circuits.
Numerous systems for ranked retrieval on text databases have been implemented by both information retrieval researchers and in the commercial sector. In contrast, software for text categorization, message filtering, t...
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ISBN:
(纸本)1581130961
Numerous systems for ranked retrieval on text databases have been implemented by both information retrieval researchers and in the commercial sector. In contrast, software for text categorization, message filtering, textual data mining, and related tasks is less common. ATTICS is an extensible text classification system we have implemented in C++. It supports incremental training and online application of classifiers and predictive models to streams of textual, numeric, symbolic, and hybrid data records. An object-oriented design allows easy addition of new preprocessors, machine learning algorithms, and classifier types.
Software repositories are often based on object-oriented or relational databases, usually with extensions to accommodate the special requirements of software. Here, we discuss a software repository based on a structur...
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We propose to use a logic meta-system as a general frame-work for aspect-oriented programming. We illustrate our approach with the implementation of a simplified version of the cool aspect language for expressing sync...
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This history of programming paradigm evolution is presented showing what practices evolved from the assembler languages to the current object-oriented environments. The continuing evolution and enhancement of applicat...
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ISBN:
(纸本)0818685859
This history of programming paradigm evolution is presented showing what practices evolved from the assembler languages to the current object-oriented environments. The continuing evolution and enhancement of applications compels current practitioners to work with the realities of the legacy application paradigms. A set of methods and processes are described that reduce the risk of project failures when an interface between legacy and object-oriented applications is required.
Realizing a shift of software engineering towards a component-based approach to software development requires the development of higher level programming systems supporting the development of systems from components. ...
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ISBN:
(纸本)0818685859
Realizing a shift of software engineering towards a component-based approach to software development requires the development of higher level programming systems supporting the development of systems from components. This paper presents a novel approach to the design of large software systems where a program-in-the-large describing the system's architecture is executed at run-time to rule over the assembly and dynamic cooperation of components. This approach has several advantages following from a clean separation of concerns between programming-in-the-small andprogramming-in-the-large issues in instantiated systems.
The purpose of this paper is to establish a set of conceptual models and paradigms that apply to the newest technology employed in ESS class switches. The author will examine how Common Object Reference Brokerage Arch...
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ISBN:
(纸本)0818685859
The purpose of this paper is to establish a set of conceptual models and paradigms that apply to the newest technology employed in ESS class switches. The author will examine how Common Object Reference Brokerage Architecture (CORBA) creates more effective processes and services within ESS based upon Object Oriented programming paradigms.
An object-oriented formal specification workbench is proposed for defining the syntax and semantics of programming languages, using which the formal properties of different languages can be elaborated and analyzed. Ou...
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ISBN:
(纸本)0818685859
An object-oriented formal specification workbench is proposed for defining the syntax and semantics of programming languages, using which the formal properties of different languages can be elaborated and analyzed. Our specification approach is an object-oriented representation structured around a denotational semantics methodology which abstracts out various common details so that formal syntax and semantics call be defined elegantly. Specific details can be inherited and specialized in defining the semantics of various programming languages, and the reusability and modifiability of many programming languages features can be manifested across language paradigms. Furthermore, prototype implementations for these languages may be automatically developed from the formal specifications, providing a mechanism for compiler/interpreter reuse at the specification level.
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