In this paper we present an automatic statistical intensity based-approach for extracting the 3D cerebrovascular system from time-of-flight (TOP) magnetic resonance angiography (MRA) data. The voxels of the dataset ar...
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In this paper we present an automatic statistical intensity based-approach for extracting the 3D cerebrovascular system from time-of-flight (TOP) magnetic resonance angiography (MRA) data. The voxels of the dataset are classified as either background tissues, which are modeled by a finite mixture of one Rayleigh and two normal distributions, or blood vessels, which are modeled by one normal distribution. We show that the proposed models fit the clinical data properly and result in fewer misclassified vessel voxels. We estimated the parameters of each distribution using the expectation maximization (EM) algorithm. Since the convergence of the EM is sensitive to the initial estimate of the parameters, a novel method for parameter initialization, based on histogram analysis, is provided. A new geometrical phantom motivated by a statistical analysis was designed to validate the accuracy of our method. The algorithm was also tested on 20 in-vivo datasets. The results showed that the proposed approach provides accurate segmentation, especially those blood vessels of small sizes.
Most methods used in functional MRI (fMRI) brain mapping require restrictive prior knowledge about the shape of the active bloodoxygenation- level-dependent (BOLD) response, thus leading to suboptimal or invalid infer...
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We present a fully automated deformable model technique for myocardium segmentation in 3D MRI. Loss of signal due to blood flow, partial volume effects and significant variation of surface grey value appearance make t...
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We present a fully automated deformable model technique for myocardium segmentation in 3D MRI. Loss of signal due to blood flow, partial volume effects and significant variation of surface grey value appearance make this a difficult problem. We integrate various sources of prior knowledge learned from annotated image data into a deformable model. Inter-individual shape variation is represented by a statistical point distribution model, and the spatial relationship of the epi- and endocardium is modeled by adapting two coupled triangular surface meshes. To robustly accommodate variation of grey value appearance around the myocardiac surface, a prior parametric spatially varying feature model is established by classification of grey value surface profiles. Quantitative validation of 60 end-diastolic 3D MRI datasets demonstrates accuracy and robustness, with 1.28±0.81 mm mean deviation from manual segmentation. We investigate the extension to 4D by incorporating a constraint on the allowed deformation based on a learned example and show illustrative results for 4D MRI.
This paper evaluates strategies to combine multiple segmentations of the same image, generated for example by different segmentation methods or by different human experts. Three methods are compared, each estimating a...
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We describe a registration and tracking technique to integrate cardiac x-ray images and cardiac magnetic resonance (MR) images acquired from a combined x-ray and MR interventional suite (XMR). Optical tracking is used...
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We describe a registration and tracking technique to integrate cardiac x-ray images and cardiac magnetic resonance (MR) images acquired from a combined x-ray and MR interventional suite (XMR). Optical tracking is used to determine the transformation matrices relating MR and x-ray image coordinates. Calibration and tracking enable us to combine x-ray projection images with registered projection MR images from a volume acquisition, and to display 3D reconstructions of catheters within the MR volume. Registration errors were assessed using phantom experiments. Errors in the combined projection images (2D root mean square target registration error - RMS TRE) were found to be 2.4 - 4.2mm, and the errors in the integrated volume representation (3D RMS TRE) were found to be 4.6 - 5.1mm. These errors are clinically acceptable for alignment of images of the heart and the great vessels. We demonstrate that our technique can be used to guide catheters and to combine electrical and mechanical information in the context of the patient-specific anatomy for a patient undergoing cardiac radio-frequency (RF) ablation.
Accurate co-registration of MR images of the brain with pathological data from the same patient is required for many applications, including validation of in-vivo MRI processing. We present preliminary results from a ...
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This paper presents a fully automated brain segmentation method that has been applied to a group of patients with infratentorial ependymoma. The purpose of the study was to test the hypothesis that fully-automated atl...
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ISBN:
(数字)9783540399032
ISBN:
(纸本)9783540204640
This paper presents a fully automated brain segmentation method that has been applied to a group of patients with infratentorial ependymoma. The purpose of the study was to test the hypothesis that fully-automated atlas-based segmentation methods provide useful normal tissue dosimetry from which dose-volume modeling may be performed in a manner equivalent to dose-volume data obtained from manual contouring. To test this hypothesis, we compared the integrated average dose for three small (chiasm, pituitary, hypothalamus) and three large (temporal lobes and total brain) normal tissue structures from ten patients using automated and manual contouring. There was no significant difference in the calculated average dose for the structures of interest. The greatest difference was noted for smaller structures which were located along the midline and in the gradient of dose. The results of this study form the basis of an ongoing larger study involving similar patients to evaluate automated and manual contouring as well as the clinical significance of any differences using dose-volume modeling.
In ENT surgery, the operating volume is very limited. This is especially true in sinus surgery, when the instrument passes through the sinus cavity to reach the pathological area. The sinus bones impose geometric cons...
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In ENT surgery, the operating volume is very limited. This is especially true in sinus surgery, when the instrument passes through the sinus cavity to reach the pathological area. The sinus bones impose geometric constraints on the work volume. During the surgery, the surgeon needs to take care of the motion of the instrument tip to accomplish some delicate procedure;meanwhile he/she needs to avoid hitting anatomic constraints. In this paper, we present a method to assist the path following task in a constrained area. We project instrument tip motion, boundary information on the joint displacement via robot kinematics, and then use a constrained quadratic optimization algorithm to compute the optimal set of corresponding joint displacements. In the preliminary study, we show that the optimization constrained control can avoid collision with geometric constraints on the work volume, while keeping the precision of the tool motion.
In this work, we present a new methodology for fully automated segmentation of prostatic adenocarcinoma from high resolution MR by using a novel feature ensemble of 3D texture features. This work represents the first ...
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In this work, we present a new methodology for fully automated segmentation of prostatic adenocarcinoma from high resolution MR by using a novel feature ensemble of 3D texture features. This work represents the first attempt to solve this difficult problem using high resolution MR. The difficulty of the problem stems from lack of shape and structure in the adenocarcinoma. Hence, in our methodology we compute statistical, gradient and Gabor alter features at multiple scales and orientations in 3D to capture the entire range of shape, size and orientation of the tumor. For an input scene, a classifier module generates Likelihood Scenes for each of the 3D texture features independently. These are then combined using a weighted feature combination scheme. The ground truth for quantitative evaluation was generated by an expert pathologist who manually segmented the tumor on the MR using registered histologic data. Our system was quantitatively compared against the performance of the individual texture features and against an expert's manual segmentation based solely on visual inspection of the 4T MR data. The automated system was found to be superior in terms of Sensitivity and Positive Predictive Value.
This paper presents a new method for extracting bronchus regions from 3D chest X-ray CT images based on structural features of the bronchus. This method enhances bronchial walls by applying a sharpening operation and ...
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