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检索条件"任意字段=5th IFAC Symposium on Modelling and Control in Biomedical Systems"

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Initial titration for people with type 1 diabetes using an artificial pancreas 11th

Initial titration for people with type 1 diabetes using an a...

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11th ifac symposium on Biological and Medical systems (BMS)

作者： Sejersen, Maria Boiroux, Dimitri Engell, Sarah Ellinor Ritschel, Tobias Kasper Skovborg Reenberg, Asbjorn thode Jorgensen, John Bagterp Tech Univ Denmark Dept Appl Math & Comp Sci DK-2800 Lyngby Denmark

For people with type 1 diabetes and some with type 2 diabetes, the problem of insulin titration, i.e. finding an adequate basal rate of insulin, is a complex and time-consuming task. this paper proposes a simple model-free algorithm and a procedure for fast initial titration in people with type 1 diabetes (T1D). A modified proportional-integral-derivative (PID) controller (i) updates the estimated insulin basal rate, and (ii) administers micro-boli of insulin every 5 minutes using glucose measurements from a continuous glucose monitor (CGM). A bolus calculator mitigates the effect of meals and reduces postprandial peaks. We evaluate the performance of our system qualitatively and numerically using a virtual clinic of 1,000 T1D patients with a broad inter-patient variability representative of a real population of people with T1D. We let the titration phase run for three consecutive days, followed by a three-day test phase using the newly computed basal insulin infusion rate. the proposed algorithm is able to provide a safe titration and individualized treatment for people with T1D. Copyright (C) 2021 the Authors.

关键词： control algorithm PID Feed-forward control Run-to-run control Diabetes Artificial pancreas

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Artificial Intelligence Methodology for Smart and Sustainable Manufacturing Industry 17th

Artificial Intelligence Methodology for Smart and Sustainabl...

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17th ifac symposium on Information control Problems in Manufacturing (INCOM)

作者： Fernandez, Santiago Ferreiro, Susana Larreina, Jon Tena, Mikel Leunda, Josu Garmendia, Iker Arnaiz, Aitor Fdn Tekniker Inaki Goenaga 5 Eibar 20600 Spain

Manufacturing industry is seeing an explosion in data availability, with potential for desired optimisation of productive systems. For instance, additive manufacturing is a novel technology that is currently advancing fast and constantly. As the physics of additive manufacturing are complex there are cases where it is of interest to monitor the process, and further to this, a potential objective is to optimize process parameters. Analytics and decision support technologies can support optimisation from data and expert knowledge. We present current status of analytics methodologies, which have not been updated in years. Also, we introduce an additive manufacturing process, laser cladding. From this context, this paper presents a methodology proposal, and further to this, applicability in a laser cladding scenario. A set of experiments is performed and quality of results, both in terms of porosity and dimensionality, assessed. A study of correlation is centred on data analysis for extracting relationships among the process data and process parameters with respect to the quality of the test outcome. As a result, in our study porosity showed up as the hardest to generate and to model of the two quality indicators studied, with the model attaining modest results, while results for dimensionality were better, and various variables showed importance for correlations. Copyright (C) 2021 the Authors.

关键词： artificial intelligence analytics methodology smart and sustainable manufacturing intelligent manufacturing systems quality predictive modelling signal processing additive manufacturing laser cladding dynamic time warping

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the separation of insulin pump hardware and software - a novel and low-cost approach to insulin pump design 11th

The separation of insulin pump hardware and software - a nov...

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11th ifac symposium on Biological and Medical systems (BMS)

作者： Payne, Matthew Pooke, Francis Chase, J. Geoffrey Campbell, Jake Holder-Pearson, Lui Knopp, Jennifer Univ Canterbury Dept Mech Engn Christchurch New Zealand

Insulin pumps are the most consistent and accurate means of regulating blood glucose levels in Types 1 and 2 diabetes. However, the technology is underutilised due to very high costs. A typical insulin pump costs US$6500, which makes this gold standard of care inaccessible to many, reducing equity of access to care. Since insulin pumps were first introduced, the simple hardware has not changed significantly. Pump manufacturers couple the low-cost and simple hardware with their own software, removing consumer choice and locking value into the product. Using both a traditional motor-driven and novel spring-loaded approach, insulin pump hardware can be replicated for US$100. Initial testing of the traditional motor-driven prototype proves the low-cost approach has comparable accuracy to commercially available pumps, with 85.1% of basal doses delivered within 5% of target. the results obtained indicate pump hardware and software can be separated with no significant loss in accuracy. If a separate market for pump software is established, costs can be driven down through market pressure given the increasing access to relatively extensive mobile and cloud computing. If open-source software is made accessible, a complete pump could be offered for US$100. A 98.5% cost reduction would drastically improve pump accessibility, particularly in developing nations, and could lead to a global improvement in diabetes treatment, outcomes and costs. Copyright (C) 2021 the Authors.

关键词： Diabetes Healthcare management Disease control Critical care Low cost technologies Mechatronic systems Open-source Design methodologies

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Production Scheduling using a Multi-Objective framework in an Automotive Company 17th

Production Scheduling using a Multi-Objective framework in a...

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17th ifac symposium on Information control Problems in Manufacturing (INCOM)

作者： Konstantinidis, Konstantinos P. Saha, Subrata Nielsen, Izabela Aalborg Univ Dept Mat & Prod Aalborg Denmark

the increased demand for highly customized products and the need for shortening lead times for competitive advantage has also affected the automotive industry. Companies that handle markets in a multi-faced network of demand, like Europe, need to be flexible, responsive, and follow a customer-focused policy. therefore, there is an increased need for automated solutions not only in product design but also in the manufacturing section. Such solutions need to replace manual effort increasing efficiency and creating new horizons of innovation and development. In this paper, a mathematical model based on Goal Programming modeling has been introduced as a part of a more flexible and automated perspective for production scheduling. the model is applied to a production scheduling process of an automotive company headquartered in Germany to handle a multi-objective problem that manual effort cannot. the paper will explain how demand management, lead time shortening, and process efficiency can be solved through a mathematical model properly modified to its cause. Copyright (C) 2021 the Authors.

关键词： Production Scheduling Goal Programming Mathematical modelling of Decision Making Support systems Demand Management Automotive Industry

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Port-Hamiltonian modelling of fluid dynamics models with variable cross-section 24

Port-Hamiltonian modelling of fluid dynamics models with var...

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24th International symposium on Mathematical theory of Networks and systems (MTNS)

作者： Bansal, Harshit Zwart, Hans Iapichino, Laura Schilders, Wil van de Wouw, Nathan Eindhoven Univ Technol Dept Math & Comp Sci NL-5612 AZ Eindhoven Netherlands Univ Twente Dept Appl Math 5 Drienerlolaan NL-7522 NB Enschede Netherlands Eindhoven Univ Technol Dept Mech Engn NL-5612 AZ Eindhoven Netherlands Univ Minnesota Dept Civil Environm & Geoengn Minneapolis MN 55455 USA

Many single- and multi-phase fluid dynamical systems are governed by non-linear evolutionary equations. A key aspect of these systems is that the fluid typically flows across spatially and temporally varying cross-sections. We, first, show that not any choice of state-variables may be apt for obtaining a port-Hamiltonian realization under spatially varying cross-section. We propose a modified choice of the state-variables and then represent fluid dynamical systems in port-Hamiltonian representations. We define these port-Hamiltonian representations under spatial variation in the cross-section with respect to a new proposed state-dependent and extended Stokes-Dirac structure. Finally, we account for temporal variations in the cross-section and obtain a suitable structure that respects key properties, such as, for instance, the property of dissipation inequality. Copyright (C) 2021 the Authors.

关键词： multi-phase non-linear evolutionary equations varying cross-sections port-Hamiltonian Stokes-Dirac structure dissipation inequality

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Algebraic modelling of Logistical systems Equipped by Wireless Monitoring Devices 5

Algebraic Modelling of Logistical Systems Equipped by Wirele...

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5th IEEE International symposium on Smart and Wireless systems within the International Conferences on Intelligent Data Acquisition and Advanced Computing systems, IDAACS-SWS 2020

作者： Letychevskyi, Oleksandr Horbatiuk, Serhii Horbatiuk, Viktor Glushkov Institute of Cybernetic of Nas of Ukraine Akademika Glushkova Ave 40 Kyiv03187 Ukraine

ISBN: (纸本)9781728199603

International and internal service logistics are advancing at a tremendous pace in a modern life, and future forecasts for this area are optimistic. For this reason, a task in the control appears, optimisation and safety and security checking of complex logistical systems with many internal agents working in a changing environment. the paper aims to show how mathematical modelling, especially behaviour algebra, can provide an opportunity for predicting the behaviour and stability of logistics environments and checking their safety and security properties. the agents are equipped by wireless devices that monitor current state of agent like coordinates, temperature etc. the procedure of modelling is a part of the model-driven development of complex software systems like logistics systems. © 2020 IEEE.

关键词： Supply chains

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Mathematical modelling of Magnesium Block-Driven NMDA Receptor Response in CA1 Pyramidal Neuron for Alzheimer’s Disease 5th

Mathematical Modelling of Magnesium Block-Driven NMDA Recept...

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5th International Conference on Nanoelectronics, Circuits and Communication systems, NCCS 2019

作者： Dave, Vijay Shrimankar, Arpit D. Gokani, Devanshi Dashora, Abha Department of Biomedical Engineering Government Engineering College Sector 28 GandhinagarGujarat382028 India

ISBN: (纸本)9789811574856

N-methyl-D-aspartate receptors (NMDA) located on the postsynaptic terminal of CA1 pyramidal neuron plays an essential role in synaptic plasticity, and the calcium(Ca) current flowing through it drives several intracellular calcium mechanisms. We have developed a single-compartment model involving least mechanisms to study the NMDA receptor response to different input condition and to obtain the voltage-dependent relationship of magnesium(Mg) block in the NMDA receptor. Using this interdependence, we have replicated a pathological condition of Alzheimer’s diseases (AD) to obtain total NMDA receptor current in AD. the results obtained at different Mg concentration suggested that the blocking rate increases linearly with the Mg concentration. In AD, there is dysfunction of Mg block which leads to the early opening of the NMDA receptor. So, using a drug which controls the blocking mechanism of Mg leads to control of NMDA receptor current. this results in the control of intracellular Ca current. © 2021, the Editor(s) (if applicable) and the Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Magnesium

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Lumped parameter model of the cardiovascular system with baroreflex 5

Lumped parameter model of the cardiovascular system with bar...

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5th International Scientific Conference on Information, control, and Communication Technologies, ICCT 2021

作者： Rubtsova, E. Telyshev, D. Institute of Biomedical Systems National Research University of Electronic Technology 1 Shokin Square Zelenograd Moscow124498 Russia Institute for Bionic Technologies and Engineering Sechenov University 8 Trubetskaya street Moscow119991 Russia

the patient's activity directly affects the state of the cardiovascular system (CVS). One of the mechanisms contribute to the regulation of the arterial blood pressure is the baroreflex. It is maintains an optimal level of the arterial pressure as a response to changes in the patient's activity. the model developed in this work simulates CVS at the different patient's activity levels. the model of baroreflex reproduces changes that occur during an increasing level of patient's activity. the correlation between heart rate (79 bpm -rest, 123 bpm - exercise) and cardiac output (5.1 l/min -rest, 8.2 l/min - exercise) was achieved. the developed model can be used for personal modelling of various states of the CVS. the model parameters possible to apply for individual patient characteristics. For further development, the model can be integrated with the ventricular assist device during the heart failure state in order to study interactions in the biotechnical system. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Blood pressure

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Electric Vehicle modelling for Function Testing of Charging Infrastructures Using Power Hardware-in-the-Loop Simulations 5

Electric Vehicle Modelling for Function Testing of Charging ...

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5th E-Mobility Power System Integration symposium, EMOB 2021

作者： Morab, Abhijit Narayan Marchand, Sophie Wille-Haußmann, Bernhard Smart Grids Department Fraunhofer Institute for Solar Energy Systems ISE Freiburg im Breisgau Germany

ISBN: (纸本)9781839536793

Based on a sustainable development scenario with a 30% Electric Vehicle (EV) market share by 2030 the International Energy Agency projects a rise of grid challenges. In parallel, Electric Vehicle Supply Equipment (EVSE) is evolving to answer these growing needs. Efforts toward its standardization and association with smart charging strategies are being made to support grid integration while minimizing costs. Still, specific testing of EVSE technologies has yet to be established. Here, we model the digital twin of an EV and build a comprehensive Power Hardware-In-the-Loop (PHIL) test bench. Used for EVSE conformity validation, this testing setup contributes as well to grid stability evaluation. First, we developed an EV model enabling uni- and bi-directional scenarios. then, we built a comprehensive PHIL setup integrating our EV model, a 22kW charging unit with a Type-2 connector, and a load emulator. Using this setup, automated procedures are established to test the charging station functionalities. Communication protocol and main mechanisms, such as defined in IEC 61851-1, are evaluated based on proposed key performance indicators. Furthermore, grid integration simulation is carried out to benchmark EV charging control strategies using a low voltage grid with representative loads as well as sources such as household loads, Photovoltaics (PV), and EVs. Regulating local bus voltages, control schemes with different access levels to grid status are designed and evaluated. We found that increased information access leads to reduced voltage deviations at the buses as well as improved power loss mitigation. © IET Conference Proceedings 2021.

关键词： Electric vehicles

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Identification of Asynchronous Effect via Pressure-Volume Loop Reconstruction in Mechanically Ventilated Breathing Waveforms 11th

Identification of Asynchronous Effect via Pressure-Volume Lo...

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11th ifac symposium on Biological and Medical systems (BMS)

作者： Zhou, Cong Chase, J. Geoffrey Sun, Qianhui Knopp, Jennifer Tawhai, Merryn H. Desaive, thomas Moller, Knut Shaw, Geoffrey M. Chiew, Yeong Shiong Benyo, Balazs Northwestern Polytech Univ Sch Civil Aviat Taicang Yangzte River Delta Res Inst Xian Peoples R China Univ Canterbury Dept Mech Engn Christchurch New Zealand Univ Canterbury Dept Mech Engn Ctr Bioengn Christchurch New Zealand Univ Auckland Auckland Bioengn Inst Auckland New Zealand Univ Liege Inst Phys GIGA In Silico Med Liege Belgium Furtwangen Univ Inst Tech Med Villingen Schwenningen Germany Christchurch Hosp Dept Intens Care Christchurch New Zealand Monash Univ Sch English Subang Jaya Hungary Budapest Univ Technol & Econ Dept Control Engn & Informat Technol Budapest Hungary

Patient-specific lung-mechanics during mechanical ventilation (MV) can be modelled via using fully ventilated/controlled waveforms. However, patient asynchrony due to spontaneous breathing (SB) effort commonly exists in patients on full MV support, leading to variability in breathing waveforms and reducing the accuracy of identified, model-based, and patient-specific lung mechanics. this study aims to extract ventilated breathing waveforms from affected asynchronous breathing cycles using an automated virtual patient model-based approach. In particular, change of lung elastance over a pressure-volume (PV) loop is identified using hysteresis loop analysis (HLA) to detect the occurrence of asynchrony, as well as its type and pattern. the identified HLA parameters are then combined with a nonlinear mechanics hysteresis loop model (HLM) to extract and replicate the ventilated waveforms from the coupled asynchronous breaths. the magnitude of asynchrony can then be quantified using an energy dissipation metric, E-asyn, comparing the area difference of PV loops between model-reconstructed and original breathing cycles. A proof-of-concept study is conducted using clinical data from 2700 breathing cycles of two patients exhibiting asynchrony during MV. the reconstruction root mean square errors are within 5-10% of the clinical data for 90% of the cycles, indicating good and robust reconstruction accuracy. Estimation of E-asyn shows significant asynchrony magnitude for Patient 1 with E-asyn greater than 10% for over 50% breaths, while asynchrony occurrence for Patient 2 is lower with 90% breaths at E-asyn < 10%, which is a minimal asynchrony magnitude. these results match direct observation, thus validating the ability of the virtual patient model and methods presented to be used for a real-time monitoring of asynchrony with different types and magnitudes, which in turn would justify prospective clinical tests. Copyright (C) 2021 the Authors.

关键词： Asynchrony Mechanical ventilation Hysteretic lung mechanics Hysteresis loop model Virtual patient

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