A model of combined antiangiogenic therapy and radiotherapy of tumors is proposed and analyzed. the model is a modified Hahnfeldt model (proposed by d'Onofrio and Gandolfi) and we discuss its properties including ...
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ISBN:
(纸本)9780889866485
A model of combined antiangiogenic therapy and radiotherapy of tumors is proposed and analyzed. the model is a modified Hahnfeldt model (proposed by d'Onofrio and Gandolfi) and we discuss its properties including its asymptotic behaviour under constant and periodic therapy. then we propose an optimization problem in the final horizon which leads to the optimal treatment protocols. We find necessary conditions of its solution and discuss their biological meaning.
Brain-Computer interfacing systems require online processing of electroencephalogram (EEG) signals. therefore, high speed signal processing is of great importance in BCI systems. In this study, we suggest and calculat...
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ISBN:
(纸本)9531841160;97
Brain-Computer interfacing systems require online processing of electroencephalogram (EEG) signals. therefore, high speed signal processing is of great importance in BCI systems. In this study, we suggest and calculate a time pattern for information variations within the EEG signal recorded during mental tasks. therefore, it is possible to limit the length of the EEG signal from beginning up to the information maximization point, hence reducing the processing time. In this work Wavelet entropy is employed for information content evaluation of the EEG signal.
the proceedings contain 94 papers. the topics discussed include: acousto-optic imaging techniques for optical diagnosis;improvement of the contrast in cancer detection by autofluorescence bronchoscopy using a narrow s...
ISBN:
(纸本)9783902661180
the proceedings contain 94 papers. the topics discussed include: acousto-optic imaging techniques for optical diagnosis;improvement of the contrast in cancer detection by autofluorescence bronchoscopy using a narrow spectral violet excitation: a preliminary study;retinal angiogram registration by estimation of distribution algorithm;diffuse reflectance spectroscopy Monte-Carlo modeling: elongated arterial tissues optical properties;a portable Raman probe for in vivo pathological tissues characterisation;analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test;isometric muscle contraction induced by repetitive peripheral magnetic stimulation;reduced model for forced expiration and analysis of its sensitivity;human skin thermal properties identification by periodic method in the frequency domain;and a comparison between two fractional multimodels structures for rat muscles modelling.
To be able to optimise performance variables such as the rates of bed-occupancy, staff utilisation and the number of delayed or cancelled admissions in any healthcare units the rate at which patients are admitted to t...
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To be able to optimise performance variables such as the rates of bed-occupancy, staff utilisation and the number of delayed or cancelled admissions in any healthcare units the rate at which patients are admitted to that unit must be controlled. this paper proposes a method for evaluating admissions controlthat may subsequently be used as the basis for improving the control of admissions. the method is demonstrated through the presentation and discussion of results from an experimental study in a hospital environment comprising a suite of operating theatres, a post-operative recovery room and two intensive-care units. (c) 2004 Elsevier Ltd. All rights reserved.
Nerve cells communicate by generation and transmission of short electrical pulses (action potentials). A cascaded feedback control scheme consisting of an optimal controller (model predictive control, MPC) and a state...
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Nerve cells communicate by generation and transmission of short electrical pulses (action potentials). A cascaded feedback control scheme consisting of an optimal controller (model predictive control, MPC) and a state feedback controller to controlthe time-courses of the biophysical state variables underlying action potential generation was developed and evaluated in simulations. the control scheme was shown to provide new means for action potential generation, suppression of oscillations and blockage of action potential transmission. these new theoretical developments could represent a starting point for the design of new closed-loop electrical stimulation systems for patients suffering from different nerve system dysfunctions. (c) 2004 Elsevier Ltd. All rights reserved.
Characterising circulatory dysfunction and choosing a suitable treatment is often difficult and time consuming. this paper outlines a numerically stable minimal model of the human cardiovascular system (CVS) specifica...
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Characterising circulatory dysfunction and choosing a suitable treatment is often difficult and time consuming. this paper outlines a numerically stable minimal model of the human cardiovascular system (CVS) specifically aimed for rapid, on-site modelling to assist in diagnosis and treatment. A minimal number of governing equations and a realistic valve law are used to accurately capture trends in CVS dynamics. the model is shown to have long-term stability and consistency with non-specific initial conditions. Examples of model verification are shown for experimentally measured static and transient response data. the model is also verified to capture commonly seen changes in CVS function as a result of disease. these examples illustrate the power of the minimal model for capturing CVS dynamics in health and disease, while its simplicity enables its use as a clinical aid. (c) 2004 Elsevier Ltd. All rights reserved.
this paper proposes a method to control muscular flexibility during training and rehabilitation. this method invokes muscular stretching by mechanical stimulation of the neuromuscular gamma loop. the specification and...
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this paper proposes a method to control muscular flexibility during training and rehabilitation. this method invokes muscular stretching by mechanical stimulation of the neuromuscular gamma loop. the specification and characterization of this method are based on a simulation model related to the biomechanical behaviour of muscle. this model was used to identify the parameters required for the implementation of mechanical stimulation on an isokinetic machine. A generic control architecture for this type of machine was proposed to carry out stimulation patterns that invoke muscular stretching. As validation, experimental data were obtained withthe help of Multi-Iso, a machine used for training and rehabilitation of the lower limbs. (c) 2004 Elsevier Ltd. All rights reserved.
Critically ill-patients often experience stress-induced hyperglycemia. this research demonstrates the effectiveness of a simple automated insulin infusion for controlling the rise and duration of blood glucose excursi...
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Critically ill-patients often experience stress-induced hyperglycemia. this research demonstrates the effectiveness of a simple automated insulin infusion for controlling the rise and duration of blood glucose excursion in critically ill-patients. Heavy derivative controllers derived from a simple, two-compartment model reduced blood glucose excursion 79-89% after a glucose input in proof-of-concept clinical trials. Modelled performance is very similar to clinical results, including a strong correlation between modelled and actual insulin consumed, validating the fundamental models and methods. However, the need for additional dynamics in the model employed is clearly illustrated despite capturing the essential dynamics for this problem. (c) 2004 Elsevier Ltd. All rights reserved.
Agitation in the critically ill damages patient health and increases length of stay and healthcare costs. the control model presented captures the essential dynamics of the agitation-sedation system, and is statistica...
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Agitation in the critically ill damages patient health and increases length of stay and healthcare costs. the control model presented captures the essential dynamics of the agitation-sedation system, and is statistically validated using recorded infusion data for 37 patients. Derivative focused control is seen to provide an essentially bolus-driven management approach, which is shown to be an effective means of managing agitation, given consistent agitation measurement. Improved agitation management using feedback of patient agitation reduces the modelled mean and peak agitation levels 68.4% and 52.9% on average, respectively, illustrating the effectiveness of simple control in this non-linear system. (c) 2004 Elsevier Ltd. All rights reserved.
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