A new method for fully automated segmentation of white matter lesions (WMLs) on cranial MR imaging is presented. the algorithm uses five types of regular MRI-scans. It is based on a k-Nearest Neighbor (KNN) classifica...
详细信息
ISBN:
(纸本)3540204628
A new method for fully automated segmentation of white matter lesions (WMLs) on cranial MR imaging is presented. the algorithm uses five types of regular MRI-scans. It is based on a k-Nearest Neighbor (KNN) classification technique, which builds a feature space from voxel intensities and spatial information. the technique generates images representing the probability per voxel being part of a WML. By application of thresholds on these probability maps binary segmentations are produced. ROC-curves show that the segmentations achieve high sensitivity and specificity. the similarity index (SI) is used for further analysis and for determination of the optimal threshold. the probabilistic equivalent of the SI allows direct evaluation of the probability maps, which provides a strong tool for comparison of different classification results. this method for automated WML segmentation reaches an accuracy that is comparable to methods for multiple sclerosis lesion segmentation.
Oblique-viewing endoscopes (oblique scopes) are widely used medically. It is essential for certain procedures such as laparoscopy, arthroscopy, and sinus endoscopy. In an oblique scope, its viewing directions are chan...
详细信息
ISBN:
(数字)9783540399032
ISBN:
(纸本)3540204644
Oblique-viewing endoscopes (oblique scopes) are widely used medically. It is essential for certain procedures such as laparoscopy, arthroscopy, and sinus endoscopy. In an oblique scope, its viewing directions are changeable by rotating the scope cylinder. Although a camera calibration method is necessary to apply augmented reality technologies to oblique endoscopic procedures, no method for oblique scope calibration has been developed yet. In the present paper, we formulate a camera model and a calibration procedure for oblique scopes. In the calibration procedure, Tsai's calibration is performed at zero-rotation of the scope cylinder, and then the variation of the external camera parameters corresponding to the rotation of the scope cylinder is modeled and estimated as a function of the rotation angle. Accurate estimation of the rotational axis is included in the procedure. the precision of this estimation was demonstrated to have a significant effect on the overall calibration accuracy in the experimental evaluation especially with large rotation angles. the projection error in the image plane was around two pixels. the proposed method was shown to be clinically applicable.
We have developed a method for forming vascular atlases using vascular distance maps and a novel vascular model-to-image registration method. Our atlas formation process begins with MR or CT angiogram data from a set ...
详细信息
ISBN:
(纸本)3540204628
We have developed a method for forming vascular atlases using vascular distance maps and a novel vascular model-to-image registration method. Our atlas formation process begins with MR or CT angiogram data from a set of subjects. We extract blood vessels from those data using our tubular object segmentation method. One subject's vascular network model is then chosen as a template, and its vascular distance map (DM) image is computed. Each of the remaining vascular network models is then registered withthe DM template using our vascular model-to-image affine registration method. the DM images from the registered vascular models are then computed. the mean and variance images formed from those registered DM images are the vascular atlas. In this paper we apply the atlas formation process to build atlases of normal brain and liver vasculature. We use Monte Carlo simulations to demonstrate the reliability of the underlying registration method. Additionally, we explain the clinical potential of those atlases and conduct z-score analyses to compare individuals withthe atlases to detect abnormal vessels.
Manual quantitative analysis of cardiac left ventricular function using multi-slice CT is labor intensive because of the large datasets. In previous work, an intrinsically three-dimensional segmentation method for car...
详细信息
ISBN:
(纸本)3540204628
Manual quantitative analysis of cardiac left ventricular function using multi-slice CT is labor intensive because of the large datasets. In previous work, an intrinsically three-dimensional segmentation method for cardiac CT images was presented based on a 3D Active Shape Model (3D-ASM). this model systematically overestimated left ventricular volume and underestimated blood pool volume, due to inaccurate estimation of candidate points during the model update steps. In this paper, we propose a novel ASM candidate point generation method based on a Fuzzy Inference System (FIS), which uses image patches as an input. Visual and quantitative evaluation of the results for 7 out of 9 patients shows substantial improvement for endocardial contours, while the resulting volume errors decrease considerably (blood pool: -39 +/- 29 cubic voxels in the previous model, -0.66 +/- 6.2 cubic voxels in the current). Standard deviation of the epicardial volume decreases by approximately 50%.
In the context of MR imaging, explicit segmentation followed by stereologic volumetry of the hippocampus (HC) has been the standard approach toward temporal lobe epilepsy (TLE) lateralization of the seizure focus. the...
详细信息
ISBN:
(纸本)3540204628
In the context of MR imaging, explicit segmentation followed by stereologic volumetry of the hippocampus (HC) has been the standard approach toward temporal lobe epilepsy (TLE) lateralization of the seizure focus. the novelty of the method presented here resides in its analysis of characteristics of large, non-specific Volumes of Interest from T1 MRI data aiming to lateralize the seizure focus in patients with TLE without segmentation. For this purpose, Principal Components Analysis (PCA) of two image features are united to create a multi-dimensional space representative of a training set population composed of 150 normal subjects. the feature instances consist of grey-level intensity and an approximation of the Jacobian matrix of non-linear registration-derived dense deformation fields. New data for TLE subjects are projected in this space, under the assumption that the distributions of the projections of normal and patients are not identical and can be used for lateralization. Results are presented following PCA modeling of the left medial temporal lobe only for all subjects. It is shown that linear discriminant analysis of the eigencoordinates can be used to lateralize the seizure focus in TLE patients with a 75% accuracy. It is expected that adding a right temporal lobe model will improve lateralization results beyond those of HC volumetry.
ImLib3D is a C++ library for 3D medicalimage processing research. It provides a carefully designed, object-oriented, standards conforming C++ library, as well as a separate visualization system. Focus has been put on...
详细信息
ISBN:
(数字)9783540399032
ISBN:
(纸本)9783540204640
ImLib3D is a C++ library for 3D medicalimage processing research. It provides a carefully designed, object-oriented, standards conforming C++ library, as well as a separate visualization system. Focus has been put on simplicity for the researcher who is considered to be the end-user. Source code is freely available and has been placed in an open collaborative development environment.
A generalized image model (GIM) is presented. images are represented as sets of 4-dimensional sites combining position and intensity information, as well as their associated uncertainty and joint variation, this model...
详细信息
A generalized image model (GIM) is presented. images are represented as sets of 4-dimensional sites combining position and intensity information, as well as their associated uncertainty and joint variation, this model seamlessly allows for the representation of bothimages and statistical models, as well as other representations such as landmarks or meshes. A GIM-based registration method aimed at the construction and application of statistical models of images is proposed. A procedure based on the iterative closest point (ICP) algorithm is modified to deal with features other than position and to integrate statistical information. Furthermore, we modify the ICP framework by using a Kalman filter to efficiently compute the transformation. the initialization and update of the statistical model are also described. V.
In this paper an automatic atlas-based segmentation algorithm for 4D cardiac MR images is proposed. the algorithm is based on the 4D extension of the expectation maximisation (EM) algorithm. the EM algorithm uses a 4D...
详细信息
ISBN:
(纸本)3540204628
In this paper an automatic atlas-based segmentation algorithm for 4D cardiac MR images is proposed. the algorithm is based on the 4D extension of the expectation maximisation (EM) algorithm. the EM algorithm uses a 4D probabilistic cardiac atlas to estimate the initial model parameters and to integrate a-priori information into the classification process. the probabilistic cardiac atlas has been constructed from the manual segmentations of 3D cardiac image sequences of 14 subjects. It provides space and time-varying probability maps for the left and right ventricle, the myocardium, and background structures such as the liver, stomach, lungs and skin. In addition to the probabilistic cardiac atlas, the segmentation algorithm incorporates spatial and temporal contextual information by using 4D Markov Random Fields (MRF). Validation against manual segmentations and computation of the correlation between manual and automatic segmentation on 249 3D volumes were calculated. Results show that the procedure can successfully segment the left ventricle (LV) (r=0.95), myocardium (r=0.83) and right ventricle (RV) (r=0.91).
Statistical shape models generally use Principal Component Analysis (PCA) to describe the main directions of shape variation in a training set of example shapes. However, PCA has the restriction that the input data mu...
详细信息
ISBN:
(纸本)3540204628
Statistical shape models generally use Principal Component Analysis (PCA) to describe the main directions of shape variation in a training set of example shapes. However, PCA has the restriction that the input data must be drawn from a Gaussian distribution and is only able to describe global shape variations. In this paper we evaluate the use of an alternative shape decomposition, Independent Component Analysis (ICA), for two reasons. ICA does not require a Gaussian distribution of the input data and is able to describe localized shape variations. With ICA however, the resulting vectors are not ordered, therefore a method for ordering the Independent Components is presented in this paper. To evaluate ICA-based Active Appearance Models (AAMs), 10 leave-15-out models were trained on a set of 150 short-axis cardiac MR images with PCA-based as well as ICA-based AAMs. the median values for the average and maximal point-to-point distances between the expert drawn and automatically segmented contours for the PCA-based AAM were 2.95 and 8.39 pixels. For the ICA-based AAM these distances were 1.86 and 5.01 pixels respectively. From this, we conclude that the use of ICA results in a substantial improvement in border localization accuracy over a PCA-based model.
A method to determine the number and location of seed images in clusters on a fluoroscopic image was developed based on a statistical analysis of cluster size in simulated fluoroscopic images. A modified 3-film techni...
详细信息
暂无评论