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Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared ii imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： optical imaging Drug visualization Fluorophore labeling Therapeutics

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Multi Objective Optimal design for Multi-State Power System Using the Non-Dominated Sorting Genetic Algorithm ii 3

Multi Objective Optimal Design for Multi-State Power System ...

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3rd International conference on Advanced Electrical engineering, ICAEE 2024

作者： Belkacem, Kamel Bali, Noureddine Labdelaoui, Hilal Faculty of Electrical Engineering Algiers Algeria

ISBN: (纸本)9798350349351

This study addresses the problem of optimal design for series-parallel multi-state power systems, where each system component is available in the market in several versions. The Non-Dominated Sorting Genetic Algorithm ii (NSGA-ii) is applied to determine the optimal system structure or the optimal combination of versions for each subsystem or component. A two-objective problem is first considered, where the aim is to maximize system reliability while minimizing the investment cost. The second problem has three objective functions and is defined to maximize reliability and performance while minimizing the investment cost. The results show that NSGA-ii can provide better solutions than another recently proposed algorithm. © 2024 IEEE.

关键词： Multi objective optimization Multi-state system Optimal design Power system Reliability

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design High Performance on Wavelength Division Multiplexing Inter Satellite optical Wireless Communication Using Different MIMO Techniques

Design High Performance on Wavelength Division Multiplexing ...

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IEEE International conference on Microwaves, Communications, Antennas, Biomedical engineering and Electronic systems (COMCAS)

作者： Rahayu, Yusnita Darma, Salsabila Desti Indraguna, Vannebula Eka Susanti, Rika Ngah, Razali Univ Riau Dept Elect Engn Pekanbaru Indonesia UIN SUSKA Dept Elect Engn Riau Indonesia Univ Teknol Malaysia Fac Elect Engn Johor Baharu Malaysia

ISBN: (纸本)9798350348194;9798350348187

Rapid data and multimedia services growth among users has increased the need for high-speed communication systems that can cover a wide global area. This study proposes an inter-satellite optical wireless communication (ISOWC) system with wavelength division multiplexing (WDM) and multiple-input multiple-output (MIMO) techniques that operate at a speed of 2 Gbps with a wavelength of 850 nm. This study aims to assemble and simulate a series of ISOWC, MIMO ISOWC, WDM ISOWC, and WDM-MIMO ISOWC systems to see which system performs better. The simulation results show that WDM-MIMO on the ISOWC system performs well, with a BER of 2.79777x10(-151) and a maximum Q-factor of 26.17120. This study also evaluates MIMO 2 x 2, 4 x 4, 8 x 8, and 16 x 16 on the ISOWC system. It was concluded that the higher the number of MIMO channels provided, the better BER with the maximum Q-factor.

关键词： ISOWC MIMO wireless optic WDM-MIMO satellite communication

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Integration of House of Quality and Black Box Analysis for the Elicitation of Mechatronic System Requirements 4th

Integration of House of Quality and Black Box Analysis for t...

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4th International conference of the Italian Association of design Methods and Tools for Industrial engineering

作者： Pasquariello, Agnese Rega, Andrea Vitolo, Ferdinando Patalano, Stanislao Univ Naples Federico II Fraunhofer J Lab IDEAS Ple V Tecchio 80 I-80125 Naples Italy

ISBN: (纸本)9783031765933;9783031765940

Requirements elicitation is a crucial phase in Requirements engineering, laying the foundation for the system design process. Gathering requirements entails employing structured methods to understand the specific requests of the stakeholders involved. Given the intricate multi-domain nature of mechatronic systems and the increasing customer expectations, establishing robust foundations during the requirements elicitation phase becomes imperative. Two widely adopted methods for requirements elicitation, namely the House of Quality (HoQ) and Black Box Analysis (BBA), are separately applied to a case study involving an automatic parking gate. The system is then designed using the RFLP (Requirements - Functional - Logical - Physical) approach for mechatronic systems design. An integrated proposal combining both methods is then presented and applied to the same case study. The aim is to address each method's limitations and improve the requirements elicitation process to generate a comprehensive list of requirements that considers customer needs and essential system functionalities. The subsequent re-application of the RFLP process highlighted the enhancements facilitated by the integrated application of both methods.

关键词： systems engineering Requirements engineering Black Box Analysis House Of Quality RFLP

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design method of aircraft Anti-Ice architecture based on model

Design method of aircraft Anti-Ice architecture based on mod...

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2024 International conference on Automation Control, Algorithm, and Intelligent Bionics, ACAIB 2024

作者： Bao, Jiejie Yu, Qiao Requirements Engineering and Aircraft Development Department Shanghai Aircraft Design and Research Institute Shanghai China

ISBN: (纸本)9781510682597

The implementation of Anti-Ice function in aircraft involves several systems, and the comprehensive system architecture has high complexity. The number of interfaces between multiple systems is huge, the interface forms are diverse, the working logic and requirement statements between multiple systems are complex. To handle this complexity, a model-based system architecture design method is proposed;SysML modeling language is applied into the architecture design and behavior analysis of aircraft Anti-Ice, which can realize the unified definition and decomposition of system architecture elements, the unified interface definition and analysis of multi-systems integrated architecture. At the same time, it also can simplify the requirement statements instead of traditional complicated statements. The architecture model and behavior model of aircraft level and system level are established, and the analysis of Anti-Ice function and the multi-systems integration design is effectively realized. The practice shows that the architecture design method based on SysML can effectively deal with the complexity of multi-systems integration design, and improve efficiency and quality of integrated design. © 2024 SPIE.

关键词： Aircraft models

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design and Implementation of an FPGA-Based 10G optical Fiber Interface Reflective Memory Card 24

Design and Implementation of an FPGA-Based 10G Optical Fiber...

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8th International conference on Electronic Information Technology and Computer engineering, EITCE 2024

作者： Xiao, Hanying Zhou, Yi Wuhan Research Institute of Posts and Telecommunications Hubei Wuhan China

ISBN: (纸本)9798400710094

To address the sharp increase in real-time data exchange volumes between nodes in real-time distributed systems, this paper designs and implements a 10G optical fiber interface reflective memory card. The paper provides a detailed explanation of the hardware design and firmware programming for the 10G optical fiber interface reflective memory card, and a physical prototype has been developed. To verify the rationality and practicality of the design, a series of experimental studies were conducted on the key performance indicators of the 10G optical fiber interface reflective memory card. Factors affecting data forwarding delay were analyzed, and potential optimization approaches were proposed. Additionally, the relationship between effective data bit length and data transmission rate, the length of data frames and average data forwarding time, as well as the overall transmission rate and bit error rate, was examined. Test results show that the 10G optical fiber interface reflective memory card, based on FPGA, exhibits high signal integrity in the 10G optical fiber interface hardware link;the data forwarding processing delay can be controlled within 794 to 838 nanoseconds;it operates stably at data transmission rates from 550MB/s to 660MB/s for 48 hours, maintaining low data forwarding delay and light bandwidth load throughout the process. This effectively meets the demand for efficient data exchange real-time distributed systems. © 2024 Copyright held by the owner/author(s).

关键词： Firmware

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A Method to design SOA-based Software Architecture and Goal Models from BPMN Models 48

A Method to Design SOA-based Software Architecture and Goal ...

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48th Annual IEEE International Computers, Software, and Applications conference (COMPSAC) - Digital Development for a Better Future

作者： Redouane, Blal Leshob, Abderrahmane Hafedh, Mili Univ Quebec Montreal Dept Analyt Operat & IT Montreal PQ Canada Univ Quebec Montreal Dept Comp Sci Montreal PQ Canada

ISBN: (纸本)9798350376975;9798350376968

In today's digital economy, organisations build software systems to support their Collaborative Business Processes (CBPs). Building such systems is a diligent and time-consuming task that requires both business and technical skills. Service-Oriented Architecture (SOA) offers design principals based on the service concept to help align CBPs with their supporting systems while helping organisations achieve their business goals. This paper aims to design a model-driven method that bridges the gap between CBPs and the systems that support them. Its objective is two-fold: i) design SOA-based software solutions that support CBPs expressed in BPMN and ii) build a set of goal models that link each service to the collaborative activity it automates and the business goals it satisfies.

关键词： Collaborative Business Process SOA Goal Model BPMN GRL Business Pattern

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Paradigm Shift in optical Payload Development: Rapid TRL Increase for CubeSat optical Payloads

Paradigm Shift in Optical Payload Development: Rapid TRL Inc...

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Accelerating Space Commerce, Exploration, and New Discovery conference, ASCEND 2023

作者： Maccarrone, Alicia Yow, Cameryn Carey, Janak Halterman, Alexander Cheff Weiner, Samantha Yacoby, Shimshone Johnson, Adam Damadeo, Robert Hill, Charles Quartus Engineering 9689 Towne Centre Drive San DiegoCA92121 United States NASA Langley Research Center 1 Nasa Drive HamptonVA23666 United States

ISBN: (数字)9781624107054

ISBN: (纸本)9781624107054

Quartus engineering Incorporated (Quartus) has been working with NASA LaRC to develop an approach to accelerate the development of spaceborne custom precision optical payloads, leveraging analytical models and existing opto-mechanical designs to provide a shift in the development of space-based optical systems for deployment on CubeSats and small satellite platforms. With this approach, science missions can focus budgets and staff on the instrumentation they need to complete their specific objectives and spend less time and money on the development of one-off designs. This approach could lead to rapid TRL progression for science missions that utilize validated components or subassemblies, saving significant cost and schedule by reducing or eliminating the needs for ground unit testing and validation, thus significantly reducing time to mature a program’s TRL from 2 to 6. Using the SAGE IV Pathfinder telescope as the subject, the SBIR Phase I focused on analysis correlation at the component level, while the SBIR Phase ii focused on analysis correlation at the system level. The Phase ii system level design used a 3-mirror telescope derived from the LaRC SAGE IV instrument design. The accuracy and repeatability of the Wavefront error (WFE) measurement process over temperature was reviewed. The Phase ii-E work builds upon the component level and system level testing to date by further developing the structural analysis validation with gathered material test data and random vibration testing for launch loads. Material test data, along with pre-test FEM results are reviewed. The Phase ii-E effort is scheduled to conclude in November 2023. The testing done under this SBIR continues to push a paradigm shift in telescope and optical system development. As the 2017 decadal survey [1] pointed out, it is important for the science community to find ways to make limited resources go further. With validation of these test and analysis tools, the science community can begin to expl

关键词： optical systems

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Simultaneous Sensor and Actuator Faults Diagnosis in Fornasini-Marchesini Second Model Using design Unknown Input Observer 32

Simultaneous Sensor and Actuator Faults Diagnosis in Fornasi...

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32nd International conference on Electrical engineering (ICEE)

作者： Mirshahi, Mehdi Shafiee, Masoud Amirkabir Univ Technol Dept Elect Engn Tehran Iran

ISBN: (纸本)9798350376357;9798350376340

This paper discusses the detection and diagnosis of sensor and actuator faults with input and output disturbance in two-dimensional linear systems described by the Fornasini-Marchesini second model. It can be rewritten as a new state variable by augmentation of the sensor fault in the output measurement equation with the state variable. The augmented equation can be rewritten as a descriptor system to estimate the state variables of the new system with actuator faults, and then the design of a new unknown input observer is proposed. This allows the errors of the new state variables and actuator faults to be estimated. The asymptotic stability conditions of the dynamic error of the observer are obtained in terms of linear matrix inequalities. A practical example is provided to demonstrate the effectiveness of the proposed method.

关键词： Fault diagnosis Sensor fault Actuator fault Fornasini-Marchesini second model (FM-ii) Unknown input observer

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The design of the aircraft control line detection device

The design of the aircraft control line detection device

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2024 International conference on Mechatronic engineering and Artificial Intelligence, MEAI 2024

作者： Lu, Guiyou Gao, Yan Army Armored Army Academician Official School Jilin Changchun130117 China

ISBN: (纸本)9781510689176

A portable detection device is designed for the control circuit of the flight device, which mainly detects the engine starting circuit and the flight control circuit. It focuses on the design of a power management module, micro high-voltage power supply module, high-voltage square wave signal module, start-up circuit detection module, and flight data storage module, to realize the safety, accuracy, comprehensiveness, and portability of the control circuit detection. © 2025 SPIE.

关键词： Resistance Control systems design Signal detection Power supplies Data storage Displays Circuit switching Gyroscopes Safety

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