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Nanofluidic Structures for Coupled Sensing and Remediation of Toxins 11

Nanofluidic Structures for Coupled Sensing and Remediation o...

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conference on smart biomedical and physiological sensor technology XI

作者： Shaw, K. Contento, N. M. Xu, Wei Bohn, P. W. Univ Notre Dame Dept Chem & Biomol Engn Notre Dame IN 46556 USA Univ Notre Dame Dept Chem & Biochem Notre Dame IN 46556 USA

ISBN: (纸本)9781628410440

One foundational motivation for chemical sensing is that knowledge of the presence and level of a chemical agent informs decisions about treatment of the agent, for example by sequestration, separation or chemical conversion to a less harmful substance. Commonly the sensing and treatment steps are separate. However, the disjoint detection/treatment approach is neither optimal, nor required. Thus, we are investigating how nanostructured architectures can be constructed so that molecular transport (analyte/reagent delivery), chemical sensing (optical or electrochemical) and subsequent treatment can all be coupled in the same physical space during the same translocation event. Chemical sensors that are uniquely well-poised for integration into 3-D micro-/nanofluidic architectures include those based on plasmonics and impedance. Following detection, treatment can be substantially enhanced if mass transport limitations can be overcome. In this context, in situ generation of reactive species within confined geometries, such as nanopores or nanochannels, is of significant interest, because of its potential utility in overcoming mass transport limitations in chemical reactivity. Solvent electrolysis in electrochemically coupled nanochannels supporting electrokinetic flow for the generation of reactive species, can produce arbitrarily tunable quantities of reagents, such as O-2 or H-2, in situ in close proximity to the site of a hydrogenation catalyst, for example. Semi-quantitative estimates of the local H2 concentration are obtained by comparing the spatiotemporal fluorescence behavior and current measurements with finite element simulations accounting for electrolysis and subsequent convection and diffusion within the confined geometry. H2 saturation can easily be achieved at modest overpotentials.

关键词： sensor nanofluidic impedance toxin remediation

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smart moving nightstand: For medical assistance of elderly people an open project

Smart moving nightstand: For medical assistance of elderly p...

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7th International conference on Health Informatics, HEALTHINF 2014 - Part of 7th International Joint conference on biomedical Engineering Systems and Technologies, BIOSTEC 2014

作者： Soucies, Nicolas Girouard, Jeremie Ouarti, Nizar Institute des Systemes Intelligents et de Robotique Universite Pierre et Marie Curie 4 place jussieu Paris France Alten 221 Boulevard Jean Jaurès Boulogne-Billancourt France

ISBN: (纸本)9789897580109

We present an open mobile platform that aims to benefit from versatile wireless sensors. This mobile assistant is a robot that can monitor different physiologic data for elderly people. Moreover it has the ability to determine the distance and potentially the position of the elderly person who use it. As an assistant it can transport some "objects" as glasses or drugs. Preliminary results show the proof of concept of our approach with a remote sensor that measures the temperature of the subject. We also present a method to assess the quality of the RSSI signal in order to determine the distance of a zigbee module attached to the arm of the subject. These results are the first steps towards a totally autonomous system that is an open platform. In this platform it will be easy to highlight the interaction or the correlation between the different physiological data and to move the robot properly in case of alert. It is possible to program different services and to integrate new sensors remotely. This platform can be convenient for developers and researchers involved in health technology. Copyright © 2014 SCITEPRESS - Science and technology Publications. All rights reserved.

关键词： Zigbee

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The human-environment interface design with a vision assistance module or a smart wheelchair

The human-environment interface design with a vision assista...

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International conference on Advanced Robotics and Intelligent Systems (ARIS)

作者： Han-Yen Yu Jiann-Jone Chen Chung-Hsien Kuo National Taiwan University of Science and Technology Taipei Taiwan

Automatic and intelligent health care service becomes important with the growth of aged population. To achieve intelligent mobility for a smart wheelchair, we proposed to construct a friend user-environment interface that users can interact with the living environment like a normal healthy person. An integrated interactive platform, including touch control panel, together with several cameras, and wireless sensors, is embedded on a wheelchair to achieve human interaction. Interaction functions, such as appliance control, semi-automatic vision assistant function, and physiological information monitoring function etc. have been developed to achieve the target. The goal of light mobility can be reached and the overall smart wheelchair system comprises: a mobile vehicle, information sensor modules, analysis control modules and an image capture unit which is set towards the headrest direction of the mobile vehicle to capture human facial image data. The physiological sensor module is used for sensing user physiological data. The analysis control module seamlessly transmits monitoring signals to a caregiver side in response to the image data or physiological data. These user-environment interaction functions are developed under the design target of human technology that the wheelchair user can interact with the environment like a normal person.

关键词： sensors biomedical monitoring Face Cameras Monitoring Image color analysis Visualization

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smart non-invasive wireless physiological monitoring system

Smart non-invasive wireless physiological monitoring system

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International conference on Embedded Systems (ICES)

作者： Pallavi K. Bhagwat Harshali Zodpe Electronics and Telecomm. Maharashtra Institute of Technology Pune India

In a country like India, patients are monitored in their recovery period, so the cost of hospitalization is also increasing day by day. The physiological parameters like body temperature, heart beat rate are monitored during recovery period of patients. This is done using a “smart Non-Invasive Wireless physiological Monitoring System”, where patients are monitored remotely. Impact sensors are used, which detects the fall of patients, so that immediate help is provided to them. In this paper the temperature, heart beat rate and impact sensors are used to measure physiological parameters which are then analysed and transmitted to PC through ZIGBEE wirelessly. Using GUI, parameters are monitored on PC by medical professionals. The high fluctuations in the parameters will be reported to doctors as a critical condition through GSM.

关键词： Temperature sensors biomedical monitoring Monitoring Temperature measurement Zigbee Wireless sensor networks

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Towards a modular, robust, and portable sensing platform for biological and point of care diagnostics

Towards a modular, robust, and portable sensing platform for...

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conference on smart biomedical and physiological sensor technology X

作者： Finch, Amethist S. Bickford, Justin R. Conn, Marvin A. Coppock, Matthew B. Sarkes, Deborah A. Stratis-Cullum, Dimitra N. US Army Res Lab Sensors & Elect Devices Directorate Adelphi MD 20783 USA

ISBN: (纸本)9780819495105

The ability to conveniently and immediately test and diagnose in a diverse and rapidly changing environment is critical for field diagnostics. smart biomedical sensors employ many different diagnostic/therapeutic methodologies;however, an ideal system would include the ability for results to be shared instantaneously with all members of the team through a software interface. We discuss our efforts towards the development and use of a robust, mobile platform (Android-based smart phone) that incorporates stable molecular recognition elements in sensor development. The inexpensive, compact, robust, archival, and portable design is ideal for rapid field diagnostics.

关键词： Point of Care Molecular Recognition Hand-Held Device smart Phone Ubiquitous Sensing

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A Health-Care Network with Service-Based Architecture

A Health-Care Network with Service-Based Architecture

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2012 International conference on Medical Physics and biomedical Engineering(ICMPBE 2012)

作者： Ching-Sung Wang Chien-Wei Liu Teng-Wei Wang Yi-Shiun Lee Cheng-Yen Li Da-Lin Lee Institute of Information and Communication Engineering Oriental Institute Technology The Third Department of Clinical Research Institute Peking University Department of Information Management St.Mary's College

This paper proposes a state-of-the-art framework on the remote household health-care system which combines a wireless sensing functionality with the wireless signal transport interface to form a physiological signal sensing *** analyzing these received physiological signals via post-signal processing units,the system can automatically subscribe a suitable health consulting message and then transmit the message back to the *** patients can monitor the physiological signals in real-time,and at the same time the patients can derive an essential health-care *** physiological signal transport interface is based on standard Bluetooth *** physiological sensor measure contains various physiological signals,e.g.,a heartbeat,oxygen saturation,blood pressure,or ECG *** signals are received via the Bluetooth access points and then passing through the internet toward the remote databank storage ***,the patients can registrate a health-care website platform,which is based on an architecture of the smart website module,to derive the essential information in the *** a health-care consulting network can make patients to get a fair share of the medical *** addition,the electronic medical record in the network is standardized in terms of HL7(Health Level Seven).Here we define XML(extensible markup language) as a tool to unify the record formats in different medical *** the proposed health-care network can play a role of bridge at medical information *** on this architecture,the patients can monitor the measurement results of various physiological signals in ***,such an integration service can significantly reduce the medical staff's diagnosis time.

关键词： Health-care system,physiological signal,Bluetooth,Real-time

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Developing a Cell-Based sensor for the Detection of Autoinducer-2'

Developing a Cell-Based Sensor for the Detection of Autoindu...

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conference on smart biomedical and physiological sensor technology X

作者： Servinsky, Matthew D. Germane, Katherine Gerlach, Elliot S. Tsao, Chen-Yu Byrd, Christopher M. Sund, Christian J. Bentley, William E. US Army Res Lab 2800 Powder Mill Rd Adelphi MD 20783 USA Univ Maryland College Pk MD 20742 USA

ISBN: (纸本)9780819495105

Bacteria use an intricate set of communication systems for sensing and interpreting environmental cues that coordinate population-based behavior. Quorum sensing is one of these systems, and it involves the production, release, and detection of small chemical signaling molecules. Recent research has revealed the role of quorum sensing molecules in the control of microbial activities such as biofilm formation. In this presentation we outline the development of a recombinant E. coli cell-based sensor for detection of the quorum sensing molecule Autoinducer-2 (AI-2), as well as engineering strategies to remove sugar and anoxic inhibition of the strain.

关键词： quorum sensing Autoinducer-2 (AI-2) sensor cell biofilm

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Non-Invasive Mechanical Properties Estimation of Embedded Objects using Tactile Imaging sensor

Non-Invasive Mechanical Properties Estimation of Embedded Ob...

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conference on smart biomedical and physiological sensor technology X

作者： Saleheen, Firdous Oleksyuk, Vira Sahu, Amrita Won, Chang-Hee Temple Univ Control Sensor Network & Percept CSNAP Lab Dept Elect & Comp Engn Philadelphia PA 19122 USA

ISBN: (纸本)9780819495105

Non-invasive mechanical property estimation of an embedded object (tumor) can be used in medicine for characterization between malignant and benign lesions. We developed a tactile imaging sensor which is capable of detecting mechanical properties of inclusions. Studies show that stiffness of tumor is a key physiological discerning parameter for malignancy. As our sensor compresses the tumor from the surface, the sensing probe deforms, and the light scatters. This forms the tactile image. Using the features of the image, we can estimate the mechanical properties such as size, depth, and elasticity of the embedded object. To test the performance of the method, a phantom study was performed. Silicone rubber balls were used as embedded objects inside the tissue mimicking substrate made of Polydimethylsiloxane. The average relative errors for size, depth, and elasticity were found to be 67.5%, 48.2%, and 69.1%, respectively. To test the feasibility of the sensor in estimating the elasticity of tumor, a pilot clinical study was performed on twenty breast cancer patients. The estimated elasticity was correlated with the biopsy results. Preliminary results show that the sensitivity of 67% and the specificity of 91.7% for elasticity. Results from the clinical study suggest that the tactile imaging sensor may be used as a tumor malignancy characterization tool.

关键词： tactile sensor optical sensing malignant tumor characterization elasticity imaging non-invasive imaging

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Hyperspectral Imaging to Discern Malignant and Benign Canine Mammary Tumors

Hyperspectral Imaging to Discern Malignant and Benign Canine...

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conference on smart biomedical and physiological sensor technology X

作者： Sahu, Amrita McGoverin, Cushla Pleshko, Nancy Sorenmo, Karin Won, Chang-Hee Temple Univ Control Sensor Network & Percept CSNAP Lab Dept Elect & Comp Engn Philadelphia PA 19122 USA Temple Univ Dept Bioengn Tissue Imaging & Spectroscopy Lab Philadelphia PA 19122 USA Univ Penn Sch Vet Med Oncol Sect Philadelphia PA 19104 USA

ISBN: (纸本)9780819495105

Hyperspectral imaging is an emerging technology in the field of biomedical engineering which may be used as a non-invasive modality to characterize tumors. In this paper, a hyperspectral imaging system was used to characterize canine mammary tumors of unknown histopathology (pre-surgery) and correlate these results with the post-surgical histopathology results. The system consisted of a charge coupled device (CCD) camera, a liquid crystal tunable filter in the near infrared range (650-1100 nm) and a controller. Spectral signatures of malignant and benign canine mammary tumors were extracted and analyzed. The reflectance intensities of malignant tumor spectra were generally lower than benign tumor spectra over the entire wavelength range. Previous studies have shown that cancerous tissues have a higher hemoglobin and water content, and lower lipid concentration with respect to benign tissues. The decreased reflectance intensity observed for malignant tumors is likely due to the increased microvasculature and therefore higher blood content of malignant tissue relative to benign tissue. Peaks at 700, 840, 900 and 970 nm were observed in the second derivative absorption spectra, these peaks were attributed to deoxy-hemoglobin, oxy-hemoglobin, lipid and water respectively. A 'Tissue Optical Index' was developed that enhances contrast between malignant and benign canine tumors. This index is based on the ratio of the reflectance intensity values corresponding to the wavelengths associated with the four chromophores. Preliminary results from 22 canine mammary tumors showed that the sensitivity and specificity of the proposed method is 85.7% and 94.6% respectively. These results show promise in the non-invasive optical diagnosis of canine mammary cancer.

关键词： Hyperspectral imaging canine mammary tumor near-infrared spectroscopy tumor characterization

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Utilizing Metalized Fabrics for Liquid and Rip Detection and Localization

Utilizing Metalized Fabrics for Liquid and Rip Detection and...

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conference on smart biomedical and physiological sensor technology X

作者： Holland, Stephen A. Mahan, Cody A. Kuhn, Michael J. Rowe, Nathan C. Univ Tennessee 1520 Middle Dr Knoxville TN 37916 USA Western Kentucky Univ Bowling Green KY 42101 USA Oak Ridge Natl Lab Oak Ridge TN 37830 USA

ISBN: (纸本)9780819495105

This paper proposes a novel technique for utilizing electrically conductive textiles as a distributed sensor for detecting and localizing liquids (e. g., blood), damage (e. g., rips, cuts, bullet holes) and, potentially, biosignals. The proposed technique is verified through both simulation and experimental measurements. Circuit theory is employed to depict conductive fabric as a bounded, near-infinite grid of resistors. Solutions to the well-known infinite resistance grid problem are used to confirm the accuracy and validity of this modeling approach. Simulations allow for discontinuities to be placed within the resistor matrix to illustrate the effects of bullet holes within the fabric. A real-time experimental system was developed that uses a multiplexed, Wheatstone bridge measurement approach to determine the resistances of a coarse electrode grid across the conductive fabric. Non-uniform resistance values of the grid infer the presence of liquids and rips in the fabric. The resistor-grid model is validated through a comparison of simulated and experimental results. Results suggest accuracy proportional to the electrode spacing in determining the presence and location of disturbances in conductive fabric samples. Future work is focused on refining the experimental system to provide more accuracy in detecting and localizing events (although just the knowledge of a penetration may be adequate for some intended applications) as well as developing a complete prototype that can be deployed for field testing. Potential applications include intelligent clothing, flexible, lightweight sensing systems, and combat wound detection.

关键词： Conductive textile distributed sensor resistance grid penetration flexible combat wound detection

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