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European solid state Device Research conference

作者： Marc Sansa Guillaume Gourlat Guillaume Jourdan Patrick Villard Gilles Sicard Sébastien Hentz CEA LETI MINATEC Campus 38054 Grenoble France Université Grenoble Alpes 38000 Grenoble France

ISBN: (纸本)9781467371360

We present a novel topology of heterodyne nanoelectromechanical (NEMS) self-oscillator, aimed at the dense integration of resonator arrays for sensing applications. This oscillator is based on an original measurement method, suitable for both open loop and closed loop operations, which simplifies current down-mixing set-ups. When implemented onchip, it will allow the reduction of the size and power consumption of readout CMOS circuitry. This is today the limiting factor for the integration density of NEMS oscillators for real-life applications. Here we characterize this method in openloop and closed-loop, and evaluate its frequency stability.

关键词： MEMS NEMS Oscillator Heterodyne Piezoresistive Mass sensor

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Sub-nanosecond avalanche transistor drivers for low impedance pulsed power applications 28

Sub-nanosecond avalanche transistor drivers for low impedanc...

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28th IEEE International conference on Plasma Science and 13th IEEE International Pulsed Power conference, PPPS 2001

作者： Molina, Luis L. Mar, Alan Zutavern, Fred J. Loubriel, Guillermo M. O'Malley, Martin W. Sandia National Laboratories AlbuquerqueNM87185-1153 United States

ISBN: (纸本)0780371208

Ultra compact, short pulse, high voltage, high current pulsers are needed for a variety of non-linear electrical and optical applications. With a fast risetime and short pulse width, these drivers are capable of producing sub-nanosecond electrical and thus optical pulses by gain switching semiconductor laser diodes. Gain-switching of laser diodes requires a sub-nanosecond puiser capable of driving a low output impedance (5 Ω or less). Optical pulses obtained had risetimes as fast as 20ps. The designed pulsers also could be used for triggering photo-conductive semiconductor switches (PCSS), gating high speed optical imaging systems, and providing electrical and optical sources for fast transient sensor applications. Building on concepts from Lawrence Livermore National Laboratory [1], the development of pulsers based on solid state avalanche transistors was adapted to drive low impedances. As each successive stage is avalanched in the circuit, the amount of over voltage increases, increasing the switching speed and improving the turn on time of the output pulse at the final stage. The output of the puiser is coupled into the load using a Blumlein configuration. The impedance and associated discharge time of this configuration is tailored to the impedance and pulse duration requirements of the load. © 2002 IEEE.

关键词： Laser pulses

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A HIGHLY STRETCHABLE pH sensor ARRAY USING ELASTOMER-EMBEDDED LASER CARBONIZED PATTERNS

A HIGHLY STRETCHABLE pH SENSOR ARRAY USING ELASTOMER-EMBEDDE...

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International conference on solid-state sensors, Actuators and Microsystems

作者： R. Rahimi M. Ochoa W. Yu B. Ziaie Purdue University West Lafayette IN USA

ISBN: (纸本)9781479989560

This paper reports on a facile and low cost method to fabricate highly stretchable potentiometric pH sensor arrays for biomedical and wearable applications. The technique uses laser carbonization of a thermoset polymer followed by transfer and embedment of carbonized nanomaterial onto an elastomeric matrix. The process combines selective laser pyrolization/carbonization with meander interconnect methodology to fabricate stretchable conductive composites with which pH sensors can be realized. The stretchable pH sensors display a sensitivity of -51 mV/pH over the clinically-relevant range of pH 4-10. The sensors remain stable for strains of up to 50 %.

关键词： pH sensor stretchable laser carbonization

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A novel biomimetic olfactory cell-based biosensor with DNA-directed site-specific immobilization of cells on a microelectrode array

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sensorS AND ACTUATORS B-CHEMICAL 2015年 217卷 186-192页

作者： Du, Liping Zou, Ling Wang, Qin Zhao, Luhang Huang, Liquan Wang, Ping Wu, Chunsheng Zhejiang Univ Dept Biomed Engn Minist Educ Biosensor Natl Special LabKey Lab Biomed Engn Hangzhou 310027 Peoples R China Zhejiang Univ Sch Med Dept Biochem & Genet Hangzhou 310058 Zhejiang Peoples R China Monell Chem Senses Ctr Philadelphia PA 19104 USA Chinese Acad Sci State Key Lab Transducer Technol Shanghai 200050 Peoples R China

The coupling of cells with transducers is a key step to develop cell-based biosensors in order to meet the specific performance requirements for biomedical applications. This study describes a novel biomimetic olfactory cell-based biosensor by the employment of a DNA-directed site-specific cell immobilization method, which can achieve controllable and high-efficient coupling between olfactory cells and the microelectrode array (MEA) chip. A pair of complementary thiol-modified single-stranded DNA (ssDNA) was designed and synthesized. One of them was covalently attached to the plasma membrane of olfactory cells that were isolated from rats. The other one was used as ssDNA probes and immobilized on the gold surface of microelectrodes on MEA chip. Based on the mechanism of complementary ssDNA hybridization, olfactory cells were site-specifically immobilized on the surface of microelectrodes. The distribution of olfactory cells on the surface of MEA chip was controlled by the pattern of ssDNA probes on the sensor surface. The fluorescent staining results indicate that olfactory cells were site-specifically coupled with the microelectrode array on the surface of a MEA chip, which formed a desirable olfactory cell array. In addition, extracellular recordings from the coupled olfactory cells demonstrate that microelectrodes can efficiently monitor the membrane potential changes originated from olfactory cells in response to odorant stimulations. This biomimetic olfactory cell-based biosensor can not only be used for the detection of odorant molecules, but also be applied for the research on the olfactory signal transduction mechanisms. This DNA-directed cell immobilization method provides a novel approach for controllable cell immobilization on solid support and consequently, contributes to the development of cell micro arrays for cell-based biosensors. (C) 2014 Elsevier B.V. All rights reserved.

关键词： Biosensor Olfactory cell DNA hybridization Cell immobilization Microelectrode array

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Ordered arrays of InGaN/GaN dot-in-a-wire nanostructures as single photon emitters 10

Ordered arrays of InGaN/GaN dot-in-a-wire nanostructures as ...

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conference on Gallium Nitride Materials and Devices X

作者： Lazic, Snezana Chernysheva, Ekaterina Gacevic, Zarko Garcia-Lepetit, Noemi van der Meulen, Herko P. Mueller, Marcus Bertram, Frank Veit, Peter Christen, Juergen Torres-Pardo, Almudena Gonzalez Calbet, Jose M. Calleja, Enrique Calleja, Jose M. Univ Autonoma Madrid Inst Nicolas Cabrera Dept Fis Mat E-28049 Madrid Spain Univ Autonoma Madrid IFIMAC E-28049 Madrid Spain Univ Politecn Madrid ISOM DIE E-28040 Madrid Spain Univ Magdeburg Inst Phys Expt D-39106 Magdeburg Germany Univ Complutense Madrid Ctr Nacl Microscopia Elect E-28040 Madrid Spain

ISBN: (纸本)9781628414530

The realization of reliable single photon emitters operating at high temperature and located at predetermined positions still presents a major challenge for the development of solid-state systems for quantum light applications. We demonstrate single-photon emission from two-dimensional ordered arrays of GaN nanowires containing InGaN nanodisks. The structures were fabricated by molecular beam epitaxy on (0001) GaN-on-sapphire templates patterned with nanohole masks prepared by colloidal lithography. Low-temperature cathodoluminescence measurements reveal the spatial distribution of light emitted from a single nanowire heterostructure. The emission originating from the topmost part of the InGaN regions covers the blue-to-green spectral range and shows intense and narrow quantum dot-like photoluminescence lines. These lines exhibit an average linear polarization ratio of 92%. Photon correlation measurements show photon antibunching with a g(2)(0) values well below the 0.5 threshold for single photon emission. The antibunching rate increases linearly with the optical excitation power, extrapolating to the exciton decay rate of similar to 1 ns(-1) at vanishing pump power. This value is comparable with the exciton lifetime measured by time-resolved photoluminescence. Fast and efficient single photon emitters with controlled spatial position and strong linear polarization are an important step towards high-speed on-chip quantum information management.

关键词： GaN/InGaN nanowire-quantum dots single photon source polarized emission

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Multi-pixel Photon Counter Module for MRI Compatible Application

Multi-pixel Photon Counter Module for MRI Compatible Applica...

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IEEE Nuclear Science Symposium and Medical Imaging conference (NSS/MIC)

作者： Shimizu, K. Hakamata, K. Sakai, T. Yamauchi, H. Uchida, H. Hirayanagi, M. Nakamura, S. Nishikido, F. Yoshida, E. Suga, M. Obata, T. Yamaya, T. Hamamatsu Photon KK Dev Ctr Hamamatsu Shizuoka 4348601 Japan Hamamatsu Photon KK Div Solid State Hamamatsu Shizuoka 4308587 Japan Natl Inst Radiol Sci Chiba 2638555 Japan Chiba Univ Chiba 2638522 Japan

ISBN: (纸本)9781467398626

A new detector for PET using multi-pixel photon counters (MPPCs) was developed for MRI compatible applications. This module has an 8 x 8 MPPC array, each segment has a 3 mm x 3 mm active area, and the pitch of the array is 4.1 mm in both directions. A temperature sensor is attached to the back of the array for temperature compensation. The MPPC array is connected to the front-end circuit with a detachable flexible printed circuit cable (FPC), which provides flexibility for detector arrangement. The front-end circuit consists of preamplifiers, a register network, buffer amplifiers, a built-in high voltage (HV) unit, and an embedded microprocessor unit. The HV unit is a down-regulator and requires an external HV supply. The preamplifier also has a sum output, which can be used for timing pick-off and energy discrimination. With LYSOs, the timing performance was evaluated using flexible printed cables of two different lengths. Set in a copper shield box, energy spectra and flood images were evaluated with a 3T-MRI. Very little interference was observed during simultaneous MRI measurements.

关键词： Magnetic resonance imaging

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Flexible, printed tactle, friction, and temperature sensor array for artificial skin

Flexible, printed tactle, friction, and temperature sensor a...

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International conference on solid state sensors and Actuators (TRANSDUCERS)

作者： Shingo Harada Kenichiro Kanao Yuki Yamamoto Takayuki Arie Seiji Akita Kuniharu Takei Osaka Prefecture University Sakai Osaka Japan

This paper describes printed, flexible, tactile, friction, and temperature sensors for the applications of an artificial electronic skin (e-skin). Conventional e-skin reported previously does not have the capability to detect friction in addition to tactile and temperature that allows us to imitate human functionalities and hold an object without dropping and/or breaking. This is due to difficulty of device fabrication on a flexible substrate. Furthermore, a printing technique is required to realize macroscale and low-cost flexible devices for the practical application. Here, we address these two challenges by arranging the structure of devices and developing the inks and printing technique.

关键词： Strain Force Temperature sensors Friction Temperature measurement arrays

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11.7 A multimodality CMOS sensor array for cell-based assay and drug screening

11.7 A multimodality CMOS sensor array for cell-based assay ...

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IEEE International conference on solid-state Circuits (ISSCC)

作者： Jong Seok Park Taiyun Chi Jessica Butts Tracy Hookway Todd McDevitt Hua Wang Georgia Institute of Technology

Cell-based assays are powerful tools to characterize cell- or tissue-specific physiological behaviors under external biochemical stimuli. External biochemical stimuli trigger endogenous cellular mechanisms that produce a cascade of physiological changes, resulting in easily measurable signals. Cell-based assays are widely used for large-scale drug screening in the pharmaceutical industry, where in vitro cultured cells are used to characterize the potency and toxicity of thousands of chemicals, leading to new drug development. This is particularly relevant in individualized medicine as patient-derived cells can test personalized drug responses. However, most current cell-based assays are conducted on single-modality sensors (electrical or optical only), which cannot capture the complexity of multi-parameter physiological responses. Sequentially transporting cell samples through different sensor platforms results in low throughput and potential abrogation of cell functions, while parallel monitoring of multiple samples with different modalities is subject to cell-to-cell variation even in a homogeneous cell population.

关键词： Optical sensors Impedance CMOS integrated circuits sensor arrays Temperature sensors

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Electrochemical detection of methyl nicotinate biomarker using functionalized anodized titania nanotube arrays

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MATERIALS RESEARCH EXPRESS 2015年第2期2卷

作者： Bhattacharyya, Dhiman Smith, York R. Misra, Mano Mohanty, Swomitra K. Univ Utah Dept Met Engn Salt Lake City UT 84112 USA Univ Utah Dept Chem Engn Salt Lake City UT 84112 USA

Sensing and detection of volatile organic compounds (VOCs) from exhaled breath is a possible method for early diagnosis of several pulmonary diseases. The use of solid-state TiO2 nanotube array sensors for VOC sensing applications has been of great interest. In this study, titania nanotubular arrays (TNAs) were synthesized through electrochemical anodization and used for the electrochemical detection of methyl nicotinate biomarker vapor. Functionalization of the TNA with cobalt was found to be necessary for methyl nicotinate detection. Titanium dioxide films synthesized through high temperature oxidation and functionalized with cobalt were also compared with cobalt functionalized TNA. The ordered TNA demonstrated itself to be an effective substrate for cobalt deposition and subsequent biomarker detection over thin titanium dioxide films. Surface analysis of the cobalt functionalized TNA by x-ray photoelectron spectroscopy (XPS) studies observed cobalt deposits exist as cobalt hydroxide on the surface. Exposure of the sensor surface to methyl nicotinate vapor results in the reduction of cobalt hydroxide to cobalt metal on the surface. Two mechanisms have been proposed to describe the binding of the nicotinate biomarker to cobalt functionalizedTNA consistent with the XPS studies and band theory.

关键词： Anodization sensor TiO2 nanotubes Volatile organic compounds

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All solid state mid-infrared dual-comb spectroscopy platform based on QCL technology 12

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conference on Quantum Sensing and Nanophotonic Devices XII

作者： Hugi, Andreas Geiser, Markus Villares, Gustavo Cappelli, Francesco Blaser, Stephane Faist, Jerome IRsweep GmbH CH-8037 Zurich Switzerland ETH Inst Quantum Elect CH-8093 Zurich Switzerland CNR INO I-50019 Sesto Fiorentino FI Italy LENS I-50019 Sesto Fiorentino FI Italy Alpes Lasers SA CH-2000 Neuchatel Switzerland

ISBN: (纸本)9781628414608

We develop a spectroscopy platform for industrial applications based on semiconductor quantum cascade laser (QCL) frequency combs. The platform's key features will be an unmatched combination of bandwidth of 100 cm(-1), resolution of 100 kHz, speed of ten to hundreds of mu s as well as size and robustness, opening doors to beforehand unreachable markets. The sensor can be built extremely compact and robust since the laser source is an all-electrically pumped semiconductor optical frequency comb and no mechanical elements are required. However, the parallel acquisition of dual-comb spectrometers comes at the price of enormous data-rates. For system scalability, robustness and optical simplicity we use free-running QCL combs. Therefore no complicated optical locking mechanisms are required. To reach high signal-to-noise ratios, we develop an algorithm, which is based on combination of coherent and non-coherent averaging. This algorithm is specifically optimized for free-running and small footprint, therefore high-repetition rate, comb sources. As a consequence, our system generates data-rates of up to 3.2 GB/sec. These data-rates need to be reduced by several orders of magnitude in real-time in order to be useful for spectral fitting algorithms. We present the development of a data-treatment solution, which reaches a single-channel throughput of 22% using a standard laptop-computer. Using a state-of-the art desktop computer, the throughput is increased to 43%. This is combined with a data-acquisition board to a stand-alone data processing unit, allowing real-time industrial process observation and continuous averaging to achieve highest signal fidelity.

关键词： Quantum cascade laser QCL frequency comb dual-comb spectroscopy semiconductor sensing

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