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development and test of an integrated microsystem for HPLC separation and detection using refractive index measurements

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sensorS AND ACTUATORS B-CHEMICAL 2004年第1-2期103卷 184-189页

作者： Brennan, D O'Brien, P O'Brien, J Freeman, N Swann, M NMRC Cork Ireland Farfield Sensors Ltd Unit 51 Manchester M6 6AJ Lancs England

In recent years optical waveguide sensors have been used for applications as biosensors and chemical sensors. Often the fluidic element of the sensor has a large working volume (mul) and full device integration is not undertaken. We look at a number of fabrication routes available to integrate microfluidic and optical detection components to achieve a fully integrated microsystem and highlight some of the technical issues arising in different integration strategies. Wafer and chip integration strategies using anodic, thin film and polymer bonding for the fluidic module and the optical sensor were investigated. The integrated microsystem was evaluated for fluidic and optical performance, integration showed no significant impact on performance of either component. The fluidic system presents a nanolitre detection volume offering reduced sample volumes in HPLC applications. Initial optical performance of the integrated structure was carried out using a refractive index measurement system, the Farfield Analight(R) Bio250. (C) 2004 Elsevier B.V. All rights reserved.

关键词： micro-fluidics micro-HPLC packaging refractive index

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development of a creatinine-sensitive sensor for medical analysis

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sensorS AND ACTUATORS B-CHEMICAL 2004年第1-2期103卷 260-264页

作者： Sant, W Pourciel-Gouzy, ML Launay, J Do Conto, T Colin, R Martinez, A Temple-Boyer, P CNRS LAAS F-31077 Toulouse 4 France HEMODIA SA F-31676 Labege France

Low-cost, disposable, SiO2/Si3N4 chemical field effect transistor (ChemFET) microsensors have been fabricated for pH measurements and adapted to biochemical applications by using polyvinyl alcohol (PVA) enzymatic layers deposited and patterned either by dip-coating, or spin-coating and photolithographic techniques. Both processes have been compared for the development and optimization of a creatinine-sensitive enzymatic field effect transistor (Creatinine-EnFET). Creatinine detection properties have been characterized in dialysate, demonstrating better properties for the spin-coated PVA enzymatic layers. Thus, creatinine sensitivity has been estimated at approximately 30 mV/pCreatinine on the [10-1000 mumol L-1] concentration range. The microsensor will be used for blood analysis and more precisely for haemodialysis. (C) 2004 Elsevier B.V. All rights reserved.

关键词： EnFET pH sensor creatinine detection medical analysis

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development of a creatinine-sensitive sensor for medical analysis

Development of a creatinine-sensitive sensor for medical ana...

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17th European conference on solid-state Transducers (Eurosensors XVII)

作者： Sant, W Pourciel-Gouzy, ML Launay, J Do Conto, T Colin, R Martinez, A Temple-Boyer, P CNRS LAAS F-31077 Toulouse 4 France HEMODIA SA F-31676 Labege France

关键词： EnFET pH sensor creatinine detection medical analysis

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Qualitative and quantitative identification of H₂S/NO₂ gaseous components in different reference atmospheres using a metal oxide sensor array

Qualitative and quantitative identification of H<sub>2</sub>...

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17th European conference on solid-state Transducers (Eurosensors XVII)

作者： Helli, O Siadat, M Lumbreras, M Univ Metz IPEM CLOES LICM F-57070 Metz France

Many environmental problems due to atmospheric pollution have increased the interest for the development of portable multisensor systems (electronic noses) for gas detection applications. In this way, we use a metal oxide sensor array dedicated to two industrial and environmental gases, alone or mixed. These gases have an antagonistic influence on the sensor layers, reducing (H2S) or oxidising (NO2). So the sensor time-responses present different behaviour according to the (low or high) concentration of the gases. In addition, humidity presents a notable reducing influence. We present in this work a new method to discriminate successfully the concentration of the atmospheric components, in three different reference atmospheres taking into account humidity and carbon dioxide. (C) 2004 Elsevier B.V. All rights reserved.

关键词： gas sensor humidity effect electronic nose environmental pollution discriminant factorial analysis

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development of pH-ISFET sensors for the detection of bacterial activity

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sensorS AND ACTUATORS B-CHEMICAL 2004年第1-2期103卷 247-251页

作者： Pourciel-Gouzy, ML Sant, W Humenyuk, I Malaquin, L Dollat, X Temple-Boyer, P CNRS LAAS F-31077 Toulouse 4 France

Ion sensitive field effect transistor (ISFET) microsensors including a SiO2/Si3N4 pH-sensitive gate structure and a titanium/gold pseudo-electrode have been used to detect the activity of the Lactobacillus Acidophilus bacterium. The first results have shown that such applications require high bacterial concentrations and, therefore, small analysis volumes. Thus, the pH-ISFETs have been adapted by fabricating micro-tanks from plexiglas or poly-dimethylsiloxane (PDMS). Bacterial detection over several minutes has been made possible by monitoring pH variations. This will allow ChemFET microsensors to be developed for bacteriological applications and for clinical analysis in particular. (C) 2004 Elsevier B.V. All rights reserved.

关键词： ISFET pH sensor bacterial activity detection

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Qualitative and quantitative identification of H₂S/NO₂ gaseous components in different reference atmospheres using a metal oxide sensor array

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sensorS AND ACTUATORS B-CHEMICAL 2004年第1-2期103卷 403-408页

作者： Helli, O Siadat, M Lumbreras, M Univ Metz IPEM CLOES LICM F-57070 Metz France

关键词： gas sensor humidity effect electronic nose environmental pollution discriminant factorial analysis

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Eddy‐Current Testing with GMR Magnetic sensor arrays

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AIP conference Proceedings 2004年第1期700卷 406-413页

作者： C. H. Smith R. W. Schneider T. Dogaru S. T. Smith 1Advanced Technology Group NVE Corporation Eden Prairie MN 55344 2Albany Instruments Charlotte NC 28209 3C. C. Cameron Applied Research Center UNC Charlotte Charlotte NC 28223

The advent of GMR magnetic sensors and GMR sensor arrays with frequency‐independent sensitivity offers improvements in speed, depth, and resolution in eddy‐current testing. arrays of GMR magnetic sensors allow rapid scanning of an area for defects in a single pass. The small size and low power consumption of these solid‐state magnetic sensors enable the fabrication of compact arrays of sensors on circuit boards and even on‐chip sensor arrays. arrays have been fabricated with sensor spacing as small as 5 micrometers when fine resolution is required. GMR sensor elements can be deposited on active silicon substrates facilitating on‐chip signal processing and multiplexing. This integration simplifies the sensor/signal‐processing interface, minimizes the number of leads, and can reduce the effect of noise. This paper will discuss the technology of fabricating arrays on GMR sensors, especially on‐chip arrays. Integrated sensor arrays with on‐chip signal processing and multiplexing will be described. Finally, some applications of arrays to crack and corrosion detection will be discussed.

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development and test of an integrated microsystem for HPLC separation and detection using refractive index measurements

Development and test of an integrated microsystem for HPLC s...

引用

17th European conference on solid-state Transducers (Eurosensors XVII)

作者： Brennan, D O'Brien, P O'Brien, J Freeman, N Swann, M NMRC Cork Ireland Farfield Sensors Ltd Unit 51 Manchester M6 6AJ Lancs England

关键词： micro-fluidics micro-HPLC packaging refractive index

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sensors applications in 21st century fossil-fuel based power generation

Sensors applications in 21st century fossil-fuel based power...

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IEEE sensors 2004 conference

作者： Chorpening, BT Tucker, D Maley, SM US DOE Natl Energy Technol Lab Washington DC 20585 USA

ISBN: (纸本)0780386922

The primary mission of the National Energy Technology Laboratory (NETL) is to assure U.S. fossil energy resources can meet increasing demand for affordable energy without compromising the quality of life for future generations of Americans. In this mission, NETL has historically focused on the development of advanced technologies as part of or in support of larger programs, such as the Clean Coal Power Initiative, FutureGen, the solid state Energy Conversion Alliance (SECA), and the Turbines program. Power generation research at NETL covers many areas, including coal and oil gasification and gas cleanup, turbine combustion, high temperature fuel cells, internal combustion engines for stationary power, and hybrid fuel-cell turbine power systems. Advancement in these areas either requires or would benefit from advances in sensor technology for harsh environments. This presentation will discuss opportunities for sensors in modern fossil-fuel based power generation, challenges posed by the operating environments, and summarize research at NETL on a sensor for in-situ monitoring of gas turbine combustors.

关键词： sensors power generation fossil fuel harsh environment

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New readout integrated circuits for position sensitive solid state detectors

New readout integrated circuits for position sensitive solid...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： T.O. Tumer V.B. Cajipe R.F. Calderwood M. Clajus S. Hayakawa Shi Yin NOVA Research and Development Inc. Riverside CA USA

We have been developing custom multi channel mixed signal readout integrated circuits (ICs) for advanced position sensitive solid-state radiation detector arrays for applications ranging from X-ray astronomy and medical imaging to security and industrial inspection. Readout ICs are an integral part of position-sensitive semiconductor detectors for X-ray, gamma-ray and charged particle imaging. Different detector applications require custom IC, which is typically designed for a specific detector array. Therefore, it is important to develop generic ICs to meet a range of applications in different complementing fields. To achieve this aim NOVA has been developing generic ICs for different fields of applications, which embodies versatile and adaptable functions as well as selectable features. An overview of generic ICs developed at NOVA is presented here. Each chip described targets a complementing application field with versatile functions and features.

关键词： solid state circuits Position sensitive particle detectors Application specific integrated circuits sensor arrays X-ray imaging Radiation detector circuits Astronomy Biomedical imaging Security Inspection

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