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SSRN 2023年

作者： Wall, Andrew Dong, Tony Benoit, Michael J. School of Engineering The University of British Columbia KelownaBCV1V 1V7 Canada Hexagon Manufacturing Intelligence DoncasterVIC3108 Australia

Solidification cracking is a defect that has been extensively studied in welding and casting and, consequently, standardised testing methods to quantify cracking have been developed for these processes. However, additive manufacturing (AM) processes currently lack any such test. The objective of the current study is to outline the development of a first-of-its-kind solidification cracking test for AM in the form of a benchmark specimen which aims to standardise quantification of solidification cracking in AM. The benchmark design utilized self-restraint to induce cracking at pre-defined locations, and was printed from Inconel 625 and 718 using laser directed energy deposition. Crack severity was quantified by optical microscopy, and it was found that the ratio of the linear crack length to the total crack length was consistently between 0.8-0.9. Further characterization revealed that the cracks propagated transgranularly along the melt pool boundaries. The commercially available finite element software package Simufact Welding was used to simulate printing of the benchmark specimen using the directed energy deposition module and confirmed high levels of stress at the crack initiation locations. Based on the characterization and simulation results, it was determined that the cause of the observed cracks was likely due to ductile fracture rather than solidification cracks. Nevertheless, the benchmark was able to show a difference in the level of cracking between alloys and the ability to initiate cracks at pre-defined locations using geometrically-induced restraint. Thus, it was concluded that while the existing benchmark design demonstrated progress towards a standardized test, further refinement to the design is required. © 2023, The Authors. All rights reserved.

关键词： Cracks

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CMM accuracy testing when measuringfree form surfaces

CMM accuracy testing when measuringfree form surfaces

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作者： vít Kumprecht Czech Technical University in Prague

This diploma thesis deals with evaluating the accuracy of coordinate measuring machines (CMM) when measuring freeform surfaces. For this work, two already machined standards were selected, on which it was necessary to choose suitable finishing operations for the possibility of performing accurate and reliable measurements and extraction of points for reverse engineering. In the first part, the work is devoted to mapping the issue of acceptance and reverification tests and testing of coordinate measuring machines according to the ČSN EN ISO 10360 standard. The work is also devoted to the description of general applications of freeform surfaces and machines for the production of these very precise surfaces. The thesis mentions the standards used in the world for acceptance and reverification tests according to metrology institutes (NIST, PTB, NPL) and maps the current state of research in the field of freeform standards. The second part of the thesis is dedicated to the freeform standards, namely their finishing. The solution itself is a step-by-step iteration of the proposed procedure to achieve the goal, which is the best possible accuracy of freeform standard production. The design of the solution takes into account the requirements for usability in the laboratories of the Faculty of Mechanical engineering of the Czech Technical University, both for production and teaching purposes. The main part is the actual completion and verification of the achieved parameters of the produced standard using measured data within the framework of reverse engineering. Using the model obtained from reverse engineering, a comparison of the possibilities of tactile and optical methods for component measurement is then made. The conclusion summarizes the evaluation of the achieved values and suggestions for possible improvements in production to achieve the required parameters.

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Industrial Resources in the design of Reconfigurable Manufacturing Systems for aerospace: A systematic literature review

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COMPUTERS IN INDUSTRY 2022年 142卷

作者： Arista, Rebeca Mas, Fernando Morales-Palma, Domingo vallellano, Carpoforo Univ Seville Dept Mech & Mfg Engn Paseo Descubrimientos S-N Seville 41092 Spain Airbus Dept Ind Syst Design & Modelling 2 Rond Point Emile Dewoitine F-31700 Blagnac France M&M Grp Ave Inventor Pedro Cawley 31 Cadiz 11500 Spain 2 Rond Point Emile Dewoitine F-31700 Blagnac France

A B S T R ACT New aerospace product developments need to be done following economic and environmental drivers like costs reduction, secure a short time-to-market, reduce total carbon footprint, among others. Aerospace manufacturing systems must quickly adapt to new products or driver changes, reusing existing industrial resources with enough flexibility to be adjusted or reconfigured in the desired scenarios. As a result, the industrial resource reconfigurability requires to be considered from the conceptual design phase of both, product and industrial resources development, in a collaborative engineering process, following Reconfigurable Manufacturing System (RMS) principles. This paper aims to support the aerospace RMS design at conceptual phase. To this end, a systematic literature review is performed focusing on the following research questions: (a) which characteristics of aerospace industrial resources need to be considered at conceptual design phase?;(b) how the industrial resources design is interlinked with the product and processes design in current RMS design methods?;(c) how to consider aerospace products non-negligible constraints during RMS design?;(d) what is the current application of RMS in the aerospace industry?. Compared to other reviews focusing on specific aspects of the RMS design and management, this study is focused on the industrial resource role in the RMS design at the conceptual phase and highlights the application or applicability of RMS in the aerospace industry. The goal is to provide the research community with an overview of the research trend on the field, and recommendations to stimulate researchers and practitioners in developing studies in this field. (c) 2022 Elsevier B.v. All rights reserved.

关键词： Reconfigurable Manufacturing Systems design of Production Systems Resource Management design Aerospace industry Systematic literature review

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Flexible fiber optoelectrodes integrating Perovskite-Nafion-ITO layers for efficient photoelectrocatalytic water purification

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Applied Catalysis B: Environmental 2024年 342卷

作者： Wang, Tzu-Heng Zhao, Zhe Garcia-Segura, Sergi Ling, Li Doong, Ruey-an Westerhoff, Paul Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu30013 Taiwan Institute of Analytical and Environmental Sciences National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu30013 Taiwan NSF Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment School of Sustainable Engineering and the Built Environment Ira A. Fulton Schools of Engineering Arizona State University TempeAZ85287-3005 United States Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal University Zhuhai519087 China

Photoelectrocatalytic processes (PECs) combine photocatalysis and electrochemical principles to enhance charge carrier generation and stability within nanomaterials (NMs). Nano-enabled PECs can be used for water purification or hydrogen production. While most PEC studies focus on nanomaterial discovery to improve charge carriers generation and separation, PEC reactor design is important to maximize energy efficiency of light delivery to activate photocatalysts. current designs face challenges due to low energy efficiencies because most reactor designs orientate light sources perpendicular to flat photocatalyst-coated electrode surfaces, and light must pass through glass materials plus water. We developed a low-cost, physically flexible catalytic polymeric optical fiber (POF) architecture, called optoelectrode fibers, embedded with electrically-conductive indium tin oxide (ITO) nanomaterials (NMs) plus TAB3Bi2Br7I2 perovskite (ABI) visible-photocatalysts in Nafion-PvDF polymers surface layer. The PEC-POF architecture achieves > 6000% larger surface area than flat glass electrodes, > 90% organic pollutant removal in water, and > 300% better incident photon-to-current than the same ABI-NM deposited on a conventional ITO-coated flat glass-plate under low energy irradiation. POFs are useful because are agonistic to the type of NM, facilitating deposition of NMs tunable to specific wavelengths using LED or polychromatic light sources. Bundling large numbers of POF optoelectrodes together achieves reactors with orders of magnitude higher packing geometries (m2 of catalyst surface per m3 of reactor volume) than flat-electrode PEC reactors, enabling the optoelectrode fiber to address environmental problems. © 2023 Elsevier B.v.

关键词： Nanostructured materials

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一种具有反压保护功能的高性能LDO设计

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微电子学 2024年第3期54卷 411-416页

作者：王建涛曲鹏达黄山松蒋佳润孟逸飞赵越肖知明南开大学电子信息与光学工程学院天津300350

针对LDO在反向电压状态下存在反灌电流现象并会对芯片造成损坏的问题,传统方案一般采用二极管进行反向保护,但这种方法会显著增大LDO的最小压差。文章采用MOS管替换二极管的方式来构成反向电压保护结构,并优化误差放大器和功率管尺寸,... 详细信息

针对LDO在反向电压状态下存在反灌电流现象并会对芯片造成损坏的问题,传统方案一般采用二极管进行反向保护,但这种方法会显著增大LDO的最小压差。文章采用MOS管替换二极管的方式来构成反向电压保护结构,并优化误差放大器和功率管尺寸,设计出的LDO最小压差在500 mA满负载下达到251 mv。然而加入防反向MOS管会使功率管的栅极驱动电容负载增大,给环路的稳定度带来难题。针对该问题,文章使用零极点抵消技术,通过引入零点的方式解决了LDO环路稳定困难的问题。电路基于TSMC 0.18μm BCD工艺设计,测试结果与仿真结果相符。结果表明,在2.5~20 v的输入电压范围内,负载电流为0~500 mA时,电路的输出电压为1.2 v,精度在±1%以内;负载调整率和线性调整率分别为0.85μv/mA和11.65μv/v;PSRR为93.4 dB@100 Hz。

关键词：反压保护最小压差环路稳定性低压差线性稳压器

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Functional analysis of an optical Real Time Locating System in production environments 55

Functional analysis of an Optical Real Time Locating System ...

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55th CIRP Conference on Manufacturing Systems, CIRP CMS 2022

作者： Bienia, Sebastian Demes, Michael Dreger, Joshua Dröder, Klaus Thiede, Sebastian Technische Universität Braunschweig Institute of Machine Tools and Production Technology Langer Kamp 19b Braunschweig38106 Germany Department of Design Production and Management Faculty of Engineering Technology University of Twente De Horst 2 Building 20 Enschede7522 LW Netherlands

Driven by the fourth industrial revolution (Industry 4.0), Real Time Location Systems (RTLS) are gaining importance. Holistic information about the position and movement of persons, vehicles and goods is an essential prerequisite for being able to efficiently automate entire process chains in the future with increasing machine autonomy. RTLS technologies enable the spatial and temporal localisation of objects within an environment. The current technological standard in the field of RTLS is based on anchors and transponders (e.g. Ultra Wide Band (UWB) systems), which use radio frequency (RF) signals to determine positions. However, the need for additional technical equipment is also a major weakness of these systems. In this paper, a new technological approach for real-time localisation of objects for industrial applications is presented. The proposed optical RTLS (ORTLS) is based on a decentralised sensor network, which enables the positioning of persons, vehicles and objects in industrial environments by means of artificial intelligence (AI) based object detection. In order to be able to use the system for safety-relevant applications in the future, certification must be obtained with regard to applicable regulations. A prerequisite for this is the validation and monitoring of the system performance with regard to the requirements of functional safety. For the analysis and evaluation of the system performance, this paper presents a methodology for the analysis of the AI-based detection under consideration of the environmental factors. © 2022 The Authors. Published by Elsevier B.v.

关键词： Artificial Intelligence Methods and Big Data Analytics for Smart Production Systems Digital Human centric Manufacturing Human-Machine Intelligent Cooperation Machine/Robot 4.0 Machines and Operators' Digital Twins Operator 4.0 Smart Factories Systems virtual

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Artificial intelligence for natural product drug discovery

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NATURE REvIEWS DRUG DISCOvERY 2023年第11期22卷 895-916页

作者： Mullowney, Michael W. Duncan, Katherine R. Elsayed, Somayah S. Garg, Neha van der Hooft, Justin J. J. Martin, Nathaniel I. Meijer, David Terlouw, Barbara R. Biermann, Friederike Blin, Kai Durairaj, Janani Gonzalez, Marina Gorostiola Helfrich, Eric J. N. Huber, Florian Leopold-Messer, Stefan Rajan, Kohulan de Rond, Tristan van Santen, Jeffrey A. Sorokina, Maria Balunas, Marcy J. Beniddir, Mehdi A. van Bergeijk, Doris A. Carroll, Laura M. Clark, Chase M. Clevert, Djork-Arne Dejong, Chris A. Du, Chao Ferrinho, Scarlet Grisoni, Francesca Hofstetter, Albert Jespers, Willem Kalinina, Olga v. Kautsar, Satria A. Kim, Hyunwoo Leao, Tiago F. Masschelein, Joleen Rees, Evan R. Reher, Raphael Reker, Daniel Schwaller, Philippe Segler, Marwin Skinnider, Michael A. Walker, Allison S. Willighagen, Egon L. Zdrazil, Barbara Ziemert, Nadine Goss, Rebecca J. M. Guyomard, Pierre volkamer, Andrea Gerwick, William H. Kim, Hyun Uk Mueller, Rolf van Wezel, Gilles P. van Westen, Gerard J. P. Hirsch, Anna K. H. Linington, Roger G. Robinson, Serina L. Medema, Marnix H. Univ Chicago Duchossois Family Inst Chicago IL USA Univ Strathclyde Strathclyde Inst Pharm & Biomed Sci Glasgow Scotland Leiden Univ Inst Biol Dept Mol Biotechnol Leiden Netherlands Georgia Inst Technol Ctr Microbial Dynam & Infect Sch Chem & Biochem Atlanta GA 30332 USA Wageningen Univ Bioinformat Grp Wageningen Netherlands Univ Johannesburg Dept Biochem Johannesburg South Africa Leiden Univ Inst Biol Biol Chem Grp Leiden Netherlands Goethe Univ Frankfurt Inst Mol Bio Sci Frankfurt Germany LOEWE Ctr Translat Biodivers Genom TBG Frankfurt Germany Tech Univ Denmark Novo Nord Fdn Ctr Biosustainabil Lyngby Denmark Univ Basel Biozentrum Basel Switzerland Leiden Acad Ctr Drug Res Drug Discovery & Safety Leiden Netherlands ONCODE Inst Leiden Netherlands Hsch Dusseldorf Ctr Digitalizat & Digital Dusseldorf Germany Eidgenoss TH ETH Zurich Inst Mikrobiol Zurich Switzerland Friedrich Schiller Univ Jena Inst Inorgan & Analyt Chem Jena Germany Univ Auckland Sch Chem Sci Auckland New Zealand Simon Fraser Univ Dept Chem Burnaby BC Canada Friedrich Schiller Univ Inst Inorgan & Analyt Chem Jena Germany Bayer AG Pharmaceut R&D Berlin Germany Univ Michigan Dept Microbiol & Immunol Ann Arbor MI USA Univ Michigan Dept Med Chem Ann Arbor MI USA Univ Paris Saclay Equipe Chim Subst Nat CNRS BioCIS Orsay France EMBL Struct & Computat Biol Unit Heidelberg Germany Univ Wisconsin Madison Sch Pharm Div Pharmaceut Sci Madison WI USA Pfizer WRDM Machine Learning Res Berlin Germany Adapsyn Biosci Hamilton ON Canada Univ St Andrews Chem Dept St Andrews Scotland Eindhoven Univ Technol Inst Complex Mol Syst Dept Biomed Engn Eindhoven Netherlands UMC Utrecht Alliance TU E WUR UUCtr Living Technol Utrecht Netherlands Swiss Fed Inst Technol Lab Phys Chem Zurich Switzerland Helmholtz Ctr Infect Res HZI Helmholtz Inst Pharmaceut Res Saarland HIPS Saarbrucken Germany Saarland Univ Med Fac Drug Bioinformat Homburg Germany Saarland Univ Ctr Bioin

developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learning have led to exciting developments in the computational drug design field, facilitating biological activity prediction and de novo drug design for molecular targets of interest. Here, we describe current and future synergies between these developments to effectively identify drug candidates from the plethora of molecules produced by nature. We also discuss how to address key challenges in realizing the potential of these synergies, such as the need for high-quality datasets to train deep learning algorithms and appropriate strategies for algorithm validation. Advances in computational omics technologies are enabling access to the hidden diversity of natural products, and artificial intelligence approaches are facilitating key steps in harnessing the therapeutic potential of such compounds, including biological activity prediction. This article discusses synergies between these fields to effectively identify drug candidates from the plethora of molecules produced by nature, and how to address the challenges in realizing the potential of these synergies.

关键词： Cheminformatics Data mining Drug discovery Natural products Target identification

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Development of the steam compressor unit for a desalination plant

Development of the steam compressor unit for a desalination ...

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2021 International Scientific and Technical Engine Conference, EC 2021

作者： Gorshkalev, A.A. Marakhova, E.A. Korneev, S.S. Urlapkin, v.v. Samara National Research University Department of Thermal Engineering and Thermal Engines Samara Russia

ISBN: (纸本)9781665448512

The analysis of the current state of scientific and technical developments in the field of seawater desalination and wastewater distillation, in particular, the designs of desalination plants using a steam compressor. A method for gas-dynamic calculation of a steam compressor has been developed. Based on this model, a one-dimensional computational model was created to search for the configuration of a steam compressor using the IOSO optimization program. A mathematical model has been created to obtain the values of the flow parameters at any point of the interscapular channel, as well as to obtain the pressure and efficiency characteristics. Calculations for the strength of the impeller of a steam compressor were made, and the natural frequency of the rotor oscillations was determined. Based on the analysis obtained, a new design solution was worked out and a full-scale experiment was carried out. © 2021 IEEE.

关键词： Steam

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Anisotropic van der Waals Crystal with High Refractive Index and Transparency for Uv-visible Range Applications

arXiv

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arXiv 2024年

作者： Slavich, Aleksandr S. Ermolaev, Georgy A. Zavidovskiy, Ilya A. Grudinin, Dmitriy v. Kravtsov, Konstantin v. Tatmyshevskiy, Mikhail K. Mironov, Mikhail S. Toksumakov, Adilet N. Tselikov, Gleb I. Fradkin, Ilia M. voronin, Kirill v. Povolotskiy, Maksim R. Matveeva, Olga G. Syuy, Alexander v. Yakubovsky, Dmitry I. Tsymbarenko, Dmitry M. Kruglov, Ivan Ghazaryan, Davit A. Novikov, Sergey M. vyshnevyy, Andrey A. Arsenin, Aleksey v. volkov, valentyn S. Novoselov, Kostya S. Emerging Technologies Research Center XPANCEO Internet City Emmay Tower Dubai United Arab Emirates Moscow Center for Advanced Studies Kulakova str. 20 Moscow123592 Russia Donostia/San Sebastián20018 Spain Department of Chemistry Lomonosov Moscow State University Moscow119991 Russia Laboratory of Advanced Functional Materials Yerevan State University Yerevan0025 Armenia University of Manchester ManchesterM13 9PL United Kingdom Department of Materials Science and Engineering National University of Singapore Singapore03-09 EA Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore117544 Singapore

Thanks to their record high refractive index and giant optical anisotropy, van der Waals (vdW) materials have accelerated the development of nanophotonics. However, traditional high refractive index materials, such as titanium dioxide (TiO2), still dominate in the most important visible range. This is due to the current lack of transparent vdW materials across the entire visible spectrum. In this context, we propose that germanium disulfide (GeS2) could offer a significant breakthrough. With its high refractive index, negligible losses, and biaxial optical anisotropy across the whole visible range, GeS2 has the potential to complement TiO2 and close the application gap of vdW materials in the visible spectrum. The addition of GeS2 could have a profound impact on the design of van der Waals nanophotonic circuits for any operation wavelength from ultraviolet to infrared, emphasizing the significance of the potential impact of GeS2 on the field of nanophotonics. © 2024, CC BY.

关键词： van der Waals forces

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ANDES, the high resolution spectrograph for the ELT: project management and system engineering approaches for mastering its preliminary design phase 10

ANDES, the high resolution spectrograph for the ELT: project...

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Conference on Modeling, Systems engineering, and Project Management for Astronomy X

作者： Di Marcantonio, P. Zanutta, A. Marconi, A. Abreu, M. Alberti, v Aliverti, M. Andersen, M., I Baldini, v Balestra, A. Baron, F. Brynnel, J. Cabral, A. Chazelas, B. Cirami, R. Coretti, I Gallo, E. Giro, E. Gaesslerk, W. Gonzalez, O. Huke, P. Kouach, D. Leao, I. C. Lunney, D. Macintosh, M. Mastowski, P. Monteiro, M. A. Oliva, E. Origlia, L. Pariani, G. Pinna, E. Redaelli, E. M. A. Riva, M. Selmi, C. Sortinor, F. Stempels, E. H. C. Wehbe, B. Xompero, M. Zimara, J. INAF Osservatorio Astron Trieste Via GB Tiepolo 11 I-34143 Trieste Italy INAF Osservatorio Astron Brera Via E Bianchi 46 I-23807 Merate Italy Univ Firenze Dipartimento Fis & Astron Via G Sansone 1 I-50019 Florence Italy Univ Copenhagen Niels Bohr Inst Blegdamsvej 17 DK-2100 Copenhagen O Denmark Univ Lisbon Fac Ciencias Inst Astrofis & Ciencias Espaco P-1749016 Lisbon Portugal INAF Osservatorio Astron Padova Vicolo Osservatorio 5 I-35122 Padua Italy Univ Montreal Inst Rech Exoplanetes Observ Mt Megant 1375 Ave Therese Lavoie Roux Montreal PQ H2V 0B3 Canada Leibniz Inst Astrophys Potsdam AIP Sternwarte 16 D-14482 Potsdam Germany Univ Geneva Observ Geneve 51 Chemin Pegasi CH-1290 Versoix Switzerland Univ Michigan Dept Astron 1085 S Univ Ann Arbor MI 48104 USA Max Planck Inst Astron Konigstuhl 17 D-69117 Heidelberg Germany STFC United Kingdom Astron Technol Ctr UK ATC Edinburgh EH9 3HJ Midlothian Scotland Georg August Univ Inst Astrophys & Geophys Friedrich Hund Pl 1 D-37077 Gottingen Germany Hsch Emden Leer Inst Laser & Opt Constantiapl 4 D-26723 Emden Germany Univ Paul Sabatier CNRS Observ Midi Pyrenees 14 V Ed Belin Belin F-31400 Toulouse France Univ Fed Rio Grande do Norte Dept Fis Teor & Expt Campus Univ BR-59072970 Natal RN Brazil Nicolaus Copernicus Univ Torun Fac Phys Astron & Informat Inst Phys Ul Grudziadzka 5 PL-87100 Torun Poland INAF Osservatorio Astron Brera Via Brera 28 I-20121 Milan Italy Uppsala Univ Dept Phys & Astron Box 516 S-75120 Uppsala Sweden Univ Porto Inst Astrofis & Ciencias Espaco CAUP Rua Estrelas P-4150762 Porto Portugal INAF Osservatorio Astrofis & Sci Spazio Via Gobetti 93-3 I-40129 Bologna Italy

ISBN: (纸本)9781510653566;9781510653559

At the end of 2021, the ESO council approved the start of the construction phase for a High Resolution Spectrograph for the ELT, formerly known as ELT-HIRES, renamed recently as ANDES (ArmazoNes high Dispersion Echelle Spectrograph). The current initial schedule foresees a 9-years development aimed to bring the instrument on-sky soon after the first-generation ELT instruments. ANDES combines high spectral resolution (up to 100,000), wide spectral range (0.4 mu m to 1.8 mu m with a goal from 0.35 mu m to 2.4 mu m) and extreme stability in wavelength calibration accuracy (better than 0.02 m/s rms over a 10-year period in a selected wavelength range) with massive optical collecting power of the ELT thus enabling to achieve possible breakthrough groundbreaking scientific discoveries. The main science cases cover a possible detection of life signatures in exoplanets, the study of the stability of Nature's physical constants along the universe lifetime and a first direct measurement of the cosmic acceleration. The reference design of this instrument in its extended version (with goals included) foresees 4 spectrographic modules fed by fibers, operating in seeing and diffraction limited (adaptive optics assisted) mode carried out by an international consortium composed by 24 institutes from 13 countries which poses big challenges in several areas. In this paper we will describe the approach we intend to pursue to master management and system engineering aspects of this challenging instrument focused mainly on the preliminary design phase, but looking also ahead towards its final construction.

关键词： ANDES astronomical instruments project management astronomical instruments system engineering ELT instrumentation high-resolution spectrograph high-precision spectrograph

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