Mercury contamination is one of the most severe issues in society due to its threats to public health and the ecological system. However, traditional methods for mercury ion detection are still limited by their timeco...
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Mercury contamination is one of the most severe issues in society due to its threats to public health and the ecological system. However, traditional methods for mercury ion detection are still limited by their timeconsuming procedures, requirement of expensive instruments, and low selectivity. In recent decades, tremendous progress has been made in the development of functional nucleic acid-based, especially DNAzyme sensors for mercury (ii) (Hg2+) determination, including RNA-cleaving DNAzymes and G-quadruplex-based DNAzymes in particular. Researchers have heavily studied the construction of Hg2+ sensors, mainly originating from in vitro selection-derived DNAzymes, by incorporating T-Hg2+-T recognition moieties in existing DNAzyme scaffolds, and interfacing Hg2+-sensitive sequences with nanomaterials. In the last case, the employment of materials (as quenchers, signal transducers and DNA immobilizers) enriches the application scenarios of current Hg2+-DNAzymes, due to a combination of their functions. We summarize a broad range of sensing approaches, including optical, electrochemical, and other sensing methods, and compare their features. This review elaborates on the rational design strategies for engineering DNAzymes to selectively sense Hg2+, critically discusses their properties in different application scenarios, and summarizes recent advances in this field. Additionally, current progress, challenges and future perspectives are also discussed. This minireview provides deeper insights into the chemistry of these functional nucleic acids when working with Hg2+, explains the design ideas of DNAzymesensors in each platform, and reveals potential opportunities in developing more advanced DNAzyme sensors for the highly selective and sensitive recognition of Hg2+.& nbsp;Environmental Implication: Mercury is one of the most toxic metallic contaminants due to its high toxicity, non biodegradability, and serious human health risks when accumulated in the body. In the r
Summary form only given. The transport of space charge dominated ion beams is of interest to many applications using high power particle beams. The most challenging demands are found in the field of ion beam driven in...
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Summary form only given. The transport of space charge dominated ion beams is of interest to many applications using high power particle beams. The most challenging demands are found in the field of ion beam driven inertial confinement fusion. Motivated by this application the space charge and current neutralized beam focusing and transport in gas discharge plasmas has been under investigation for a number of years. Paralleled by engineeringdesign work of a modified HILIFE ii reactor with discharge channel based final beam transport, and by experimental investigations of laser initiated high current discharges at the Lawrence Berkeley National Laboratory (LBNL) the ion optical properties of such a channel will be studied for the first time with a heavy ion beam at GSI.
This paper presents a capacitor selector software tool for a proper on-board Power Distribution Network (PDN) design in those high-speed applications which have strict requirements on voltage noise up to the first hun...
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This paper presents a capacitor selector software tool for a proper on-board Power Distribution Network (PDN) design in those high-speed applications which have strict requirements on voltage noise up to the first hundreds of megahertz. current commercial tools for PDN design only offer a manual choice of the capacitor value and their number simulating the board impedance profile. This manual resolution becomes very hard when the design has high power consumption and noise requirements are very strict. The aim of this software is to solve a basic on-board PDN design minimizing the number of "change simulate-analyze" iterations that have to be carried out in the manual PDN design. This software, PDN designer, uses the FDTIM method introducing some design specifications. Thus, it offers an on board PDN design with low number of capacitors, reducing space on board and total cost. A particular case of PDN design using PDN designer will be shown for a module using multigigabit optical connectors connected to an Altera Stratix ii GX FPGA. This board is working with data rates of 75 Gbps for a high-energy physics application. Results of PDN designer for this board are introduced in Cadence Allegro SPB 16.2 PI tool, obtaining an impedance profile that meets noise specifications and validates the PDN design.
Recently, van der Waals heterostructure has attracted interest both theoretically and experimentally for their potential applications in photoelectronic devices, photovoltaic devices, plasmonic devices and photocataly...
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Distributed tactile sensing for multi-force detection is crucial for various aerial robot interaction tasks. However, current contact sensing solutions on drones only exploit single end-effector sensors and cannot pro...
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Optimization of a broadband metamaterial absorber usually adopts evolutionary algorithms, which require many objective function evaluations. To remedy this issue, a dual-objective surrogate-based constrained optimizat...
Optimization of a broadband metamaterial absorber usually adopts evolutionary algorithms, which require many objective function evaluations. To remedy this issue, a dual-objective surrogate-based constrained optimization algorithm is proposed to increase the absorption bandwidth and reduce the thickness of the absorber. To decrease the number of expensive evaluations, Kriging models are used to approximate objective functions. Then, a dual-objective expected improvement infill sampling criterion and probability of feasibility sampling criterion are considered to find current optimal solution and update the surrogate model. The optimal trade-off is obtained by Pareto front technique. The proposed algorithm is compared with a well-known multi-objective evolutionary algorithm NSGA-ii to verify its feasibility and efficiency. Finally, a broadband metamaterial absorber is optimized with the absorption bandwidth from 9.77GHz to 32.21GHz and the thickness of 2.93mm.
Three-dimensional printing technology has fundamentally revolutionized the product development processes in several industries. Three-dimensional printing enables the creation of tailored prostheses and other medical ...
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Three-dimensional printing technology has fundamentally revolutionized the product development processes in several industries. Three-dimensional printing enables the creation of tailored prostheses and other medical equipment, anatomical models for surgical planning and training, and even innovative means of directly giving drugs to patients. Polymers and their composites have found broad usage in the healthcare business due to their many beneficial properties. As a result, the application of 3D printing technology in the medical area has transformed the design and manufacturing of medical devices and prosthetics. Polymers and their composites have become attractive materials in this industry because of their unique mechanical, thermal, electrical, and optical qualities. This review article presents a comprehensive analysis of the current state-of-the-art applications of polymer and its composites in the medical field using 3D printing technology. It covers the latest research developments in the design and manufacturing of patient-specific medical devices, prostheses, and anatomical models for surgical planning and training. The article also discusses the use of 3D printing technology for drug delivery systems (DDS) and tissue engineering. Various 3D printing techniques, such as stereolithography, fused deposition modeling (FDM), and selective laser sintering (SLS), are reviewed, along with their benefits and drawbacks. Legal and regulatory issues related to the use of 3D printing technology in the medical field are also addressed. The article concludes with an outlook on the future potential of polymer and its composites in 3D printing technology for the medical field. The research findings indicate that 3D printing technology has enormous potential to revolutionize the development and manufacture of medical devices, leading to improved patient outcomes and better healthcare services.
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