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Acceptor engineering of MRI-sensitive conjugated polymers for tumor microenvironment-responsive bio-imaging and combined therapy

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CHEMICAL engineering JOURNAL 2025年 504卷

作者： Li, Xiliang Lu, Ziwei Gao, Yijian Yang, Yuliang Huang, Zhongming Liu, Ying Ma, Yujie Wang, Yu Du, Enming Li, Shengliang Soochow Univ Affiliated Hosp 1 Coll Pharmaceut Sci Suzhou Med Coll Suzhou 215123 Peoples R China Soochow Univ Affiliated Hosp 1 Dept Radiol Suzhou 215006 Peoples R China Zhengzhou Univ Henan Eye Hosp Henan Prov Peoples Hosp Peoples Hosp Zhengzhou 450003 Peoples R China Henan Acad Innovat Med Sci Henan Eye Inst Zhengzhou 450003 Peoples R China

Enormous developments have been achieved in the design of organic theranostics agents simultaneously with diagnostic and therapeutic performances, especially in the second near-infrared (NIR-ii, 1000-1700 nm) window. One major challenge for the further progress of organic theranostics agents is the rarity of efficient materials simultaneously integrated with optical and magnetic performances, especially with tumor-responsive performance. Herein, a magnetic resonance imaging (MRI)-sensitive, NIR-ii-excitable conjugated polymer material is developed as a multifunctional nanoplatform for efficient tumor microenvironment (TME)-activated multimodal cancer theranostics. With D-A molecular engineering and ferrocene anchoring, the absorption capability of ferrocene-typed conjugated polymers (FCPs) can be rationally regulated to achieve NIR-ii absorption. The water-dispersive FCP-3 NPs demonstrate superior NIR-ii-excitable photothermal performance (PCE = 54 %) and T2-weighted MRI responses toward tumor endogenous H2O2. Upon NIR-ii irradiation, FCP-3 NPs can efficiently generate reactive oxygen species (ROS) through NIR-ii photothermal-augmented Fenton reaction in the TME. Both in vitro and in vivo experiments confirm that the FCP-3 NPs have high-performance combination therapy of NIR-ii photothermal therapy and augmented chemodynamic therapy with TME-sensitive magnetic resonance and photoacoustic dual-modal imaging, which realizes 100 % tumor elimination with high safety. This work offers a major step toward designing tumor microenvironment-activated polymeric materials for smart multimodal cancer theranostics.

关键词： Tumor microenvironment MRI NIR-ii Photothermal Conjugated polymer

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Review on Advancements and Challenges in Terahertz optical Communication

Review on Advancements and Challenges in Terahertz Optical C...

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2024 International Conference on Smart Electronics and Communication Systems, ISENSE 2024

作者： Anujan, Titto Jose, Tony Vijayan, Vismaya Karunya Institute of Technology and Sciences Division of ECE Tamil Nadu Coimbatore641114 India College of Engineering Trivandrum Department of Electronics and Communication Engineering Kerala 695016 India

ISBN: (纸本)9798331528126

The frequency range of terahertz (THz) has shown great promise for optical communication due to its enormous bandwidth and low interference. This review paper provides a thorough analysis of the latest developments and current obstacles in THz optical *** microwave and infrared wavelengths, the terahertz (THz) frequency range has special possibilities for optical communication *** investigates how THz frequencies and optical communication are convergent, emphasising the latter's promise for high-bandwidth, low-latency data transfer. We investigate possible uses of THz optical communication, such as sensing, imaging, and wireless networks, highlighting the revolutionary influence of this new sector on the design of communication systems in the future. © 2024 IEEE.

关键词： Bandwidth

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Power and Efficiency Scaling of GaAs-Based Edge-Emitting High-Power Diode Lasers

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IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 2025年第2期31卷

作者： Crump, Paul Boni, Anisuzzaman Elattar, Mohamed Khamari, S. K. Marko, Igor P. Sweeney, Stephen J. Arslan, Seval King, Ben Miah, Md. Jarez Martin, Dominik Knigge, Andrea Casa, Pietro Della Traenkle, Guenther Ferdinand Braun Inst FBH D-12489 Berlin Germany Univ Glasgow Glasgow City G12 8QQ Scotland FBH Berlin D-12489 Berlin Germany RRCAT Indore 452013 India Univ Glasgow Glasgow City G12 8LT Scotland

current progress in the scaling of continuous wave optical output power and conversion efficiency of broad-area GaAs-based edge emitters, broad-area lasers (BALs), operating in the 900 & mldr;1000 nm wavelength range is presented. Device research and engineering efforts have ensured that BALs remain the most efficient of all light sources, so that in the past 10 years, power conversion efficiency at 20 W continuous wave (CW) output power from BA lasers with a 90 & mldr;100 mu m wide stripe has increased 1.5-fold to 57% (via epitaxial layer design developments), whilst peak CW power per single emitter has increased around 3-fold to 70 W (via scaling of device size), with further scaling underway, for example via use of multi-junction designs. However, the peak achievable CW power conversion efficiency and CW specific output power (defined here as peak output power from a 100 mu m stripe diode lasers with a single p-n junction) has changed remarkably little, remaining around 70% and 25 W, respectively, for the past decade. Fortunately, research to understand the limits to peak efficiency and specific output power has also shown progress. Specifically, recent studies indicate that spatial non-uniformity in optical field and temperature play a major role in limiting both power and conversion efficiency. Technological efforts motivated by these discoveries to flatten lateral and longitudinal temperature profiles have successfully increased both power and efficiency. In addition, epitaxial layer designs with very high modal gain successfully reduce threshold current and increase slope at 25 degrees C to values comparable to those observed at 200 K, offering a path toward the 80% conversion efficiency range currently seen only at these cryogenic temperatures. Overall, whilst operating efficiency and power continue to scale rapidly, a technological path for increased specific power and peak efficiency is also emerging.

关键词： optical resonators Semiconductor lasers Power generation Diode lasers Power lasers optical reflection Epitaxial layers Stimulated emission Reflectivity Power conversion Quantum well lasers power conversion

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Benzobisthiadiazole-Based Small Molecular Near-Infrared-ii Fluorophores: From Molecular engineering to Nanophototheranostics

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ACS NANO 2024年第6期18卷 4683-4703页

作者： Wang, Leichen Li, Na Wang, Weili Mei, Anqing Shao, Jinjun Wang, Wenjun Dong, Xiaochen Nanjing Tech Univ NanjingTech Key Lab Flexible Elect KLOFE Nanjing 211816 Peoples R China Nanjing Tech Univ NanjingTech Inst Adv Mat IAM Nanjing 211816 Peoples R China Liaocheng Univ Sch Physicals & Informat Technol Liaocheng 252059 Shandong Peoples R China Jiangsu Normal Univ Sch Chem & Mat Sci Xuzhou 221116 Jiangsu Peoples R China

Organic fluorescent molecules with emission in the second near-infrared (NIR-ii) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely utilized as the electron acceptor in constructing donor-acceptor-donor (D-A-D) structured fluorophores with intensive near-infrared (NIR) absorption and NIR-ii fluorescence. Until now, numerous BBT-based NIR-ii dyes have been employed in tumor phototheranostics due to their exceptional structure tunability, biocompatibility, and photophysical properties. This review systematically overviews the research progress of BBT-based small molecular NIR-ii dyes and focuses on molecule design and bioapplications. First, the molecular engineering strategies to fine-tune the photophysical properties in constructing the high-performance BBT-based NIR-ii fluorophores are discussed in detail. Then, their biological applications in optical imaging and phototherapy are highlighted. Finally, the current challenges and future prospects of BBT-based NIR-ii fluorescent dyes are also summarized. This review is believed to significantly promote the further progress of BBT-derived NIR-ii fluorophores for cancer phototheranostics.

关键词： benzobisthiadiazole NIR-ii fluorophores molecularengineering phototheranostics NIR-ii fluorescenceimaging photoacoustic imaging photothermal therapy multimodal therapy

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Halogen source illumination optimization using a beam shaping biconic lens array 14

Halogen source illumination optimization using a beam shapin...

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current developments in Lens design and optical engineering XXIV 2023

作者： Smeesters, Lien Rosseel, Dries Vervaeke, Michael Thienpont, Hugo Department of Applied Physics and Photonics Pleinlaan 2 Brussels1050 Belgium

ISBN: (纸本)9781510665460

Illumination optical design using non-coherent sources is of major interest for sensing applications requiring a uniform illumination. We present the development of a custom biconic lens array, enabling beam shaping of a halogen source array to a rectangular uniform illumination. First, the tungsten halogen sources were accurately modelled considering the near-field emission pattern and broadband spectrum. Following, the illumination lens array is optimized, including a study on the optimal arrangement and pitch of the array, and ensuring a manufacturable design by taking the optical and mechanical tolerances into account. The optimized lens array comprises of custom lenses (Ø 20 mm) featuring a first spherical surface and a second biconic surface with different radii of curvature and aspherical coefficients (up to the 8th order) in the X and Y direction. A spatial uniformity, defined as the standard deviation of the flux distribution, of 0.0002 was achieved within the envisioned illumination area of 50 x 20 mm2 being close to a perfect uniformity considering a targeted value of 0. Finally, the aspheric biconic lens is manufactured using ultraprecision diamond tooling (Nanotech 350FG), and its performance is successfully validated in a laboratory demonstrator setup, giving rise to an optimized and uniform halogen source illumination. © 2023 SPIE.

关键词： optical design

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Dioptric Plan Multi Apochromat objectives for microscopes. optical design 14

Dioptric Plan Multi Apochromat objectives for microscopes. O...

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current developments in Lens design and optical engineering XXIV 2023

作者： Frolov, Dmitry N. Vinogradova, Olga A. Frolov, Alexey D. Pavlii, Aleksandr D. Project Labor-microscopes St.-Petersburg Russia LLC "Optotekhnika" St.-Petersburg Russia

ISBN: (纸本)9781510665460

For some types of studies on a microscope, optics is required, which has a multi apochromatic aberration correction in a continuous spectral range from the nearest short -wave UV to the nearest IR spectral areas. In the NUV range, in some cases, it is required to ensure the focus of laser sources radiation on the wavelengths of 248, 222, 213 and even 193 Nm. The work is also required for the near IR region, for example, for focusing laser sources radiation on wavelengths 1315, 1523 and even 2010 and 2080 nm. A priori such optics should also work in a visible spectral range. All studies can be carried out within the indicated a continuous NUV - NIR of the range. We propose to investigate the fundamental possibility of creating lens objectives for which chromatic aberrations are corrected in a wide spectral range. In addition, optics are required for research in the SWIR, MWIR, and LWIR spectral ranges. © 2023 SPIE.

关键词： Microscopes

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Brightness Strategies toward NIR-ii Emissive Conjugated Materials: Molecular design, Application, and Future Prospects

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ACS APPLIED BIO MATERIALS 2024年第12期7卷 8019-8039页

作者： Li, Xiliang Chen, Huan Su, Zihan Zhao, Qi Wang, Yu Li, Ning Li, Shengliang Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Peoples R China

Recent advances have been made in second near-infrared (NIR-ii) fluorescence bioimaging and many related applications because of its advantages of deep penetration, high resolution, minimal invasiveness, and good dynamic visualization. To achieve high-performance NIR-ii fluorescence bioimaging, various materials and probes with bright NIR-ii emission have been extensively explored in the past few years. Among these NIR-ii emissive materials, conjugated polymers and conjugated small molecules have attracted wide interest due to their native biosafety and tunable optical performance. This review summarizes the brightness strategies available for NIR-ii emissive conjugated materials and highlights the recent developments in NIR-ii fluorescence bioimaging. A concise, detailed overview of the molecular design and regulatory approaches is provided in terms of their high brightness, long wavelengths, and superior imaging performance. Then, various typical cases in which bright conjugated materials are used as NIR-ii probes are introduced by providing step-by-step examples. Finally, the current problems and challenges associated with accessing NIR-ii emissive conjugated materials for bright NIR-ii fluorescence bioimaging are briefly discussed, and the significance and future prospects of these materials are proposed to offer helpful guidance for the development of NIR-ii emissive materials.

关键词： NIR-ii conjugated materials fluorescence brightness bioimaging

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Exploring the optoelectronic properties of medium-wave dual-color detectors based on asymmetric InAs/InAsSb superlattice niBin structure

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INFRARED PHYSICS & TECHNOLOGY 2025年 145卷

作者： Huang, Wenya Yang, Shuai Yu, Yilun Liu, Beituo Ge, Rui Xia, Changsheng Yue, Fangyu East China Normal Univ Dept Elect Key Lab Polar Mat & Devices MOE Shanghai 200241 Peoples R China GMPT Co Ltd 8th FloorBldg 426 Qiuyue RdPudong New Area Shanghai 201120 Peoples R China Chinese Acad Sci Shanghai Inst Tech Phys State Key Lab Infrared Phys Shanghai 200083 Peoples R China

The short-mid-/mid-wave infrared (SMWIR/MWIR) detectors can capture target information in two bands simultaneously, enhancing the recognition accuracy in challenging interference scenarios by suppressing complex background. Here, we explore the optoelectrical properties of InAs/InAsSb-superlattice-based dual-band niBin detectors consisting of SMWIR/MWIR absorbers separated by an AlGaAsSb unipolar barrier. The experimental and simulated results show that: i) The bandgaps of both SMWIR and MWIR absorbers can be consistently determined via transmission and photocurrent spectra, giving cutoff wavelengths of 4.16 mu m and 5.21 mu m (77 K), respectively, well in line with the design values;ii) The device structure shows n-type conductivity by Hall measurements, based on which the conduction and scattering mechanisms at various temperatures can be clarified;iii) Dark current density analysis reveals the temperature dependent dominant current mechanisms, i. e., the generation-recombination current in 150 K - 210 K and the diffusion current above 210 K;and iv) The Burstein-Moss effect can make the determined optical bandgap slightly redshifted ( 34 meV), as compared to that of electrical techniques. This work provides new insights into bandgap engineering and structural design for MWIR dual-color detectors based on InAs/InAsSb superlattices.

关键词： InAs/InAsSb type-ii superlattice Short-mid-/mid-wave Infrared detectors

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design of ophthalmic contact lens using Q-type aspheres with reduced error budget for high visual acuity 25

Design of ophthalmic contact lens using Q-type aspheres with...

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Conference on current developments in Lens design and optical engineering XXV

作者： Peng, Wei-Jei Lee, Tsung-Xian Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol 43Sec 4Keelung Rd Taipei 106 Taiwan Natl Taiwan Univ Sci & Technol Grad Inst Color & Illuminat Technol 43Sec 4Keelung Rd Taipei 106 Taiwan

ISBN: (纸本)9781510679221;9781510679238

This paper investigates the design of an ophthalmic rigid contact lens (CL) that has a Q-type aspheric surface to reduce the tolerance error budget and produce higher visual acuity. CLs for myopia correction are typically made with spherical surfaces;when such CLs are worn in darkness, the visual acuity degrades severely due to the spherical aberration generated by pupil dilation. To maximize visual acuity, an aspheric CL is essential because it can correct the spherical aberration. In this study, a CL is designed based on a schematic eye model for evaluating the modulation transfer function (MTF) on the retina, and the result shows that the visual acuity produced by an aspheric CL is superior to that produced by a spherical CL. The traditional power-series polynomial is commonly used for aspheric surface design, but the aspheric slope cannot be controlled during optimization. The large slope departure from a best-fit sphere leads to high tolerance sensitivity and an inflection point;however, the CL does not permit such results. To solve this problem, the Q-type polynomial with slope constraint proposed by Forbes is applied to the aspheric CL in this study. The Q-type aspheric polynomial can not only enhance the optimization efficiency due to its orthogonal characteristics, but also reduce error budget for maximal manufacturing yield. The simulation results demonstrated that the spherical aberration is successfully reduced by the Q-type aspheric CL for better visual acuity in darkness.

关键词： Rigid contact lens Q-type asphere power-series asphere myopia correction spherical aberration schematic eye model

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Scalable dataset acquisition for data-driven lensless imaging 2

Scalable dataset acquisition for data-driven lensless imagin...

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Computational optical Imaging and Artificial Intelligence in Biomedical Sciences ii 2025

作者： Hung, Clara S. Kabuli, Leyla A. Ponomarenko, Vasilisa Waller, Laura Department of Electrical Engineering and Computer Sciences University of California Berkeley United States

ISBN: (纸本)9781510684140

Data-driven developments in lensless imaging, such as machine learning-based reconstruction algorithms, require large datasets. In this work, we introduce a data acquisition pipeline that can capture from multiple lensless imaging systems in parallel, under the same imaging conditions, and paired with computational ground truth registration. We provide an open-access 25,000 image dataset with two lensless imagers, a reproducible hardware setup, and open-source camera synchronization code. Experimental datasets from our system can enable data-driven developments in lensless imaging, such as machine learning-based reconstruction algorithms and end-to-end system design. © 2025 SPIE.

关键词： Imaging systems

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