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检索条件"任意字段=Frontiers in Biological Detection: From Nanosensors to Systems IX"

共 85 条记录，以下是1-10 订阅

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frontiers in biological detection: from nanosensors to systems XVII

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XVII 2025

ISBN: (纸本)9781510684249

The proceedings contain 12 papers. The topics discussed include: optical sensors for monitoring enzymatic activity;enhanced fluorescence detection of Tau protein using photonic crystal based biochips: a novel tool for Alzheimer's disease diagnostics;optomicrofluidic platforms for rapid and sensitive detection of biomarkers in medical diagnostics;beads stacked nano-sieve for on-chip concentration and surface enhanced Raman sensing of silver nanoparticles;single optical chemosensors for pattern recognition-driven chemical sensing;printed paper-based optical sensor array devices;and porous silicon on paper sensors: factors affecting biosensing performance.

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Optomicrofluidic Platforms for Rapid and Sensitive detection of Biomarkers in Medical Diagnostics 17

Optomicrofluidic Platforms for Rapid and Sensitive Detection...

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frontiers in biological detection: from nanosensors to systems XVII 2025

作者： Funari, Riccardo Armaghan Ayaz, Rana M. Oton, Claudio J. Shen, Amy Q. Di Pasquale, Fabrizio Scuola Superiore Sant’Anna Institute of Mechanical Intelligence Via G. Moruzzi 1 Pisa Italy Okinawa Institute of Science and Technology Micro/Bio/Nanofluidics Unit 1919-1 Tancha Okinawa Onna-son Japan

ISBN: (纸本)9781510684249

Optomicrofluidic sensing platforms, which integrate optical detection methods with microfluidic technology, have shown significant promise in laboratory settings. These platforms utilize functionalized optical transducers, such as plasmonic nanostructures or periodic gratings, for rapid and accurate detection of specific biological molecules. Here, we report on the design and application of optomicrofluidic platforms based on localized surface plasmon resonance (LSPR) with gold nanospikes and short-length long-period gratings (SL-LPG) in detecting and quantifying biomarkers like anti-SARS-CoV-2 antibodies and prostate cancer (PCa) biomarkers in real samples. © 2025 SPIE.

关键词： Surface plasmon resonance

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Enhanced fluorescence detection of Tau protein using photonic crystal-based biochips: a novel tool for Alzheimer's disease diagnostics 17

Enhanced fluorescence detection of Tau protein using photoni...

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frontiers in biological detection: from nanosensors to systems XVII 2025

作者： Sinibaldi, Alberto Chiavaioli, Francesco Occhicone, Agostino Danz, Norbert Munzert, Peter Baldini, Francesco Giannetti, Ambra Michelotti, Francesco SAPIENZA University of Rome Department of Basic and Applied Sciences for Engineering Via A. Scarpa 16 Rome00161 Italy Center for Life Nano and Neuro Science Viale Regina Elena 291 Rome00161 Italy Sesto Fiorentino Firenze50019 Italy A.Einstein-Str. 7 Jena07745 Germany

ISBN: (纸本)9781510684249

In this study, we present an innovative approach for the detection of Tau protein, a key biomarker of Alzheimer disease, using enhanced fluorescence detection. The methodology utilizes a bio-conjugation process to adapt 1D photonic crystal surface for precise molecular recognition. Our results demonstrate the successful detection of Tau protein in a simple environment, with a detection limit of 0.5 ng/mL and a quantification limit of 1.2 ng/mL. This work introduces optical disposable biochips as a novel diagnostic tool for Alzheimer disease and related neurodegenerative disorders, addressing critical challenges in biomarker detection and paving the way for advancements in therapeutic development. © 2025 SPIE.

关键词： Neurodegenerative diseases

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PHOTONIC INTEGRATED CIRCUIT BIOSENSORS FOR SENSING IN COMPLEX MEDIA 17

PHOTONIC INTEGRATED CIRCUIT BIOSENSORS FOR SENSING IN COMPLE...

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frontiers in biological detection: from nanosensors to systems XVII 2025

作者： Morales, Jennifer M. Bickford, Justin R. Winton, Alexandar Liu, Sanchao Coppock, Matthew Pellegrino, Paul M. Photonics Electronics & Quantum Sciences Division Integrated Photonics Branch United States Biological and Biotechnology Sciences Division Bio-materials Synthesis and Assembly Branch U.S. Army DEVCOM Army Research Laboratory 2800 Powder Mill Rd AdelphiMD20783 United States

ISBN: (纸本)9781510684249

Real-time tracking of biomarker levels is an increasingly diverse field with impacts ranging from athletic performance to medical emergencies. Although there are many current commercial-off-the-shelf devices available for measuring ions, heart rhythm, and activity, there are few options for protein detection. Here we developed a cold-chain-free biosensing platform using photonic integrated circuits (PICs) and protein catalyzed capture (PCC) peptides for protein detection. PCC peptides are short chains of synthetic D-amino acid peptides computationally designed and empirically tested to bind to targets of interest. This provides a shelf-stable antibody alternative with a custom sensitivity range. PICs are complete photonic and electronic systems on chip, which multiplex many sensors on one device and can be produced using the same tools available at CMOS foundries. In addition, they are small (millimeter), lightweight, have low power needs, and can be mass produced at low cost (low SWaP-C). Here we crosslink an interleukin-6 targeting PCCs to the surface of a microring resonator sensor and measure its response under perfusion of increasing levels of interleukin-6 in 10% serum. This work demonstrates the label-free detection of streptavidin and interlukin-6 in 10% serum for detecting proteins on chip. © 2025 SPIE.

关键词： Silicon photonics

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Investigating angiotensin converting enzyme-2 and SARS CoV-2 spike protein interactions using a combined label-free and fluorescence detection approach 17

Investigating angiotensin converting enzyme-2 and SARS CoV-2...

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frontiers in biological detection: from nanosensors to systems XVII 2025

作者： Sinibaldi, Alberto Chiappetta, Daniele Occhicone, Agostino Matteo, Paola Di Gaganina, Anastasiia Danz, Norbert Munzert, Peter Michelotti, Francesco SAPIENZA University of Rome Department of Basic and Applied Sciences for Engineering Via A. Scarpa 16 Rome00161 Italy Center for Life Nano and Neuro Science Viale Regina Elena 291 Rome00161 Italy A.-Einstein-Str. 7 Jena07745 Germany

ISBN: (纸本)9781510684249

The emergence of Coronavirus Disease in 2019, driven by the novel pathogen SARS-CoV 2, has posed a profound challenge to global health. In this context, we employed a combined label-free and fluorescence-based approach to investigate the interaction between two forms of the SARS-CoV-2 spike protein: the receptor-binding domain and the trimeric form. This study utilized one-dimensional photonic crystals supporting Bloch surface waves as optical biosensors. Through the analysis of label-free signals from spike protein probes and ACE-2 molecules, crucial data were gathered, including surface mass coverage and molecular density. The adaptability of this method holds great potential for advancing diagnostic tools and enhancing the understanding of disease biomarkers. These findings provide novel insights into the molecular interactions at the core of the COVID-19 pandemic, deepening our knowledge on the receptor-binding processes involved during SARS-CoV-2 outbreak. © 2025 SPIE.

关键词： Coronavirus

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Study of Foundry-Compatible Local Evanescent Array-Coupled (LEAC) Biosensor for COVID Serology 17

Study of Foundry-Compatible Local Evanescent Array-Coupled (...

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frontiers in biological detection: from nanosensors to systems XVII 2025

作者： Holmes, Cameron D. Lear, Kevin L. Geiss, Brian Anderson, Loran Kipper, Matt J. Lynd, Matthew C. Madruga, Liszt Y.C. Kramer, Joe Worthing, Molly Price, William Moslehi, Behzad Fahrenkopf, Nicholas Colorado State University Department of Electrical and Computer Engineering Fort CollinsCO United States Colorado State University School of Biomedical Engineering Fort CollinsCO United States Colorado State University Department of Microbiology Immunology and Pathology Fort CollinsCO United States Colorado State University Department of Chemical and Biological Engineering Fort CollinsCO United States MilpitasCA United States AlbanyNY United States Research Foundation for SUNY AlbanyNY United States

ISBN: (纸本)9781510684249

Preliminary immunobinding experiments, photonic simulations, and chip layout investigations support the use of local evanescent array-coupled (LEAC) biosensors for serological applications, such as antibody titers for SARSCoV-2. Antibody titers, the determination of antibody levels in blood serum samples, can inform immunization decisions in both human and veterinary health. Initial experiments focused on investigating the binding of SARS-CoV-2 antibodies to nucleocapsid protein (NCP) using lab-generated reagents on silicon nitride (SiN) wafers. Fluorescence measurements indicated relatively low binding rates, but a refined method involving the cleaving of captured tagged antibodies and using commercial reagents suggested that areal mass densities of approximately 1 ng/mm2 could be achieved. To integrate the LEAC biosensors with a silicon nitride photonics foundry process, Beam Propagation Method (BPM) and Finite Difference Time Domain (FDTD) simulations were conducted. Silicon nitride photonic integrated circuit (PIC) technology was selected for its superior performance, including ultra-low loss and broadband transparency. Small process modifications were introduced, allowing the integration of thin SiN waveguide cores above germanium detector arrays. These simulations demonstrated adequate sensitivity and successfully addressed concerns about crosstalk along the waveguide. Finally, the biosensor concepts were implemented in photonic chip layouts compatible with AIM Photonics. The integration of photonics, electrical connections, and microfluidics on a single platform posed significant challenges. Two sensor layouts-parallel and series-were investigated, each with its advantages. The series design, which requires lower light power and offers easier access to fluidics and electronics, was ultimately assessed as more viable despite the higher optical power required. © 2025 SPIE.

关键词： Silicon photonics

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frontiers in biological detection: from nanosensors to systems XV

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XV 2023

ISBN: (纸本)9781510658998

The proceedings contain 7 papers. The topics discussed include: on-chip integration of optical microbottles for biosensing;improved molecular detection sensitivity through photonic crystal unit cell design;infrared spectroscopy for neurochemical monitoring of alcohol and its metabolites;a simple, pipette-free, and power-free device for virus nucleic acid detection;solid-state optical chemosensor array devices for real-sample analysis;lossy mode resonance based single mode fiber structure for detection of ascorbic acid;and the study of aerosolized droplets with nanometer absorbing structures using a contactless photoacoustic technique and the finite-difference time-domain method.

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frontiers in biological detection: from nanosensors to systems V

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems V

ISBN: (纸本)9780819493392

The proceedings contain 22 papers. The topics discussed include: a computational approach to optimize microring resonators for biosensing applications;cascaded microring resonators for biomedical applications: improved sensitivity at large tuning range;real-time detection of small and large molecules using a porous silicon grating-coupled bloch surface wave label-free biosensor;silicon photonic crystal microarrays for high throughput label-free detection of lung cancer cell line lysates with sensitivity and specificity;evanescent field trapping of bacterial spores using photonic crystal cavities;two dimensional photonic crystal biosensors as a platform for label-free sensing of biomolecules;high yield silicon photonic crystal microcavity biosensors with 100fm detection limit;microscale tools for measuring spatiotemporal chemical gradients in biological systems;and detection, isolation, and capture of circulating breast cancer cells with photoacoustic flow cytometry.

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frontiers in biological detection: from nanosensors to systems XIII

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XIII 2021

ISBN: (纸本)9781510641594

The proceedings contain 8 papers. The topics discussed include: viral nucleic acid detection with CRISPR-Cas12a using high contrast cleavage detection on micro-ring resonator biosensors;optical horn effect via hour-glass type nanostructure for biomolecule analysis;optical horn effect via hour-glass type nanostructure for biomolecule analysis;hydrogel microlasers for versatile biomolecular analysis based on lasing microarray;microfluidic reaction design for real time chemical reactions monitoring;photonics-enabled lateral flow assay diagnostics;reducing detection limits of porous silicon thin film optical sensors using signal processing;and plasmonic nanovoids for monitoring sanitary conditions of a public place by surface-enhanced Raman spectroscopy.

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frontiers in biological detection: from nanosensors to systems XI

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XI 2019

ISBN: (纸本)9781510624320

The proceedings contain 18 papers. The topics discussed include: rapid and multiplexed detection of lyme disease using a grating coupled-fluorescent plasmonics (GC-FP) biosensor platform;nanoplasmonic discrimination of organic solvents using a bimetallic optical tongue;double emulsion optofluidic microlasers;speckle based sensing of chemicals by an acoustic excitation in aqueous solutions;monitoring of ammonia in an aqueous environment using a supercontinuum-based photoacoustic sensing system;high-throughput droplet-based microfluidic optical calorimeter;packaged microbubble resonators as a robust field sensing device;and long-range surface plasmon waveguide biosensors for disease detection.

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