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检索条件"任意字段=Frontiers in Biological Detection: From Nanosensors to Systems IX"

共 85 条记录，以下是1-10 订阅

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frontiers in biological detection: from nanosensors to systems XVI

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XVI 2024

ISBN: (纸本)9781510669819

The proceedings contain 12 papers. The topics discussed include: detection and imaging of multiple immunotherapy markers in the tumor microenvironment with SERS nanoprobes for automated treatment response monitoring;nanowire mesh sensor for SERS breath analysis;at-home measurement of blood biomarkers on the SiPhox home silicon photonics platform;fixed wavelength interferometer sensors for low-cost chem-bio sensing applications;sub-wavelength waveguide Michelson interferometer sensors;aspect ratio measurement of water-based rod-shaped particles in optical microcavities;molecular self-assembled chemosensors and their arrays;assessing food degradation and microbial growth by sensor read-out with fluorescence spectroscopy;manipulating light for the detection of viruses in resource-limited settings;a rapid fluorescent plasmonic biosensor platform to diagnose Lyme disease from serum antibodies;and 3D-printed nanoplasmonic device with super-hydrophobic sample concentrator for biosensing.

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frontiers in biological detection: from nanosensors to systems XV

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XV 2023

ISBN: (纸本)9781510658998

The proceedings contain 7 papers. The topics discussed include: on-chip integration of optical microbottles for biosensing;improved molecular detection sensitivity through photonic crystal unit cell design;infrared spectroscopy for neurochemical monitoring of alcohol and its metabolites;a simple, pipette-free, and power-free device for virus nucleic acid detection;solid-state optical chemosensor array devices for real-sample analysis;lossy mode resonance based single mode fiber structure for detection of ascorbic acid;and the study of aerosolized droplets with nanometer absorbing structures using a contactless photoacoustic technique and the finite-difference time-domain method.

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frontiers in biological detection: from nanosensors to systems XVII

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XVII 2025

ISBN: (纸本)9781510684249

The proceedings contain 12 papers. The topics discussed include: optical sensors for monitoring enzymatic activity;enhanced fluorescence detection of Tau protein using photonic crystal based biochips: a novel tool for Alzheimer's disease diagnostics;optomicrofluidic platforms for rapid and sensitive detection of biomarkers in medical diagnostics;beads stacked nano-sieve for on-chip concentration and surface enhanced Raman sensing of silver nanoparticles;single optical chemosensors for pattern recognition-driven chemical sensing;printed paper-based optical sensor array devices;and porous silicon on paper sensors: factors affecting biosensing performance.

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frontiers in biological detection: from nanosensors to systems XIV

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XIV 2022

ISBN: (纸本)9781510648296

The proceedings contain 9 papers. The topics discussed include: packaged microbubble resonators as a robust biosensing device;exceptional point of nanocylinder-loaded silicon microring for single nanoparticle detection;detecting aflatoxin m1 using wavelength-scanned fiber cavity attenuated phase shift spectroscopy;a magnetic modulation biosensing-based molecular assay for rapid and highly sensitive clinical diagnosis of COVID-19;identification of inhibitors for the S1-ACE2 interaction of the SARS-CoV-2 using magnetically modulated biosensors;analysis of machine learning techniques for capture agent free biosensing with porous silicon arrays;developing ultrabithorax-based sensing platforms;enhanced fluorescence detection of miRNAs using one-dimensional photonic crystal-based biochips;and chasing the green echiuran worm Bonellia in tidal pools of Okinawa.

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frontiers in biological detection: from nanosensors to systems XIII

Frontiers in Biological Detection: From Nanosensors to Syste...

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frontiers in biological detection: from nanosensors to systems XIII 2021

ISBN: (纸本)9781510641594

The proceedings contain 8 papers. The topics discussed include: viral nucleic acid detection with CRISPR-Cas12a using high contrast cleavage detection on micro-ring resonator biosensors;optical horn effect via hour-glass type nanostructure for biomolecule analysis;optical horn effect via hour-glass type nanostructure for biomolecule analysis;hydrogel microlasers for versatile biomolecular analysis based on lasing microarray;microfluidic reaction design for real time chemical reactions monitoring;photonics-enabled lateral flow assay diagnostics;reducing detection limits of porous silicon thin film optical sensors using signal processing;and plasmonic nanovoids for monitoring sanitary conditions of a public place by surface-enhanced Raman spectroscopy.

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Manipulating Light for the detection of Viruses in Resource-Limited Settings 16

Manipulating Light for the Detection of Viruses in Resource-...

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Conference on frontiers in biological detection - from nanosensors to systems XVI

作者： Qavi, Abraham J. Jiang, Qisheng Aman, M. Javad Vu, Hong Zetlin, Larry Dye, John M. Froude, Jeffrey W. Leung, Daisy W. Holtsberg, Frederick Crick, Scott L. Amarasinghe, Gaya Univ Calif Irvine Dept Pathol & Lab Med Irvine CA 92617 USA Auragent Biosci St Louis MO 63108 USA Integrated Biotherapeut Rockville MD 20850 USA Mapp Biopharmaceut Inc San Diego CA 92121 USA US Army Med Res Inst Infect Dis Ft Detrick MD 21702 USA US Army Nucl & Countering Weap Mass Destruct Agcy Ft Belvoir VA 22060 USA Washington Univ Sch Med Dept Med St Louis MO 63110 USA Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA

ISBN: (纸本)9781510669826;9781510669819

Neglected tropical diseases, including filoviruses, constitute a class of diseases affecting some of the most impoverished and vulnerable populations worldwide. Despite their significant impact, there is a pressing need for diagnostics that can effectively and rapidly detect pathogens in field settings. Herein, we present a portable diagnostic platform leveraging plasmonic fluors and lateral flow assays for the detection of filoviruses. Plasmonic fluors are a class of engineered, ultrabright fluorescent probes whose versatility and amenability towards use in a variety of diagnostics is a major clinical strength. Our resulting assay has a rapid turnaround time and sensitivities amenable for field deployment.

关键词： Diagnostics neglected tropical diseases pathogens plasmonics

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detection and imaging of multiple immunotherapy markers in the tumor microenvironment with SERS nanoprobes for automated treatment response monitoring 16

Detection and imaging of multiple immunotherapy markers in t...

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Conference on frontiers in biological detection - from nanosensors to systems XVI

作者： Andreou, Chrysafis Plakas, Konstantinos Berisha, Naxhije Gigoux, Matthieu Pal, Suchetan Merghoub, Taha Detty, Michael Kircher, Moritz Univ Cyprus Nicosia Cyprus Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY 10021 USA SUNY Buffalo Buffalo NY USA Indian Inst Technol Bhilai Bhilai India Weill Cornell Med New York NY USA

ISBN: (纸本)9781510669826;9781510669819

Detecting multiple molecular markers related to immune cells in vivo can revolutionize tumor phenotyping, monitor the effects of immunotherapy, and provide personalized treatment. Raman imaging with surface enhanced Raman scattering (SERS) nanoprobes is an optical imaging technique with high sensitivity and unparalleled multiplexing capacity. Here, we present a generalized methodology for the synthesis and visualization of SERS nanoprobes to detect multiple targets in vivo after intravenous administration in mouse models of cancer. A multiplexed imaging approach allows simultaneous scanning, unmixing, quantification, and visualization of the nanoprobes. We use this method to monitor the response of tumor-bearing mice (murine breast and colon cancer) to immune checkpoint blockade therapy. We visualize 8 immunological markers simultaneously, with subsequent immunohistological verification of each target. A spatially-aware multivariate approach is used for the segmentation of the acquired spectral images, which allowed their subsequent classification into responders or non-responders using machine learning.

关键词： Multiplexed imaging SERS immune checkpoint blockade

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A Simple, Pipette-free, and Power-free Device for Virus Nucleic Acid detection 15

A Simple, Pipette-free, and Power-free Device for Virus Nucl...

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Conference on frontiers in biological detection - from nanosensors to systems XV

作者： Bao, Mengdi Zhang, Shuhuan ten Pas, Chad Dollery, Stephen J. Bushnell, Ruth V. Yuqing, Fnu Liu, Rui Lu, Guoyu Tobin, Gregory J. Du, Ke Univ Calif Riverside Dept Chem & Environm Engn Riverside CA 92521 USA Rochester Inst Technol Dept Mech Engn Rochester NY 14623 USA Biol Mimet Inc 124 Byte Dr Ft Detrick MD 21702 USA Univ Georgia Dept Elect & Comp Engn Athens GA 30602 USA

ISBN: (纸本)9781510658998;9781510659001

A portable, inexpensive, and easy-to-manufacture microfluidic device is developed for the detection of SARS-CoV-2 dsDNA fragments. In this device, four reaction chambers separated by carbon fiber rods are pre-loaded with isothermal amplification and CRISPR-Cas12a reagents. The reaction is carried out by simply pulling the rods, without the need for manual pipetting. To facilitate power-free pathogen detection, the entire detection is designed to be heated with a disposable hand warmer. After the CRISPR reaction, the fluorescence signal generated by positive samples is identified by naked eye, using an inexpensive flashlight. This simple and sensitive device will serve as a new model for the next-generation viral diagnostics in either hospital or resource-limited settings.

关键词： nucleic acid detection CRISPR-Cas microfluidic device

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Improved molecular detection sensitivity through photonic crystal unit cell design 15

Improved molecular detection sensitivity through photonic cr...

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Conference on frontiers in biological detection - from nanosensors to systems XV

作者： Zhang, Yanrong Layouni, Rabeb Whittington, Christopher S. Halimi, Sami I. Weiss, Sharon M. Vanderbilt Univ Dept Elect & Comp Engn 221 Kirkland Hall Nashville TN 37235 USA Vanderbilt Univ Dept Chem & Biomol Engn 221 Kirkland Hall Nashville TN 37235 USA Vanderbilt Univ Interdisciplinary Mat Sci Program 221 Kirkland Hall Nashville TN 37235 USA

ISBN: (纸本)9781510658998;9781510659001

We report improved surface sensing capabilities of photonic crystal biosensors through the inclusion of a subwavelength dielectric feature inside the photonic crystal unit cell. Incorporation of a 50 nm silicon bar (i.e., anti-slot) spanning a traditional silicon photonic crystal unit cell increases the local energy density and consequently increases the resonance shift when molecules are captured on the sensor surface. Simulations and corroborating proof-of-concept experimental results based on a layer-by-layer polymer deposition are demonstrated. A perturbation theory approach for more computationally efficient predictions of photonic crystal biosensor performance is also reported, along with a discussion of the biosensor performance as a function of the spatial position of molecule attachment on the different sensor surfaces.

关键词： Photonic crystal Biosensor Layer-by-layer deposition Perturbation theory Silicon photonics

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Lossy mode resonance based single mode fiber structure for detection of ascorbic acid 15

Lossy mode resonance based single mode fiber structure for d...

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Conference on frontiers in biological detection - from nanosensors to systems XV

作者： Gupta, Vivek Kumar Choudhary, Kuldeep Raghuwanshi, Sanjeev Kumar Kumar, Santosh DIT Univ Sch Engn & Technol Dept EECE NPBRL Dehra Dun 248009 Uttarakhand India Indian Inst Technol Indian Sch Mines Dept Elect Engn Dhanbad 826004 Bihar India Liaocheng Univ Sch Phys Sci & Informat Technol Shandong Key Lab Opt Commun Sci & Technol Liaocheng 252059 Shandong Peoples R China

ISBN: (纸本)9781510658998;9781510659001

This article presents a lossy mode resonance (LMR) phenomenon based single mode fiber (SMF) structure for the detection of ascorbic acid (vitamin C). The fiber was etched for specified duration and then analyzed for Ascorbic acid detection. Ascorbic acid belongs to the group of drugs known as antioxidants. The body need it to boost the immune system, promote wound healing, and improve the absorption of iron from plant-based meals. The ascorbic acid test is useful for rapidly determining the levels of naturally occurring vitamin C in meals like fruit and vegetable juices etc. It can also be used to determine amount of ascorbic acid present in particular foods as a preservative or antioxidant. The proposed SMF structure will be used for the detection of ascorbic acid using graphene oxide (GO).

关键词： Lossy mode resonance single mode fiber ascorbic acid sensors graphene oxide nanoparticles etching

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