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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Boldt, Niklas P. Spath, Jana Hartmann, Stephan Birkholz, Mario Thewes, Roland Tu Berlin Faculty of Eecs Chair of Sensor and Actuator Systems Berlin Germany Tu Berlin Institute for Biotechnology Chair of Bioprocess Engineering Berlin Germany Ihp - Leibniz-Institut für Innovative Mikroelektronik Oder Frankfurt Germany

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

The impact of signal quality on dielectrophoresis experiments is investigated. Three frequencies providing a positive, a negative, and a vanishing real part of the Clausius Mossotti factor are compared using different signal resolutions. Sinusoidal signals are applied with 3 to 10 bit resolution, a total harmonic distortion of -60 to -20 dB, and a spurious free dynamic range from 27 to 65 dB. An experiment is performed with carboxyl functionalized 4.5 μm polystyrene microspheres in deionized water using an electrode pair in a microfluidic channel. Signal qualities with resolutions smaller than 7 bit induce unwanted DEP forces or lower the net force. © 2022 ieee.

关键词： Electrophoresis

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A Wide Linear Range Ultra-low Transconductance Amplifier for biomedical Sensor Applications 5

A Wide Linear Range Ultra-low Transconductance Amplifier for...

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5th International conference on circuits and systems, ICCS 2023

作者： Sun, Haoning Li, Zhipeng Wu, Ruihuang Feng, Yan Huang, Yuxuan Liu, Jingjing He, Jin Wei, Yiqun School of Electronics and Communication Engineering Sun Yat-Sen University Shenzhen China Shenzhen SoC Key Laboratory Peking University Shenzhen Institute and PKU-HKUST Shenzhen-Hong Kong Institution Shenzhen China Shenzhen SoC Key Laboratory Peking University Shenzhen Institute Shenzhen China

ISBN: (纸本)9798350308273

In the field of biomedical sensors, active filters with very low cutoff frequencies are required because of the weak electrical signals from the human body. The Gm-C filters are more prominent among the filter designs, which consist of an operational transconductance amplifier (OTA) and a capacitor. The key design issues are transconductance and linearity. In this paper, a new ultra-low transconductance OTA structure is proposed. The basic idea is to extend the linear input range of the OTA using the source degeneration pseudo-resistor technique and the bulk-driven technique. The transconductance is reduced by using series-parallel current mirrors for the OTA. This ultra-low transconductance OTA has an extremely low bias current of 0.1nA and a shunt factor of 100, reducing the OTA transconductance to 0.4pS with 39.55μVrms noise. It also increases the linear input range from ±50mV to ±2.5V, extending it by a factor of 50. © 2023 ieee.

关键词： Operational amplifiers

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Method for Increasing the OpAmp's Speed on the Basis of Complementary 'Folded' Cascodes

Method for Increasing the OpAmp's Speed on the Basis of Comp...

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2024 conference of Young Researchers in Electrical and Electronic Engineering, ElCon 2024

作者： Kleimenkin, Dmitriy V. Pakhomov, Ilya V. Denisenko, Darya Y. Don State Technical University Dept. of Scientific Research Dept. of Information Systems and Radio Engineering Rostov-on-Don Russia Don State Technical University Dept. of Scientific Research Dept. of Instrumentation and Biomedical Engineering Rostov-on-Don Russia Don State Technical University Dept. of Scientific Research Rostov-on-Don Russia Southern Federal University Dept. of Automatic Control Systems Rostov-on-Don Russia

ISBN: (纸本)9798350360646

The paper presents a promising method of increasing by more than an order of magnitude the maximum slew rate (SR) of integrated operational amplifiers (OpAmps) based on two-cycle 'folded' cascodes. This method is based on the introduction of special differentiating transient correction circuits into the classical circuits of OpAmps. Developed on the basis of the MH2XA031 array chip, the high-speed OpAmp is recommended for practical use in the subclass of so-called discrete-analog SC-filters on switched capacitors, for which (in some important cases) higher SR values are required. The effect of significantly improving the OpAmp's speed is to provide higher output current levels of the two-cycle 'folded' cascode that recharges the integrating correction capacitor during the transient edge. The OpAmp's speed performance in the large-signal mode is increased from 248.7 ~V / μ s to 4148 ~V / μ s as a result of this. © 2024 ieee.

关键词： BJT GaAs high-temperature chips high-temperature integrated resistors nJFET operational amplifier

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Reducing Drift in CMOS ISFET Arrays with Monolayer Graphene Sheets

Reducing Drift in CMOS ISFET Arrays with Monolayer Graphene ...

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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Goel, Karina Panteli, Christoforos Moser, Nicolas Georgiou, Pantelis Dept. of Electrical and Electronic Engineering Imperial College London SW7 2BT United Kingdom Centre for Bio-Inspired Technology Institute of Biomedical Engineering Imperial College London SW7 2AZ United Kingdom

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

In this paper, we present the scaling of a post-processing method to reduce drift in CMOS Ion-Sensitive Field-Effect Transistor (ISFET) arrays using monolayer graphene sheets. Graphene sheets were transferred using a Polymer Assisted Graphene Transfer (PAGT) process on a 4mm x 4mm chip with a 78x56 dimensional ISFET sensor array. The resulting performance parameters: drift, capacitive attenuation, pH sensitivity, and trapped charge were found, and averaged across all active pixels in the array for 5 dies. The results show, on average, a 55% reduction in drift and an 8% reduction in pH sensitivity for monolayer graphene ISFET arrays compared to plain ISFET arrays, with no effect on trapped charge and capacitive attenuation. Graphene's impermeability limits the modification of the sensing layers while providing physisorption sites to maintain pH sensitivity for the ISFETs. Furthermore, there is no effect on the spatial distribution of performance parameters across the ISFET array associated with transferring monolayer graphene. © 2022 ieee.

关键词： Graphene

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Real-Time, Dynamic Sensory Feedback Using Neuromorphic Tactile Signals and Transcutaneous Electrical Nerve Stimulation

Real-Time, Dynamic Sensory Feedback Using Neuromorphic Tacti...

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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Tian, Yucheng Slepyan, Ariel Iskarous, Mark M. Sankar, Sriramana Hunt, Christopher L. Thakor, Nitish V. Johns Hopkins University Department of Biomedical Engineering Baltimore United States Johns Hopkins University Department of Electrical and Computer Engineering Baltimore United States

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

Despite advances in motor control of current upper limb prosthetic devices, many prosthetic users still experience poor prosthesis embodiment due to a lack of sensory feedback. Previous studies have focused on novel tactile sensor development, neuron-like (neuromorphic) encoding, and sensory stimulation to develop sensorized prosthetics. However, the real-time dynamics of the tactile information and sensory feedback have not yet been addressed. In this work, we developed a neuromorphic closed-loop system that integrates tactile sensing and transcutaneous electrical nerve stimulation in real time. We demonstrate the dynamic characteristics of the sensory stimulation pulses that change in response to real-time neuromorphic tactile information, which is the foundation of enhanced sensory perception and dexterous motor control in upper limb amputees. © 2022 ieee.

关键词： Sensory feedback

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Automatically Controlled Flow and Pressure Conditions in a Bioreactor System for Medium- to Large-Sized Tissue-Engineered Vascular Grafts

Automatically Controlled Flow and Pressure Conditions in a B...

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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Stanislawski, Nils Lindwedel, Noah Blume, Cornelia Blume, Holger Institute of Microelectronic Systems Leibniz University Hannover Hannover Germany Institute of Technical Chemistry Leibniz University Hannover Hannover Germany

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

To support vascular tissue generation and maturation in vitro, a suitable environment providing dynamic cultivation is essential and can be achieved within specialized bioreactor systems. This paper describes the implementation and evaluation of a fluid circuit for automatically controlled flow and pressure conditions in medium to large vascular grafts with an inner diameter of up to 8 mm. Shear stresses exerted on the cultivating vascular graft's inner wall and fluid flow patterns were computed using Computational Fluid Dynamic simulations. Adjustment of the nutrient medium's viscosity ensures laminar flow and reduces the required flow rate for shear stresses of at least 20 dyn/cm2. A custom pressure sensor suited for steam sterilization with an accuracy of 0.1 mmHg was developed and optimized with regard to its impact on the laminar velocity profile. The presented system provides comprehensive conditioning for the cultivation of medium to large vessels to meet the clinical needs of viable tissue grafts but also for physiological research applications. © 2022 ieee.

关键词： Bioreactors

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20 Years of biomedical Image Acquisition and Processing at BioCAS

20 Years of Biomedical Image Acquisition and Processing at B...

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ieee biomedical circuits and systems (BIOCAS)

作者： Amine Bermak Tianyi Liu Ziyao Zhao Bo Wang Milin Zhang College of Science and Engineering Hamad Bin Khalifa University Doha Qatar Department of Electronic Engineering Tsinghua University Beijing China

ISBN: (数字)9798350354959

ISBN: (纸本)9798350354966

The development of biomedical image technology has brought significant advancements to healthcare and frontier research. Over the past 20 years, BioCAS has witnessed and documented comprehensive achievements in biomedical image sensor design and processing algorithms. This paper provides a systematic review of the work related to biomedical image acquisition and processing technology in BioCAS and offers a perspective on future developments in this field.

关键词： circuits and systems Medical services Artificial intelligence biomedical imaging Systematic literature review

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A firing rate independent threshold estimation for neuronal spike detection methods

A firing rate independent threshold estimation for neuronal ...

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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Tambaro, Mattia Vassanelli, Stefano University of Padua Padova Neuroscience Center Padova Italy University of Padua Padova Neuroscience Center Department of Biomedical Sciences Padova Italy

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

Setting the threshold for a spike detection method is always challenging. The amplitude of the spikes that can be recognized really depends on the noise present in the recording and the threshold must set a good tradeoff between the false detection of noise fluctuations and the smaller spikes. In this work we demonstrate how common approaches to automatic threshold estimation are highly affected by changes in the firing rate of neurons, causing the threshold to become an unreliable yardstick of evaluation between different channels and even within the same recording. For this reason, here we propose a noise estimation method relying on the base 2 logarithm, suitable for the automatic setting of a firing-rate independent threshold for spike detection methods. We compare its performances against other statistical variability indices as the widely used RMS, the mean, and the median of the absolute value of the signal both qualitatively and quantitatively, while varying the firing rate exhibited by the testbench dataset. Our results indicate that while the RMS and the mean are heavily affected by the firing rate, our proposed method performs almost equally to the median-based estimation, but the complexity of the latter poses it as an optimal solution for applications requiring a real-time definition of the threshold. © 2022 ieee.

关键词： Digital signal processing

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Improving The ResNet-based Respiratory Sound Classification systems With Focal Loss

Improving The ResNet-based Respiratory Sound Classification ...

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2022 ieee biomedical circuits and systems conference, BioCAS 2022

作者： Li, Jun Wang, Xiao Wang, Xiaoqin Qiao, Shushan Zhou, Yumei Institute of Microelectronics of the Chinese Academy of Sciences The Ime of Cas Beijing China Nanjing Institute of Intelligence Technology Nanjing China University of Chinese Academy of Sciences Beijing China

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

Automated respiratory sound classification aims to provide a rapid and reliable diagnosis of respiratory disease. However, the database used to develop a lung sounds classification system usually suffers from class imbalance issues, resulting in a lower recall of adventitious sounds compared to the normal class. In this paper, we adopt the focal loss for the ResNet-based systems to solve class imbalance issues. The experiments are conducted on the SPRSound dataset. At the event level, with ResNet18 of 11.3M parameters as the backbone, when trained with class-balanced methods, the best binary and multi-class scores of the validation set are 0.933 and 0.879, and those of the test set are 0.889 and 0.82. While at the record level, contributing to the focal loss, the best ternary score of the validation set is 0.833, achieved by TC-ResNet of 12.2M parameters, and the multi-class score is 0.673 with ResNet18. The ternary and multi-class scores of the test set are 0.718 and 0.533 with TC-ResNet. © 2022 ieee.

关键词： Classification (of information)

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Session 28 Overview: biomedical systems Imagers, Medical, Mems and Displays Subcommittee

Digest of Technical Papers - IEEE International Solid-State ...

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Digest of Technical Papers - ieee International Solid-State circuits conference 2021年 64卷 384-385页

作者： Bae, Joonsung Lloyd, Jennifer Van Hoof, Chris Kangwon National University Chuncheon Korea Republic of Analog Devices Santa ClaraCA United States Imec Leuven Belgium

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