检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

852 篇 会议
25 篇 期刊文献
2 册 图书

馆藏范围

879 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

298 篇 工学
- 210 篇 计算机科学与技术...
- 121 篇 生物工程
- 112 篇 软件工程
- 74 篇 生物医学工程（可授...
- 65 篇 电气工程
- 37 篇 信息与通信工程
- 32 篇 化学工程与技术
- 31 篇 控制科学与工程
- 13 篇 机械工程
- 11 篇 电子科学与技术（可...
- 9 篇 动力工程及工程热...
- 8 篇 材料科学与工程（可...
- 7 篇 仪器科学与技术
- 5 篇 交通运输工程
195 篇 理学
- 150 篇 生物学
- 75 篇 数学
- 32 篇 统计学（可授理学、...
- 30 篇 化学
- 25 篇 系统科学
- 17 篇 物理学
51 篇 管理学
- 30 篇 管理科学与工程(可...
- 24 篇 图书情报与档案管...
- 13 篇 工商管理
40 篇 医学
- 29 篇 基础医学(可授医学...
- 24 篇 临床医学
- 17 篇 药学(可授医学、理...
- 7 篇 公共卫生与预防医...
33 篇 农学
- 28 篇 作物学
6 篇 法学
- 6 篇 社会学
4 篇 经济学
- 4 篇 应用经济学
3 篇 文学
1 篇 哲学
1 篇 教育学

主题

588 篇 bioinformatics
289 篇 genomics
138 篇 proteins
86 篇 biological syste...
83 篇 biology computin...
82 篇 sequences
74 篇 dna
72 篇 databases
65 篇 computational mo...
62 篇 gene expression
61 篇 computer science
61 篇 computational bi...
56 篇 diseases
51 篇 humans
49 篇 genetics
46 篇 data mining
42 篇 organisms
42 篇 testing
35 篇 laboratories
34 篇 rna

机构

4 篇 university of ca...
4 篇 ieee
4 篇 tianjin institut...
4 篇 drexel univ phil...
3 篇 school of comput...
3 篇 department of el...
3 篇 california insti...
3 篇 department of co...
3 篇 pacific northwes...
2 篇 aes-tietê
2 篇 univ brasilia de...
2 篇 fudan univ sch c...
2 篇 pacific nw natl ...
2 篇 department of em...
2 篇 scylla bioinform...
2 篇 institute of com...
2 篇 department of co...
2 篇 scripps institut...
2 篇 university of de...
2 篇 mechanical engin...

作者

9 篇 v. olman
9 篇 ying xu
6 篇 tatsuya akutsu
6 篇 h. ali
5 篇 fdez-riverola fl...
5 篇 zhengchang su
4 篇 morihiro hayashi...
4 篇 y. xu
4 篇 hu xiaohua
4 篇 soda paolo
4 篇 kim sun
4 篇 atanassov krassi...
4 篇 sicilia rosa
3 篇 z. su
3 篇 zeyad mohammad
3 篇 m. baba
3 篇 p. dam
3 篇 h. peng
3 篇 x. chen
3 篇 cordelli ermanno

语言

876 篇 英文
2 篇 中文
1 篇 其他

检索条件"任意字段=IEEE Computational Systems Bioinformatics Conference"

共 879 条记录，以下是791-800 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Haplotype motifs: an algorithmic approach to locating evolutionarily conserved patterns in haploid sequences

Haplotype motifs: an algorithmic approach to locating evolut...

引用

ieee conference on bioinformatics

作者： R. Schwartz Department of Biological Sciences Carnegie Mellon University Pittsburgh PA USA

The promise of plentiful data on common human genetic variations has given hope that we will be able to uncover genetic factors behind common diseases that have proven difficult to locate by prior methods. Much recent interest in this problem has focused on using haplotypes (contiguous regions of correlated genetic variations), instead of the isolated variations, in order to reduce the size of the statistical analysis problem. In order to most effectively use such variation data, we will need a better understanding of haplotype structure, including both the general principles underlying haplotype structure in the human population and the specific structures found in particular genetic regions or sub-populations. This paper presents a probabilistic model for analyzing haplotype structure in a population using conserved motifs found in statistically significant sub-populations. It describes the model and computational methods for deriving the predicted motif set and haplotype structure for a population. It further presents results on simulated data, in order to validate the method, and on two real datasets from the literature, in order to illustrate its practical application.

关键词： Genetics Humans bioinformatics Diseases Genomics Testing Statistical analysis computational modeling Biology Predictive models

来源：评论

学校读者我要写书评

暂无评论

computational inference of regulatory pathways in microbes

Computational inference of regulatory pathways in microbes

引用

ieee conference on bioinformatics

作者： Z. Su P. Dam X. Chen V. Olman T. Jiang B. Palenik Y. Xu Divisions of Life Sciences and Computer Sciences & Mathematics Oak Ridge National Laboratory Protein Informatics Group Department of Computer Science and Engineering University of California Riverside USA Scripps Institute of Oceanography University of California San Diego USA

We present a computational protocol for inference of regulatory and signaling pathways in a microbial cell, through mining "high-throughput" biological data of various types, literature search, and computer-assisted human inference. This protocol consists of four key components: (a) construction of template pathways for microbial genomes related to the target genome, which have either been thoroughly studied or had a significant amount of relevant experimental data, (b) inference of target pathways for the target genome, by combining the template pathway models and target genome-specific information, (c) assignment of genes of the target genome to each individual functional roles in the pathway model, and (d) validation and refinement of the pathway models using pathway-specific experimental data or other information. To demonstrate the effectiveness of this procedure, we have applied this computational protocol to the construction of the phosphorus assimilation pathways in synechococcus WH8102. In this paper, we present a model of the core component of this pathway and provide our justification in support of the predicted model.

关键词： bioinformatics Genomics Protocols Biology computing Predictive models Application software Protein engineering Informatics Mathematics Laboratories

来源：评论

学校读者我要写书评

暂无评论

Can we identify cellular pathways implicated in cancer using gene expression data?

Can we identify cellular pathways implicated in cancer using...

引用

ieee conference on bioinformatics

作者： N. Shah J. Lepre Y. Tu G. Stolovitzky Pennsylvania State University University Park PA USA IBM Computational Biology Center Yorktown Heights NY USA

The cancer state of a cell is characterized by alterations of important cellular processes such as cell proliferation, apoptosis, DNA-damage repair, etc. The expression of genes associated with cancer related pathways, therefore, may exhibit differences between the normal and the cancerous states. We explore various means to find these differences. We analyze 6 different pathways (p53, Ras, Brca, DNA damage repair, NF/spl kappa/b and /spl beta/-catenin) and 4 different types of cancer: colon, pancreas, prostate and kidney. Our results are found to be mostly consistent with existing knowledge of the involvement of these pathways in different cancers. Our analysis constitutes proof of principle that it may be possible to predict the involvement of a particular pathway in cancer or other diseases by using gene expression data. Such method would be particularly useful for the types of diseases where biology is poorly understood.

关键词： Cancer Gene expression DNA bioinformatics Noise measurement Colon Pancreas Diseases Biomedical measurements Genomics

来源：评论

学校读者我要写书评

暂无评论

Fold recognition using sequence fingerprints of protein local substructures

Fold recognition using sequence fingerprints of protein loca...

引用

ieee conference on bioinformatics

作者： A. Kryshtafovych T.R. Hvidsten J. Komorowski K. Fidelis Lawrence Livermore National Laboratories Livermore CA USA The Linnaeus Centre for Bioinformatics University of Uppsala Uppsala Sweden

A protein local substructure (descriptor) is a set of several short nonoverlapping fragments of the polypeptide chain. Each substructure describes local environment of a particular residue and includes only those segments of the main chain that are located in the proximity of that residue. Similar descriptors from the representative set of proteins were analyzed to reveal links between the substructures and the sequences of their segments. Using the detected sequence-based fingerprints, specific geometrical conformations are assigned to new sequences. The ability of the approach to recognize correct SCOP folds was tested on 273 sequences from the 49 most popular folds. Good predictions were obtained in 85% of cases. No performance drop was observed with decreasing sequence similarity between target sequences and sequences from the training set of proteins.

关键词： Fingerprint recognition Libraries Shape Assembly Protein engineering Amino acids Laboratories bioinformatics Testing Prediction methods

来源：评论

学校读者我要写书评

暂无评论

Initial large-scale exploration of protein-protein interactions in human brain

Initial large-scale exploration of protein-protein interacti...

引用

ieee conference on bioinformatics

作者： J.Y. Chen A.Y. Sivachenko R. Bell C. Kurschner I. Ota S. Sahasrabudhe Myriad Proteomics Inc. Salt Lake UT USA

Study of protein interaction networks is crucial to post-genomic systems biology. Aided by high-throughput screening technologies, biologists are rapidly accumulating protein-protein interaction data. Using a random yeast two-hybrid (R2H) process, we have performed large-scale yeast two-hybrid searches with approximately fifty thousand random human brain cDNA bait fragments against a human brain cDNA prey fragment library. From these searches, we have identified 13,656 unique protein-protein interaction pairs involving 4,473 distinct known human loci. In this paper, we have performed our initial characterization of the protein interaction network in human brain tissue. We have classified and characterized all identified interactions based on gene ontology (GO) annotation of interacting loci. We have also described the "scale-free" topological structure of the network.

关键词： Large-scale systems Proteins Humans Fungi Cloning Libraries Data analysis systems biology bioinformatics Proteomics

来源：评论

学校读者我要写书评

暂无评论

Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks

Combining microarrays and biological knowledge for estimatin...

引用

ieee conference on bioinformatics

作者： S. Imoto T. Higuchi T. Goto K. Tashiro S. Kuhara S. Miyano Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan Institute for Statistical Mathematics Tokyo Japan Graduate School of Genetic Resources Technology Kyushu University Fukuoka Japan

We propose a statistical method for estimating a gene network based on Bayesian networks from microarray gene expression data together with biological knowledge including protein-protein interactions, protein-DNA interactions, binding site information, existing literature and so on. Unfortunately, microarray data do not contain enough information for constructing gene networks accurately in many cases. Our method adds biological knowledge to the estimation method of gene networks under a Bayesian statistical framework, and also controls the trade-off between microarray information and biological knowledge automatically. We conduct Monte Carlo simulations to show the effectiveness of the proposed method. We analyze Saccharomyces cerevisiae gene expression data as an application.

关键词： Bayesian methods Biological system modeling Gene expression Proteins bioinformatics Biological control systems Humans Genomics Mathematics Genetics

来源：评论

学校读者我要写书评

暂无评论

A query language to support scientific discovery

A query language to support scientific discovery

引用

ieee conference on bioinformatics

作者： B. Eckman K. Deutsch M. Janer Z. Lacroix L. Raschid IBM Life Sciences West Chester PA USA Institute for system Biology Seattle WA USA Arizona State University Tempe AZ USA University of Maryland College Park MD USA

Traditional data management approaches need to be leveraged to support scientific discovery. A query language that supports biological science must be capable of expressing and implementing biological investigations. The biological query language (BQL) presented in this paper aims to enhance the scientists querying ability by: (1) providing an intermediate query language between scientific workflows and traditional query languages such as SQL, (2) expressing operators such as ranking and validating, not made directly available by traditional query languages and often difficult to express (by complex queries), and (3) constraining the evaluation of their operators by various semantics. This paper shows step by step how the overall problem of identifying genes related to a disease may be translated into a succession of BQL queries.

关键词： Database languages bioinformatics

来源：评论

学校读者我要写书评

暂无评论

Substrate recognition by enzymes: a theoretical study

Substrate recognition by enzymes: a theoretical study

引用

ieee conference on bioinformatics

作者： K. Ueno-Noto K. Takano M. Hara-Yokoyama Graduate School of Humanities and Sciences Ochanomizu University Japan Graduate School of Dental Tokyo Medical and Dental University Japan

We previously reported that a series of gangliosides inhibited the activity of an enzyme NAD glycohydrolase (CD38), and that those with tandem sialic acid residues in the sugar chain had great inhibitory effect. We describe the results of computer simulations on three-dimensional and electronic structures of gangliosides to clarify the causative factors of difference in the inhibitory effect and the recognition mechanisms of the enzyme. We found that dipole moments and HOMO were correlated with inhibitory effect by conformational analyses and molecular orbital (MO) calculations. CD38 is likely to recognize the two carboxyl groups in tandem sialic acid residues of gangliosides, as well as the phosphate groups in NAD. A strong correlation was found between the orbital energies of HOMO by MO calculations and the extent of the inhibitory effect. Salvation effects were also considered to interpret the substrate recognition mechanisms in the biological system, which supported the above results.

关键词： Biochemistry Orbital calculations Dentistry Computer simulation Solid modeling Biological systems Extracellular Performance analysis Algorithm design and analysis bioinformatics

来源：评论

学校读者我要写书评

暂无评论

Automatic construction of 3D structural motifs for protein function prediction

Automatic construction of 3D structural motifs for protein f...

引用

ieee conference on bioinformatics

作者： M.P. Liang D.L. Brutlag R.B. Altman Department of Genetics Stanford Medical Informatics USA Department of Biochemistry Stanford Medical Informatics USA

Structural genomics initiatives are on the verge of generating a vast number of protein structures. The biological roles for many of these proteins are still unknown, and high-throughput methods for determining their function are necessary. Understanding the function of these proteins will have profound impact in drug development and protein engineering. Current methods for protein function prediction on structures require manual creation of structural motifs. Thus only few structural motifs are available. The lack of structural motifs limits the use of these methods for function prediction at a structural-genomics scale. To overcome this limitation, we describe a method for automatically creating a library of three dimensional structural motifs. Automatically generating a library of structural motifs can be used for structural-genomic scale function prediction on protein structures.

关键词： bioinformatics Protein engineering Genomics Biomedical informatics Libraries Atomic measurements Genetics Calcium Amino acids Databases

来源：评论

学校读者我要写书评

暂无评论

Identifying regulatory signals in DNA-sequences with a nonstatistical approximation approach

Identifying regulatory signals in DNA-sequences with a nonst...

引用

ieee conference on bioinformatics

作者： C.-Q. Zhang Y. Liu E.M. Eschen K. Wu Department of Mathematics West Virginia University Morgantown WV USA Lane Department of Computer Science and Elec. Engineering West Virginia University Morgantown WV USA Department of Biology West Virginia University Morgantown WV USA

The identification of regulatory signals is one of the most challenging tasks in bioinformatics. The development of gene-profiling technologies now makes it possible to obtain vast data on gene expression in a particular organism under various conditions. This has created the opportunity to identify and analyze the parts of the genome believed to be responsible for transcription control-the transcription factor DNA-binding motifs (TFBMs). Developing a practical and efficient computational tool to identify TFBMs will enable us to better understand the interplay among thousands of genes in a complex eukaryotic organism. This problem, which is mathematically formulated as the motif finding problem in computer science, has been studied extensively in recent years. We develop a new mathematical model and approximation technique for motif searching. Based on the graph theoretic and geometric properties of this approach, we propose a nonstatistical approximation algorithm to find motifs in a set of genome sequences.

关键词： Signal processing bioinformatics Genomics Gene expression Organisms Biology computing Mathematical model Mathematics Computer science Approximation algorithms

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共88页 << < 76 77 78 79 80 81 82 83 84 85 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：