Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
ISBN:
(纸本)9781538655566;9781538655559
Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
Uncertainty over model structures poses a challenge for many approaches exploring effect strength parameters at system-level. Monte Carlo methods for full Bayesian model averaging over model structures require conside...
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ISBN:
(纸本)9781467389884
Uncertainty over model structures poses a challenge for many approaches exploring effect strength parameters at system-level. Monte Carlo methods for full Bayesian model averaging over model structures require considerable computational resources, whereas bootstrapped graphical lasso and its approximations offer scalable alternatives with lower complexity. Although the computational efficiency of graphical lasso based approaches has prompted growing number of applications, the restrictive assumptions of this approach are frequently ignored. We demonstrate using an artificial and a real-world example that full Bayesian averaging using Bayesian networks provides detailed estimates through posterior distributions for structural and parametric uncertainties and it is a feasible alternative, which is routinely applicable in mid-sized biomedical problems with hundreds of variables. We compare Bayesian estimates with corresponding frequentist quantities from bootstrapped graphical lasso using pairwise Markov Random Fields, discussing also their different interpretations. We present results using synthetic data from an artificial model and using the UK Biobank data set to construct a psychopathological network centered around depression (this research has been conducted using the UK Biobank Resource under Application Number 1602).
The papers in this special section were presented at the 10th International symposium on bioinformatics Research and Applications ISBRA 2014, which was held at Zhangjiajie, China, June 28-30, 2014.
The papers in this special section were presented at the 10th International symposium on bioinformatics Research and Applications ISBRA 2014, which was held at Zhangjiajie, China, June 28-30, 2014.
We describe efficient methods for consistently coloring and visualizing collections of rigid cluster decompositions obtained from variations of a protein structure, and lay the foundation for more complex setups, that...
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We describe efficient methods for consistently coloring and visualizing collections of rigid cluster decompositions obtained from variations of a protein structure, and lay the foundation for more complex setups, that may involve different computational and experimental methods. The focus here is on three biological applications: the conceptually simpler problems of visualizing results of dilution and mutation analyses, and the more complex task of matching decompositions of multiple Nucleic Magnetic Resonance (NMR) models of the same protein. Implemented into the KINematics And RIgidity (KINARI) web server application, the improved visualization techniques give useful information about protein folding cores, help examining the effect of mutations on protein flexibility and function, and provide insights into the structural motions of Protein Data Bank proteins solved with solution NMR. These tools have been developed with the goal of improving and validating rigidity analysis as a credible coarse-grained model capturing essential information about a protein's slow motions near the native state.
Glycosylation of proteins in eukaryote cells is an important and complicated post-translation modification due to its pivotal role and association with crucial physiological functions within most of the proteins. Iden...
Glycosylation of proteins in eukaryote cells is an important and complicated post-translation modification due to its pivotal role and association with crucial physiological functions within most of the proteins. Identification of glycosylation sites in a polypeptide chain is not an easy task due to multiple impediments. Analytical identification of these sites is expensive and laborious. There is a dire need to develop a reliable computational method for precise determination of such sites which can help researchers to save time and effort. Herein, we propose a novel predictor namely iGlycoS-PseAAC by integrating the Chou's Pseudo Amino Acid Composition (PseAAC) and relative/absolute position-based features. The self-consistency results show that the accuracy revealed by the model using the benchmark dataset for prediction of O-linked glycosylation having serine sites is 98.8 percent. The overall accuracy of predictor achieved through 10-fold cross validation by combining the positive and negative results is 97.2 percent. The overall accuracy achieved through Jackknife test is 96.195 percent by aggregating of all the prediction results. Thus the proposed predictor can help in predicting the O-linked glycosylated serine sites in an efficient and accurate way. The overall results show that the accuracy of the iGlycoS-PseAAC is higher than the existing tools.
In many evolutionary optimization domains evaluations are noisy. The candidates are tested on a number of randomly drawn samples, such as different games played, different physical simulations, or different user inter...
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ISBN:
(纸本)9781538627266
In many evolutionary optimization domains evaluations are noisy. The candidates are tested on a number of randomly drawn samples, such as different games played, different physical simulations, or different user interactions. As a result, selecting the winner is a multiple hypothesis problem: The candidate that evaluated the best most likely received a lucky selection of samples, and will not perform as well in the future. This paper proposes a technique for selecting the winner and estimating its true performance based on the smoothness assumption: Candidates that are similar perform similarly. Estimated fitness is replaced by the average fitness of candidate's neighbors, making the selection and estimation more reliable. Simulated experiments in the multiplexer domain show that this technique is reliable, making it likely that the true winner is selected and its future performance is accurately estimated.
The proceedings contain 40 papers. The topics discussed include: an effective approach to identify gene-gene interactions for complex quantitative traits using generalized fuzzy accuracy;control strategies for intelli...
ISBN:
(纸本)9781467394727
The proceedings contain 40 papers. The topics discussed include: an effective approach to identify gene-gene interactions for complex quantitative traits using generalized fuzzy accuracy;control strategies for intelligent adjustment of pressure in intermittent pneumatic compression systems;protein fold identification using machine learning methods on contact maps;compressed sensing denoising for segmentation of localization microscopy data;computational prediction of bacterial type iv-b effectors using c-terminal signals and machine learning algorithms;a cross-entropy method for change-point detection in four-letter DNA sequences;gene selection using interaction information for microarray-based cancer classification;and computationalintelligence for metabolic pathway design: application to the pentose phosphate pathway.
The papers in this special section were presented at the 11th International Conference on Intelligent Computing ICIC held in Fuzhou, China, on August 20-23, 2015. This conference was formed to provide an annual forum ...
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The papers in this special section were presented at the 11th International Conference on Intelligent Computing ICIC held in Fuzhou, China, on August 20-23, 2015. This conference was formed to provide an annual forum dedicated to the emerging and challenging topics in artificial intelligence, machine learning, bioinformatics, etc. It aims to bring together researchers and practitioners from both academia and industry to share ideas, problems, and solutions related to the multifaceted aspects of intelligent computing.
Bio-hybrid systems in which living organisms interact and self-organize with multi-robot systems are a novel approach in engineering and biology. We show here how a group of honeybees and robots can interact in collec...
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ISBN:
(纸本)9781538627266
Bio-hybrid systems in which living organisms interact and self-organize with multi-robot systems are a novel approach in engineering and biology. We show here how a group of honeybees and robots can interact in collective decision making and how computer code that adds feedback loops to the system may affect the global system properties. This study contains a series of experiments with living honeybees and robots as well as a cellular-automaton inspired model that is simple, yet still in good agreement with the empirical findings presented here. Using this model, we explore the most likely candidates for local parameters in the proximate mechanisms of the animals, thus further the understanding of this natural system in a context that is relevant for such bio-hybrid manifestations. We identify positive feedback based on bee-to-bee collision and temperature as an important factor governing collective decision making and found the stopping probability after close-encounters among bees as a crucial local parameter. This study is the first step towards using computer and robotic technology to monitor and control complex animal societies like honeybees.
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