It has become very important to study non-coding RNAs in the recent years. The Z curve is a very useful method for visualizing and analyzing DNA sequences among the approaches of researching ncRNAs. It is a three-dime...
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It has become very important to study non-coding RNAs in the recent years. The Z curve is a very useful method for visualizing and analyzing DNA sequences among the approaches of researching ncRNAs. It is a three-dimensional space curve that constitutes a unique representation of a given DNA sequence, i.e., both the Z-curver and the given DNA sequence can be uniquely reconstructed from the other. Using Z curve method, we select 15 disease related ncRNAs sequences from the NONCODE database, which relate with Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are obtained. These features indicate that the ncRNAs sequences, which play same roles in the celluar process, have almost the same Z-curves. And the base content in these sequences is almost same too, in spite of coming from different organisms.
The NDRG4 gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase *** protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic...
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The NDRG4 gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase *** protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscle *** map this gene in the chicken chromosome,a 6000 rads chicken-hamster radiation hybrid panel(ChickRH6) was *** were designed according to the published human sequence for amplification of the chicken NDRG4 gene by comparative *** compared the corresponding human mRNA sequence with the predicted coding sequence of the chicken NDRG4 gene,and found that the assembled contig shared a high percentage of similarity with that of the human *** of samples from the ChickRH6 revealed the locations of the NDRG4 gene to be linked to the marker PARD6G(5 cR away)with a LOD score of *** present results support the idea that the RH technique is indeed a powerful tool for mapping genes due to its rapidity,precision, convenience and reproducibility.
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