Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes extracellular process elements such as the bioreactor design and mode of op...
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Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes extracellular process elements such as the bioreactor design and mode of operation, medium formulation, culture conditions, feeding rates, and so on. However, these elements are frequently insufficient for achieving optimal process performance or precise product composition. One can use metabolic and genetic engineering methods for optimization at the intracellular level. Nevertheless, those are often of static nature, failing when applied to dynamic processes or if disturbances occur. Furthermore, many bioprocesses are optimized empirically and implemented with little-to-no feedback control to counteract disturbances. The concept of cybergenetics has opened new possibilities to optimize bioprocesses by enabling online modulation of the gene expression of metabolism-relevant proteins via external inputs (e.g., light intensity in optogenetics). Here, we fuse cybergenetics with model-based optimization and predictive control for optimizing dynamic bioprocesses. To do so, we propose to use dynamic constraint-based models that integrate the dynamics of metabolic reactions, resource allocation, and inducible gene expression. We formulate a model-based optimal control problem to find the optimal process inputs. Furthermore, we propose using model predictive control to address uncertainties via online feedback. We focus on fed-batch processes, where the substrate feeding rate is an additional optimization variable. As a simulation example, we show the optogenetic control of the ATPase enzyme complex for dynamic modulation of enforced ATP wasting to adjust product yield and productivity. Metabolic cybergenetic feedback in fed-batch bioreactors exploiting dynamic optimization and model predictive control: Key proteins, like enzyme preg ${p}_{reg}$, adjust using inducible gene systems to achieve various metabolic modes, influenced by fa
In response to the complex nonlinear operational characteristics of large wind turbines, a hybrid semi-mechanistic modeling method for multi-condition operations is proposed, based on a refined 5MW wind turbine model ...
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This paper presents a comprehensive exploration of the optimization of spare parts configuration schemes for ship equipment using a multi-agent simulation methodology. The focus lies in leveraging the failure rates of...
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ISBN:
(数字)9781510686809
ISBN:
(纸本)9781510686793
This paper presents a comprehensive exploration of the optimization of spare parts configuration schemes for ship equipment using a multi-agent simulation methodology. The focus lies in leveraging the failure rates of life-limited parts and employing advanced multi-agent modeling technologies to conduct simulated calculations pertaining to a ship's offshore operations. Through these simulations, the paper aims to ascertain the optimal outcomes for the spare parts configuration scheme. The research methodology involves the development and application of a multi-agent simulation method, specifically tailored to address the challenges associated with the mathematical modeling of complex systems. The proposed approach not only enhances the accuracy of spare parts configuration but also contributes to overcoming difficulties in modeling intricate systems. To substantiate the effectiveness of the proposed multi-agent simulation method, the paper includes illustrative examples demonstrating its application in real-world scenarios. The findings of the research highlight the method's efficacy in optimizing spare parts configuration schemes for ship equipment. This paper contributes to the field by presenting a sophisticated and practical approach to address the complexities inherent in mathematical modeling within the context of maritime operations. Based on the multi-agent simulation method, this paper primarily discusses the optimization of spare parts configuration schemes for ship equipment. By means of failure rates of life-limited parts as well as multi-agent modeling technologies, this method can be employed to perform the simulating calculation of a ship's offshore operations, thus determining the optimization outcomes of the spare parts configuration scheme. Research findings demonstrate that the multi-agent simulation method proposed in this paper addresses the difficulties related to the mathematical modeling of complex systems, with an example presented to illust
Supply chains are vulnerable to an array of exogenous disruptions, including operational contingencies, natural disasters, terrorism, and political and geopolitical instability. In order to ensure resilience to these ...
In-situ exploration of extraterrestrial area of scientific interest remains largely impossible with the state-of-the-art wheeled rovers. To combine the advantages of wheeled and legged robots, DLR’s Institute of Syst...
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Artificial intelligence (AI)-aided communications have gained significant traction in recent years due to the widespread application of machine learning (ML) and deep learning (DL) machines with algorithms to solve ma...
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Artificial intelligence (AI)-aided communications have gained significant traction in recent years due to the widespread application of machine learning (ML) and deep learning (DL) machines with algorithms to solve math problems in wireless communications. This study offers an overview of the use of ML models in antenna design and optimization. This incorporates DL on ML frameworks, categories, and structure to get practical and broad insights using ML techniques for high throughput, quick data analysis, and prediction. This article also comprehensively reviews recent research papers on antenna design via ML. This includes an analysis of several ML algorithms that have been applied to produce antenna parameters such as the reflection coefficient (S-parameters), efficiency and gain values, and radiation patterns of the antennas. However, the current antenna design's structure, variables, and external factors remain complex. In addition, the expense of time and processing resources is inescapable and unacceptable to most designers. ML-based antennas have been created to increase antenna modeling efficiency and accuracy to solve these challenges. Techniques for modeling data may be used to predict the performance of an antenna for a certain set of antenna factors of design. As a result, this study highlights the most sophisticated applied ML techniques that have been presented to increase antenna modeling efficiency and accuracy. The results demonstrate that AI, ML, and DL may minimize simulation needs, predict antenna behavior, and reduce time with high accuracy.
In recent years, false data injection (FDI) poses a serious security threat to the operational status of smart grid. Aiming at the current difficulty of smart grid to detect FDI attacks, this paper proposes a FDI dete...
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ISBN:
(纸本)9798350350920
In recent years, false data injection (FDI) poses a serious security threat to the operational status of smart grid. Aiming at the current difficulty of smart grid to detect FDI attacks, this paper proposes a FDI detection method for smart grid based on IBFO-CNN. Firstly, the simulationmodeling of FDI is completed based on the state estimation of smart grid. Then the convolutional neural network (CNN) is introduced as the basic FDI detection model, and for the problem of inefficient parameter optimization, the bacterial foraging optimization (BFO) algorithm improved by the multivariate updating strategy is used to realize automatic parameter optimization of the CNN, so as to obtain the FDI detection model of smart grid based on IBFO-CNN. Finally, the designed model is applied to the IEEE 14 bus system to test the model's detection performance for FDI. The experimental results show that the IBFO-CNN model proposed in this paper has high precision for FDI detection in the IEEE 14 bus system, which has a better detection performance and anti-noise performance compared with other models. The proposed method has good performance in engineering practice can effectively guarantee the data security of the smart grid.
When a power outage occurs, it may cause significant economic losses for industries. However, previous studies on power system resilience have seldom focused on user-side microgrids. This study proposes composite resi...
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ISBN:
(纸本)9798350375596;9798350375589
When a power outage occurs, it may cause significant economic losses for industries. However, previous studies on power system resilience have seldom focused on user-side microgrids. This study proposes composite resilience indices for user-side microgrids to quantify their ability to withstand extreme events. The proposed resilience indices consider load value, minimum power supply, energy shortages, and the degradation characteristics of islanded microgrids. Additionally, this study introduces a two-stage resilience optimization and reconfiguration strategy, including energy-level scheduling and grid-level feeder reconfiguration. A genetic algorithm based multiobjective optimization approach is used for energy scheduling, followed by feeder reconfiguration using particle swarm algorithm integrated with DIgSILENT system modeling to meet the grid codes and maximize demand supply. The proposed methods are validated using a realistic steel corporation as a test system, showing the flexibility and practical feasibility of the system. Userside microgrid resilience can be effectively enhanced by the proposed method considering load priority.
With the rapid construction of China's high-speed rail, the gradual improvement of network layout, and the increasing track connections in the station, issues emerge such as the difficulty in selecting the stop tr...
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ISBN:
(纸本)9781510674479
With the rapid construction of China's high-speed rail, the gradual improvement of network layout, and the increasing track connections in the station, issues emerge such as the difficulty in selecting the stop train strategy of the station and the ambiguity of checking the calculation of station carrying capacity. In view of this situation, a carrying capacity calculation model based on multi-objective optimization and simulation verification is proposed for the railroad station integration scheme. Firstly, a multi- objective optimization calculation model is constructed to determine the objective function and constraints related to the issues. Secondly, the train tracking scenario simulation is applied and realized, and then the train operation plan is inferred based on the algorithm to realize the construction of the simulation environment for the cluster operation of the EMU. Finally, a high-speed railway intermediate station in southern China is taken as the simulation target, and the track connection scheme of the station is used as the simulation basis, so as to map the line information and abstract it for verification based on the real railroad network environment and station equipment data. The test results show that the multi-objective optimization and simulation verification model can effectively help develop a reasonable stop train strategy for the station and thereby obtain the station carrying capacity.
This paper proposes a reinforcement learning (RL)based method to optimize power plane design with multiple voltage domains. The proposed method enables the simultaneous selection of the plane for expansion and its exp...
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ISBN:
(纸本)9798350347401
This paper proposes a reinforcement learning (RL)based method to optimize power plane design with multiple voltage domains. The proposed method enables the simultaneous selection of the plane for expansion and its expansion direction, determining the size and shape of multiple power planes. The results show that the proposed method provides various optimized power plane designs that satisfy the target impedance and ensure the reference plane for the input/output (I/O) interface.
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