检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

367 篇 会议
3 篇 期刊文献
1 册 图书

馆藏范围

371 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

60 篇 工学
- 55 篇 计算机科学与技术...
- 39 篇 软件工程
- 27 篇 生物工程
- 20 篇 生物医学工程（可授...
- 14 篇 信息与通信工程
- 13 篇 控制科学与工程
- 9 篇 化学工程与技术
- 7 篇 电气工程
- 6 篇 动力工程及工程热...
- 6 篇 电子科学与技术（可...
- 3 篇 力学（可授工学、理...
- 3 篇 光学工程
- 3 篇 安全科学与工程
- 2 篇 机械工程
- 2 篇 航空宇航科学与技...
44 篇 理学
- 29 篇 生物学
- 24 篇 数学
- 10 篇 化学
- 10 篇 统计学（可授理学、...
- 9 篇 物理学
- 2 篇 系统科学
12 篇 管理学
- 7 篇 管理科学与工程(可...
- 7 篇 图书情报与档案管...
- 4 篇 工商管理
7 篇 医学
- 7 篇 基础医学(可授医学...
- 5 篇 临床医学
- 5 篇 药学(可授医学、理...
- 2 篇 特种医学
2 篇 法学
- 1 篇 法学
1 篇 经济学
- 1 篇 应用经济学
1 篇 教育学

主题

261 篇 bioinformatics
154 篇 genomics
70 篇 proteins
68 篇 sequences
52 篇 biology computin...
48 篇 dna
42 篇 databases
42 篇 biological syste...
39 篇 computer science
39 篇 gene expression
35 篇 humans
32 篇 genetics
31 篇 testing
30 篇 diseases
29 篇 organisms
27 篇 computational bi...
24 篇 data mining
23 篇 laboratories
21 篇 data analysis
18 篇 computational mo...

机构

3 篇 department of el...
2 篇 pacific nw natl ...
2 篇 department of co...
2 篇 bioinformatics r...
2 篇 department of el...
2 篇 genome institute...
2 篇 ieee
2 篇 school of biomed...
2 篇 department of co...
2 篇 ntt data company...
2 篇 department of co...
2 篇 lawrence livermo...
2 篇 department of co...
2 篇 department of bi...
2 篇 oak ridge nation...
2 篇 school of comput...
2 篇 ieee computer so...
2 篇 department of en...
2 篇 department of co...
2 篇 university of ma...

作者

9 篇 v. olman
9 篇 ying xu
6 篇 zhengchang su
6 篇 h. ali
4 篇 phuongan dam
3 篇 y. xu
3 篇 s. imoto
3 篇 w.s. noble
3 篇 l. raschid
3 篇 s. aluru
3 篇 t. higuchi
3 篇 n. shah
3 篇 d. adjeroh
3 篇 e. uberbacher
2 篇 z. su
2 篇 k. najarian
2 篇 r. schwartz
2 篇 j. lepre
2 篇 d. chen
2 篇 a. darvish

语言

371 篇 英文

检索条件"任意字段=Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004"

共 371 条记录，以下是111-120 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

A prediction model for the drug efficacy of interferon in CHC patients based on SNPs

A prediction model for the drug efficacy of interferon in CH...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： E. Lin D. Chen Yuchi Hwang A. Chang Z.J. Gu Vita Genomics Inc. Taipei Taiwan

In the studies of pharmacogenomics, genetic predisposition information, such as single nucleotide polymorphisms (SNPs), can be used to understand the relationship between genetic variations (or population variations) and drug efficacy. In this paper, a prediction model is resulted from analyzing chronic hepatitis C (CHC) patient's SNPs, comparing to control groups, to predict the responsiveness of interferon (IFN) combination treatment. We have developed an advanced methodology with the combination of artificial neural network (ANN) and other algorithms to achieve a prediction with high accuracy among the patients. Filtering through thousands of SNPs of 150 genes, we found nearly 30 SNPs relevant to the responsiveness of IFN. With a statistical analysis of sensitivity (SEN), specificity (SPE), positive prediction value (PPV), and negative prediction value (NPV), our model achieves a higher successful rate of prediction, i.e., > 90% accuracy. This model allows patients and doctors to make more informed decisions based on SNP genotyping data. The data was generated in the high-throughput genomics lab of Vita Genomics, Inc.

关键词： Predictive models Drugs Genetics Delay Artificial neural networks Genomics bioinformatics Liver diseases Medical treatment Accuracy

来源：评论

学校读者我要写书评

暂无评论

Identifyng microRNAs in plant genomes

Identifyng microRNAs in plant genomes

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： C. Maher M. Timmermans L. Stein D. Ware Cold Spring Harbor Laboratory USA

The ability to control gene expression during development in plants could be used for improving crop yields, resistance to disease, and environmental adaptability. It has been suggested that microRNAs, or miRNAs, control developmental processes such as meristem cell identity, organ polarity, and developmental timing by interfering with the expression of mRNAs. Our preliminary analysis focuses on the miR166 family since it has been shown to mediate repression of rolled-leaf1 (rdl1) in maize. Based on maize sequences derived from degenerate primers, we computationally identified miR166b, miR166c, miR166d, and four more closely related putative maize precursors. Patscan, a pattern-matching program that allows RNA basepairing and mismatches, was used to identify functional elements in the putative hairpins. Each hairpin was further supported by their stable secondary structures determined with Mfold. Using this pattern matching approach we expanded the analysis for 19 Arabidopsis miRNA families in rice and maize.

关键词： Genomics bioinformatics Gene expression Crops Diseases Process control Timing RNA Pattern matching Pattern analysis

来源：评论

学校读者我要写书评

暂无评论

Design and implementation of a computational Grid for bioinformatics

Design and implementation of a computational Grid for bioinf...

引用

proceedings - 2004 ieee International conference on e-Technology, e-Commerce and e-Service, EEE 2004

作者： Yang, Chao-Tung Kuo, Yu-Lun Lai, Chuan-Lin High-Perf. Computing Laboratory Department of Computer Science Tunghai University Taichung 407 Taiwan

ISBN: (纸本)0769520731

The popular technologies, internet computing and Grid technologies promise to change the way we tackle complex problems. They will enable large-scale aggregation and sharing of computational, data and other resources across institutional boundaries. And harnessing these new technologies effectively will transform scientific disciplines ranging from high-energy physics to the life sciences. The computational analysis of biological sequences is a kind of computation driven science. Cause the biology data growing quickly and these databases are heterogeneous. We can use the grid system sharing and integrating the heterogeneous biology database. As we know, bioinformatics tools can speed up analysis the large-scale sequence data, especially about sequence alignment and analysis. The FASTA is a tool for aligning multiple protein or nucleotide sequences. These two bioinformatics software which we used is a distributed and parallel version. The software uses a message-passing library called MPI (Message Passing Interface) and runs on distributed workstation clusters as well as on traditional parallel computers. A grid computing environment is proposed and constructed on multiple Linux PC Clusters by using Globus Toolkit (GT) and SUN Grid Engine (SGE). The experimental results and performances of the bioinformatics tool using on grid system are also presented in this paper.

关键词： Information technology

来源：评论

学校读者我要写书评

暂无评论

Predicting gene ontology annotations from sequence data using kernel-based machine learning algorithms

Predicting gene ontology annotations from sequence data usin...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： J.J. Ward J.S. Sodhi B.F. Buxton D.T. Jones Department of Computer Science University College London London UK

In this early part of the post-genomic era, the inference of the functions associated with gene products is a necessary first step in understanding the development and maintenance of living cells. We describe the development of a machine learning method for predicting biological process as defined by the gene ontology (GO). The algorithm uses features that can be generated from amino acid sequence alone, and does not require further experimental studies such as microarrays, 2-hybrid screens or systematic 'pull-down' assays. The budding yeast Saccharomyces cerevisiae is used because of its comprehensive set of functional annotations, but the approach is sufficiently general for application to other eukaryote genomes. The input data include phylogenetic profiles, which represent the distribution of orthologous proteins in the genomes of other organisms, position-specific scoring matrices, and secondary structure and dynamic disorder predictions. These are encoded using diffusion kernels, which are used to represent pair-wise relationships such as sequence or secondary structure element similarity between nodes (proteins) in a graph. These kernels are benchmarked on the process prediction problem using a maximal margin (SVM) learning algorithm.

关键词： Ontologies Machine learning algorithms Genomics bioinformatics Proteins Kernel Learning systems Biological processes Inference algorithms Amino acids

来源：评论

学校读者我要写书评

暂无评论

PRUNER: algorithms for finding monad patterns in DNA sequences

PRUNER: algorithms for finding monad patterns in DNA sequenc...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： R. VijayaSatya A. Mukheqee School of Computer Science University of Central Florida Orlando FL USA University of Central Florida Orlando FL US Central Florida Univ. Orlando FL USA

We present new algorithms for discovering monad patterns in DNA sequences. Monad patterns are of the form (l,d)-k, where l is the length of the pattern, d is the maximum number of mismatches allowed, and k is the minimum number of times the pattern is repeated in the given sample. The time-complexity of some of the best known algorithms to date is O(nt/sup 2/l/sup d/|/spl Sigma/|/sup d/2/), where t is the number of input sequences, and n is the length of each input sequence. The first algorithm that we present takes O(n/sup 2/t/sup 2/l/sup d/2/|/spl Sigma/|/sup d/2/) and space O(ntl/sup d/2/|/spl Sigma/|/sup d/2/), and the second algorithm takes O(n/sup 3/t/sup 3/l/sup d/2/|/spl Sigma/|/sup d/2/ time using O(l/sup d/2/|/spl Sigma/|/sup d/2/) space. In practice, our algorithms have much better performance provided the d/l ratio is small.

关键词： DNA Sequences Computer science computational biology Genetic mutations Graph theory NP-complete problem bioinformatics

来源：评论

学校读者我要写书评

暂无评论

Analysis of population dynamics in beta-cell destruction lead to identification of novel candidate genes for type 1 diabetes

Analysis of population dynamics in beta-cell destruction lea...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： Yizhou Xie Xujing Wang Max McGee National Research Center for Juvenile Diabetes Medical College Milwaukee WI USA Max McGee National Research Center for Juvenile Diabetes and Human and Molecular Genetics Center Medical College Milwaukee WI USA

ISBN: (纸本)0769521940

A major difficulty in the genetic study of type 1 diabetes (T1D) is the lack of means to identify candidate disease genes, as the exact disease etiology is still unclear. We have developed a minimal model for T1D where we mathematically formulate the population dynamics for the most critical components in /spl beta/-cell destruction: macrophages, T lymphocytes, /spl beta/ cells and /spl beta/-cell autoantigens. System dynamic stability analysis revealed that the disease process for adult individuals is critically regulated by several major gene regulation pathways. Together they provide a comprehensive picture of where the candidate genes most likely lie. We will present our model, our bioinformatics platform to retrieve and update the gene information involved in the pathways, and our candidate gene database. In addition we will present our plan of candidate gene genotyping. Our approach represents the first time understanding the disease dynamics is integrated with the genetic study of a complex disease.

关键词： Diabetes Diseases Genetics bioinformatics Databases Educational institutions Humans Mathematical model Information retrieval Pancreas

来源：评论

学校读者我要写书评

暂无评论

Technology for Life: North Carolina Symposium on Biotechnology and bioinformatics - 2004 proceedings

Technology for Life: North Carolina Symposium on Biotechnolo...

引用

Technology for Life: North Carolina Symposium on Biotechnology and bioinformatics - 2004 proceedings

ISBN: (纸本)0780388267

The proceedings contain 19 papers from the Technology for Life: North Carolina Symposium on Biotechnology and bioinformatics - 2004 proceedings. The topics discussed include: free energy analysis of the coding region of saccharomyces cerevisiae;computational methods for coherent analysis of large-scale transcriptional, metabolic and histomorphometric profiles of a biological system: application to biomarker discovery;healthcare and life sciences standards overview;relational learning from drug adverse events reports;emerging standards for inter-operable biological systems;a practical multi-ontology approach to knowledge exploration;and novel automated, grid based, web accessible technology for computer-aided drug discovery.

关键词： Biomedical engineering

来源：评论

学校读者我要写书评

暂无评论

Fractal genomics modeling: a new approach to genomic analysis and biomarker discovery

Fractal genomics modeling: a new approach to genomic analysi...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： S. Shaw P. Shapshak Health Discovery Corporation Inc. Savannah GA USA Department of Psychiatry & Behavioral Sciences University of Miami School of Medicine Miami FL USA

Reverse engineering of genetic networks generally requires establishing correlative behavior within and between a very large number of genes. This becomes a difficult analytical problem for even a few hundred genes and the difficulty tends to grow exponentially as more genes are examined. Using a hybrid data analysis method known as fractal genomics modeling (FGM), this problem is reduced to examining correlative behavior within small gene groups that can then be compared and integrated to produce a picture of larger networks using a type of shotgun approach. We have applied FGM toward examining genetic networks involved in HIV infection in the brain. These networks have relevance both to processes related to HIV infection and neurodegenerative disorders. Our preliminary findings have produced conjectures of related pathways and networks as well new candidates for genetic markers in HIV brain infection. Evidence has also been produced which appears to show the presence of a hierarchical network structure within the genes studied. We will discuss the background and methodology of FGM as well as our recent findings.

关键词： Genomics bioinformatics Fractals Biomarkers Genetics Human immunodeficiency virus Gene expression Reverse engineering Psychiatry Data analysis

来源：评论

学校读者我要写书评

暂无评论

Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs

Comparative genomics of cyclin-dependent kinases suggest co-...

引用

proceedings of the ieee computational systems bioinformatics conference, csb

作者： Zhenhua Guo J.W. Stiller Howell Science Complex N108 Department of Biology East Carolina University Greenville NC USA

We identify 101 cyclin-dependent kinases (CDKs) family members from animals, plants, yeasts and three protists with complete genome sequences. Comparative analyses suggest that cell-cycle CDKs are present in all organisms sampled in this study. In contrast, no clear orthologs of transcription-related CDKs are detected in the most putatively ancestral eukaryotes, Trypanosoma or Giardia. Kinases involved in C- terminal domain (CTD) of RNA polymerase II phosphorylation, CDK7, CDK8 and CDK9, all are recovered as well-supported and distinct orthologous families. Significantly, clear orthologs of CDK7 and CDK8 are restricted to those organisms belonging to groups in which the RNAP II CTD is strongly conserved suggesting co-evolution of the CTD and these CTD-directed CDKs. Alternatively, extensive CTD phosphorylation may occur in only a subset of eukaryotes and, when present, this interaction results in greater stabilizing selection on both CTD and CDK sequences. Overall, our results suggest that transcription-related kinases originated after cell-cycle related CDKs.

关键词： Genomics bioinformatics RNA Polymers Animals Fungi Bayesian methods Sequences Organisms Proteins

来源：评论

学校读者我要写书评

暂无评论

Genetic data acquirement, construction and analysis based on microarray technology

Genetic data acquirement, construction and analysis based on...

引用

26th Annual International conference of the ieee-Engineering-in-Medicine-and-Biology-Society

作者： Lu, ZH Southeast Univ Natl Lab Mol & Biomol Elect Nanjing 210096 Peoples R China

ISBN: (纸本)0780384393

Several novel microarray technology platforms to be applied to acquire both genetic and epigenetic data from biological systems have been developed. Genetic database and the related bioinformatics analytic tools are being constructed. Here, some on-going projects related to bioinformatics analysis based on the microarray technology, such as such as the high density microarrray design, combinational analyses of the data based on microarrays for gene expressions, methylation of CG islands, trans-factor protein level and mutation detection, and the disease related SNPs in human genomes are presented.

关键词： bioinformatics igh density microarray design SNPs

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共38页 << < 8 9 10 11 12 13 14 15 16 17 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：