The following topics are dealt with: genomes to life; microarray data analysis; pathways, networks, and systems biology; biomedical research and visualization; data mining; pattern recognition; sequence alignment; dat...
The following topics are dealt with: genomes to life; microarray data analysis; pathways, networks, and systems biology; biomedical research and visualization; data mining; pattern recognition; sequence alignment; data integration; functional genomics; genomic annotation; genotyping and SNPs; molecular simulation; phylogeny and evolution; predictive methods; sequence comparison; strings, graphs, and algorithms; structural biology; text mining and ontologies; and systems biology.
The following topics are dealt with: biology computing; genetics; microorganisms; pattern classification; pattern clustering; phylogeny and evolution; transcriptomes; proteomics; structural bioinformatics; pathways an...
The following topics are dealt with: biology computing; genetics; microorganisms; pattern classification; pattern clustering; phylogeny and evolution; transcriptomes; proteomics; structural bioinformatics; pathways and networks; data mining and ontology.
Copyright and Reprint Permissions: Abstracting is permitted with credit to the source. Libraries may photocopy beyond the limits of US copyright law, for private use of patrons, those articles in this volume that carr...
Copyright and Reprint Permissions: Abstracting is permitted with credit to the source. Libraries may photocopy beyond the limits of US copyright law, for private use of patrons, those articles in this volume that carry a code at the bottom of the first page, provided that the per-copy fee indicated in the code is paid through the Copyright Clearance Center. The papers in this book comprise the proceedings of the meeting mentioned on the cover and title page. They reflect the authors' opinions and, in the interests of timely dissemination, are published as presented and without change. Their inclusion in this publication does not necessarily constitute endorsement by the editors or the Institute of Electrical and Electronics Engineers, Inc.
The following topics were dealt with: computational methods in genomics and proteomics; bioethics in biotechnology; health informatics; and medical information processing.
The following topics were dealt with: computational methods in genomics and proteomics; bioethics in biotechnology; health informatics; and medical information processing.
Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremely challenging. Current computational a...
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ISBN:
(纸本)0769521940
Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremely challenging. Current computational attempts to predict cleavage sites are limited, representing these amino acid sequences as patterns or frequency matrices. Here we present PoPS, a publicly accessible bioinformatics tool (http://***/)which provides a novel method for building computational models of protease specificity that, while still being based on these amino acid sequences, can be built from any experimental data or expert knowledge available to the user. PoPS specificity models can be used to predict and rank likely cleavages within a single substrate, and within entire proteomes. Other factors, such as the secondary or tertiary structure of the substrate, can be used to screen unlikely sites. Furthermore, the tool also provides facilities to infer, compare and test models, and to store them in a publicly accessible database.
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