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Label-Free QCL-Based Mid-IR Reflection Microspectroscopy for molecular imaging of Biofilms

Label-Free QCL-Based Mid-IR Reflection Microspectroscopy for...

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Advanced Chemical Microscopy for Life Science and Translational Medicine 2025

作者： Lee, Bei Shi Godejohann, Matthias Liu, Mengyang Leitgeb, Rainer Drexler, Wolfgang Berney, Michael Haindl, Richard Epidemiology Biostatistics and Prevention Institute University of Zurich Zurich Switzerland MG Optical Solutions GmbH Utting/Ammersee86919 Germany Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria Albert Einstein College of Medicine Bronx United States

ISBN: (纸本)9781510684126

We present a label-free hyperspectral imaging approach using quantum cascade laser (QCL)-based mid-infrared (mid-IR) reflection microspectroscopy (Spero® QT 340) to visualize and characterize biofilms of Mycobacterium tuberculosis (mc2 6230 AE16011). This technique facilitates rapid data acquisition (~1 minute) across the fingerprint region (950–1800 cm-1), enabling the identification of key biomolecular features without the need for external labels or destructive sample preparation. Spectral absorbance was evaluated at 1650 cm-1, 1450 cm-1, 1240 cm-1, and 1080 cm-1, corresponding to proteins (amide I), lipids (CH2 scissoring), phosphodiesters, and polysaccharides, respectively. To address baseline variability arising from sample thickness heterogeneities, z-score normalization was applied, improving the interpretability of chemical maps. The spatial distribution of these biomolecular signatures revealed distinct biochemical compartments within the biofilm matrix, shedding light on potential structural and functional interactions. Lipid-rich domains were frequently segregated from regions enriched in polysaccharides and phosphodiesters, suggesting spatial compartmentalization within the biofilm. These findings highlight the utility of mid-IR reflection microspectroscopy for investigating native microbial architectures while preserving overall sample morphology. Integrating QCL-based imaging with complementary techniques could provide deeper insights into biofilm resilience and mechanisms of antimicrobial resistance. This methodology offers a robust and versatile platform for rapid analysis of microbial specimens across medical, environmental, and industrial applications. © 2025 spie.

关键词： Quantum cascade lasers

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Three-dimensional Microwave imaging with Incorporated Prior structural Information

Three-dimensional Microwave Imaging with Incorporated Prior ...

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conference on Medical imaging - biomedical applications in molecular, structural and functional imaging

作者： Golnabi, Amir H. Meaney, Paul M. Epstein, Neil R. Paulsen, Keith D. Dartmouth Coll Thayer Sch Engn 14 Engn Dr Hanover NH 03755 USA

ISBN: (纸本)9780819489661

Microwave imaging for biomedical applications, especially for early detection of breast cancer and effective treatment monitoring, has attracted increasing interest in last several decades. This fact is due to the high contrast between the dielectric properties of the normal and malignant breast tissues at microwave frequencies. The available range of dielectric properties for different soft tissue can provide important functional information about tissue health. Nonetheless, one of the limiting weaknesses of microwave imaging is that unlike conventional modalities, such as X-ray CT or MRI, it inherently cannot provide high-resolution images. The conventional modalities can produce highly resolved anatomical information but often cannot provide the functional information required for diagnoses. Previously, we have developed a regularization strategy that can incorporate prior anatomical information from MR or other sources and use it in a way to refine the resolution of the microwave images, while also retaining the functional nature of the reconstructed property values. In the present work, we extend the use of prior structural information in microwave imaging from 2D to 3D. This extra dimension adds a significant layer of complexity to the entire image reconstruction procedure. In this paper, several challenges with respect to the 3D microwave imaging will be discussed and the results of a series of 3D simulation and phantom experiments with prior structural information will be studied.

关键词： Microwave imaging Soft-prior Regularization Multi-modality imaging Breast Cancer A-priori Information

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Optimization and performance evaluation of a conical mirror based fluorescence molecular tomography imaging system

Optimization and performance evaluation of a conical mirror ...

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spie biomedical applications in molecular, structural and functional imaging conference

作者： Zhao, Yue Zhang, Wei Zhu, Dianwen Li, Changqing Univ Calif Merced Sch Engn 5200 N Lake Rd Merced CA 95343 USA

ISBN: (纸本)9781510600232

We performed numerical simulations and phantom experiments with a conical mirror based fluorescence molecular tomography (FMT) imaging system to optimize its performance. With phantom experiments, we have compared three measurement modes in FMT: the whole surface measurement mode, the transmission mode, and the reflection mode. Our results indicated that the whole surface measurement mode performed the best. Then, we applied two different neutral density (ND) filters to improve the measurement's dynamic range. The benefits from ND filters are not as much as predicted. Finally, with numerical simulations, we have compared two laser excitation patterns: line and point. With the same excitation position number, we found that the line laser excitation had slightly better FMT reconstruction results than the point laser excitation. In the future, we will implement Monte Carlo ray tracing simulations to calculate multiple reflection photons, and create a look-up table accordingly for calibration.

关键词： Fluorescence molecular tomography optimization conical mirror

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Microwave imaging of the Breast with Incorporated structural Information

Microwave Imaging of the Breast with Incorporated Structural...

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conference on Medical imaging 2010 - biomedical applications in molecular, structural, and functional imaging

作者： Golnabi, Amir H. Meaney, Paul M. Geimer, Shireen D. Paulsen, Keith D. Dartmouth Coll Thayer Sch Engn Hanover NH 03755 USA

ISBN: (纸本)9780819480279

Microwave imaging for biomedical applications, especially for early detection of breast cancer and effective treatment monitoring, has attracted increasing interest in last several decades. This fact is due to the high contrast between the dielectric properties of the normal and malignant breast tissues at microwave frequencies ranging from high megahertz to low gigahertz. The available range of dielectric properties for different soft tissue can provide considerable functional information about tissue health. Nonetheless, one of the limiting weaknesses of microwave imaging is, unlike that for conventional modalities such as X-ray CT or MRI, it cannot inherently provide high-resolution images. The conventional modalities can produce highly resolved anatomical information but often cannot provide the functional information required for diagnoses. We have developed a soft prior regularization strategy that can incorporate the prior anatomical information from X-ray CT, MR or other sources, and use it in a way to exploit the resolution of these images while also retaining the functional nature of the microwave images. The anatomical information is first used to create an imaging zone mesh, which segments separate internal substructures, and an associated weighting matrix that numerically groups the values of closely related nodes within the mesh. This information is subsequently used as a regularizing term for the Gauss-Newton reconstruction algorithm. This approach exploits existing technology in a systematic way without making potentially biased assumptions about the properties of visible structures. In this paper we continue our initial investigation on this matter with a series of breast-shaped simulation and phantom experiments.

关键词： Microwave imaging Breast Cancer Soft Prior Regularization Inverse Problem Tikhonov Regularization

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Optimization of an Iodine-based Nanoparticle Contrast Agent for molecular CT imaging

Optimization of an Iodine-based Nanoparticle Contrast Agent ...

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spie conference on Medical imaging - biomedical applications in molecular, structural, and functional imaging

作者： Ghaghada, Ketan B. Patel, Chandreshkumar Annapragada, Ananth Texas Childrens Hosp Singleton Dept Pediat Radiol Houston TX 77030 USA

ISBN: (数字)9781510616462

ISBN: (纸本)9781510616462

Recent advances in CT hardware have renewed interest in the development of contrast agents for molecular CT imaging. Nanoparticle platforms are attractive for CT imaging agent development due to their ability to carry a high payload of imaging moieties, thereby facilitating signal amplification at target site, and ease of surface modification to enable selective in vivo targeting against cells/molecules of interest. In this work, we performed investigations for optimizing an iodine-based liposomal nanoparticle platform for molecular CT imaging applications. Since signal intensity is directly proportional to the imaging moiety concentration, optimization studies were performed to rationally design an iodinated nanoparticle construct with maximal iodine carrying capacity. The effect of particle size, liposomal bilayer composition, iodine moiety and starting iodine concentration were systematically investigated. The in vitro stability of the optimal formulation was evaluated using plasma assay and the in vivo stability was tested by performing longitudinal micro-CT imaging in live animals. Simulations were performed to study the effects of iodine per nanoparticle and iodine contrast sensitivity on detectability of nanoparticles per image voxel. In vitro optimization studies demonstrated that particle size, type of iodine moiety and starting iodine concentration strongly influenced the iodine loading per nanoparticle. A nanoparticle composition was identified that demonstrated highest iodine loading capacity (similar to 8 million iodine atoms per particle). Micro-CT imaging demonstrated in vivo stability of the high-iodine containing nanoparticle construct. Simulation studies demonstrated a non-linear effect of iodine contrast sensitivity and image voxel size on the limit of nanoparticle detectability.

关键词： contrast agent nanoparticle liposomes molecular imaging CT

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MSB Estimation of Bound Fraction: Bias from Binding Energy Uncertainty

MSB Estimation of Bound Fraction: Bias from Binding Energy U...

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conference on Medical imaging - biomedical applications in molecular, structural and functional imaging

作者： Weaver, John B. Dartmouth Med Sch Dept Radiol Lebanon NH USA

ISBN: (纸本)9780819489661

Magnetic spectroscopy of nanoparticle Brownian motion, MSB, uses the magnetization produced by magnetic nanoparticles in a sinusoidal magnetic field, which can be observed remotely at low enough concentrations to enable it to be used for "molecular imaging". The MSB signal is sensitive to chemical binding, temperature and viscosity. If the MSB signals from nanoparticles in multiple bound states are known, a mixture model can be used to find the concentration of nanoparticles in each bound state. The accuracy has been shown to be high for two and three bound states. However, if the bound states are not accurately known, as is often the case in vivo, the model is perturbed significantly. Using simulations of two bound states based on the effective field approximation to the Fokker-Planck equations, we show that the error in the bound fraction is roughly proportional to the error in the bound state relaxation time. The errors in bound fraction were roughly proportional to the error in the relaxation time for the bound state used in the mixture model. The largest errors occurred for short relaxation time bound states. But for all bound state relaxation times, 10% errors in the relaxation time of the bound state resulted in errors in the bound fraction of less than 10%.

关键词： Nanoparticles Magnetism In vivo imaging Error analysis imaging spectroscopy Iron Medical imaging molecular imaging Oxides Spectroscopy

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Alternations of functional connectivity in amblyopia patients: A resting-state fMRI study

Alternations of functional connectivity in amblyopia patient...

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conference on Medical imaging - biomedical applications in molecular, structural, and functional imaging

作者： Wang, Jieqiong Hu, Ling Li, Wenjing Xian, Junfang Ai, Likun He, Huiguang Chinese Acad Sci State Key Lab Management & Control Complex Syst Inst Automat Beijing Peoples R China Chinese Acad Sci Key Lab Molecular Imaging Inst Automat Beijing Peoples R China Capital Med Univ Beijing Tongren Dept Radiol Beijing Peoples R China

ISBN: (纸本)9780819498311

Amblyopia is a common yet hard-to-cure disease in children and results in poor or blurred vision. Some efforts such as voxel-based analysis, cortical thickness analysis have been tried to reveal the pathogenesis of amblyopia. However, few studies focused on alterations of the functional connectivity (FC) in amblyopia. In this study, we analyzed the abnormalities of amblyopia patients by both the seed-based FC with the left/right primary visual cortex and the network constructed throughout the whole brain. Experiments showed the following results: (1)As for the seed-based FC analysis, FC between superior occipital gyms and the primary visual cortex was found to significantly decrease in both sides. The abnormalities were also found in lingual gyms. The results may reflect functional deficits both in dorsal stream and ventral stream. (2)Two increased functional connectivities and 64 decreased functional connectivities were found in the whole brain network analysis. The decreased functional connectivities most concentrate in the temporal cortex. The results suggest that amblyopia may be caused by the deficits in the visual information transmission.

关键词： amblyopia resting-state fIVIRI functional connectivity

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Alternative Spatial Encoding for imaging Magnetic Nanoparticles

Alternative Spatial Encoding for Imaging Magnetic Nanopartic...

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conference on Medical imaging - biomedical applications in molecular, structural and functional imaging

作者： Weaver, John B. Dartmouth Med Sch Dept Radiol Lebanon NH 03756 USA

ISBN: (纸本)9780819489661

Magnetic particle imaging (MPI) was introduced in 2005 and is one of the very few imaging methods capable of sensitivities that allow the term "molecular imaging" to be applied. Estimates of sensitivity allow nanograms of iron oxide nanoparticles to be imaged. MPI cyclically saturates the nanoparticles with an alternating magnetic field termed the drive field. The signal from the harmonics of the drive frequency is recorded. Localization is achieved by saturating the nanoparticles outside a "field free point." We present an alternative method of encoding the position of the magnetic nanoparticles. Signal is generated at the 2nd harmonic of the drive field only when a static magnetic field is present. Localization is achieved by placing a small static magnetic field gradient across the sample and the phase of the signal depends on the sign of the static field. The response of the nanoparticles at different static fields provides the localization. The localization can be modeled as a wavelet transform if the gradient is approximately linear. Smaller field gradients are required than in MPI. The sensitivity is potentially significantly higher than that of MPI;when minimum bandwidths are employed to achieve the maximum SNR, the SNR is 85% larger for new method. Variable resolution can be achieved. This is the first method capable of imaging the signal from a single harmonic independently of other harmonics. The new method has promise for low cost screening applications where only coarse localization might be required.

关键词： Nanoparticles Magnetism Computer programming Magnetic particle imaging Wavelets Signal to noise ratio molecular imaging Iron Oxides Signal generators

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2D Pattern matching of frontal plane radiograph to 3D model identifies structural and functional deficiencies of the spinal pelvic system in consideration of mechanical spine pain©

2D Pattern matching of frontal plane radiograph to 3D model ...

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conference on Medical imaging - biomedical applications in molecular, structural, and functional imaging

作者： Wiegand, Raymond Spine Rehabil Inst Missouri Weldon Spring MO 63304 USA

ISBN: (纸本)9781510625549

Worldwide, back pain is the single leading cause of disability, preventing many people from engaging in work as well as other everyday activities. Back pain affects nearly 80% of the population at some point and is the most common cause for missed work (1). Most cases of back pain are mechanical or non-organic—meaning they are not caused by serious conditions, such as inflammatory arthritis, infection, fracture or cancer (2). However, there is no single procedure to identify the mechanical components related to spine pain. This study reports on the development and application of a computer aided drafting (CAD) program that identifies structural and functional deficits of the spinal pelvic system from two dimensional radiographs. When injury to the spinal system disturbs balance or visual orientation, the righting reflex activates a compensatory response using muscle contraction and mass displacement. This mechanical displacement process proceeds along the pathway of the coupled motions of gait including pelvic and spine rotation. The gait cycle is the motion pathway of the body and the gait cycle is the primary pathway of mechanical compensation. As a result of injury, the spine adapts into a compensatory non-neutral position of gait with all its associated coupled motions. This compensatory, non-neutral position of gait becomes inherent to the spinal system and is recorded on a patient’s weight bearing x-rays. Therefore, a static biomechanical model of the spine and pelvis in a non-neutral position of gait is needed for patient comparison to assess structural integrity including mechanical and functional efficiency.

关键词： Spine 3D modeling Gait analysis Distortion Data modeling Image segmentation Injuries Radiography 3D image processing Motion models

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Developing hyperpolarized silicon particles for advanced biomedical imaging applications

Developing hyperpolarized silicon particles for advanced bio...

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conference on Medical imaging - biomedical applications in molecular, structural, and functional imaging

作者： Whiting, Nicholas Hu, Jingzhe Constantinou, Pamela Millward, Niki Zacharias Bankson, James Gorenstein, David Sood, Anil Carson, Daniel Bhattacharya, Pratip Univ Texas MD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Rice Univ Dept Bioengn Houston TX 77000 USA Rice Univ Dept Biosci Houston TX 77005 USA Univ Texas MD Anderson Canc Ctr Dept Imaging Phys Houston TX 77030 USA Univ Texas Hlth Sci Ctr Houston Dept NanoMed & Biomed Engn Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Gynecol Oncol & Reprod Med Houston TX 77030 USA

ISBN: (纸本)9781628415070

Silicon-based nanoparticles are ideally suited as biomedical imaging agents, due to their biocompatibility, biodegradability, and simple surface chemistry that is amenable to drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization (DNP), which increases magnetic resonance imaging (MRI) signals by 4-5 orders of magnitude through enhanced nuclear spin alignment, has recently been developed and shown viable as a contrast agent for in vivo MRI. Naturally occurring electronic defects on the particle surface obviate the need for exogenous radicals, and the enhanced spin polarization lasts for significantly longer than other hyperpolarized agents (tens of minutes, instead of <1 minute for other species). We report our recent advances in determining the MR characteristics of hyperpolarized silicon particles, which could lead to non-invasive, non-radioactive molecular targeted imaging of various cancer systems. A variety of particle sizes (20 nm-2 mu m) were found to have hyperpolarized relaxation times ranging from similar to 10-50 minutes. The addition of various functional groups to the particle surface, including biocompatible polymers, aptamers, and antibodies had no effect to the hyperpolarization dynamics or relaxation times, and appear to satisfactorily survive the harsh temperature conditions of DNP. Preliminary in vivo studies examined a variety of particle administration routes in mice, including intraperitoneal, tail vein, and rectal injections, as well as oral gavage. Ongoing experiments include targeted molecular imaging in orthotopic murine models of ovarian and colorectal cancers.

关键词： Hyperpolarization silicon particles molecular imaging nanomedicine MRI

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