A high-performance algorithm for generating isosurfaces is presented. In this algorithm, extrema points in a scalar field are first extracted. A graph is then generated in which the extrema points are taken as nodes. ...
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(纸本)9780780325210
A high-performance algorithm for generating isosurfaces is presented. In this algorithm, extrema points in a scalar field are first extracted. A graph is then generated in which the extrema points are taken as nodes. Each arc of the graph has a list of IDs of the cells that are intersected by the arc. A boundary cell list ordered according to cells' values is also generated. The graph and the list generated in this pre-process are used as a guide in searching for seed cells. Isosurfaces are generated from seed cells that are found in arcs of the graph. In this process, isosurfaces appear to propagate themselves. The algorithm visits only cells that are intersected by an isosurface and cells whose IDs an included in cell lists. It is especially efficient when many isosurfaces are interactively generated in a huge volume. Some benchmark tests described show the efficiency of the algorithm.< >
An interactive graphic viewer, ChromoScope, was developed to explore scientific visualization of complicated genome data. Escherichia coli was selected as the test organism. An ASN.1 data set has been built for the en...
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An interactive graphic viewer, ChromoScope, was developed to explore scientific visualization of complicated genome data. Escherichia coli was selected as the test organism. An ASN.1 data set has been built for the entire E. Coli chromosome, including a genetic map, a physical (ordered restriction) map, the alignment between the two maps, Kohara clones and some short repeat features. The E. coli sequence is modeled as a segmented sequence, incorporating both the sequence and the physical map data. The alignment between the contig and the published sequences is stored as sequence history, allowing direct access to the same sequence in the public databases. The alignment is displayed graphically, with both the sequence alignment and feature annotations. The alignment viewer also supports a detailed text display, providing information to resolution at residue level with annotated features.< >
We have developed a new computer language that describes three-dimensional graphical objects in visual simulation. The language, 3D-Talk is a powerful tool for visualizing the process of protein folding simulation. 3D...
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We have developed a new computer language that describes three-dimensional graphical objects in visual simulation. The language, 3D-Talk is a powerful tool for visualizing the process of protein folding simulation. 3D-Talk is designed as an object-oriented language with which users can create, manipulate, and edit graphical objects using commands with a syntax similar to that of a natural language. We developed two novel molecular biology applications using 3D-Talk. The first, ProView, is a protein visualization tool. ProView converts PDB (Protein Data Bank) data into 3D-Talk statements. The second is a visual simulation system for protein folding. It simulates the motion of protein folding using simulated annealing techniques and Hidden Markov Models. In short, 3D-Talk serves as a powerful animation tool.< >
Policy should be directed toward increased scientific rigor in clinical trails, not rigor mortis of the review process. New technologies such as biomedical imaging can increase rigor by providing objective, quantitati...
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Policy should be directed toward increased scientific rigor in clinical trails, not rigor mortis of the review process. New technologies such as biomedical imaging can increase rigor by providing objective, quantitative measures of device efficacy. Furthermore, a variety of digital technologies for management of clinical trails data and for computerization of the regulatory submission and review process should also be encouraged. In sum, policy should encourage technologies that facilitate the clinical trails and regulatory review process, while increasing scientific rigor. Specific recommendations: 1) Encourage more early information exchange between sponsor companies and FDA regarding the optimal conduct of clinical trials and submission of data. this would help to avoid insufficient submissions, lengthy reviews and extended development timelines. 3) Encourage appropriate applications of biomedical imaging technology to generate more objective and quantitative data. Such technology can reduce subjectivity that often hampers validation of clinical information. 4) Encourage digital submission technology that enhances data review. The same benefits anticipated in the computerization of patient medical records would apply to the "digitilization" of the clinical trails and regulatory review process.
How cells move and navigate within a 3D tissue mass is of central importance in such diverse problems as embryonic development, wound healing and metastasis. This locomotion can now be visualized and quantified using ...
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How cells move and navigate within a 3D tissue mass is of central importance in such diverse problems as embryonic development, wound healing and metastasis. This locomotion can now be visualized and quantified using computational optical-sectioning microscopy, which permits non-destructive 3D imaging of living specimens over long time periods. This technique, however, presents several technical challenges. Image restoration methods must be fast enough to process numerous I Gbyte time-lapse data sets (16 Mbytes per 3D image/spl times/60 time points). Because some cells are weakly labeled and background intensity is often high due to unincorporated dye, the SNR in some of these images is poor. Also required are accurate, automated-tracking procedures to generate both 3D trajectories for individual cells and 3D flows for a group of cells. Finally, sophisticated visualization techniques are needed to view the 3D movies of cell locomotion. Here, I discuss our current approaches to these problems and note present limitations.< >
There is a need for frameless guidance systems to help neurosurgeons to plan the exact location of a craniotomy, to define the margins of tumors and to precisely identify locations of neighboring critical structures. ...
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There is a need for frameless guidance systems to help neurosurgeons to plan the exact location of a craniotomy, to define the margins of tumors and to precisely identify locations of neighboring critical structures. We have developed an automatic technique for registering clinical data, such as segmented MRI or CT reconstructions, with the patient's head on the operating table. A second method calibrates the position of a video camera relative to the patient. The combination allows a visual mix of live video of the patient with the segmented 3D MRI or CT model, enabling enhanced reality techniques for planning and guiding neurosurgical procedures, and to interactively view extracranial or intracranial structures non-intrusively. Extensions of the method include image guided biopsies, focused therapeutic procedures and clinical studies involving change detection over time sequences of images.< >
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