Six malignant Brenner tumors of the ovary were studied electronmicroscopically. The histologic features of the tumors resemble to those of nonkeratinized squamous cell carcinoma of the uterine cervix. The ultrastructu...
Six malignant Brenner tumors of the ovary were studied electronmicroscopically. The histologic features of the tumors resemble to those of nonkeratinized squamous cell carcinoma of the uterine cervix. The ultrastructural features of malignant Brenner tumor included intracytoplasmic glands and cysts, presence of cilia, abundant glycogen, numerous desmosometonofilament complex, of which the cilium is most characteristic in the ovarian surface epithelium or Mullerian epithelium, but not in ***-tonofilament complex, the uitrastructure specific for the squamous epithelium, was not seen in the uroepithelium. We conclude that the appearance of cilium in malignant Brenner tumor indicates that the tumor is derived from the Mullerian epithelium, and that the presence of desmosome-tonofilament complex evidences that the tumor cells have differentiated into squamous epithelium. Our findings have proved that the malignant Brenner tumor arises from the Mullerian epithelium and recapitulates the vaginocervical epithelium.
Eight cases of malignant and 12 of benign Brenner tumor are reported, patient ages ranged 31-69 and 39-53 years. The malignant tumor was bilateral in 6 of 8 cases, and the benign in 1 of *** greatest diameter of the m...
Eight cases of malignant and 12 of benign Brenner tumor are reported, patient ages ranged 31-69 and 39-53 years. The malignant tumor was bilateral in 6 of 8 cases, and the benign in 1 of *** greatest diameter of the malignant tumors averaged around 11 cm, and the benign 10. Six of the malignant Brenner tumor patients died, one was lost to follow up, and one survived for 10 years. Pathologic and microscopic findings were presented in some detail. Based on the analysis of the association between the histologic features and type of Mullerian epithelium, we believe that the so-called Brenner tumor is in effect a tumor arising from the Mullerian epithelium with a tendency to differentiate into vaginocervical type epithelium.
第二届全国妇产科病理学术会议于1989年5月26至29日在株州市召开。出席会议代表201人,收到论文381篇,大会报告18篇,分组交流90篇。内容广泛,涉及围产和胎盘病理,外阴、阴道、宫颈和子宫输卵管病理及卵巢病理等方面。研究方法除光镜观察外,有电镜、组化、免疫组化、流式细胞计数对肿瘤细胞 DNA 含量的测定、核酸分子杂交检测宫颈
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