Using ultrasonography we measured the living structures of the eyeball in patients with angleclosure glaucoma (ACG) and their first degree relatives (siblings and offspring). The results indicate that the occurrence o...
Using ultrasonography we measured the living structures of the eyeball in patients with angleclosure glaucoma (ACG) and their first degree relatives (siblings and offspring). The results indicate that the occurrence of ACG is closely related to the anatomical features of the eyeball and that genetic factors play an important role in the development of ACG. For further exploring the hereditary pattern of ACG, a thorough investigation of ACG patients’pedigree, incidence in relatives, sex difference and the frequency of consanguineous marriage was undertaken. The results show that polygenic inheritance is most likely the hereditary pattern in ACG. Falconer’s model of polygenic inheritance is used to explain the hereditary pattern in ACG patients. The heritability of ACG is 65%, indicating that genetio factors are more important than environmental ones in the development of ACG. We also studied the association between ACG and the human leucocyte antigen (HLA) and the erythrocytic blood groups ABC, MN, P and Rh system. These blood group antigens can not be used as genetic markers for inheritance of ACG, because no significant association is found between them.
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