Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue,medical polyetheretherketone(PEEK) is considered a desirable candidate for bone-implant ***,its poor oss...
Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue,medical polyetheretherketone(PEEK) is considered a desirable candidate for bone-implant ***,its poor osseointegrative and antibacterial properties greatly limit its clinical *** address these concerns,a functional PEEK implant is ***,a novel photo-responsive multifunctional PEEK-based implant material(sPEEK/BP/E7) with both effective osteogenesis and good disinfection properties was constructed via the self-assembly of black phosphorus(BP) nanosheets,mussel-inspired polydopamine(PDA),and bioactive short peptide E7 on sulfonated PEEK(sPEEK).The versatile micro-/nano-structured PEEK surface provides superior hydrophilicity,a favorable osteogenic microenvironment,and excellent photothermal effects under near-infrared(NIR) *** in vitro results showed that sPEEK/BP/E7 displays enhanced cytocompatibility and osteogenicity in terms of cell adhesion,proliferation,alkaline phosphatase(ALP) activity,matrix mineralization,and osteogenesis-related gene expression,superior to those of the sPEEK and sPEEK/BP *** addition to osteogenesis,the multifunctional coating exhibited strong antibacterial activity against both Staphylococcus aureus(***) and Escherichia coli(***).Furthermore,it was confirmed in a rat femoral infection model that sPEEK/BP/E7 effectively resisted infection caused by *** under NIR light irradiation and promoted osseointegration in ***,this work presents a facile strategy to realize improvement of the "functional integration" of new polymer bone-implant materials and provide new ideas for their clinical application.
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