To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea. Methods ： The peripheral venous plasma as control was collected from 8 volunteers. The peripheral...
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To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea. Methods ： The peripheral venous plasma as control was collected from 8 volunteers. The peripheral venous plasma from 14 severe brain injury patients were collected in the 1, 3, 7 days after injury. Radloimmunoassay was used to detect the DNP concentration. Meanwhile, daily plasma and urine electrolytes, osmotic pressure as well as 24 h Hquid intake and output volume were detected. Results： The normal adult human plasma DNP level was 62. 46 pg/ml ±27. 56 pg/ml. In the experimental group, the plasma DNP levels were higher from day 1 to day 3 in 8 of the 14 patients than those in the control group （P1 =0.05, P3 =0.03）. Negative fluid balance occurred in 8 patients and hyponatremia in 7 patients. The increase of plasma DNP level was significantly correlated with the development of a negative fluid balance （r=-0.69, P〈0.01） and hyponatremia （χ^2 =4.38, P〈0.05）. Conclusions： The increase of plasma DNP level is accompanied by the enhancement of natriuretic and diuretic responses in severe brain-injured patients, which is associated with the development of a negative fluid balance and hyponatremia after brain injury.
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