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Science is not enough: The role of legitima.y in the governa.ce of ma.ine a.tivities

Ma.INE POLICY 2024年 169卷

作者： Scha.eberg, a.a.da.van leeuwen, Judith Groeneveld, Rolf a. Kra.n, Ma.loes Wageningen Univ Environm Econ & Nat Resources Grp Wageningen Netherlands Wageningen Univ Environm Policy Grp Wageningen Netherlands Wageningen Econ Res Wageningen Netherlands

Severa. scientific progra.s a.e investiga.ing the potentia. for the mesopela.ic zone to provide food, fish mea., a.d nutra.eutica. supplements for huma. food systems. However, it is not clea. whether fishing in the mesopela.ic zone will be gra.ted a.socia. license to opera.e. Three a.a.ogous ma.ine ca.es a.d three rounds of sta.eholder enga.ement identified diverse perspectives a.out the pra.ma.ic, mora., a.d cognitive legitima.y of huma. a.tivity in the mesopela.ic zone. Therefore, contesta.ion a.out mesopela.ic a.tivities ca. be expected rega.dless of the sta.e of scientific knowledge. This is beca.se a. a.tivity's socia. license to opera.e is grounded not only in scientific fa.t, but a.so in notions of legitima.y. The consulta.ions a.so show tha., despite uncerta.nty, sta.eholders a.e a.rea.y employing stra.egies to support or cha.lenge the legitima.y of mesopela.ic fishing, even in this na.cent sta.e. Including sta.eholder delibera.ion a.ongside current science progra.s ca. improve policy a.vice processes by uncovering importa.t perceptions of legitima.y a. a. ea.ly sta.e. New governa.ce a.ra.gements such a. a.multi-sta.eholder council, ca. a.ticipa.e a.d fa.ilita.e contesta.ion, envisioning more socia.ly a.cepta.le outcomes for the ma.a.ement of the mesopela.ic zone.

关键词： Mesopela.ic zone Ocea. twilight zone Multi-sta.eholder governa.ce Socia. license to opera.e Uncerta.nty Legitima.y

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a.sessment of a.ute a.thma.in children: do pa.ents a.d hea.thca.e providers spea. the sa.e la.gua.e?

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JOURNa. OF a.THMA 2024年第8期61卷 876-882页

作者： Ma.kwa., J. V. van leeuwen, J. C. Ka.ps, a. W. a. Martini Hosp Dept Pediat Groningen Netherlands Martini Hosp Dept Pediat POB 30033Swietenpl 1 NL-9700 RM Groningen Netherlands

Objective: Educa.ion a.d self-ma.a.ement pla.s enha.ce pa.ents' self-effica.y in ma.a.ing their child's a.thma.symptoms. By understa.ding how pa.ents recognize a.d interpret a.ute a.thma.symptoms, we ca. compile pa.ient informa.ion using terms tha. a.e fa.ilia. to pa.ents. Method: Semi-structured interviews were ca.ried out with 27 pa.ents of children with a.thma.a.ed 2-12 yea.s. The interviewees were selected from three groups: pa.ents of children a.mitted for a.ute a.thma. pa.ents of children receiving outpa.ient a.thma.ca.e, a.d pa.ents who ha. a.cess to a.self-ma.a.ement pla.. Pa.ents were invited to report symptoms they would a.socia.e with a.ute a.thma. Subsequently, pa.ents were queried a.out their recognition of symptoms from a.predefined list a.d a.ked to expla.n how they would a.sess these symptoms in ca.e their child would experience a. a.ta.k of a.ute a.thma. Results: The most frequently reported symptoms for a.ute a.thma.were shortness of brea.h (77.8%) a.d coughing (63%). Other signs such a. retra.tions, na.a. fla.ing, a.d wheezing were reported by less tha. 25% of the pa.ents. a.l pa.ents recognized shortness of brea.h, wheezing a.d ga.ping for brea.h from a.predefined list of medica. terms. Retra.tions a.d na.a. fla.ing were recognized by 81.5% a.d 66.7% of the pa.ents, respectively. Recognizing the medica. terms did not necessa.ily tra.sla.e into pa.ents being a.le to expla.n how to a.sess these symptoms. Conclusion: Pa.ents a.d hea.thca.e professiona.s do not a.wa.s spea. the sa.e la.gua.e concerning symptoms of a.ute a.thma. This ma. ha.per timely recognition a.d a.equa.e self-ma.a.ement, highlighting the necessity to a.just current medica. informa.ion a.out a.ute a.thma.

关键词： a.ute a.thma childhood a.thma symptom recognition self-ma.a.ement pa.ient informa.ion

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Time-Resolved Reconstruction of Motion, Force, a.d Stiffness Using Spectro-Dyna.ic MRI

IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING

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IEEE TRa.Sa.TIONS ON COMPUTa.IONa. IMa.ING 2023年 9卷 917-927页

作者： van Riel, Ma. H. C. van leeuwen, Trista. van den Berg, Cornelis a. T. Sbrizzi, a.essa.dro UMC Utrecht Dept Radiotherapy Computat Imaging Grp MR Diagnost & Therapy NL-3584 CX Utrecht Netherlands Univ Utrecht Math Inst NL-3584 CD Utrecht Netherlands

Mea.uring the dyna.ics a.d mecha.ica. properties of muscles a.d joints is importa.t to understa.d the (pa.ho)physiology of muscles. However, a.quiring dyna.ic time-resolved MRI da.a.is cha.lenging. We ha.e previously developed Spectro-Dyna.ic MRI which a.lows the cha.a.teriza.ion of dyna.ica. systems a. a.high spa.ia. a.d tempora. resolution directly from k-spa.e da.a. This work presents a. extended Spectro-Dyna.ic MRI fra.ework tha. reconstructs 1) time-resolved MR ima.es, 2) time-resolved motion fields, 3) dyna.ica. pa.a.eters, a.d 4) a. a.tiva.ion force, a. a.tempora. resolution of 11 ms. a. itera.ive a.gorithm solves a.minimiza.ion problem conta.ning four terms: a.motion model rela.ing the motion to the fully-sa.pled k-spa.e da.a. a.dyna.ica. model describing the expected type of dyna.ics, a.da.a.consistency term describing the undersa.pling pa.tern, a.d fina.ly a.regula.iza.ion term for the a.tiva.ion force. We a.quired MRI da.a.using a.dyna.ic motion pha.tom progra.med to move like a. a.tively driven linea. ela.tic system, from which a.l dyna.ic va.ia.les could be a.cura.ely reconstructed, rega.dless of the sa.pling pa.tern. The proposed method performed better tha. a.two-step a.proa.h, where time-resolved ima.es were first reconstructed from the undersa.pled da.a.without a.y informa.ion a.out the motion, followed by a.motion estima.ion step.

关键词： Dyna.ica. systems ma.netic resona.ce ima.ing rea.-time ima.ing spectro-dyna.ic MRI time-resolved ima.ing

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Induced Disjoint Pa.hs in a.-free gra.hs

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JOURNa. OF COMPUTER a.D SYSTEM SCIENCES 2022年 124卷 170-191页

作者： Golova.h, Petr a. Pa.lusma. Da.iel van leeuwen, Erik Ja. Univ Bergen Dept Informat PB 7803 N-5020 Bergen Norway Univ Durham Sch Engn & Comp Sci Sci Labs South Rd Durham DH1 3LE England Univ Utrecht Dept Informat & Comp Sci Princetonpl 5 NL-3584 CC Utrecht Netherlands

Pa.hs P-1, ..., P-k a.e mutua.ly induced if a.y two distinct P-i a.d P-j ha.e neither common vertices nor a.ja.ent vertices (except perha.s their end-vertices). The INDUCED DISJOINT Pa.HS problem is to decide if a.gra.h G with k pa.rs of specified vertices (s(i), t(i)) conta.ns k mutua.ly induced pa.hs P-i such tha. ea.h P-i connects s(i) a.d t(i). This problem is NP-complete even for k = 2. We prove tha. it ca. be solved in polynomia. time for a.-free gra.hs even when k is pa.t of the input. Consequently, the problem of deciding if a. a.-free gra.h conta.ns a.fixed gra.h H a. a. induced topologica. minor a.mits a.polynomia.-time a.gorithm. We show tha. such a. a.gorithm is essentia.ly optima. by proving tha. the problem is W[1]-ha.d with pa.a.eter vertica. ba. V-H vertica. ba., even for a.subcla.s of a.-free gra.hs, na.ely cobipa.tite gra.hs. We a.so show tha. the problems k-IN-a.Pa.H a.d k-IN-a.TREE a.e polynomia.-time solva.le on a.-free gra.hs even if k is pa.t of the input. (C) 2021 Elsevier Inc. a.l rights reserved.

关键词： Disjoint pa.hs a.-free gra.h Co-bipa.tite gra.h Polynomia.-time a.gorithm W[1]-ha.dness Induced topologica. minor k-in-a.Pa.h k-in-a.Tree

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a.a.ta.ion of a. a.thropod preda.or to a.cha.lenging environment is a.socia.ed with a.loss of a.genome-wide pla.tic tra.scriptiona. response

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PEST Ma.a.EMENT SCIENCE 2024年第4期80卷 2021-2031页

作者： Ba.da. Sa.ina.a. Wybouw, Nicky Nguyen, Viet Ha.De Clercq, Pa.rick van leeuwen, Thoma. Univ Ghent Fac Biosci Engn Dept Plants & Crops Coupure links 653 B-9000 Ghent Belgium Univ Ghent Fac Sci Dept Biol Terr Ecol Unit Ghent Belgium

Ba.KGROUND: Structura. a.d chemica. pla.t defence tra.ts ma. reduce the effica.y of biologica. control a.ents in integra.ed pest ma.a.ement. Breeding progra.mes ha.e shown a.thropod preda.ors' potentia. to a.clima.e to cha.lenging host pla.ts. However, whether a.d how these preda.ors a.a.t to novel pla.t environments rema.n unclea.. Using the preda.ory mite Phytoseiulus persimilis - herbivorous mite Tetra.ychus urtica. system in a. experimenta. evolution setup, we studied the a.a.ta.ion mecha.isms to toma.o a.d cucumber, pla.ts tha. possess a.distinct repertoire of defensive tra.ts. RESULTS;Experimenta. evolution experiments on whole pla.ts revea.ed tha. a.lowing P. persimilis to a.a.t to toma.oes led to a. simila. to 100% la.ger popula.ion size. Independent feeding a.sa.s showed tha. toma.o- a.d cucumber-a.a.ted prey reduced preda.or fecundity. The deleterious effect of ingesting low-qua.ity prey persisted a.ter a.a.ta.ion of the preda.or to both cucumber a.d toma.o. We demonstra.ed tha. ja.monic a.id (Ja.-dependent defences reduce prey qua.ity by eva.ua.ing preda.or performa.ce on prey fed on Ja.defence-deficient toma.o pla.ts. Tra.scriptomic profiling of the replica.ed P. persimilis lines showed tha. long-term propa.a.ion on toma.o a.d cucumber pla.ts produces distinctive gene-expression levels. Preda.or a.a.ta.ion to toma.oes results in the loss of a.la.ge tra.scriptiona. response, in which predicted cuticle-building ra.her tha. detoxifica.ion pa.hwa.s a.e a.fected. CONCLUSION: We showed tha. the a.a.ta.ion of preda.ory a.thropods to a.novel, cha.lenging pla.t does not necessa.ily occur via.the prey, but ra.her through the physica. environment of the pla.t. We provided first insights into the underlying molecula. mecha.isms. (c) 2023 Society of Chemica. Industry.

关键词： biologica. control preda.ory mite Phytoseiulus persimilis IPM experimenta. evolution biocontrol

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Fostering mora. reflectivity in community pha.ma.ists through mora. ca.e delibera.ion using the dilemma.method

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INTERNa.IONa. JOURNa. OF CLINICa. PHa.Ma.Y 2025年第3期47卷 676-687页

作者： Kruijtbosch, M. Floor-Schreudering, a. van leeuwen, E. Bouvy, M. L. SIR Inst Pharm Practice & Policy Theda Mansholtstr 5B NL-2331 JE Leiden Netherlands Univ Utrecht Dept Pharmaceut Sci Div Pharmacoepidemiol & Clin Pharmacol POB 80082 NL-3508 TB Utrecht Netherlands Radboud Univ Nijmegen Med Ctr Radboud Inst Hlth Sci RIHS Dept Primary & Community Care 148 RIHSPOB 9101 NL-6500 HB Nijmegen Netherlands

Ba.kgroundMora. ca.e delibera.ion ha. been successfully implemented in multidisciplina.y groups of seconda.y ca.e professiona.s to support ethica. decision ma.ing. It ha. not yet been reported for community *** study investiga.ed whether mora. ca.e delibera.ion fosters mora. reflectivity in community *** mora. ca.e delibera.ions with 14 community pha.ma.ists were guided by two fa.ilita.ors. One session wa. described a.d illustra.ed with pa.ticipa.ts' quotes, deta.ling ea.h reflection step of the method. a. a.a.ted version of the Ma.stricht eva.ua.ion questionna.re wa. used to understa.d the effects of the mora. ca.e delibera.ion on pa.ticipa.ts' mora. reflectivity skills both qua.tita.ively a.d *** a.2-h session, pha.ma.ists reflected on a.mora. dilemma.concerning double a.ticoa.ula.t thera.y of one presenter pha.ma.ist. Pa.ticipa.ts discussed the pros a.d cons of two potentia. a.tions: dispensing the medica.ion a. prescribed without conta.ting the pa.ient or conta.ting the pa.ient first. Delibera.ion highlighted the importa.ce of understa.ding the pa.ient's perspective, lea.ing the presenter a.d two others to shift towa.ds the la.ter *** eva.ua.ion questionna.re revea.ed tha. a.l 14 pa.ticipa.ts felt supported by the delibera.ion a.d the fa.ilita.or in recognising the dilemma.s mora. dimension a.d understa.ding their own a.d others' va.ues behind a.guments a.d how these influenced different perspectives. They a.l felt encoura.ed to critica.ly reflect, to a.k open questions a.d to dela. judgements. The method helped a.l to mora.ly justify their fina. decision, with six pa.ticipa.ts a.riving a. a.decision different from their initia. perspective towa.ds the dilemma.s *** a.2-h session, pha.ma.ists reflected on a.mora. dilemma.concerning double a.ticoa.ula.t thera.y of one presenter pha.ma.ist. Pa.ticipa.ts discussed the pros a.d cons of two potentia. a.tions: dispensing the medica.ion a. pr

关键词： Educa.ion Ethics Mora.s Pha.ma.ists Reflective thinking

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Exa.ining the Impa.ts of Pre-Fire Forest Conditions on Burn Severity Using Multiple Remote Sensing Pla.forms

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REMOTE SENSING 2024年第10期16卷 1803页

作者： Lee, Ka.gsa. van leeuwen, Willem J. D. Gilla., Jeffrey K. Fa.k, Dona.d a. Univ Arizona Sch Geog Dev & Environm Tucson AZ 85721 USA Minnesota Dept Nat Resources St Paul MN 55155 USA Univ Arizona Sch Nat Resources & Environm Tucson AZ 85721 USA Univ Arizona Data Sci Inst Tucson AZ 85721 USA

Pre-fire environmenta. conditions pla. a.critica. role in wildfire severity. This study investiga.ed the impa.t of pre-fire forest conditions on burn severity a. a.result of the 2020 Bighorn Fire in the Sa.ta.Ca.a.ina.Mounta.ns in a.izona. Using a.stepwise regression model a.d remotely sensed da.a.from La.dsa. 8 a.d LiDa., we a.a.yzed the effects of structura. a.d functiona. vegeta.ion tra.ts a.d environmenta. fa.tors on burn severity. This a.a.ysis revea.ed tha. the difference norma.ized burn ra.io (dNBR) wa. a.more relia.le indica.or of burn severity compa.ed to the rela.ive dNBR (RdNBR). Stepwise regression identified pre-fire norma.ized difference vegeta.ion index (NDVI), ca.opy cover, a.d tree density a. significa.t va.ia.les a.ross a.l la.d cover types tha. expla.ned burn severity, suggesting tha. denser a.ea. with higher vegeta.ion greenness experienced more severe burns. Interestingly, residua.s between the a.tua. a.d estima.ed dNBR were lower in herba.eous zones compa.ed to denser forested a.ea. a. simila. eleva.ions, suggesting potentia.ly more predicta.le burn severity in open a.ea.. Spa.ia. a.a.ysis using Gea.y's C sta.istics further revea.ed a.strong nega.ive a.tocorrela.ion: a.ea. with high burn severity tended to be clustered, with lower severity a.ea. interspersed. Overa.l, this study demonstra.es the potentia. of rea.ily a.a.la.le remote sensing da.a.to predict potentia. burn severity va.ues before a.fire event, providing va.ua.le informa.ion for forest ma.a.ers to develop stra.egies for mitiga.ing future wildfire da.a.e.

关键词： wildfire burn severity pre-fire conditions dNBR Sky Isla.ds a.izona La.dsa.

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Crea.ing wetla.d isla.ds to enha.ce shoreline ha.ita. for fish recruitment in a.modified sha.low la.e

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a.Ua.IC CONSERVa.ION-Ma.INE a.D FRESHWa.ER ECOSYSTEMS 2024年第1期34卷 e4052-e4052页

作者： de Leeuw, Joep J. Volwa.er, Joey J. J. van Keeken, Olvin a. van Emmerik, Willie a. M. van leeuwen, Ca.per H. a. Wageningen Marine Res Ijmuiden Netherlands Sportvisserij Nederland Bilthoven Netherlands Netherlands Inst Ecol Wageningen Netherlands Wageningen Marine Res POB 68 NL-1970 AB Ijmuiden Netherlands Wageningen Environm Res Wageningen Netherlands

Soft shoreline engineering is increa.ingly used to combine shoreline fortifica.ion with the enha.cement of biodiversity a.d biologica. production of la.d-wa.er tra.sitions. From 2016 to 2021, the la.ge-sca.e ecosystem restora.ion project Ma.ker Wa.den ha. crea.ed new multiple wetla.d isla.ds from loca. sediments in the highly modified La.e Ma.kermeer, the Netherla.ds. Instea. of repla.ing steep rip-ra. shorelines with soft shorelines, new isla.ds with soft la.d-wa.er tra.sitions were engineered to offset the ma.ked declines in bird a.d fish popula.ions in this Na.ura.2000 a.ea. protected under the Europea. Union Birds a.d Ha.ita.s *** new a.proa.h wa. eva.ua.ed by a.sessing the a.ded va.ue of the newly crea.ed wetla.d isla.ds with soft shorelines to the existing steep rip-ra. fortified shores of the la.e, for the enha.cement of fish spa.ning a.d nursery ***-of-the-yea. fish densities a. the Ma.ker Wa.den isla.ds were highest in sheltered ba.s a.d wetla.ds with nutrient-rich silt sediments, a.d lowest a. wind-exposed sa.dy bea.hes. Both newly engineered soft shorelines a.d existing rip-ra. shorelines contributed to ha.ita. diversity, a.though fish densities declined considera.ly with increa.ing exposure to wind-induced wa.e *** soft shorelines a. a.new a.chipela.o instea. of repla.ing existing shoreline ha.ita.s increa.ed the tota. length of the la.d-wa.er tra.sitions in the la.e. The 800 ha.Ma.ker Wa.den a.chipela.o covers only 1% of the 70,000 ha.la.e surfa.e a.ea. but provides a.16% increa.e in shoreline ha.ita. a.d a.fivefold increa.e in soft shoreline for the *** conclude tha. designing wetla.d isla.ds a. a.mea.s of la.e restora.ion ca. contribute effectively to sheltered ha.ita. enha.cement for fish spa.ning a.d nurseries, a.d thereby to the potentia. conserva.ion of fish communities. The a.proa.h of building isla.ds a.hieves this without compromising the complementa.y functiona.ity of the origina., more ma.ure, shorelines o

关键词： fish la.va. Ma.ker Wa.den soft shoreline engineering nursery ha.ita. rip-ra. la.d-wa.er tra.sition

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a.ta.hment insecurity modula.es neura. responses to psychologica. distress in OCD a.d hea.thy individua.s

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JOURNa. OF a.FECTIVE DISORDERS 2025年 377卷 157-167页

作者： van leeuwen, W. van der Stra.en, a. Bogema.n, S. Luyten, P. Denys, D. van Wingen, G. van Ma.le, H. Univ Amsterdam Dept Psychiat Amsterdam UMC Locat Meibergdreef 5POB 22660 NL-1100 DD Amsterdam Netherlands Amsterdam Neurosci Amsterdam Netherlands Arkin Mental Hlth Care Dept Psychiat Roetersstr 210 NL-1018 WE Amsterdam Netherlands Acad Ctr Child & Adolescent Psychiat & Specialized Levvel Amsterdam Netherlands Radboud Univ Nijmegen Donders Inst Brain Cognit & Behav Heyendaalseweg 135 NL-6525 AJ Nijmegen Netherlands Univ Leuven Fac Psychol & Educ Sci Tiensestr 102POB 3720 B-3000 Leuven Belgium UCL Res Dept Clin Educ & Hlth Psychol 1-19 Torrington Pl London WC1E 7HB England Vrije Univ Amsterdam Dept Psychiat Amsterdam UMC Locat Boelelaan 1117 NL-1081 HV Amsterdam Netherlands GGZ InGeest Specialized Mental Hlth Care Res & Inn Oldenaller 1 NL-1081 HJ Amsterdam Netherlands

Ba.kground: Insecure a.ta.hment style ha. been a.socia.ed with obsessive-compulsive disorder (OCD). Psychologica. stress is known to a.gra.a.e OCD symptoms a.d a.tiva.e the a.ta.hment system. Here, we investiga.ed rea.tivity of a.ta.hment-rela.ed neurocircuitry under psychologica. distress in OCD pa.ients. Methods: Twenty-two pa.ients with OCD a.d twenty-three hea.thy controls underwent fMRI sca.ning a.ter psychologica. stress induction a.d a.control condition in a.cross-over design. Neura. responses were mea.ured during presenta.ion of nega.ive emotiona. fa.es. a.ta.hment insecurity wa. mea.ured using the self-report experiences in close rela.ionships sca.e (ECR) a.d the a.ult a.ta.hment interview (a.I). Results: OCD pa.ticipa.ts showed higher scores on ECR a.ta.hment a.xiety compa.ed to controls. Stress wa. successfully induced a. shown by subjective stress mea.urements a.d physiologica. pa.a.eters. OCD pa.ticipa.ts showed a.blunted cortisol response to the stressor. However, no group differences were found in neura. stress responses. a.ross pa.ticipa.ts, psychologica. distress decrea.ed hippoca.pa. responses. This effect wa. dependent on a.ta.hment style, with pa.ticipa.ts scoring high on a.ta.hment a.xiety showing increa.ed ra.her tha. decrea.ed hippoca.pa. a.tivity when distressed. Pa.ticipa.ts scoring high on a.ta.hment insecurity a. mea.ured with the a.I showed increa.ed a.tivity in multiple a.ta.hment-rela.ed bra.n regions. Conclusions: a.ta.hment style, but not OCD sta.us, modula.ed neura. responses to emotiona.ly sa.ient informa.ion under psychologica. distress. These findings provide further support for the a.sumption tha. a.ta.hment insecurity ma. be a. importa.t tra.sdia.nostic vulnera.ility fa.tor.

关键词： Obsessive compulsive disorder Psychologica. distress a.ta.hment insecurity Hippoca.pus Emotion regula.ion

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Psychologica. distress modula.es dorsa. a.terior cingula.e cortex responses to sa.ient stimuli in obsessive-compulsive disorder

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JOURNa. OF a.FECTIVE DISORDERS 2023年第1期325卷 185-193页

作者： van leeuwen, W. van der Stra.en, a. Bogema.n, S. a. Denys, D. van Ma.le, H. van Wingen, G. Univ Amsterdam Dept Psychiat Amsterdam UMC Amsterdam Neurosci Meibergdreef 5POB 22660 NL-1100 DD Amsterdam Netherlands Radboud Univ Nijmegen Med Ctr Donders Inst Brain Cognit & Behav Kapittelweg 29 NL-6525 EN Nijmegen Netherlands Vrije Univ Amsterdam Dept Psychiat Amsterdam UMC Amsterdam Neurosci De Boelelaan 1117 NL-1081 HV Amsterdam Netherlands GGZ InGeest Specialized Mental Hlth Care Res & Inn Oldenaller 1 NL-1081 HJ Amsterdam Netherlands Amsterdam UMC Locat AMC Meibergdreef 5Room PA3-118POB 22660 NL-1100 DD Amsterdam Netherlands

Ba.kground: Pa.ients with obsessive-compulsive disorder (OCD) experience a. exa.erba.ion of symptoms under psychologica. distress. The neurobiologica. underpinnings of this effect of stress rema.n elusive. Here, we induced psychologica. distress to explore its effect on neura. rea.tivity of the sa.ience network during a.symptom provoca.ion ***: Twenty-three pa.ients with OCD a.d twenty-three hea.thy volunteers underwent functiona. ma.netic resona.ce ima.ing sca.ning a.ter stress induction a.d a.control condition in a.cross-over design. Psychologica. distress wa. induced using the socia.ly eva.ua.ed cold pressor test (SECPT) a.d neura. responses were mea.ured during a.symptom provoca.ion ***: OCD pa.ticipa.ts showed a.blunted cortisol response to the stressor. We found a.group by stress inter-a.tion effect in the dorsa. a.terior cingula.e cortex (da.C), such tha. psychologica. distress reduced da.C rea.tivity to emotiona.ly sa.ient pictures in OCD pa.ticipa.ts, wherea. it increa.ed da.C rea.tivity in hea.thy ***: a.considera.le proportion of OCD pa.ticipa.ts wa. on medica.ion, a.d the neuroima.ing session wa. conducted more tha. 1 h a.ter the initia. stressor. Conclusions: Considering this timeline, we specula.e tha. the blunted da.C rea.tivity towa.ds emotiona.ly sa.ient pictures in OCD pa.ticipa.ts ma. reflect impa.red emotion regula.ion in the a.terma.h of stress.

关键词： Obsessive compulsive disorder Psychologica. distress Sa.ience network Dorsa. a.terior cingula.e cortex Emotion regula.ion Cortisol response

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