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Molecular Mechanism of lncRNAs in Regulation of Breast Cancer Metastasis;a Comprehensive Review

CELL BIOCHEMISTRY AND BIOPHYSICS 2025年第1期83卷 229-245页

作者： Ahmadi, Shokoufeh Yazdi, Farzaneh Khastar, Sahar Kaur, Irwanjot Ahmed, Mareb Hamed Kumar, Abhishek Rathore, Gulshan Kaur, Parjinder Shahsavan, Mohammad Dehghani-Ghorbi, Mahmoud akhavan-sigari, reza RabeRashidi Univ Dept Microbiol Tabriz Iran Kerman Univ Med Sci Inst Neuropharmacol Neurosci Res Ctr Kerman Iran Shahid Beheshti Univ Med Sci Sch Med Dept Immunol Tehran Iran Jain Deemed to be Univ Dept Biotechnol & Genet Bengaluru 560069 Karnataka India Vivekananda Global Univ Dept Allied Healthcare & Sci Jaipur 303012 Rajasthan India Alnoor Univ Coll Dent Mosul Iraq Shobhit Univ Adarsh Vijendra Inst Pharmaceut Sci Sch Pharm Gangoh 247341 Uttar Pradesh India Arka Jain Univ Dept Pharm Jamshedpur 831001 Jharkhand India NIMS Univ Rajasthan NIMS Inst Pharm Dept Pharmaceut Jaipur India Chandigarh Pharm Coll Chandigarh Grp Coll Jhanjeri Mohali 140307 Punjab India Isfahan Univ Med Sci Dept Orthoped Surg Esfahan Iran Shahid Beheshti Univ Med Sci Imam Hossein Educ Hosp Hematol Oncol Dept Tehran Iran Univ Med Ctr Dept Neurosurg Tubingen Germany Coll Humanum Warsaw Management Univ Warsaw Dept Hlth Care Management & Clin Res Warsaw Poland

Although the number of breast cancer deaths has decreased, and there have been developments in targeted therapies and combination treatments for the management of metastatic illness, metastatic breast cancer is still the second most common cause of cancer-related deaths in U.S. women. Numerous phases and a vast number of proteins and signaling molecules are involved in the invasion-metastasis cascade. The tumor cells penetrate and enter the blood or lymphatic vessels, and travel to distant organs via the lymphatic or blood vessels. Tumor cells enter cell cycle arrest, adhere to capillary beds in the target organ, and then disseminate throughout the organ's parenchyma, proliferating and enhancing angiogenesis. Each of these processes is regulated by changes in the expression of different genes, in which lncRNAs play a role in this regulation. Transcripts that are longer than 200 nucleotides and do not translate into proteins are called RNAs. LncRNA molecules, whose function depends on their unique molecular structure, play significant roles in controlling the expression of genes at various epigenetic levels, transcription, and so on. LncRNAs have essential functions in regulating the expression of genes linked to cell development in healthy and pathological processes, specialization, programmed cell death, cell division, invasion, DNA damage, and spread to other parts of the body. A number of cancer types have been shown to exhibit aberrant expression of lncRNAs. In this review, we describe the general characteristics, potential molecular mechanisms and targeted therapy of lncRNAs and discuss the emerging functions of lncRNAs in breast cancer.

关键词： Long non-coding RNAs Breast cancer Metastasis lncRNAs miRNAs

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Long Non-Coding RNAs in Non-Alcoholic Fatty Liver Disease;Friends or Foes?

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CELL BIOCHEMISTRY AND BIOPHYSICS 2025年第1期83卷 279-294页

作者： Soltanieh, Sina Kalantari Khastar, Sahar Kaur, Irwanjot Kumar, Abhishek Bansal, Jaya Fateh, Ata Nathiya, Deepak Husseen, Beneen Rajabivahid, Mansour Dehghani-Ghorbi, Mahmoud akhavan-sigari, reza MVZ Lab Synlab Berlin Berlin Germany Shahid Beheshti Univ Med Sci Sch Med Dept Immunol Tehran Iran Jain Univ Dept Biotechnol & Genet Bengaluru 560069 Karnataka India Vivekananda Global Univ Dept Allied Healthcare & Sci Jaipur 303012 Rajasthan India Shobhit Univ Adarsh Vijendra Inst Pharmaceut Sci Sch Pharm Gangoh 247341 Uttar Pradesh India Arka Jain Univ Dept Pharm Jamshedpur 831001 Jharkhand India Chandigarh Grp Coll Chandigarh Engn Coll Dept Appl Sci Mohali 140307 Punjab India Pasteur Inst Iran Microbiol Res Ctr MRC Tehran Iran NIMS Univ Rajasthan Inst Pharm Dept Pharm Practice Jaipur India Islamic Univ Med Lab Tech Coll Najaf Iraq Islamic Univ Al Diwaniyah Med Lab Tech Coll Al Diwaniyah Iraq Zanjan Univ Med Sci Valiasr Hosp Dept Internal Med Zanjan Iran Shahid Beheshti Univ Med Sci Imam Hossein Educ Hosp Hematol Oncol Dept Tehran Iran Univ Med Ctr Tuebingen Dept Neurosurg Tubingen Germany Warsaw Management Univ Warsaw Dept Hlth Care Management & Clin Res Coll Humanum Warsaw Poland

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a range of conditions that start with the accumulation of fat in the liver (hepatic steatosis) and can progress to more severe stages like steatohepatitis (NASH) and fibrosis without drinking alcohol. Environmental and genetic variables both contribute to MAFLD's development, with various biological processes and mediators involved at every phase. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are not translated into protein and are over 200 nucleotides long. They can impact genes that encode protein by controlling transcriptional and post-transcriptional procedures. Dysregulation of lncRNA has been connected to several liver diseases, including MAFLD. Recent research has linked lncRNAs to MAFLD pathology in both patients and animal models. However, the roles of most lncRNAs in MAFLD pathology are still not well recognized. This review provides a comprehensive catalog of recently reported lncRNAs in the pathogenesis of MAFLD and summarizes the current knowledge of lncRNAs usage as therapeutic strategies in MAFLD, the most common liver disease. Collectively, lncRNA's targeting could potentially offer a therapeutic approach by modulating MAFLD.

关键词： Non-alcoholic fatty liver disease lncRNA MAFLD liver disease

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To be or not to be: navigating the influence of MicroRNAs on cervical cancer cell death

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CANCER CELL INTERNATIONAL 2025年第1期25卷 1-23页

作者： Taghizadieh, Mohammad Kalantari, Masoumeh Bakhshali, Roksana Kobravi, Sepehr Khalilollah, Shayan Baghi, Hossein Bannazadeh Bayat, Mobina Nahand, Javid Sadri akhavan-sigari, reza Tabriz Univ Med Sci Fac Med Dept Pathol Tabriz Iran Tehran Univ Hlth Sci Dept Biol Tehran Iran Omid Canc Ctr Ahvaz Iran Islamic Azad Univ Fac Dent Dept Oral & Maxillofacial Surg Tehran Med Sci Branch Tehran Iran Islamic Azad Univ Fac Med Dept Neurosurg Tehran Med Sci Tehran Iran Tabriz Univ Med Sci Infect & Trop Dis Res Ctr Tabriz Iran Univ Med Ctr Tuebingen Dept Neurosurg Tubingen Germany Coll Humanum Warsaw Management Univ Dept Hlth Care Management & Clin Res Warsaw Poland

With all diagnostic and therapeutic advances, such as surgery, radiation- and chemo-therapy, cervical cancer (CC) is still ranked fourth among the most frequent cancers in women globally. New biomarkers and therapeutic targets are warranted to be discovered for the early detection, treatment, and prognosis of CC. As component of the non-coding RNA's family, microRNAs (miRNAs) participate in several cellular functions such as cell proliferation, gene expression, many signaling cascades, apoptosis, angiogenesis, etc. MiRNAs can suppress or induce programmed cell death (PCD) pathways by altering their regulatory genes. Besides, abnormal expression of miRNAs weakens or promotes various signaling pathways associated with PCD, resulting in the development of human diseases such as CC. For that reason, understanding the effects that miRNAs exert on the various modes of tumor PCD, and evaluating the potential of miRNAs to serve as targets for induction of cell death and reappearance of chemotherapy. The current study aims to define the effect that miRNAs exert on cell apoptosis, autophagy, pyroptosis, ferroptosis, and anoikis in cervical cancer to investigate possible targets for cervical cancer therapy. Manipulating the PCD pathways by miRNAs could be considered a primary therapeutic strategy for cervical cancer.

关键词： Cervical cancer MicroRNAs Apoptosis Ferroptosis Pyroptosis Autophagy

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Critical roles of miR-21 in promotions angiogenesis: friend or foe?

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CLINICAL AND EXPERIMENTAL MEDICINE 2025年第1期25卷 1-23页

作者： Saadh, Mohamed J. Jasim, Nisreen Yasir Ahmed, Mareb Hamed Ballal, Suhas Kumar, Abhishek Atteri, Shikha Vashishth, Raghav Rizaev, Jasur Alhili, Ahmed Jawad, Mahmood Jasem Yazdi, Farzaneh Salajegheh, Amirali akhavan-sigari, reza Middle East Univ Fac Pharm Amman 11831 Jordan Natl Univ Sci & Technol Coll Dent Nasiriyah Dhi Qar Iraq Al Noor Univ Coll Dept Dent Nineveh Iraq JAIN Sch Sci Dept Chem & Biochem Bangalore Karnataka India Shobhit Univ Adarsh Vijendra Inst Pharmaceut Sci Sch Pharm Gangoh 247341 Uttar Pradesh India ARKA Jain Univ Dept Biotechnol Jamshedpur 832108 Jharkhand India Chandigarh Grp Coll Chandigarh Pharm Coll Mohali 140307 Punjab India Nims Univ Rajasthan Natl Inst Med Sci Dept Pharmacol Jaipur India Samarkand State Med Univ Dept Publ Hlth & Healthcare Management Rector 18 Amir Temur St Samarkand Uzbekistan Al Farahidi Univ Med Tech Coll Baghdad Iraq Al Zahrawi Univ Coll Dept Pharm Karbala Iraq Kerman Univ Med Sci Inst Neuropharmacol Neurosci Res Ctr Kerman Iran Univ Tehran Med Sci Tehran Iran Dr Schneiderhan GmbH Munich Germany ISAR Klinikum Munich Germany Management Univ Warsaw Dept Hlth Care Management & Clin Res Coll Humanum Warsaw Warsaw Poland

MiRNAs are small RNA strands that are managed following transcription and are of substantial importance in blood vessel formation. It is essential to oversee the growth, differentiation, death, movement and construction of tubes by angiogenesis-affiliated cells. If miRNAs are not correctly regulated in regard to angiogenesis, it can deteriorate the health and lead to various illnesses, which include cancer, cardiovascular disorder, critical limb ischemia, Crohn's disease, ocular diseases, diabetic microvascular complications, and more. Consequently, it is vital to understand the crucial part that miRNAs play in the development of blood vessels, so we can develop reliable treatment plans for vascular diseases. This write-up will assess the critical role of miR-21/exosomal miR-21 in managing angiogenesis associated with bone growth, wound recovery, and other pathological conditions like tumor growth, ocular illnesses, diabetes, and other diseases connected to formation of blood vessels. Previous investigations have demonstrated that miR-21 is present at higher amounts in certain cancerous cells, and it influences a multitude of genes that moderate the increased creation of blood vessels. Furthermore, studies demonstrated that exosomal miR-21 has the capacity to interact with endothelial cells to foster tumor angiogenesis. For that reason, this review explains the critical importance of miR-21/exosomal miR-21 in managing both healthy and diseased states of angiogenesis.

关键词： Angiogenesis microRNA miR-21 Tumor angiogenesis Wound healing

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Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis

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CANCER CELL INTERNATIONAL 2025年第1期25卷 1-14页

作者： Saadh, Mohamed J. Ahmed, Hanan Hassan Chandra, Muktesh Al-Hussainy, Ali Fawzi Hamid, Junainah Abd Mishra, Anurag Taher, Waam Mohammed Alwan, Mariem Jawad, Mahmood Jasem Al-Nuaimi, Ali M. Ali Alsaikhan, Fahad Farhood, Bagher akhavan-sigari, reza Middle East Univ Fac Pharm Amman 11831 Jordan Al Noor Univ Coll Dept Pharm Nineveh Iraq Marwadi Univ Res Ctr Fac Engn & Technol Dept Bioinformat Rajkot 360003 Gujarat India Ahl Al Bayt Univ Coll Pharm Kerbala Iraq Management & Sci Univ Shah Alam Selangor Malaysia NIMS Univ NIMS Inst Pharm Dept Pharmaceut Chem Jaipur Rajasthan India Natl Univ Sci & Technol Coll Pharm Dhi Qar Iraq Al Farahidi Univ Pharm Coll Baghdad Iraq Al Zahrawi Univ Coll Dept Pharm Karbala Iraq Gilgamesh Ahliya Univ Baghdad Iraq Prince Sattam Bin Abdulaziz Univ Coll Pharm Alkharj Saudi Arabia Ibn Sina Natl Coll Med Studies Pharm Jeddah Saudi Arabia Kashan Univ Med Sci Fac Paramed Sci Dept Med Phys & Radiol Kashan Iran Dr Schneiderhan GmbH Munich Germany ISAR Klinikum Munich Germany Univ Warsaw Dept Hlth Care Management & Clin Res Coll Humanum Warsaw Management Warsaw Poland

ObjectiveOral malignancies are among the common head and neck cancers. Various therapeutic modalities are used for targeting oral cancers. It was shown that quercetin (a flavonoid) has an anti-cancer effect on different cancers. In the current study, the anti-cancer potentials of quercetin against oral cancer cells were *** current systematic review was conducted in accordance with the PRISMA guideline for the identification of relevant studies in various electronic databases up to April 2023. After reviewing and screening 193 articles, 18 were chosen for this study based on our inclusion and exclusion *** was shown that quercetin significantly reduced cancer cell proliferation, cell viability, tumor volume, invasion, metastasis and migration. This anti-cancer agent induced oxidative stress and apoptosis in the cancer cells. Quercetin treatment could also induce some biochemical alterations in the cancer *** to the results, it can be mentioned that quercetin administration has an anti-cancer effect against oral cancer cells. This agent exerts its anticancer effects via reduced cell viability and different mechanisms, including induce oxidative damage, apoptosis, and reduced invasion and metastasis. However, suggesting the use of quercetin as a therapeutic agent of oral cancer patients requires further clinical studies due to its poor absorption rates, and the exact molecular mechanisms are still not well understood.

关键词： Apoptosis Quercetin Oral cancer Oxidative stress Systemic review

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Stevens Johnson Syndrome-An Adverse Drug Reaction Occurred after Uncomplicated Removal of an Intracerebral Cavernous Hemangioma

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JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY 2013年第Sup1期74卷 E58-E61页

作者： akhavan-sigari, reza Rohde, Veit Abili, Mehdi Univ Gottingen Univ Med Ctr Gottingen Dept Neurosurg D-37075 Gottingen Germany Imam Reza Univ Razavi Hosp Dept Neurosurg Mashhad Iran

BackgroundToxic epidermal necrolysis (TEN) is a rare, severe adverse drug reaction. Steven-Johnson syndrome (SJS) represents the milder end of the spectrum. The exact pathogenesis of TEN and SJS is still unknown. Many drugs, including prednisolone, cyclosporin, and intravenous immunoglobulin (IVIG), have been used in an attempt to halt the disease process. The use of phenytoin as a prophylactic anticonvulsant after brain surgery, particularly for brain tumors, is a common practice, regardless of whether the patient has a previous history of convulsions. This treatment policy assumes that the benefits exceed the risks. CaseIn this paper, we describe a young patient who underwent a total removal of an intracerebral cavernous hemangioma following development of SJS after taking phenytoin postoperatively. ConclusionWe suggest that the practice of routine use of phenytoin following brain surgery should be re-evaluated because the treatment may be neither essential nor without side effects.

关键词： Phenytoin Steven-Johnson syndrome adverse drug reaction

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Connection between expression of inducible nitric oxide synthase (iNOS) in skull base chordoma and lower urinary tract symptoms

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INTERNATIONAL UROLOGY AND NEPHROLOGY 2014年第11期46卷 2109-2116页

作者： akhavan-sigari, reza Ostertag, Helmut Rohde, Veit Tezval, Hossein Univ Gottingen Dept Neurosurg Univ Med Ctr Gottingen D-37075 Gottingen Germany Klinikum Hannover Dept Pathol Nordstadt Med Ctr D-30167 Hannover Germany Hannover Med Sch Dept Urol D-30625 Hannover Germany

To provide first insights into the potential role of iNOS expressed by skull base chordoma, which causes brainstem compression in and around Barrington's nucleus, and its effect on the micturition center. Urodynamic testing of 22 symptomatic patients was performed. All women and men with skull base chordoma treated in two hospitals in Germany between 1986 and 2007 were studied. Lower urinary tract symptoms (LUTS) were documented in patients with acute brainstem compression due to local chordoma growth positive for iNOS expression. Brain magnetic resonance (MRI) images of the lesions of the symptomatic patients were performed. Of 74 treated patients, 22 (7 women, 15 men) with a median age of 37 years were evaluated with voiding diaries and computer urodynamic investigation. Urodynamic testing of 22 symptomatic patients with positive iNOS expression of skull base chordoma revealed detrusor overactivity in 55 %, low-compliance bladder in 14 %, detrusor sphincter dyssynergia in 45 % and uninhibited sphincter relaxation in 27 %. There was a significant correlation between strong iNOS expression (score 3-6) in skull base chordoma and severe urinary symptoms (p = 0.003, Spearman rho = 0.526). The expression of iNOS in skull base chordoma compressing the dorsolateral pons, in and around Barrington's nucleus, may influence the pontine micturition center (PMC) and be responsible for lower urinary tract symptoms. Nitric oxide may possibly act as a neurotransmitter. We assume that the high infiltration of chordoma with monocyte/macrophages enhances the release of nitric oxide, as monocyte/macrophages are the main source of iNOS.

关键词： Lower urinary tract symptoms Skull base chordoma Brainstem INOS

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Uninstrumented Posterior Lumbar Interbody Fusion-Evidence Based or Matter of Habit? Perspective Statement

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WORLD NEUROSURGERY 2018年 115卷 506-508页

作者： akhavan-sigari, reza Rohde, Veit Prasad, Srinivas K. Vahedi, Payman Univ Med Ctr Gottingen Dept Neurosurg Gottingen Germany Thomas Jefferson Univ Div Spine Dept Neurol Surg Philadelphia PA 19107 USA

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A review of the role of ERp57 in cancerous and non-cancerous cell physiology and its potential as a therapeutic target

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MCB Molecular and Cellular Biomechanics 2021年第4期18卷 187-199页

作者： Rahbar, Fatemeh Fagheh, Avid Farhang Khosravi, Ayda Shariatzadeh, Siavash akhavan-sigari, reza Islamic Azad University Tehran Medical Branch Tehran Iran Tehran University of Medical Sciences Tehran Iran Department of Pharmacology School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery University Medical Center Tuebingen Tuebingen Germany

The protein ERp57 is a stress-responsive protein, mainly exists in the endoplasmic reticulum (ER), and a small amount in the cell membrane, cytoplasm, nucleus and mitochondria, which is involved in the signal transduction from the cell surface, the regulation process that occurs in the nucleus, and the formation of polymer protein complexes involved in DNA repair. Various degrees of ERp57 dysregulation has been observed in many types of non-communicable diseases especially in cancers. Previous studies showed that the expression of ERp57 could play a key role in occurrence and development of cancers such as breast cancer, gastric cancer, ovarian cancer, etc.;in addition, it has been suggested to play a pivotal role in disease progression of non-cancerous diseases such as neurodegeneration, liver disease, kidney disease, intestinal irritability syndrome and airway hypersensitivity. Thus, abnormal expression of ERp57 could be used as promising biomarker for cancer diagnosis and prognosis based on the previous studies. In this regard, current study was aimed to review the literature, which have been elucidate the role of ERp57 protein expression in both non-cancer and cancer disease. Overall, most studies have shown that inhibiting/knocking out of ERp57 could inhibit the cell proliferation and also induce apoptosis in both human cancerous and non-cancerous cells. Also, it has been suggested that the overexpression of ERp57 could intensify the cancer development. Therefore, it could be hypothesized that targeting of ERp57 might be a potential treatment in cancerous and non-cancerous diseases. © 2021 Tech Science Press. All rights reserved.

关键词： Proteins

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Enlightening the Cerebellopontine Angle: Intraoperative Indocyanine Green Angiography in Microvascular Decompression for Trigeminal Neuralgia

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JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY 2017年第2期78卷 161-166页

作者： von Eckardstein, Kajetan L. Mielke, Dorothee akhavan-sigari, reza Rohde, Veit Univ Med Gottingen Dept Neurosurg Robert Koch Str 40 D-37075 Gottingen Germany

Background and Study Aims In microvascular decompression of the trigeminal nerve for trigeminal neuralgia (TN), the site of conflict is occasionally difficult to identify. Endoscopy has been described to better evaluate the anatomical conflict in such situations. We hypothesized that indocyanine green (ICG) angiography could allow for better visualization of the compressing artery and its anatomical relation to the nerve. Material and Methods ICG angiography was performed in 17 TN patients undergoing microvascular decompression. We focused on whether ICG angiography is helpful in determining the site of conflict, particularly when not directly visible via the microscope, and whether fluorescence is strong enough to shine through the nerve obliterating the direct view of the compressing vessel. Results In four patients, the site of conflict was immediately apparent after opening the cerebellopontine cistern, and ICG angiography did not provide the neurosurgeon with additional information. In another two patients, imaging quality and fluorescence were too poor. Of the remaining 11 patients with a hidden site of nerve-vessel conflict, ICG angiography was found to be helpful in anticipating the site of compression and the course of the artery in 7 patients, particularly in regard to the so-called shining-through effect through fiber bundles of the thinned nerve. Of all the patients, 88% reported at least improvement or cessation of their symptoms, including all of the patients with a shine-through effect. Conclusion ICG angiography could be a helpful adjunct in decompressing the trigeminal nerve and can guide the surgeon to the nerve-vessel conflict. Intensity of the fluorescence is powerful enough to shine through thinned and splayed trigeminal nerve fiber bundles.

关键词： indocyanine green angiography microvascular decompression trigeminal neuralgia

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