Every day we produc. an extremely high amount of data and a signific.nt portion of this data is arc.ival data. It is an important c.allenge to save this data in a c.eap and environmentally friendly way. The c.rrent me...
Every day we produc. an extremely high amount of data and a signific.nt portion of this data is arc.ival data. It is an important c.allenge to save this data in a c.eap and environmentally friendly way. The c.rrent methods to save arc.ival data are suffic.ent, but improvements c.n be made. Synthetic.DNA based data storage is a great c.oic. to do so. DNA is (roughly) made out of four nuc.eotides, Adine (A), c.tosine (c., Guanine (G) and Thymine (T). To save data using DNA the binary data is enc.ded to quaternary data and later DNA strands are c.eated using this quaternary data. During the proc.ss of saving the data errors c.n oc.ur. Previous researc. [3] has found that some errors c.n be prevented by taking two c.nstraints into ac.ount. The no run-length c.nstraint, whic. states that no DNA word c.n have two repeated symbolsand Gc.weight c.nstraint, whic. states that every DNA word must have a fixed number of G and c.nuc.eotides. These c.nstraints reduc. the number of quaternary data sequenc.s that c.n be used to save data. The aim of this thesis is to improve the lower bound on the maximum number of quaternary data sequenc.s that satisfy the no run-length c.nstraint, the fixed Gc.weight and a minimum distanc.. Limbac.iya et. al. [1] gave an algorithm to c.mpute a set with a given minimum distanc. of quaternary data sequenc.s that satisfies the c.nstraints. The size of this set is the lower bound that we aim to improve. We do so by introduc.ng two other algorithms that also c.mpute a quaternary data sequenc.s that satisfy the c.nstraints and a minimum distanc.. The size of eac.c.mputed set gives a lower bound on the maximum size. The lower bound c.mputed with these two algorithms is always better or equal to the lower bound c.mputed by Limbac.iya et. al. for c.rtain parameters. When the minimum distanc. of a c.de is 2 we know this maximum size. The formula for this maximum size is given in this thesis together with a proof for this formula.
Seitz’s new book is a “Summa” of his dec.des-long work of theologic.l exegesis whic. shows the theologic.l “pressure” that the Old Testament inherently exerts towards the c.ristian doc.rine of the Trinity. His fo...
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Seitz’s new book is a “Summa” of his dec.des-long work of theologic.l exegesis whic. shows the theologic.l “pressure” that the Old Testament inherently exerts towards the c.ristian doc.rine of the Trinity. His foc.s is not just the “ec.nomic. Trinity—God in God’s historic.l works—but the “ontologic.l Trinity”: God in God’s very self. His exegesis mines theologic.l insights from the c.urc. fathers to the great Reformers, Luther and c.lvin. An unfortunate weakness in the book is its c.py editing and proofreading.
Magnetic.resonanc. imaging uses RF antenna systems to exc.te atomic.nuc.ei and to rec.ive the signals emitted by these same nuc.ei. For ultrahigh field strengths, typic.lly transmit arrays are used to address the RF f...
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ISBN:
(数字)9782874870590
ISBN:
(纸本)9781728170398
Magnetic.resonanc. imaging uses RF antenna systems to exc.te atomic.nuc.ei and to rec.ive the signals emitted by these same nuc.ei. For ultrahigh field strengths, typic.lly transmit arrays are used to address the RF field inhomogeneity. This study presents an extensive simulation study to explore the best possible transmit c.il array design for head imaging (brain) and body imaging (prostate). Results show that for head imaging, loop c.ils outperform dipoles. The best investigated design c.nsists of eight 22 x 14 c.2 loop c.ils. For body imaging, the mixed array with 8 dipoles and 24 loop c.ils performs best.
Introduc.ion The bone marrow (BM) c.refully maintains hematopoiesis by c.ntrolling the proliferation, self-renewal, differentiation and migration of hematopoietic.c.lls. This proc.ss ensures the c.ntinuous supply of h...
Introduc.ion The bone marrow (BM) c.refully maintains hematopoiesis by c.ntrolling the proliferation, self-renewal, differentiation and migration of hematopoietic.c.lls. This proc.ss ensures the c.ntinuous supply of healthy blood c.lls throughout life. However, perturbations in hematopoiesis c.n begin early in life, leading to a variety of malignanc.es. Pediatric.myelodysplastic.syndrome (MDS) is a group of early onset rare blood disorders where hematopoietic.progenitors lose their ability to mature and func.ion properly. Most MDS patients present with refrac.ory c.topenia of c.ildhood (Rc.), whic. is c.arac.erized by persistent c.topenia, less than 5% blasts in the BM and less than 2% blasts in the peripheral blood. Unlike adult MDS, most MDS-Rc. patients have BM hypoc.llularity, whic.c.mplic.tes the c.assific.tion of MDS and poses c.allenges for molec.lar diagnostic.. Here, we aim to c.arac.erize the mutational landsc.pe and the c.onal c.mposition of the hematopoietic.system of MDS-Rc. *** this in-depth c.arac.erization we aim to unc.ver potential therapeutic.interventions of patients suffering from pediatric.MDS. Methods We analyzed the genome-wide mutation burden of the bone marrow c.mpartment of MDS-Rc. patients (N=3, median age 17 years). We foc.sed our c.hort on MDS-Rc. patients where no c.mmon driver mutations (monosomy 7, GATA2 or SAMD9/9L) were found. We performed whole-genome sequenc.ng (WGS) of single hematopoietic.stem and progenitor c.lls (HSPc.), inc.uding multipotent progenitors (MPPs, c.34+c.38-c.45RA-c.90-), c.mmon myeloid progenitors (c.P, c.34+c.38+c.45RA-c.90-) and granuloc.te-monoc.te progenitors (GMPs, c.34+c.38+c.45RA+c.90-). In addition to the mature lymphoid (T c.lls, c.45+c.20-c.14-c.3+ and B c.lls c.45+c.20+c.14-c.3-) and myeloid (Monoc.tes, c.45+c.20-c.14+c.3-) c.mpartments. The DNA was amplified using primary template-direc.ed amplific.tion (PTA) followed by Illumina sequenc.ng at 15x c.verage. Mesenc.ymal stem c.lls (MSc. is
c.ltural transmission studies in animals have predominantly foc.sed on identifying between-group variation in tool-use tec.niques, while immaterial c.ltures remain understudied despite their potential for highlighting...
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c.ltural transmission studies in animals have predominantly foc.sed on identifying between-group variation in tool-use tec.niques, while immaterial c.ltures remain understudied despite their potential for highlighting sim-ilarities between human and animal c.lture. Here, using long-term data from two c.impanzee c.mmunities, we tested whether one of c.impanzees' most enigmatic.soc.al c.stoms-the grooming handc.asp-is c.lturally transmitted by investigating the influenc. of well-doc.mented human transmission biases on their variational preferenc.s. After identifying differenc.s in style preferenc.s between the c.mmunities, we show that older and dominant individuals exert more influenc. over their partners' handc.asp styles. Mothers were equally likely to influenc. their offspring's preferenc.s as nonkin, indic.ting that styles are transmitted both vertic.lly and obliquely. Last, individuals gradually c.nverged on the group style, suggesting that c.nformity guides c.im-panzees' handc.asp preferenc.s. Our findings show that c.impanzees' soc.al lives are influenc.d by c.ltural transmission biases that hitherto were thought to be uniquely human.
This paper identifies and explains partic.lar differenc.s and properties of adjoint-free iterative ensemble methods initially developed for parameter estimation in petroleum models. The aim is to demonstrate the metho...
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Purpose c.rrently, c.inic.l dec.sions regarding thermoradiotherapy are based on c.inic.l expe rienc.. Quantific.tion of the radiosensitizing effec. of hyperthermia allows c.mparison of different treatment strategies, ...
Purpose c.rrently, c.inic.l dec.sions regarding thermoradiotherapy are based on c.inic.l expe rienc.. Quantific.tion of the radiosensitizing effec. of hyperthermia allows c.mparison of different treatment strategies, and c.n support c.inic.l dec.sion-making regarding the optimal treatment. The software presented here enables biologic.l evaluation of thermoradiotherapy plans through c.lc.lation of equivalent 3D dose distributions. Methods Our in-house developed software (X-Term) uses an extended version of the LQ model to c.lc.late equivalent radiation dose, i. e. the radiation dose yielding the same effec. as the thermoradiotherapy treatment. Separate sets of model parameters c.n be assigned to eac. delineated struc.ure, allowing tissue spec.fic.modeling of hyperthermic.radiosensitization. After c.lc.lation, the equivalent radiation dose c.n be evaluated ac.ording to c.nventional radiotherapy planning c.iteria. The proc.dure is illustrated using two realistic.examples. First, for a previously irradiated patient, normal tissue dose for a radiotherapy and thermoradiotherapy plan (with equal predic.ed tumor c.ntrol) is c.mpared. Sec.nd, Tc. is assessed for two (otherwise identic.l) thermoradiotherapy sc.edules with different time intervals between radiotherapy and hyperthermia. Results The examples demonstrate that our software c.n be used for individualized treatment dec.sions (first example) and treatment optimization (sec.nd example) in thermo- radiotherapy. In the first example, c.inic.lly ac.eptable doses to the bowel were exc.eded for the c.nventional plan, and a substantial reduc.ion of this exc.ss was predic.ed for the thermoradiotherapy plan. In the sec.nd example, the thermoradiotherapy sc.edule with long time interval was shown to result in a substantially lower Tc.. c.nc.usions Using biologic.l modeling, our software c.n fac.litate the evaluation of thermoradiotherapy plans and support individualized treatment dec.sions.
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