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食品安全导刊 2022年第17期 35-38页

作者：崔绪辉王树文北京爱绿色信息技术有限公司北京100088 古贝春集团有限公司山东德州253300

随着我国人们生活水平的不断提升,食品消费结构也发生了变化,人们对食品安全和食品质量都有很高的要求,使食品安全的可追溯性备受关注。结合多年的工作经验,在参考文献的基础上,从多个角度对目前我国食品安全信息追溯情况进行了分析,总... 详细信息

随着我国人们生活水平的不断提升,食品消费结构也发生了变化,人们对食品安全和食品质量都有很高的要求,使食品安全的可追溯性备受关注。结合多年的工作经验,在参考文献的基础上,从多个角度对目前我国食品安全信息追溯情况进行了分析,总结了我国食品安全信息追溯的现状和存在的问题。为解决目前我国食品安全信息追溯工作存在的问题,本文从政府层面、企业层面、行业引领等方面提出了相关建议。

关键词：食品安全信息追溯问题解决方法

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Isotopic Records of Ancient Wildfires in C4 Grasses Preserved in the Sediment of the Ross Sea, Antarctica

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GEOPHYSICAL RESEARCH LETTERS 2022年第13期49卷

作者： Ren, Peng Luo, Chunle Zhang, Hongmei cui, Chao Sun, shuwen Song, Hongying Xu, Liping Rebesco, Michele De Santis, Laura Liu, Yanguang Wang, Xuchen Ocean Univ China Frontiers Sci Ctr Deep Ocean Multispheres & Eart Qingdao Peoples R China Ocean Univ China Key Lab Marine Chem Theory & Technol Qingdao Peoples R China Natl Lab Marine Sci & Technol Ctr Isotope Geochem & Geochronol Qingdao Peoples R China Ist Nazl Oceanog & Geofis Sperimentale Sgonico Italy First Inst Oceanog Key Lab Marine Geol & Metallogeny Minist Nat Resources Qingdao Peoples R China

We report carbon isotopic values in total organic carbon (TOC) and pyrogenic carbon (PyC) preserved in two sediment cores from the Ross Sea, Antarctica. The delta C-13 values of PyC ranged from -10.9 parts per thousand to -17.2 parts per thousand, with distinct differences from the delta C-13 values of TOC (-24.1 parts per thousand to -26.1 parts per thousand) in the sediments. The radiocarbon ages of PyC were 9,128 and 8,410 years old on average in the two cores but were thousands of years younger than the ages of TOC at the same core depth. These isotopic records provide strong evidence indicating that the PyC was produced from ancient wildfires predominantly in C-4 vegetation and transported to Antarctica in the atmosphere. We suggest that ancient wildfires in predominantly C-4 grasslands likely frequently occurred on a large scale and at a high intensity in the Southern Hemisphere during the last deglaciation to mid-Holocene period of 14,800-4,200 years ago.

关键词： Ross Sea sediment Antarctica Pyrogenic carbon wildfires carbon isotope

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RETRACTION: A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells (Retraction of Vol 16, 10.1186/S12906-016-1341-4, 2016)

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BMC COMPLEMENTARY MEDICINE AND THERAPIES 2022年第1期22卷 1-1页

作者： Cao, Xiaocheng Zou, Hui Cao, Jianguo cui, Yinghong Sun, shuwen Ren, Kaiqun Song, Zhenwei Li, Duo Quan, Meifang Hunan Normal Univ Coll Life Sci Changsha Peoples R China Hunan Normal Univ Coll Med Lab Med Engn Changsha Peoples R China

This article has been retracted. Please see the Retraction Notice for more detail: https://***/10.1186/s12906-022-03569-2.

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Investigation of high temperature electrical insulation property of MgO ceramic films and the influence of annealing process

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CERAMICS INTERNATIONAL 2019年第18期45卷 24343-24347页

作者： Liu, Hao Mao, Xiling cui, Jinting Jiang, shuwen Zhang, Wanli Univ Elect Sci & Technol China State Key Lab Elect Thin Films & Integrated Devic Sch Elect Sci & Engn Chengdu 611731 Sichuan Peoples R China

MgO ceramic films were deposited as insulating films for thin film sensors by electron beam evaporation on Ni-based substrate at 25 degrees C, 200 degrees C and 300 degrees C (denoted as MgO-25, MgO-200, and MgO-300). The structures and morphologies of the MgO ceramic films were investigated by X-ray diffraction and scanning electron microscopy, which indicated that MgO films exhibited (111) and (222) preferential orientation growth and a more compact microstructure with increasing substrate temperature. Furthermore, the insulation resistance of MgO films was enhanced at higher substrate temperature, the MgO-300 ceramic film increased by approximately one order of magnitude compared to MgO-25 ceramic film. Notably, the insulation resistance of the MgO-300 ceramic film was 1.5 M Omega when the test temperature reached 1000 degrees C. Additionally, the influence of annealing on the electrical insulation properties of MgO-300 was evaluated via a leakage current test at 25-1000 degrees C. The results showed that the stability of the electrical insulation performance was improved mainly due to the growth of grains and repair of defects. Moreover, the conductivity was below 1.2 x 10(-6) S/m and the calculated insulation resistance was greater than 0.55 M Omega at 1000 degrees C after the fourth annealing, which displays that the relative error of the apparent resistance is less than 0.03% by the shunt circuit law. Therefore, their excellent electrical insulation performance demonstrated that MgO films have the potential to be employed as an insulating layer for thin film sensors at high temperature.

关键词： Insulation property MgO ceramic film High temperature Leakage current Annealing

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脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进展

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吉林大学学报（医学版） 2024年第6期50卷 1751-1756页

作者：陈海霞李泓儒刘婧怡徐枝芳刘淑文杨媛陈阳骆雨崔银洁天津中医药大学针灸推拿学院实验针灸学研究中心天津301617 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300193 天津中医药大学中医学院天津301617 天津中医药大学医学技术学院天津301617

肠道菌群是一个巨大的微生物生态系统,特异性地存在于机体,并与其代谢产物共同对机体的健康或疾病状态起重要调节作用。脊髓损伤后,创伤局部复杂的病理生理导致轴突再生困难,脊髓损伤诱导的自主神经运动功能障碍破坏胃肠道功能并引起肠... 详细信息

肠道菌群是一个巨大的微生物生态系统,特异性地存在于机体,并与其代谢产物共同对机体的健康或疾病状态起重要调节作用。脊髓损伤后,创伤局部复杂的病理生理导致轴突再生困难,脊髓损伤诱导的自主神经运动功能障碍破坏胃肠道功能并引起肠道菌群紊乱。既往脊髓损伤后神经修复策略的临床疗效并不理想。紊乱的肠道菌群和脊髓损伤后神经炎症与患者预后有密切关联。肠道菌群对脊髓损伤后神经炎症的潜在作用机制可能包括失衡菌群激活肠道相关淋巴组织并破坏肠道屏障,肠道菌群及其代谢产物脂多糖(LPS)、短链脂肪酸(SCFAs)、5-羟色胺(5-HT)和色氨酸等及免疫细胞、炎症因子和神经递质通过循环系统影响脊髓局部炎症反应。现对脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进行综述,为探索脊髓损伤后神经炎症改善提供新靶点和新思路。

关键词：脊髓损伤神经炎症肠道菌群代谢

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流动注射在线分析法测定水源水中的总氮

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化学分析计量 2023年第9期32卷 78-83页

作者：贺舒文褚莹倩崔晗曹文军大连海关技术中心辽宁大连116400

采用流动注射在线分析法测定水源水中总氮的含量。研究了样品预处理过程中水样浊度干扰、实验用水、试剂纯度选择、试剂配制及存放、气泡的干扰、干扰物的消除、显色剂浓度优化等对实验结果的影响。在磺胺和盐酸萘乙二胺溶液的质量浓度... 详细信息

采用流动注射在线分析法测定水源水中总氮的含量。研究了样品预处理过程中水样浊度干扰、实验用水、试剂纯度选择、试剂配制及存放、气泡的干扰、干扰物的消除、显色剂浓度优化等对实验结果的影响。在磺胺和盐酸萘乙二胺溶液的质量浓度分别为35、1 g/L的最优条件下,水源水中的总氮质量浓度在0.040~10.0 mg/L范围内与吸收峰面积具有良好的线性关系,相关系数为0.9999。水源水中总氮的检出限为0.010 mg/L,加标回收率为92.5%~105%,测定结果的相对标准偏差为0.22%~1.10%(n=6)。该方法运行成本低,操作方便,分析速度快,稳定性和安全性好,适用于大批量水源水中总氮的测定,能够满足水源水监测的技术要求。

关键词：流动注射法水源水总氮

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Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020年 189卷 112048页

作者： Liao, Yixian Ye, Yilu Li, Sumei Zhuang, Yilian Chen, Liye Chen, Jianxin cui, Zining Huo, Lijian Liu, shuwen Song, Gaopeng South China Agr Univ Coll Mat & Energy Guangzhou 510642 Peoples R China South China Agr Univ Integrat Microbiol Res Ctr State Key Lab Conservat & Utilizat Subtrop Agrobi Guangdong Prov Key Lab Microbial Signals & Dis Co Guangzhou 510642 Peoples R China Southern Med Univ Sch Pharmaceut Sci Guangzhou 510515 Peoples R China Jinan Univ Sch Med Dept Human Anat Guangzhou 510632 Peoples R China South China Agr Univ Coll Vet Med Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet Guangzhou 510642 Peoples R China

Currently, influenza PA(N) endonuclease has become an attractive target for development of new drugs to treat influenza infections. Herein we report the discovery of new PA(N) endonuclease inhibitors derived from a chelating agent dopamine moiety. A series of dopamine amide derivatives and their conformationally constrained 1,2,3,4-tetrahydroisoquinoline-6,7-diol-based analogs were elaborated and assayed against influenza virus A/WSN/33 (H1N1). Most compounds exhibited moderate to excellent antiviral activities, generating a preliminary SARs. Among them, compounds 14 and 19 showed stronger anti-IAV activity compared with the reference Peramivir. Moreover, 14 and 19 demonstrated a concentration-dependent inhibition of PA(N) endonuclease based on both FRET assay and SPR assay. Docking studies were also performed to elucidate the binding mode of 14 and 19 with the PA(N) protein and to identify amino acids involved in their mechanism of action, which were well consistent with the biological data. This finding was beneficial to laying the foundation for the rational development of more effective PA(N) endonuclease inhibitors. (C) 2020 Elsevier Masson SAS. All rights reserved.

关键词： Influenza a virus PA(N) endonuclease inhibitors Polyphenols SARs

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小规模限制性在线课程在放射科住培生临床教学中的研究进展

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影像研究与医学应用 2025年第7期9卷 8-10页

作者：董淑雯崔园园樊荣荣王祥徐少春萧毅海军军医大学第二附属医院放射诊断科上海200003

随着医学教育的变革,小规模限制性在线课程(SPOC)这种新兴教学模式在医学领域逐渐兴起。放射科因其学科特性,需充分掌握专业技能,方可获得更为精准的检查结果,以辅助临床各类疾病的诊疗,故对住院医师规范化培训的教学质量要求颇高。SPO... 详细信息

随着医学教育的变革,小规模限制性在线课程(SPOC)这种新兴教学模式在医学领域逐渐兴起。放射科因其学科特性,需充分掌握专业技能,方可获得更为精准的检查结果,以辅助临床各类疾病的诊疗,故对住院医师规范化培训的教学质量要求颇高。SPOC教学具有小规模、限制性及在线教学等特点,带教老师能精准关注学生个体,限制性保证学生基础和能力相近,在线教学则提供丰富且灵活的学习资源。近年来,SPOC在医学领域的多学科教学中广泛应用,并取得一定的成效,本文综述了其在放射科住培生临床教学中的应用进展。

关键词：小规模限制性在线课程放射科住培生临床教学临床技能虚拟影像系统

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Particulate matter of air pollution may increase risk of kidney failure in IgA nephropathy

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KIDNEY INTERNATIONAL 2022年第6期102卷 1382-1391页

作者： Luo, Chengwen Ouyang, Yan Shi, Sufang Li, Guisen Zhao, Zhanzheng Luo, Huimin Xu, Feifei Shao, Leping Chen, Zijin Yu, shuwen Jin, Yuanmeng Xu, Jing Du, Wen Fang, Zhengying Hussain, Hafiz Muhammad Jafar Zhang, Wen Wang, Weiming cui, Yidan Zhang, Hong Chen, Nan Yu, Zhangsheng Xie, Jingyuan Shanghai Jiao Tong Univ Ruijin Hosp Inst Nephrol Sch Med Shanghai Peoples R China Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Dept Bioinformat & Biostat Shanghai Peoples R China Wenzhou Med Univ Taizhou Hosp Zhejiang Prov Evidence Based Med Ctr Zhejiang Peoples R China Peking Univ First Hosp Dept Med Renal Div Beijing Peoples R China Sichuan Prov Peoples Hosp Dept Nephrol Chengdu Peoples R China Zhengzhou Univ Affiliated Hosp 1 Dept Nephrol Zhengzhou Peoples R China First Peoples Hosp Yunnan Prov Dept Nephrol Kunming Peoples R China Wenzhou Med Univ Affiliated Hosp 1 Dept Nephrol Wenzhou Peoples R China Qingdao Municipal Hosp Dept Nephrol Qingdao Peoples R China Shanghai Jiao Tong Univ Clin Res Ctr Sch Med Shanghai Peoples R China Shanghai Jiao Tong Univ Ruijin Hosp Inst Nephrol Sch MedDept Nephrol 197 Ruijin Er Rd Shanghai 200025 Peoples R China Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Dept Bioinformat & Biostat 800 Dong Chuang Rd Shanghai 200240 Peoples R China

IgA nephropathy (IgAN) is characterized by deposition of galactose-deficient IgA1 (Gd-IgA1) in glomerular mesangium associated with mucosal immune disorders. Since environmental pollution has been associated with the progression of chronic kidney disease in the general population, we specifically investigated the influence of exposure to fine particulate matter less than 2.5 mm in diameter (PM2.5) on IgAN progression. Patients with biopsy-proven primary IgAN were recruited from seven Chinese kidney centers. PM2.5 exposure from 1998 to 2016 was derived from satellite aerosol optical depth data and a total of 1,979 patients with IgAN, including 994 males were enrolled. The PM2.5 exposure levels for patients from different provinces varied but, in general, the PM2.5 exposure levels among patients from the north were higher than those among patients from the south. The severity of PM2.5 exposure in different regions was correlated with regional kidney failure burden. In addition, each 10 mg/m3 increase in annual average concentration of PM2.5 exposure before study entry (Hazard Ratio, 1.14;95% confidence interval, 1.06-1.22) or time-varying PM2.5 exposure after study entry (1.10;1.01-1.18) were associated with increased kidney failure risk after adjustment for age, gender, estimated glomerular filtration rate, urine protein, uric acid, hemoglobin, mean arterial pressure, Oxford classification, glucocorticoid and renin-angiotensin system blocker therapy. The associations were robust when the time period, risk factors of cardiovascular diseases or city size were further adjusted on the basis of the above model. Thus, our results suggest that PM2.5 is an independent risk factor for kidney failure in patients with IgAN, but these findings will require validation in more diverse populations and other geographic regions.

关键词： end-stage renal disease fine particulate matter 2 5 mm in aerodynamic diameter galactose-deficient IgA1 IgA nephropathy

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Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

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MACROMOLECULAR RAPID COMMUNICATIONS 2021年第19期42卷 e2100264页

作者： Wang, Cheng Wang, Ziyu Chen, Shaoqing cui, Pengfei Qiu, Lin Zhou, shuwen Jiang, Hua Jiang, Pengju Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Soochow Univ State Key Lab Radiat Med & Protect Sch Radiol & Interdisciplinary Sci RAD X 199 Renai Rd Suzhou 215123 Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Dept Oncol Changzhou 213003 Jiangsu Peoples R China Zhejiang Univ Coll Pharmaceut Sci 866 Yuhangtang Rd Hangzhou 310058 Peoples R China

Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.

关键词： aggregation-caused quenching aggregation-induced emission cancer therapy fluorescence resonance energy transfer theranostics

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