检索结果-内蒙古大学图书馆

Facile preparation of TiO2/ZnO composite aerogel with excellent antibacterial activities

MATERIALS LETTERS 2019年 234卷 253-256页

作者： Suo, Hao Peng, Changxin Jing, Feng Yu, shuwen cui, Sheng Shen, Xiaodong Nanjing Tech Univ Dept Mat Sci & Engn Nanjing 210009 Jiangsu Peoples R China Nanjing Tech Univ Jiangsu Collaborat Innovat Ctr Adv Inorgan Funct Nanjing 210009 Jiangsu Peoples R China

TiO2/ZnO composite aerogel is synthesized using Zn(NO3)(2)center dot H2O and titanium butoxide as precursors through sol-gel route combined with C2H5OH superfluid drying technique. The effects of the Zn2+/Ti4+ molar ratios and concentration on the antibacterial properties of TiO2/ZnO composite aerogels are investigated. The results show that the specific surface area is as high as 180 m(2)/g for the samples with the Zn2+/Ti4+ molar ratios of 1.5. The composite aerogels have the maximum inhibition zone of 23 nm and 19.5 nm for E. coll. and S. aureus, and the minimum inhibitory concentration for E. coll. and S. aureus of 100 ppm. (C) 2018 Elsevier B.V. All rights reserved.

关键词： TiO2 Nanocomposites Composite materials Sol-gel preparation Antibacteria

来源：评论

学校读者我要写书评

暂无评论

Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

引用

MACROMOLECULAR RAPID COMMUNICATIONS 2021年第19期42卷 e2100264页

作者： Wang, Cheng Wang, Ziyu Chen, Shaoqing cui, Pengfei Qiu, Lin Zhou, shuwen Jiang, Hua Jiang, Pengju Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Soochow Univ State Key Lab Radiat Med & Protect Sch Radiol & Interdisciplinary Sci RAD X 199 Renai Rd Suzhou 215123 Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Dept Oncol Changzhou 213003 Jiangsu Peoples R China Zhejiang Univ Coll Pharmaceut Sci 866 Yuhangtang Rd Hangzhou 310058 Peoples R China

Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.

关键词： aggregation-caused quenching aggregation-induced emission cancer therapy fluorescence resonance energy transfer theranostics

来源：评论

学校读者我要写书评

暂无评论

On the applicability of Young-Laplace equation for nanoscale liquid drops

引用

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A 2016年第3期90卷 635-640页

作者： Yan, Hong Wei, Jiuan cui, shuwen Xu, Shenghua Sun, Zhiwei Zhu, Ruzeng Changzhi Univ Dept Elect Informat & Phys Changzhi 046011 Peoples R China Chinese Acad Sci Inst Mech State Key Lab Nonlinear Mech LNM Beijing 100190 Peoples R China Adv Semicond Mat ASM Technol Singapore 2 Yishun Ave 7 Singapore 768924 Singapore Cangzhou Normal Univ Dept Phys & Elect Informat Cangzhou 061000 Peoples R China Chinese Acad Sci Inst Mech Key Lab Micrograv Beijing 100190 Peoples R China

Debates continue on the applicability of the Young-Laplace equation for droplets, vapor bubbles and gas bubbles in nanoscale. It is more meaningful to find the error range of the Young-Laplace equation in nanoscale instead of making the judgement of its applicability. To do this, for seven liquid argon drops (containing 800, 1000, 1200, 1400, 1600, 1800, or 2000 particles, respectively) at T = 78 K we determined the radius of surface of tension R (s) and the corresponding surface tension gamma (s) by molecular dynamics simulation based on the expressions of R (s) and gamma (s) in terms of the pressure distribution for droplets. Compared with the two-phase pressure difference directly obtained by MD simulation, the results show that the absolute values of relative error of two-phase pressure difference given by the Young-Laplace equation are between 0.0008 and 0.027, and the surface tension of the argon droplet increases with increasing radius of surface of tension, which supports that the Tolman length of Lennard-Jones droplets is positive and that Lennard-Jones vapor bubbles is negative. Besides, the logic error in the deduction of the expressions of the radius and the surface tension of surface of tension, and in terms of the pressure distribution for liquid drops in a certain literature is corrected.

关键词： liquid drop surface tension surface of tension Young-Laplace equation molecular dynamics simulation

来源：评论

学校读者我要写书评

暂无评论

虾壳活性肽对斑马鱼氧化应激损伤的保护作用

引用

食品与机械 2023年第9期39卷 140-147页

作者：贺舒雯朱豪杰韩鹏薇杨赛杰崔波程云辉李虹辉文李长沙理工大学食品与生物工程学院湖南长沙410114 齐鲁工业大学食品科学与工程学院山东济南250353

目的:探究虾壳活性肽(PCSBP)对机体氧化应激损伤的保护作用。方法:采用碱性蛋白酶水解制备虾壳活性肽,测定其体外抗氧化活性,并分析PCSBP对禁食胁迫下斑马鱼氧化应激损伤的保护作用。结果:PCSBP在体外表现出潜在的抗氧化能力,其对DPPH... 详细信息

目的:探究虾壳活性肽(PCSBP)对机体氧化应激损伤的保护作用。方法:采用碱性蛋白酶水解制备虾壳活性肽,测定其体外抗氧化活性,并分析PCSBP对禁食胁迫下斑马鱼氧化应激损伤的保护作用。结果:PCSBP在体外表现出潜在的抗氧化能力,其对DPPH自由基和羟自由基的清除率分别为(46.35±1.32)%和(75.22±2.18)%。禁食胁迫下斑马鱼的终末体重、体长和肌肉氨基酸含量均有所降低,而摄入PCSBP后能有效提高其生长性能和肌肉氨基酸含量;肌肉组织结构显示,禁食后斑马鱼肌纤维间隙增宽,出现断裂现象,摄入PCSBP后肌纤维排列整齐,形态结构完整,未见明显断裂;在抗氧化应激方面,PCSBP显著增强了斑马鱼肌肉超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)活性和谷胱甘肽(GSH)含量,同时还减少了氧化损伤指标丙二醛(MDA)和蛋白质羰基(PC)的生成量;进一步分析发现,PCSBP显著上调抗氧化信号分子nrf2基因表达,下调keap1表达,并增加其下游抗氧化酶基因转录表达,有效改善了斑马鱼肌肉氧化应激损伤。结论:虾壳活性肽对斑马鱼的氧化应激损伤有一定保护作用,可作为潜在的抗氧化剂。

关键词：克氏原螯虾壳生物活性肽斑马鱼氧化应激保护作用

来源：评论

学校读者我要写书评

暂无评论

Antimicrobial nanozyme-enzyme complex catalyzing cascade reaction of glucose to hydroxyl radical to combat bacterial infection

引用

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2022年 75卷

作者： Wang, Cheng Li, Yuting Liu, Li Liu, Min Chen, Xi Zhou, shuwen cui, Pengfei Du, Xuancheng Qiu, Lin Wang, Jianhao Jiang, Pengju Xia, Jiang Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Chinese Univ Hong Kong Dept Chem Hong Kong Peoples R China Jiangsu Traumark Med Instrument Co Ltd Changzhou 213149 Jiangsu Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Changzhou 213003 Peoples R China Shandong Univ Inst Adv Interdisciplinary Sci Sch Phys Jinan 250100 Peoples R China

Bacterial infection is a serious threat to patients and cytotoxic agents that can kill bacterial cells in the high -glucose environment will be a potential therapy. In this work, we load hollow mesoporous Prussian blue nanoparticle (HMPBNP) with glucose oxidase (GOx) to devise a nanozyme-enzyme complex HMPBNP@GOx to achieve the generation of the cytotoxic hydroxyl radical (& BULL;OH) in situ at the infected wounds. The HMPBNP with peroxidase-like activity can catalyze the conversion of the non-natural, toxic substrate, hydrogen peroxide (H2O2) to & BULL;OH. Here, encapsulation of GOx in HMPBNP couples GOx-catalyzed conversion of glucose to H2O2 with HMPBNP-catalyzed reaction of H2O2 to & BULL;OH, which exerts a short-range bacterial killing effect. One of the challenges of the nanozyme-enzyme cascade systems is the incompatibility of the reaction conditions of the two catalysts. In our design, GOx catalyzed oxidation also produces glucuronic acid, which increases the acidity of the microenvironment to increase the activity of HMPBNP. This synergy drives efficient cascade flow towards the production of & BULL;OH. The HMPBNP@GOx complex effectively inhibits the growth of Staphylococcus aureus and Escherichia coli and their infectivity to mammalian cells, reduces bacterial infection in vivo, and promotes wound healing in the animal model of Staphylococcus infected wounds.

关键词： Hollow mesoporous Prussian blue nanoparticle Nanozyme Hydroxyl radical Glucose Bacterial infection

来源：评论

学校读者我要写书评

暂无评论

分光光度法测定改性麦饭石对回收Cr^(3+)废液吸附性能研究实验设计

引用

实验技术与管理 2023年第8期40卷 197-202页

作者：王静宋福想张秉乾崔文薇唐林王书文高洪涛青岛科技大学化学与分子工程学院山东青岛266042 青岛科技大学材料科学与工程学院山东青岛266042

该文从绿色环保角度出发,引导学生思考处理实验教学中回收Cr^(3+)废液的方法。实验制备了MnO_(2)改性麦饭石,并用XRD和SEM表征其结构;设计了分光光度法测定改性后麦饭石对回收Cr^(3+)废液的吸附作用;考查了吸附剂用量、吸附时间和温度... 详细信息

该文从绿色环保角度出发,引导学生思考处理实验教学中回收Cr^(3+)废液的方法。实验制备了MnO_(2)改性麦饭石,并用XRD和SEM表征其结构;设计了分光光度法测定改性后麦饭石对回收Cr^(3+)废液的吸附作用;考查了吸附剂用量、吸附时间和温度对吸附性能的影响;得出在最佳吸附条件下的吸附率达到96.2%的结论。该创新设计实验综合了多个实验的相关知识和操作技能,有助于低年级本科生分析问题、解决问题能力的培养,拓展专业思维视野、培养创新意识、提升研究能力和科学素养。

关键词：创新设计改性麦饭石吸附性能基础化学实验

来源：评论

学校读者我要写书评

暂无评论

锥形端面对铝/钢连续驱动摩擦焊接头界面温度及摩擦扭矩影响的研究

引用

机械工程学报 2022年第10期58卷 95-102页

作者：张昌青师文辰罗德春王树文刘晓崔国胜陈波阳辛舟芮执元兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 兰州理工大学材料科学与工程学院兰州730050 兰州理工大学机电工程学院兰州730050

铝/钢复合结构在汽车制造、能源、航空航天领域广泛应用,在连续驱动摩擦焊接(Continuousdrivefriction welding,CDFW)过程中,由于母材流动特性与径向摩擦扭矩分布不同,界面上的氧化物和杂质难以排出、界面产热功率与界面金属间化合物(In... 详细信息

铝/钢复合结构在汽车制造、能源、航空航天领域广泛应用,在连续驱动摩擦焊接(Continuousdrivefriction welding,CDFW)过程中,由于母材流动特性与径向摩擦扭矩分布不同,界面上的氧化物和杂质难以排出、界面产热功率与界面金属间化合物(Internetallic compounds,IMCs)不均匀分布等问题,将对接头性能产生不利影响。以1060纯铝和Q235低碳钢棒为研究对象,在钢棒待焊端面设计5°、10°、15°、20°、25°的锥度角θ开展焊接试验研究,分析不同锥度下界面温度、摩擦扭矩、能量输入及接头强度的变化规律。结果表明,随着锥度角的增大,初始峰值扭矩减小,稳态扭矩、后峰值扭矩、焊接全过程能量输入先增大后减小,初始摩擦阶段能量输入增大;10°~15°的接头径向方向的温度与强度变化趋于平缓。锥形结构使界面处热流的高温区域发生移动,20°之后峰值温度出现在1/3R附近区域,最高强度出现在1/2R附近区域。在CDFW过程,合适的锥度角可在焊接产热足够的情况下改善界面温度与力学性能的不均匀性,从而得到性能良好的接头,为异种金属的端面结构设计提供一定的理论指导。

关键词：锥度角不均匀性界面温度摩擦扭矩抗拉强度

来源：评论

学校读者我要写书评

暂无评论

热电耦合对铝/钢连续驱动摩擦焊接头组织的影响机理

引用

材料工程 2022年第5期50卷 35-42页

作者：张昌青王树文罗德春师文辰刘晓崔国胜陈波阳辛舟芮执元兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 兰州理工大学材料科学与工程学院兰州730050 兰州理工大学机电工程学院兰州730050

采用连续驱动摩擦焊技术焊接纯铝1060/Q235低碳钢异质接头,开展两个周期(30天/60天)热电耦合实验(静载392 N+高温300℃+直流60 A),研究热电耦合对铝/钢异质接头焊缝微观组织、力学性能及界面生长的影响。结果表明:原始态接头界面径向金... 详细信息

采用连续驱动摩擦焊技术焊接纯铝1060/Q235低碳钢异质接头,开展两个周期(30天/60天)热电耦合实验(静载392 N+高温300℃+直流60 A),研究热电耦合对铝/钢异质接头焊缝微观组织、力学性能及界面生长的影响。结果表明:原始态接头界面径向金属间化合物(IMCs)层厚度不均匀,中心区域无明显IMCs生成。热电耦合30天后界面中心生成宽度为0.3~0.5μm且以颗粒状由钢侧向铝侧弥散分布的IMCs层,整体拉伸断裂在铝母材的热力影响区。热电耦合60天后IMCs层与钢侧之间出现腐蚀沟槽,IMCs破碎,钢侧无裂纹产生,铝侧形成大量由IMCs层向铝母材内部扩展的裂纹和孔洞,焊缝及裂纹尖端处成分偏析,整体拉伸断裂在焊缝处。界面腐蚀和失效速率与界面IMCs层的厚度成正比,即v_(center)

关键词：铝/钢异质接头连续驱动摩擦焊热电耦合微观组织

来源：评论

学校读者我要写书评

暂无评论

基于NLRP3/Caspase-1/GSDMD通路探讨阿霉素纳米凝胶载药对H22肝癌荷瘤小鼠的作用机制

引用

中国实验诊断学 2025年第1期29卷 74-78页

作者：张书文崔佳乐邱春辉刘腾予黄可欣吉林大学基础医学院吉林长春130021

目的通过检测NOD样受体蛋白3(NLRP3)/半胱氨酸天冬氨酸蛋白水解酶-1(Caspase-1)/消皮素D(GSDMD)通路,探讨阿霉素纳米凝胶载药(Nanogel drug loading,NG)对H22肝癌荷瘤小鼠的作用机制。方法将H22肝癌细胞珠每只1.25×10^(6)个/100μ... 详细信息

目的通过检测NOD样受体蛋白3(NLRP3)/半胱氨酸天冬氨酸蛋白水解酶-1(Caspase-1)/消皮素D(GSDMD)通路,探讨阿霉素纳米凝胶载药(Nanogel drug loading,NG)对H22肝癌荷瘤小鼠的作用机制。方法将H22肝癌细胞珠每只1.25×10^(6)个/100μl接种于Balb/c小鼠右前肢腋窝皮下,待肿瘤体积至50~60mm^(3)时,将40只Balb/c小鼠随机分为5组(n=8),分别为肿瘤对照组、阿霉素3mg组(DOX-3.0)、阿霉素6mg组(DOX-6.0)、阿霉素纳米凝胶载药3mg组(NG/DOX-3.0)和阿霉素纳米凝胶载药6mg组(NG/DOX-6.0)。各组均采用尾静脉注射给药治疗,分别给予生理盐水(5ml/kg)、DOX(3mg/kg)、DOX(6mg/kg)、NG/DOX(3mg/kg)和NG/DOX(6mg/kg),1次/3d,给药4次,于给药结束第3d处死动物取材。通过苏木精-伊红(hematoxylin-eosin,HE)染色,观察肿瘤生长情况和坏死面积;采用免疫组织化学染色检测NLRP3/Caspase-1/GSDMD凋亡基因的表达情况。结果HE染色与肿瘤对照组比较,各治疗组肿瘤生长状态较差,且DOX-3.0、NG/DOX-3.0、DOX-6.0、NG/DOX-6.0肿瘤坏死面积百分率依次增大,组间差异均有统计学意义(P<0.05);与肿瘤对照组比较,DOX-3.0、NG/DOX-3.0、DOX-6.0、NG/DOX-6.0组肿瘤组织中NLRP3、Caspase-1、GSDMD的蛋白阳性表达水平依次减弱,组间差异均有统计学意义(P<0.05),纳米凝胶载药组作用优于单纯阿霉素给药组。结论纳米凝胶载药组治疗H22肝癌的作用优于阿霉素单独用药,它能通过下调NLRP3/Caspase-1/GSDMD通路,有效抑制肿瘤生长、降低药物使用剂量及提高抗癌效果,具有良好发展前景,其作用机制有待于进一步探讨。

关键词：阿霉素纳米凝胶免疫组织化学 NLRP3/Caspase-1/GSDMD通路 H22荷瘤

来源：评论

学校读者我要写书评

暂无评论

EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization

引用

CARDIOVASCULAR RESEARCH 2022年第9期118卷 2179-2195页

作者： Wei, Xiaoqiong Zou, Song Xie, Zhonghui Wang, Zhen Huang, Nongyu Cen, Zhifu Hao, Yan Zhang, Chengxin Chen, Zhenyu Zhao, Fulei Hu, Zhonglan Teng, Xiu Gui, Yiyue Liu, Xiao Zheng, Huaping Zhou, Hong Chen, shuwen Cheng, Juan Zeng, Fanlian Zhou, Yifan Wu, Wenling Hu, Jing Wei, Yuquan cui, Kaijun Li, Jiong Sichuan Univ West China Hosp State Key Lab Biotherapy 1 Keyuan 4th Rd Chengdu 610041 Sichuan Peoples R China Sichuan Univ West China Hosp Canc Ctr 1 Keyuan 4th Rd Chengdu 610041 Sichuan Peoples R China Collaborat Innovat Ctr Biotherapy 1 Keyuan 4th Rd Chengdu 610041 Sichuan Peoples R China Sichuan Univ West China Hosp Dept Cardiol 37 Guoxue Rd Chengdu 610041 Sichuan Peoples R China Sichuan Univ West China Hosp Dept Liver Surg & Liver Transplantat 37 Guo Xue Rd Chengdu 610041 Sichuan Peoples R China Collaborat Innovat Ctr Biotherapy 37 Guo Xue Rd Chengdu 610041 Sichuan Peoples R China Univ Michigan Dept Computat Med & Bioinformat 100 Washtenaw Ave Ann Arbor MI 48109 USA

Aims After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and monocytes/macrophages to myocardium, which in turn initiates inflammatory and reparative cascades, respectively. Either insufficient or excessive inflammation impairs cardiac healing. As an endogenous inhibitor of neutrophil adhesion, EDIL3 plays a crucial role in inflammatory regulation. However, the role of EDIL3 in MI remains obscure. We aimed to define the role of EDIL3 in cardiac remodelling after MI. Methods and results Serum EDIL3 levels in MI patients were negatively associated with MI biomarkers. Consistently, WT mice after MI showed low levels of cardiac EDIL3. Compared with WT mice, Edil3(-/-) mice showed improvement of post-MI adverse remodelling, as they exhibited lower mortality, better cardiac function, shorter scar length, and smaller LV cavity. Accordingly, infarcted hearts of Edil3(-)(/)(-) mice contained fewer cellular debris and lower amounts of fibrosis content, with decreased collagen I/III expression and the percentage of alpha-smooth muscle actin myofibroblasts. Mechanistically, EDIL3 deficiency did not affect the recruitment of monocytes or T cells, but enhanced neutrophil recruitment and following expansion of pro-inflammatory Mertk(-)MHC-IIlo-int (myeloid-epithelial-reproductive tyrosine kinase/major histocompatibility complex II) macrophages. The injection of neutrophil-specific C-X-C motif chemokine receptor 2 antagonist eliminated the differences in macrophage polarization and cardiac function between WT and Edil3(-)(/)(-) mice after MI. Neutrophil extracellular traps (NETs), which were more abundant in the hearts of Edil3(-)(/)(-) mice, contributed to Mertk(-)MHC-IIlo-int polarization via Toll-like receptor 9 pathway. The inhibition of NET formation by treatment of neutrophil elastase inhibitor or DNase I impaired macrophage polarization, increased cellular debris and aggravated cardiac adverse remodelling, thus removed the differences of cardiac func

关键词： NETs Myocardial infarction Macrophages EDIL3 Fibrosis

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：