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Effect of thickness on the electrical properties of PdCr strain sensitive thin film

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS 2019年第11期30卷 10475-10482页

作者： Liu, Hao Mao, Xiling cui, Jinting Jiang, shuwen Zhao, Xiaohui Jiang, Hongchuan Zhang, Wanli Univ Elect Sci & Technol China Sch Elect Sci & Engn State Key Lab Elect Thin Films & Integrated Devic Chengdu 610054 Sichuan Peoples R China

The electrical properties of palladium chromium strain sensitive films with various thicknesses were fabricated onto sapphire substrates by direct current magnetron sputtering are investigated. The results show that the electrical properties of PdCr strain films are strongly dependent on their thickness. The square resistance and the temperature coefficient of resistance of PdCr strain sensitive films are dramatically decreased when the thickness of PdCr films that thinner than 232nm, then the downward trend of electrical properties tends to be stabilized until 933nm. The PdCr films with 933nm thickness show a relative minimum temperature coefficient of resistance and excellent repeatability from room temperature to 800 degrees C. Furthermore, the stability of PdCr thin film strain gauges are measured at 600 and 800 degrees C by drift test, which reveals that the average resistance drift rate of PdCr strain film with 48nm is almost ten times larger than that of the films with thickness of 933nm. The above results further verify that the PdCr film with thickness of 933nm possesses relatively superior electrical properties. Moreover, the strain response of PdCr thin film strain gauge with 933nm on DZ22 Ni-based superalloys is studied, which indicates that the values of resistance are synchronous response to the strain implying the PdCr thin film strain gauge has a fast response to strain, and the gauge factor is 1.80, 1.88, 1.90 and 1.93 at 25, 400, 600 and 800 degrees C, respectively.

关键词： Binary alloys

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Candidate lncRNA-microRNA-mRNA networks in predicting non-small cell lung cancer and related prognosis analysis

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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2020年第4期146卷 883-896页

作者： Li, Sixuan cui, Zhigang Zhao, Yuxin Ma, shuwen Sun, Yinghui Li, Hang Gao, Min Li, Na Wang, Ying Tong, Lianwei Song, Mingyang Yin, Zhihua China Med Univ Shenyang 110122 Peoples R China China Med Univ Sch Publ Hlth Dept Epidemiol Shenyang 110122 Peoples R China Univ Liaoning Prov Key Lab Canc Etiol & Intervent Shenyang North New Area 77 Puhe Rd Shenyang 110122 Peoples R China

Purpose The role of non-coding RNA, once thought to be dark matter, is increasingly prominent in cancer. Our article explores the effect of non-coding RNA in lung adenocarcinoma and lung squamous cell carcinoma by mining TCGA public database. Methods Download the data by applying the official TCGA software. The data were analyzed by R data analysis packages, 'edgeR', 'gplots' and 'survival'. We better illustrate the potential networks of lung cancer genes by constructing ceRNAs, using Cytoscape software. Results We obtained genes which were differentially expressed in lung adenocarcinoma and lung squamous cell carcinoma analysis. Within these differentially expressed genes, we also conducted a survival analysis to find differentially expressed genes associated with prognosis in both lung adenocarcinoma and lung squamous cell carcinoma. Based on genes differentially expressed of both lung adenocarcinoma and lung squamous cell carcinoma, we constructed a ceRNA network to illustrate the mechanism of lung adenocarcinoma and lung squamous cell carcinoma. Our study analyzed genes which were differentially expressed in lung adenocarcinoma and lung squamous cell carcinoma using the TCGA database. Conclusion Based on this, the prognosis in both lung squamous cell carcinoma and lung adenocarcinoma was analyzed. We have also constructed a ceRNA network to provide a basis for the study of ceRNA in lung adenocarcinoma and lung squamous cell carcinoma.

关键词： TCGA Non-coding RNA Lung cancer Prognosis ceRNA

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Study on the Application of Zeolitic Imidazolate Framework-8 Loaded With Artemisia Argyi Essential Oil in the Treatment of Bacterial Infected Wounds

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Journal of biomedical materials research. Part A 2025年第6期113卷 e37937页

作者： Yiyang Xu Ying Li Zixuan Ye Cheng Wang Pengfei cui shuwen Zhou Lin Qiu Jianhao Wang School of Pharmacy Changzhou University Changzhou China.

Wound bacterial infection deteriorates with antibiotic misuse, boosting bacterial drug resistance, threatening human health. Therefore, combining natural antibacterials with efficient broad-spectrum materials offers new solutions. Artemisia argyi is a kind of medicinal plant distributed in Asia, known for its rich biological active compounds. With the advancement of modern analytical technology, Artemisia argyi has shown excellent antibacterial and anti-inflammatory potential, particularly Artemisia argyi essential oil (AAEO) which is considered to be the most active substance in Artemisia argyi. However, its practical application is limited due to its poor water solubility, strong volatility, high sensitivity to light and heat, and its irritating odor. Zeolitic imidazolate framework-8 (ZIF-8) is a type of metal-organic framework material (MOF) with good biocompatibility, simple synthesis, high porosity, and antimicrobial activity. ZIF-8 can be used as an ideal vehicle for the preparation of antibacterial materials. In this study, we loaded AAEO onto ZIF-8 to successfully develop AAEO@ZIF-8 antibacterial nanomaterial. The bactericidal ability and antibacterial mechanism of AAEO@ZIF-8 were evaluated through in vitro experiments such as bacterial coating, Live/Dead staining, and crystal violet staining. It was confirmed that AAEO@ZIF-8 had significant antibacterial activity against both Staphylococcus aureus and Escherichia coli. In in vivo experiments, the wound model using C57BL/6 male mice was established, and wound tissue staining with Gram, CD31 immunohistochemistry, H&E, and Masson staining was performed to evaluate the antibacterial activity of AAEO@ZIF-8. The results showed that AAEO@ZIF-8 exhibited the best wound repair performance in the model. These findings suggested that AAEO@ZIF-8 is a novel and effective antimicrobial nanomaterial targeting pathogenic bacteria. This study successfully transformed the storage mode of AAEO from liquid to solid, providing

关键词： Staphylococcus aureus antibacterial artemisia argyi essential oil wound infection zeolitic imidazolate framework‐8

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Poor functional recovery is better predicted than conversion in studies of outcomes of clinical high risk of psychosis: insight from SHARP

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PSYCHOLOGICAL MEDICINE 2020年第9期50卷 1578-1584页

作者： Zhang, TianHong Yang, shuwen Xu, LiHua Tang, XiaoChen Wei, YanYan cui, HuiRu Li, HuiJun Tang, YingYing Hui, Li Li, ChunBo Chen, XingShi Wang, JiJun Shanghai Jiao Tong Univ Sch Med Shanghai Mental Hlth Ctr Shanghai Key Lab Psychot Disorders Shanghai 200030 Peoples R China Florida A&M Univ Dept Psychol Tallahassee FL 32307 USA Soochow Univ Affiliated Guangji Hosp Inst Mental Hlth Suzhou 215137 Jiangsu Peoples R China Minist Educ BioX Inst Key Lab Genet Dev & Neuropsychiat Disorders Shanghai Peoples R China Shanghai Jiao Tong Univ Brain Sci & Technol Res Ctr Shanghai Peoples R China

Background Few of the previous studies of clinical high risk of psychosis (CHR) have explored whether outcomes other than conversion, such as poor functioning or treatment responses, are better predicted when using risk calculators. To answer this question, we compared the predictive accuracy between the outcome of conversion and poor functioning by using the NAPLS-2 risk calculator. Methods Three hundred CHR individuals were identified using the Chinese version of the Structured Interview for Prodromal Symptoms. Of these, 228 (76.0%) completed neurocognitive assessments at baseline and 199 (66.3%) had at least a 1-year follow-up assessment. The latter group was used in the NAPLS-2 risk calculator. Results We divided the sample into two broad categories based on different outcome definitions, conversion (n= 46)***-conversion (n= 153) or recovery (n= 138)*** functioning (n= 61). Interestingly, the NAPLS-2 risk calculator showed moderate discrimination of subsequent conversion to psychosis in this sample with an area under the receiver operating characteristic curve (AUC) of 0.631 (p= 0.007). However, for discriminating poor functioning, the AUC of the model increased to 0.754 (p< 0.001). Conclusions Our results suggest that the current risk calculator was a better fit for predicting a poor functional outcome and treatment response than it was in the prediction of conversion to psychosis.

关键词： Follow-up prediction risk calculator transition ultra-high risk

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Observation on the Therapeutic Effects of Wenjing Decoction on Menstrual Disorders

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Journal of Clinical and Nursing Research 2020年第6期4卷 63-66页

作者： Diancui Zhang Junxia cui shuwen Gai Tongzhen Zhao Liqiang Wu Health Management Center Binzhou Municipal Hospital of Traditional Chinese MedicineBinzhou 256600Shandong ProvinceChina Department of Gastroenterology.Binzhou People's Hospital Binzhou 256600Shandong ProvinceChina Critical Care Medicine Laiyang City Hospital of Traditional Chinese MedicineYantai 256600Shandong ProvinceChina Department of Oncology Binzhouu Municipal Hospital of Traditional Chinese MedicineBinzhou 256600Shandong ProvinceChina Department of Emergency medicine Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

Objective:To treat patients with menstrual disorders with Wenjing Decoction and analyze its therapeutic ***:80 patients with menstrual disorders were selected as the research subjects,and they were divided into two groups(experimental group and control group),with each group given different treatment *** control group was given conventional Western medical treatment while the experimental group was given Wenjing Decoction treatment,and the effects of different treatment methods on the patients were ***:The total number of effectively treated patients in the experimental group(39 cases,97.50%)was more than the that of the control group(25 cases,62.50%)。and the quality of life score of the experimental group(91.56±4.44 points)was higher that of the control group(81.72±3.19 points),and the number of menstnual recovery cycles(1.11±0.41)was less than that of the control group patients(2.42±1.25 times),P<***:The application of Wenjing Decoction for patients with menstrual disorders can significantly improve the treatment efficacy and is beneficial to improve the quality of life of the patients and shorten the number of cycles that menstruation starts to return to normal.

关键词： Wenjing Decoction Menstnal Disorders Treatment Eficacy

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多轴机械臂3D打印的运动-挤料协同控制方法

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机械设计与研究 2021年第6期37卷 141-147,154页

作者：张帆肖述文涂一文崔坤腾武汉理工大学机电工程学院武汉430070

多轴机械臂3D打印能够拓展传统熔融沉积式三轴打印的空间自由度实现无支撑一体成型。但由于机械臂多关节运动与3D打印多参量的分离控制所导致的运动-挤料不同步,大大影响打印质量。针对多轴机械臂3D打印末端运动与挤料的协同性问题,提... 详细信息

多轴机械臂3D打印能够拓展传统熔融沉积式三轴打印的空间自由度实现无支撑一体成型。但由于机械臂多关节运动与3D打印多参量的分离控制所导致的运动-挤料不同步,大大影响打印质量。针对多轴机械臂3D打印末端运动与挤料的协同性问题,提出基于EtherCAT的协同控制方法。以EtherCAT实时工业以太网构建控制系统框架,满足多关节运动与多工艺执行机构的控制需求;基于此,提出量化的“运动-挤料”速度匹配关系与通讯反馈机制,确保运动与挤料的协同控制。通过对帧周期的检测、标准路径与无支撑模型的打印测试,结果表明,主从通讯周期可达500us.数据帧遍历各从站延时为25±10 us,能够满足机械臂3D打印控制精度要求,保证运动-挤料的协同控制。

关键词： 3D打印多轴机械臂 EtherCAT技术协同控制

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面向临床应用的抗菌肽:递送和剂型

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科学通报 2021年第26期66卷 3365-3366页

作者：周舒文王程邱琳崔朋飞蒋鹏举王建浩夏江常州大学药学院常州213164 香港中文大学化学系香港999077

抗菌肽作为传统抗生素的潜在替代物已经引起了人们的极大关注[1,2].虽然抗生素是人类对抗细菌感染的有效武器,但细菌种类的快速适应和抗生素的滥用导致了耐药菌株的出现和广泛传播.因此,迫切需要在机制上开发不同于现有抗生素的新抗菌方... 详细信息

抗菌肽作为传统抗生素的潜在替代物已经引起了人们的极大关注[1,2].虽然抗生素是人类对抗细菌感染的有效武器,但细菌种类的快速适应和抗生素的滥用导致了耐药菌株的出现和广泛传播.因此,迫切需要在机制上开发不同于现有抗生素的新抗菌方案.事实证明,抗菌肽有望替代抗生素成为一种理想的抗菌剂.除了具有显著的杀菌效果外,抗菌肽还能抑制生物膜的形成并破坏现有的生物膜[3].

关键词：替代抗生素抗菌肽细菌种类抗细菌感染生物膜耐药菌株传统抗生素剂型

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锥形端面对铝/钢连续驱动摩擦焊温度场的数值模拟研究

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材料导报 2022年第15期36卷 153-159页

作者：张昌青师文辰罗德春王树文刘晓崔国胜陈波阳张忠科辛舟芮执元兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 兰州理工大学材料科学与工程学院兰州730050 兰州理工大学机电工程学院兰州730050

接头结构设计是连续驱动摩擦焊的一项重要工艺措施,对改善界面产热功率的不均匀性和提升接头力学性能有显著作用。本工作在钢侧待焊端面设计5°、10°、15°、20°、25°的锥度角,利用ABAQUS进行有限元分析,采用耦... 详细信息

接头结构设计是连续驱动摩擦焊的一项重要工艺措施,对改善界面产热功率的不均匀性和提升接头力学性能有显著作用。本工作在钢侧待焊端面设计5°、10°、15°、20°、25°的锥度角,利用ABAQUS进行有限元分析,采用耦合的欧拉-拉格朗日方法,建立了焊接过程的三维热力耦合模型,分析了锥度大小对接头成型、温度场分布、塑性金属形成的变化规律,并开展焊接实验,验证了计算结果的准确性。结果表明:接头宏观形貌、轴向缩短量与实验结果吻合较好,计算温度与实测数据相对误差约为3.5%~4.8%,变化趋势相同;锥形结构使界面高温区域发生移动,5°与15°接头2/3 R处温度最高,25°接头1/3 R处温度最高,产热集中位置向界面中心移动,产热集中区域宽度变窄,塑性环的位置、宽度与计算的温度场具有较好的一致性。

关键词：连续驱动摩擦焊锥度接头耦合的欧拉-拉格朗日法数值模拟温度场

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Two Bariatric Surgical Procedures Differentially Alter the Intestinal Microbiota in Obesity Patients

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OBESITY SURGERY 2020年第6期30卷 2345-2361页

作者： Chen, Guolin Zhuang, Jingshen cui, Qianwen Jiang, shuwen Tao, Weihua Chen, Wanqun Yu, Shuqing Wu, Lina Yang, Wah Liu, Fucheng Yang, Jingge Wang, Cunchuan Jia, Shiqi Jinan Univ Affiliated Hosp 1 Huangpu Ave West 613 Guangzhou Guangdong Peoples R China Joint Inst Metab Med Jinan Univ & Univ Hong Kong Huangpu Ave West 613 Guangzhou Guangdong Peoples R China Jinan Univ Inst Obes & Metab Huangpu Ave West 613 Guangzhou Guangdong Peoples R China Jinan Univ Sch Basic Med Sci Dept Biochem & Mol Biol Guangzhou Peoples R China Jinan Univ Affiliated Hosp 1 Dept Cardiol Guangzhou Peoples R China Jinan Univ Inst Clin Med Huangpu Ave West 613 Guangzhou Guangdong Peoples R China

Aims To explore the intestinal microbiota composition affected by the two most widely used procedures of bariatric surgery, laparoscopic sleeve gastrectomy (LSG) and laparoscopic roux-en-Y gastric bypass (LRYGB), in Chinese obesity patients. Methods Stool samples were collected from the obese patients before (n = 87) and with follow-up after the surgery (n = 53). After DNA extraction, 16S rDNA (V3 + V4 regions) sequencing was completed on Illumina HiSeq 2500 sequencing platform. The samples were analyzed base on four groups, pre-LSG (n = 54), pre-LRYGB (n = 33), post-LSG (n = 33), and post-LRYGB (n = 20). The linear mixed models were used to analyze the alteration of intestinal microbiota before and after the surgeries of LSG or LRYGB. Student's t test and chi(2) test were used for analysis of independent groups;Metastats analysis was used to compare the relative abundance of bacteria, and Pearson correlation and Spearman correlation analysis were used to test the correlation between indicated groups. Results 87 patients were included and 53 (60.92%) of them completed the follow-up (9.60 +/- 3.92 months). Body mass index (BMI) decreased from 37.84 +/- 6.16 kg/m(2) to 26.22 +/- 4.33 kg/m(2) after LSG and from 45.75 +/- 14.26 kg/m(2) to 33.15 +/- 10.99 kg/m(2) after LRYGB. The relative abundance of 5 phyla and 42 genera were altered after the surgery in the cohort. Although no alteration of Firmicutes was observed at phylum level, 54.76% of the altered genera belong to phylum Firmicutes. Both LSG and LRYGB procedures increased the richness and evenness of intestinal microbiota in obese patients after the surgery. Particularly, 33 genera altered after LSG and 19 genera altered after LRYGB, in which 11 genera were common alterations in both procedures. Conclusion Both LSG and LRYGB altered the composition of intestinal microbiota in Chinese obesity patients, and particularly increased the richness and evenness of microbiota. Genera belonging to phylum Firmicutes were th

关键词： Obesity Bariatric surgery Intestinal microbiota

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Fabrication and characterization of nickel thin film as resistance temperature detector

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VACUUM 2020年 176卷 109288-109288页

作者： cui, Jinting Liu, Hao Li, Xingliang Jiang, shuwen Zhang, Bin Song, Ying Zhang, Wanli Univ Elect Sci & Technol China Sch Elect Sci & Engn State Key Lab Elect Thin Films & Integrated Devic Chengdu 610054 Peoples R China Beijing Precis Engn Inst Aircraft Ind Aviat Key Lab Sci & Technol Precis Mfg Beijing 100076 Peoples R China

In practical applications, thin film resistance temperature detectors (RTD) are often used in the environments that the attached substrates cannot stand high temperature. Therefore, it is necessary to prepare thin film RTDs by a low temperature process. In this study, the fabrication of nickel (Ni) thin film RTDs at low temperatures is investigated by direct-current (DC) magnetron sputtering. It is found that the dense and uniform Ni thin film can be prepared even at room temperature. The effects of sputter pressure and power on thin film microscopic morphology and structure are also investigated. The Ni thin film RTDs prepared at room temperature exhibit a value of temperature coefficient of resistance (TCR) about 3000 ppm/degrees C and excellent repeatability under cycling temperatures.

关键词： Ni film RTD Temperature sensor Room temperature preparation TCR value

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