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科学通报 2020年第34期65卷 3851-3852页

作者：洪婷婷邱琳周舒文崔朋飞王建浩蒋鹏举常州大学药学院常州213164

细菌感染对人类生命构成了严重的威胁,1929年青霉素的发现为人类的抗菌战役提供了强有力的武器[1,2].随后,科研工作者发现了一系列的抗菌药物.然而,长期大量使用抗生素引发的耐药性问题日益严重,亟需探索基于新型抗菌机制的治疗策略[3~... 详细信息

细菌感染对人类生命构成了严重的威胁,1929年青霉素的发现为人类的抗菌战役提供了强有力的武器[1,2].随后,科研工作者发现了一系列的抗菌药物.然而,长期大量使用抗生素引发的耐药性问题日益严重,亟需探索基于新型抗菌机制的治疗策略[3~6].因此,本研究团队与香港中文大学夏江团队和山东大学李永强团队合作提出了通过蛋白之间相互作用而达到抑制相关信号通路传导,最终抑制细菌感染的抗菌新方法,该抗菌机制主要是针对宿主细胞而不是致病菌的预防性抗菌治疗,在Proc Natl Acad Sci USA上发表了题为“Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction,a preventive antibacterial mechanism”的研究论文.

关键词： intestine 抗菌机制细菌感染蛋白间相互作用耐药性问题抗菌药物李永强团队合作

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AIE-active boron complexes based on benzothiazole-hydrazone chelates

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ORGANIC & BIOMOLECULAR CHEMISTRY 2018年第27期16卷 4977-4984页

作者： Duan, Wenzeng Liu, Qingsong Huo, Yanmin cui, Jichun Gong, shuwen Liu, Zhipeng Liaocheng Univ Sch Chem & Chem Engn Inst Funct Organ Mol & Mat 1 Hunan Rd Liaocheng 252000 Peoples R China Nanjing Tech Univ Nanjing Tech Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM Key Lab Flexible Elect KLOFE 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China Nanjing Tech Univ Nanjing Tech Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM IAM 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China

A new family of aggregation-induced emission (AIE)-active monoboron and bisboron complexes based on benzothiazole-hydrazone chelates was synthesized. These complexes showed very weak fluorescence in fluid solution due to active intramolecular rotation and were emissive in high-viscosity solvents or in the aggregation state. Single crystal X-ray diffraction analyses and theoretical calculations were carried out to explain AIE behavior. The large Stokes shifts (3590-7400 cm(-1)) and relatively highly efficient solid-state emission make these complexes valuable AIE luminophores for further potential applications.

关键词： Synthesis (chemical)

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General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19

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JOURNAL OF ORTHOPAEDIC TRANSLATION 2021年 31卷 1-9页

作者： Li, Wenlong Huang, Zeqing Tan, Biao Chen, Gang Li, Xugui Xiong, Kan Zhu, Ruizheng Li, Ruihan Li, shuwen Ye, Hengli Liang, Zhi Dong, Xiaojun Zhou, Shijing Chen, Song Xi, Haixiang Cheng, Hao Xu, Rongpeng Tu, Shenghao Chen, Zhe Qi, Lihua Song, Jiandong Xiao, Ruoran Liu, Huilan Nan, Qian Yu, Huiyong cui, Hongsheng Shen, Yanguang Wang, Chengxiang Lin, Na Zhang, Yanqiong Chen, Weiheng Beijing Univ Chinese Med Affiliated Hosp 3 51 Anwai Xiaoguanjie Beijing 100029 Peoples R China China Acad Chinese Med Sci Wangjing Hosp Beijing 100102 Peoples R China Hubei Coll Chinese Med Jingzhou 434020 Peoples R China Hubei Univ Chinese Med Wuhan 430065 Peoples R China Hubei 672 Orthopaed Hosp Integrated Chinese & Wes Wuhan 430079 Peoples R China Wuhan Jiangxia Dist Hosp Tradit Chinese Med Wuhan 430200 Peoples R China Guizhou Univ Tradit Chinese Med Guiyang 550025 Peoples R China Wuhan Hosp Tradit Chinese Med Wuhan 430014 Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Wuhan 430030 Peoples R China Hubei Prov Hosp Tradit Chinese Med Wuhan 430061 Peoples R China Hubei Integrated Tradit Chinese & Western Med Hos Wuhan 430015 Peoples R China China Acad Chinese Med Sci Inst Chinese Mat Med 16 Dongzhimen Nei Nanxiaojie Beijing 100700 Peoples R China

Background/objective: Coronavirus disease 2019 (COVID-19) is a disaster in human medical history and glucocorticoids remain the most promising therapy. Osteonecrosis is a disease caused by reduced intraosseous blood flow to bones in the joints, which will rapidly induce joint destruction. Approximately one-third patients with severe acute respiratory syndrome (SARS) who received high cumulative doses and long treatment durations of glucocorticoids occurred osteonecrosis. Considering the similarity of SARS and COVID-19 on their pathogen, clinical characteristics, and therapeutic strategies, it is particularly desirable to investigate whether osteonecrosis will become a common sequela among convalescent COVID-19 patients. Methods: This multi-strategy study was designed by integrating different research methods, such as meta-analysis, systematic review, and cross-sectional investigations to address above study objectives. At first, two meta-analyses were performed on the osteonecrosis incidence among SARS patients and the clinical data of glucocorticoid exposure among COVID-19 patients. Then, a systematic review of low-dosage glucocorticoid associated osteonecrosis and a cross-sectional investigation of glucocorticoid exposure of COVID-19 patients in Wuhan city of China were also conducted. Moreover, the pathogenesis, diagnosis, prevention, and treatment options for osteonecrosis patients with COVID-19 infection were further presented and discussed. Results: Our meta-analysis showed that 32% of SARS patients had developed osteonecrosis after receiving glucocorticoid treatment with high dose, and our system review supported that low level glucocorticoid exposure might also lead to the occurrence of osteonecrosis. Similarly, 40% of COVID-19 patients had undergone glucocorticoid treatment according to our meta-analysis. The cross-sectional investigation in Wuhan city of China found that the average of cumulative glucocorticoid exposure level was 504 mg calculated by the d

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome Glucocorticoids Osteonecrosis Disease prevention and control

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Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression

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Oncogene 2025年 2025 Jun 14页

作者： Jing Zhao Mengmeng cui Xiaojuan Yao Zhixiong Jiang Lixia Qi Jiaxing Chen Chunhui Fan shuwen Bai Chengying Zhou Rui Wei Hongliang Liu Qi Yang Lixin Wan Dengke Bao Laboratory of Cancer Biomarkers and Liquid Biopsy School of Pharmacy Henan University Kaifeng 475000 Henan China. The Zhongzhou Laboratory for Integrative Biology Henan University Zhengzhou Henan 450000 China. Henan Engineering Research Center for Molecular Diagnosis and Therapy of Esophageal Cancer Nanyang central Hospital Henan University Nanyang Henan 473000 China. State key Laboratory of Antiviral Drugs School of Pharmacy Henan University Kaifeng Henan 475000 China. First Affiliated Hospital of Henan University Kaifeng Henan 475000 China. Huaihe Hospital of Henan University Kaifeng Henan 475000 China. Laboratory of Cancer Biomarkers and Liquid Biopsy School of Pharmacy Henan University Kaifeng 475000 Henan China. yangqi_456@***. First Affiliated Hospital of Henan University Kaifeng Henan 475000 China. yangqi_456@***. Henan Engineering Research Center for Molecular Diagnosis and Therapy of Esophageal Cancer Nanyang central Hospital Henan University Nanyang Henan 473000 China. nanyang1967@***. Laboratory of Cancer Biomarkers and Liquid Biopsy School of Pharmacy Henan University Kaifeng 475000 Henan China. bdkmydy12004@***. The Zhongzhou Laboratory for Integrative Biology Henan University Zhengzhou Henan 450000 China. bdkmydy12004@***. Henan Engineering Research Center for Molecular Diagnosis and Therapy of Esophageal Cancer Nanyang central Hospital Henan University Nanyang Henan 473000 China. bdkmydy12004@***. State key Laboratory of Antiviral Drugs School of Pharmacy Henan University Kaifeng Henan 475000 China. bdkmydy12004@***. First Affiliated Hospital of Henan University Kaifeng Henan 475000 China. bdkmydy12004@***.

The infiltration of TAMs mediates an immunosuppressive tumor microenvironment, which plays a crucial role in the malignant progression of HCC. TFAM is a key molecule that regulates mtDNA replication and transcription, and its expression frequently downregulated in various tumors, including HCC. Our previous study indicated that the downregulation of TFAM triggers mtDNA stress, thereby inducing autophagy and promoting ESCC survival through the STING pathway. However, it remains unclear whether cytosolic mtDNA stress, mediated by TFAM downregulation, is implicated in microenvironment regulation, particularly in the infiltration of TAMs in HCC. In this study, we found that TFAM expression was significantly decreased and correlated with CD163 expression in HCC tissues. The downregulated expression of TFAM in HCC cells contributed to TAM infiltration. Mechanistically, the downregulation of TFAM induced cytosolic mtDNA stress, which activated the NLRP3 inflammasome and promoted the expression of IL-18 and IL-1β in HCC cells, thereby inducing macrophage recruitment and M2 polarization. Depleting cytosolic mtDNA using DNase I or blocking NLRP3 inflammasome activation with an NLRP3 antagonist in HCC cells with TFAM downregulation significantly suppresses the infiltration of M2-TAMs. Moreover, blocking the mtDNA-NLRP3 pathway significantly inhibited TAM infiltration and orthotopic mouse HCC model progression. Taken together, our results reveal a novel mechanism by which cytosolic mtDNA stress mediates TAM infiltration in HCC.

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High temperature static and dynamic strain response of PdCr thin film strain gauge prepared on Ni-based superalloy

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SENSORS AND ACTUATORS A-PHYSICAL 2019年 298卷

作者： Liu, Hao Mao, Xiling Yang, Zhengbing cui, Jinting Jiang, shuwen Zhang, Wanli Univ Elect Sci & Technol China State Key Lab Elect Thin Films & Integrated Devic Chengdu 611731 Sichuan Peoples R China Sichuan Gas Turbine Estab Aero Engine Corp China Chengdu 610500 Sichuan Peoples R China

Thin film resistance strain gauges are being developed to monitor the in-situ static and dynamic strain of engine blades in aerospace propulsion and power generation system. In this work, the palladium chromium thin film strain gauge, which consists of four layers: graded buffer layer, insulating layer, strain sensitive element and protective layer, is prepared on Ni-based superalloy by vacuum sputtering deposition technique. The static and dynamic strain responses are investigated from room temperature up to 800 degrees C. The results of static testing demonstrate that the resistance of the gauge exhibits a linear change dependent on strain and displays excellent repeatability. The gauge factor shows temperature dependence, which is calibrated to be 1.78, 1.94, 2.03 and 2.13 at 25, 400, 600 and 800 degrees C, respectively. For dynamic strain response, the resistance of palladium chromium thin film strain gauge varies periodically, which keeps the same frequency with the K465 test bar vibrates driven by the shaker system at the resonance frequency. The results indicate that PdCr thin film strain gauge has a fast response enough to monitor the dynamic strain change. Then, the dynamic strain can be derived from the dynamic variation of resistance of the thin film strain gauge up to 800 degrees C. Therefore, palladium chromium thin film strain gauge provides an effective approach for the measurement of in-situ static and dynamic strain of engine blades in aerospace propulsion. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Static and dynamic strain FFT analysis PdCr thin film Strain gauge High temperature

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Ultraviolet to near infrared titanium nitride broadband plasmonic absorber

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OPTICAL MATERIALS 2019年 97卷

作者： Gao, Huixuan Peng, Wei cui, Wenli Chu, shuwen Yu, Li Yang, Xiong Dalian Univ Technol Sch Phys Dalian 116024 Peoples R China

In this paper, we theoretically design and numerically verify a broadband plasmonic absorber that works continuously in ultraviolet to near-infrared region. Different from the traditional metal-insulator-metal (MIM) three-layer structure, our perfect absorber is based on insulator-metal-insulator-metal (IMIM) four-layer structure. This perfect absorber owns a 280 nm ultra-thin thickness, a configuration of refractory metal titanium nitride and high-melting-point insulator silica equips it with strong thermal stability. The novel titanium nitride ring-square array layer combines the absorption of different wavelength bands so that the absorber can achieves a continuous absorption of more than 90% from wavelength 200-1200 nm. Using Finite-difference time-domain (FDTD) method, we get a calculated average absorption rate as 94.85%, which includes a 99.40% maximum absorption at wavelength 270 nm and a 90.30% minimum absorption at 390 nm. In addition, this perfect absorber demonstrates polarization independence under normal incidence and large incident angle insensitivity under oblique incidence, which has significant application potentials in many areas such as solar energy collection, photothermal conversion, and invisibility cloak.

关键词： Broadband absorber Ultraviolet to near infrared Polarization independence Large incident angle insensitivity Plasmonic

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血小板聚集率联合同型半胱氨酸对脑出血保守治疗患者下肢静脉血栓形成的预测价值

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陕西医学杂志 2024年第12期53卷 1645-1648,1653页

作者：苏万强范经世张磊崔敬任焕欣李树文任祎贺亚伟肖春风佟建洲保定市第一中心医院神经外二科河北保定071023 保定市第一中心医院全科医疗三科河北保定071023 正定县中医院内科河北石家庄050800

目的:探讨血小板聚集率(PAgT)联合同型半胱氨酸(Hcy)对脑出血保守治疗患者下肢静脉血栓形成(VT)的预测价值。方法:纳入脑出血患者108例为研究组,另选取同期健康人群108例为对照组,比较两组PAgT和Hcy水平。根据是否发生VT,将研究组患者... 详细信息

目的:探讨血小板聚集率(PAgT)联合同型半胱氨酸(Hcy)对脑出血保守治疗患者下肢静脉血栓形成(VT)的预测价值。方法:纳入脑出血患者108例为研究组,另选取同期健康人群108例为对照组,比较两组PAgT和Hcy水平。根据是否发生VT,将研究组患者又分为VT组(35例)和非VT组(73例),比较两组临床资料。分析脑出血保守治疗患者下肢VT影响因素及PAgT、Hcy对下肢VT发生的预测价值。结果:研究组PAgT、Hcy水平高于对照组(均P<0.05)。VT组糖尿病史占比、高脂血症史占比以及PAgT、Hcy水平高于非VT组(均P<0.05)。糖尿病史、高脂血症史以及PAgT、Hcy水平是脑出血保守治疗患者发生下肢VT的危险因素(均P<0.05)。PAgT和Hcy水平对脑出血患者发生下肢VT具有一定预测价值,两项联合的预测价值更高(均P<0.05)。结论:脑出血患者保守治疗后PAgT、Hcy水平升高,对下肢VT发生具有较高的预测价值。

关键词：下肢静脉血栓形成脑出血血小板聚集率同型半胱氨酸危险因素预测价值

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Solvatochromism, acidochromism and aggregation-induced emission of propeller-shaped spiroborates

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DALTON TRANSACTIONS 2018年第42期47卷 15002-15008页

作者： Li, Kang cui, Jichun Yang, Zeren Huo, Yanmin Duan, Wenzeng Gong, shuwen Liu, Zhipeng Liaocheng Univ Inst Funct Organ Mol & Mat Sch Chem & Chem Engn 1 Hunan Rd Liaocheng 252000 Peoples R China Nanjing Tech Univ NanjingTech Key Lab Flexible Elect KLOFE 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China Nanjing Tech Univ NanjingTech IAM Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China

Propeller-shaped pyridyl-enolato-catecholate/-salicyl spiroborates (Sborepy1-6) were synthesized. The complexes Sborepy3-6 show weak emission in fluid solution and aggregation-induced emission enhancement in the aggregation state with large Stokes shifts of 4025-5237 cm(-1). Moreover, intense solid-state emissions with high phi(f) ranging from 25% to 37% were observed for Sborepy3-6 owing to the weak intermolecular interactions in their solid-state. The AIE and intense solid-state emission have been revealed via the X-ray diffraction analysis and theoretical calculations. Furthermore, the solvatochromism in the solution state and the potential application as a fluorescent acidic vapour sensor in the solid state of Sborepy3 and Sborepy6 were also demonstrated.

关键词： Propellers

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佛山市青少年口腔健康相关生活质量及影响因素分析

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中国学校卫生 2021年第4期42卷 560-564页

作者：苏淑文张建明邓瑞冰王伟萍崔添强苏育武李霞佛山科学技术学院附属口腔医院/佛山市口腔医院广东528225 佛山科学技术学院口腔医学院

目的调查佛山市12~15岁青少年口腔健康相关生活质量,并探索其影响因素,为青少年的口腔健康促进提供对策建议。方法采用多阶段分层等容量随机抽样的方式招募佛山市3840名12~15岁青少年,对青少年口腔健康进行横断面研究。采用口腔临床检... 详细信息

目的调查佛山市12~15岁青少年口腔健康相关生活质量,并探索其影响因素,为青少年的口腔健康促进提供对策建议。方法采用多阶段分层等容量随机抽样的方式招募佛山市3840名12~15岁青少年,对青少年口腔健康进行横断面研究。采用口腔临床检查和口腔健康问卷调查收集信息,并利用描述性分析、非参数检验和等级Logistic回归分析法对青少年口腔健康相关生活质量及相关影响因素进行分析。结果口腔问题对佛山地区青少年生活质量的中等至严重程度影响主要反映在进食方面(27.1%)。等级Logistic回归分析结果显示,低糖摄入频率、牙龈出血牙数较少,无过去12个月内牙疼及牙齿碰伤或摔伤史、居住地(南海、顺德)等因素与口腔健康相关生活质量呈正相关(OR=0.6~0.8,P值均<0.05)。结论佛山地区青少年口腔健康相关生活质量略优于全国总体平均水平。建议根据细分区域的综合情况精准制定实施口腔公共卫生措施,联合多方力量加强青少年人群饮食限糖,预防牙龈出血,及时缓解并治疗牙痛,重点关注有牙外伤史的青少年人群,并且改变青少年自身、家长和教师有关口腔检查的就医观念,帮助其养成定期进行口腔检查的习惯。

关键词：口腔卫生生活质量健康促进回归分析青少年

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Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli

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JOURNAL OF STRUCTURAL BIOLOGY 2019年第3期206卷 322-334页

作者： cui, Di Deng, Aihua Bai, Hua Yang, Zhao Liang, Yong Liu, Zhe Qiu, Qidi Wang, Laiyou Liu, shuwen Zhang, Yun Shi, Yi Qi, Jianxun Wen, Tingyi Chinese Acad Sci Inst Microbiol CAS Key Lab Pathogen Microbiol & Immunol Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Univ Chinese Acad Sci Savaid Med Sch Beijing 100049 Peoples R China

3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is responsible for the biosynthesis of essential aromatic compounds in microorganisms and plants. It plays a crucial role in the regulation of the carbon flow into the shikimate pathway. Until now, the crystal structures and regulatory mechanisms of dimeric DAHPS enzymes from type I alpha subclass have not been reported. Here, we reported dimeric structures of the tyrosine-regulated DAHPS from Escherichia call, both in its apo form and complex with the inhibitor tyrosine at 2.5 and 2.0 angstrom resolutions, respectively. DAHPS(Tyr) has a typical (beta/alpha)(8) TIM barrel, which is decorated with an N-terminal extension and an antiparallel beta sheet, beta 6a/beta 6b. Inhibitor tyrosine binds at a cavity formed by residues of helices alpha 3, alpha 4, strands beta 6a, beta 6b and the adjacent loops, and directly interacts with residues P148, Q152, S181, 1213 and N8*. Although the small angle X-ray scattering profiles from DAHPS(Tyr) with and without tyrosine shows that tyrosine binding leaves most of DAHPS(Tyr) structures unaffected. The comparison of the liganded and unliganded crystal structures reveals that conformational changes of residues P148, Q152 and 1213 initiate a transmission pathway to propagate the allosteric signal from the tyrosine-binding site to the active site, which is different from DAHPS(Phe), a phenylalanine-regulated isozyme from E. coli. In addition, mutations of five tyrosine-binding residues P148, Q152, S181, 1213 and N8* leads to tyrosine-resistant DAHPS(Tyr) enzymes. These findings provide a new insight into the regulatory mechanism of DAHPS enzymes and a basis for further engineering studies.

关键词： 3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) Escherichia coli Crystal structure Aromatic amino acid biosynthesis Feedback inhibition Allosteric regulation

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